Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice
Open accessAbstract
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly attributed to PJ ellagitannins (ETs). Our aim was to assess whether ETs or their metabolites ellagic acid and urolithins reach the human prostate upon consumption of ET-rich foods and to evaluate the effect on the expression of three proliferation biomarkers. Sixty-three patients with BPH or PCa were divided into controls and consumers of walnuts (35 g walnuts/day) or pomegranate (200 mL PJ/day) for 3 days before surgery. Independently of the ETs source, the main metabolite detected was urolithin A glucuronide, (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one glucuronide) (up to 2 ng/g) together with the traces of urolithin B glucuronide, (3-hydroxy-6H-dibenzo[b,d]pyran-6-one glucuronide) and dimethyl ellagic acid. The small number of prostates containing metabolites was likely caused by clearance of the compounds during the fasting. This was corroborated in a parallel rat study and thus the presence of higher quantities of metabolites at earlier time points cannot be discarded. No apparent changes in the expression of CDKN1A, MKi-67 or c-Myc were found after consumption of the walnuts or PJ. Our results suggest that urolithin glucuronides and dimethyl ellagic acid may be the molecules responsible for the beneficial effects of PJ against PCa.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The concentration of serum urolithins can reach up to micromolar levels without displaying toxicity in certain populations.
“The concentration of serum urolithins can reach up to micromolar levels without displaying toxicity in certain populations.132,134,138,144,145”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lost in Transcription: p21 Repression, Mechanisms, and Consequences
Gartel, A. L., & Radhakrishnan, S. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3995 · Cited by 819 · see citing works
Pantuck, A. J., Leppert, J. T., Zomorodian, N., Aronson, W. J., Hong, J., Barnard, R. J., Seeram, N. P., Liker, H. R., Wang, H., Elashoff, R. M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2290 · Cited by 463 · see citing works
Larrosa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.09.004 · Cited by 461 · see citing works
Self-citationCerdá, B., Tomás-Barberán, F. A., & Espı́n, J. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049144d · Cited by 448 · see citing works
Self-citationInternational epidemiology of prostate cancer: Geographical distribution and secular trends
Baade, P. D., Youlden, D. R., & Krnjacki, L. J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700511 · Cited by 446 · see citing works
Cerd�, B., Esp�n, J. C., Parra, S., Mart�nez, P., & Tom�s-Barber�n, F. A. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0461-7 · Cited by 435 · see citing works
Self-citationRole of Diet in Prostate Cancer Development and Progression
Chan, J. M., Gann, P. H., & Giovannucci, E. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.1492 · Cited by 413 · see citing works
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer
Malik, A., Afaq, F., Sarfaraz, S., Adhami, V. M., Syed, D. N., & Mukhtar, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505870102 · Cited by 401 · see citing works
Espín, J. C., González-Barrio, R., Cerdá, B., López-Bote, C., Rey, A. I., & Tomás-Barberán, F. A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0723864 · Cited by 352 · see citing works
Self-citationCerdá, B., Periago, P., Espín, J. C., & Tomás-Barberán, F. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050384i · Cited by 301 · see citing works
Self-citationSeeram, N. P., Aronson, W. J., Zhang, Y., Henning, S. M., Moro, A., Lee, R., Sartippour, M. R., Harris, D. M., Rettig, M. B., Suchard, M. A., et al. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071303g · Cited by 293 · see citing works
Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC–MSn
Mullen, W., Yokota, T., Lean, M. E. J., & Crozier, A. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00281-4 · Cited by 265 · see citing works
Larrosa, M., González‐Sarrías, A., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0527403 · Cited by 261 · see citing works
Self-citationKresty, L. A., Morse, M. A., Morgan, C., Carlton, P. S., Lu, J., Gupta, A. K., Blackwood, M., & Stoner, G. D. (2001) · PubMed · Cited by 249 · see citing works
Albrecht, M., Jiang, W. G., Kumi-Diaka, J. K., Lansky, E. S., Gommersall, L. M., Patel, A. N., Mansel, R. E., Neéman, I., Geldof, A. A., & Campbell, M. J. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.274 · Cited by 244 · see citing works
Myc confers androgen-independent prostate cancer cell growth
Bernard, D., Pourtier, A., Gil, J., & Beach, D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319035 · Cited by 223 · see citing works
González‐Sarrías, A., Espı́n, J. C., Tomás-Barberán, F. A., & García‐Conesa, M. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800150 · Cited by 158 · see citing works
Self-citationJemal, A., Ward, E., Wu, X., Martin, H. J., McLaughlin, C. C., & Thun, M. J. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0522 · Cited by 154 · see citing works
Pomegranate derived products for cancer chemoprevention
Syed, D. N., Afaq, F., & Mukhtar, H. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.05.004 · Cited by 144 · see citing works
Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis
Luo, J., Dunn, T. A., Ewing, C. M., Sauvageot, J., Chen, Y., Trent, J. M., & Isaacs, W. B. (2002) · The Prostate · doi:10.1002/pros.10087 · Cited by 138 · see citing works
Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo
Sartippour, M. R., Seeram, N. P., Rao, J. Y., Moro, A., Harris, D., Henning, S. M., Firouzi, A., Rettig, M. B., Aronson, W. J., Pantuck, A. J., et al. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.2.475 · Cited by 121 · see citing works
Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia
Zhong, W., Peng, J., Hui-chan, H., Wu, D., Han, Z., Bi, X., & Dai, Q.-S. (2008) · Clinical and investigative medicine · doi:10.25011/cim.v31i1.3136 · Cited by 104 · see citing works
The effect of walnut intake on factors related to prostate and vascular health in older men
Spaccarotella, K., Kris‐Etherton, P. M., Stone, W. L., Bagshaw, D. M., Fishell, V. K., West, S. G., Lawrence, F., & Hartman, T. J. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-13 · Cited by 93 · see citing works
Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer
Savinainen, K., Linja, M. J., Saramäki, O. R., Tammela, T. L. J., Chang, G. T. G., Brinkmann, A. O., & Visakorpi, T. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601648 · Cited by 84 · see citing works
Prostate cancer and vegetable consumption
Chan, R., Lok, K. Y. W., & Woo, J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800113 · Cited by 76 · see citing works
INTEGRATIVE BIOLOGY OF PROSTATE CANCER PROGRESSION
Tomlins, S. A., Rubin, M. A., & Chinnaiyan, A. M. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100047 · Cited by 65 · see citing works
Correlations of dietary patterns with prostate health
Stacewicz‐Sapuntzakis, M., Borthakur, G., Burns, J. L., & Bowen, P. E. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600296 · Cited by 63 · see citing works
Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype
Roy, S., Singh, R. P., Agarwal, C., Siriwardana, S., Sclafani, R. A., & Agarwal, R. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6024 · Cited by 53 · see citing works
Induction of Cell Cycle Arrest in Prostate Cancer Cells by the Dietary Compound Isoliquiritigenin
Lee, Y. M., Lim, D. Y., Choi, H. J., Jung, J. I., Chung, W., & Park, J. H. Y. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0039 · Cited by 53 · see citing works
Prevention of Hormone-Related Cancers: Prostate Cancer
Parnes, H. L., Thompson, I. M., & Ford, L. G. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.08.027 · Cited by 49 · see citing works
Apoptosis-related gene expression in benign prostatic hyperplasia and prostate carcinoma.
Iacopino, F., Angelucci, C., Lama, G., Zelano, G., Torre, G. L., D’Addessi, A., Giovannini, C., Bertaccini, A., Pavone‐Macaluso, M., Martorana, G., et al. (2006) · PubMed · Cited by 33 · see citing works
Nagy, B., Szendrői, A., & Romics, I. (2008) · Pathology & Oncology Research · doi:10.1007/s12253-008-9077-1 · Cited by 33 · see citing works
Rigaud, J., Tiguert, R., Decobert, M., Hovington, H., Latulippe, É., Laverdière, J., LaRue, H., Lacombe, L., & Fradet, Y. (2003) · The Prostate · doi:10.1002/pros.10329 · Cited by 31 · see citing works
Royuela, M., Arenas, M. I., de Bethencourt, F. R., Sánchez‐Chapado, M., Fraile, B., & Paniagua, R. (2001) · PubMed · Cited by 30 · see citing works
Nikoleishvili, D., Pertia, A., Trsintsadze, O., Gogokhia, N., Managadze, L., & Chkhotua, A. B. (2008) · International Urology and Nephrology · doi:10.1007/s11255-008-9350-y · Cited by 26 · see citing works
Quantitative real-time RT-PCR of CD24 mRNA in the detection of prostate cancer
Schostak, M., Krause, H., Miller, K., Schrader, M., Weikert, S., Christoph, F., Kempkensteffen, C., & Köllermann, J. W. (2006) · BMC Urology · doi:10.1186/1471-2490-6-7 · Cited by 23 · see citing works
Molecular markers in the diagnosis of prostate cancer
van der Poel, H. G. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.07.003 · Cited by 23 · see citing works
Lack of Effect of Walnuts on Serum Levels of Prostate Specific Antigen: A Brief Report
Simon, J. A., Tanzman, J. S., & Sabaté, J. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719617 · Cited by 13 · see citing works
Angelucci, C., Iacopino, F., Lama, G., Zelano, G., Gianesini, G., Sica, G., & Bono, A. V. (2005) · PubMed · Cited by 10 · see citing works
Faulks (2000) · doi:10.1002/(sici)1097-0010(20000515)80:7
Flagged first, then by citations
Research works printed but not linked: 1
- Clifford, M. N.; Scalbert, A., Elagitannins-nature, occurrence and dietary burden, J. Sci. Food Agric. 2000, 80, 118-25.
Cited by
Sorted by citations
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4132 · Cited by 1,105 · see citing works
The strawberry: Composition, nutritional quality, and impact on human health
Giampieri, F., Tulipani, S., Álvarez-Suárez, J. M., Quiles, J. L., Mezzetti, B., & Battino, M. A. (2011) · Nutrition · doi:10.1016/j.nut.2011.08.009 · Cited by 1,051 · see citing works
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
Landete, J. M. (2011) · Food Research International · doi:10.1016/j.foodres.2011.04.027 · Cited by 733 · see citing works
Espín, J. C., Larrosa, M., García-Conesa, M. T., & Tomás-Barberán, F. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/270418 · Cited by 576 · see citing works
Self-citationKawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563 · see citing works
Tomás‐Barberán, F. A., González‐Sarrías, A., García‐Villalba, R., Núñez‐Sánchez, M. A., Selma, M. V., García‐Conesa, M. T., & Espín, J. C. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500901 · Cited by 465 · see citing works
Self-citationTomás-Barberán, F. A., García-Villalba, R., González-Sarrías, A., Selma, M. V., & Espín, J. C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5024615 · Cited by 419 · see citing works
Self-citationEllagitannins, ellagic acid and vascular health
Larrosa, M., García‐Conesa, M., Espı́n, J. C., & Tomás-Barberán, F. A. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.005 · Cited by 378 · see citing works
Self-citationÇatalkaya, G., Venema, K., Lucini, L., Rocchetti, G., Delmas, D., Daglia, M., Filippis, A. D., Xiao, H., Quiles, J. L., Xiao, J., et al. (2020) · Food Frontiers · doi:10.1002/fft2.25 · Cited by 339 · see citing works
Selma, M. V., Beltrán, D., García-Villalba, R., Espín, J. C., & Tomás-Barberán, F. A. (2014) · Food Funct. · doi:10.1039/c4fo00092g · Cited by 304 · see citing works
Self-citationEllagic acid: Pharmacological activities and molecular mechanisms involved in liver protection
García‐Niño, W. R., & Zazueta, C. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.04.008 · Cited by 279 · see citing works
Pomegranate as a Functional Food and Nutraceutical Source
Johanningsmeier, S. D., & Harris, G. K. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030810-153709 · Cited by 270 · see citing works
Pomegranate for Prevention and Treatment of Cancer: An Update
Sharma, P., McClees, S. F., & Afaq, F. (2017) · Molecules · doi:10.3390/molecules22010177 · Cited by 257 · see citing works
Antioxidants: Positive or Negative Actors?
Salehi, B., Martorell, M., Arbiser, J. L., Sureda, A., Martins, N. A., Maurya, P. K., Sharifi‐Rad, M., Kumar, P., & Sharifi‐Rad, J. (2018) · Biomolecules · doi:10.3390/biom8040124 · Cited by 259 · see citing works
Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
Ceci, C., Lacal, P. M., Tentori, L., Martino, M. G. D., Miano, R., & Graziani, G. (2018) · Nutrients · doi:10.3390/nu10111756 · Cited by 254 · see citing works
The chemistry of gut microbial metabolism of polyphenols
Stevens, J. F., & Maier, C. S. (2016) · Phytochemistry Reviews · doi:10.1007/s11101-016-9459-z · Cited by 244 · see citing works
Núñez‐Sánchez, M. Á., Garcı́a-Villalba, R., Monedero‐Saiz, T., Espin, N. V. G.-T., Gómez‐Sánchez, M. B., Sánchez‐Álvarez, C., García‐Albert, A. M., Rodríguez‐Gil, F. J., Ruiz‐Marín, M., Pastor-Quirante, F. A., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300931 · Cited by 235 · see citing works
Self-citationSelma, M. V., Beltrán, D., Luna, M. C., Romo‐Vaquero, M., Garcı́a-Villalba, R., Mira, Á., Espı́n, J. C., & Tomás-Barberán, F. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01521 · Cited by 212 · see citing works
Self-citationRecent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review
Evtyugin, D. D., Magina, S. P., & Evtuguin, D. V. (2020) · Molecules · doi:10.3390/molecules25122745 · Cited by 211 · see citing works
Cortés‐Martín, A., Garcı́a-Villalba, R., González‐Sarrías, A., Romo‐Vaquero, M., Loria‐Kohen, V., de Molina, A. R., Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2018) · Food & Function · doi:10.1039/c8fo00956b · Cited by 205 · see citing works
Self-citationBioactivation of Phytoestrogens: Intestinal Bacteria and Health
Landete, J. M., Arqués, J. L., Médina, M., Gaya, P., Rivas, B. D. L., & Múñoz, R. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.789823 · Cited by 204 · see citing works
Chang, S. K., Alasalvar, C., Bolling, B. W., & Shahidi, F. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.06.029 · Cited by 199 · see citing works
Antiglycative and neuroprotective activity of colon‐derived polyphenol catabolites
Verzelloni, E., Pellacani, C., Tagliazucchi, D., Tagliaferri, S., Calani, L., Costa, L. G., Brighenti, F., Borges, G., Crozier, A., Conte, A., et al. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000525 · Cited by 190 · see citing works
Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy
Turrini, E., Ferruzzi, L., & Fimognari, C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/938475 · Cited by 188 · see citing works
Marín, M., Giner, R. M., Rı́os, J.-L., & Recio, M. C. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.09.030 · Cited by 180 · see citing works
Preventive and Prophylactic Mechanisms of Action of Pomegranate Bioactive Constituents
Viladomiu, M., Hontecillas, R., Lu, P., & Bassaganya-Riera, J. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/789764 · Cited by 177 · see citing works
El‐Saadony, M. T., Yang, T., Saad, A. M., Alkafaas, S. S., Elkafas, S. S., Eldeeb, G. S. S., Mohammed, D. M., Salem, H. M., Korma, S. A., Loutfy, S. A., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134223 · Cited by 174 · see citing works
González‐Barrio, R., Truchado, P., Ito, H., Espı́n, J. C., & Tomás-Barberán, F. A. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103894m · Cited by 171 · see citing works
Self-citationGiménez‐Bastida, J. A., González‐Sarrías, A., Larrosa, M., Tomás-Barberán, F. A., Espı́n, J. C., & García‐Conesa, M. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100677 · Cited by 166 · see citing works
Self-citationSelma, M. V., González‐Sarrías, A., Salas‐Salvadó, J., Andrés‐Lacueva, C., Alasalvar, C., Örem, A., Tomás-Barberán, F. A., & Espı́n, J. C. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.03.012 · Cited by 168 · see citing works
Self-citationHealth benefits of walnut polyphenols: An exploration beyond their lipid profile
Sánchez‐González, C., Ciudad, C. J., Noé, V., & Izquierdo-Pulido, M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1126218 · Cited by 160 · see citing works
Pomegranate Peel as a Source of Bioactive Compounds: A Mini Review on Their Physiological Functions
Mo, Y., Ma, J., Gao, W., Zhang, L., Li, J., Li, J., & Zang, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.887113 · Cited by 157 · see citing works
Zhang, M., Cui, S., Mao, B., Zhang, Q., Zhao, J., Zhang, H., Tang, X., & Chen, W. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2036693 · Cited by 160 · see citing works
Pomegranate: a fruit that ameliorates metabolic syndrome
Medjakovic, S., & Jungbauer, A. (2012) · Food & Function · doi:10.1039/c2fo30034f · Cited by 148 · see citing works
Possible use of Punica granatum (Pomegranate) in cancer therapy
Khwairakpam, A. D., Bordoloi, D., Thakur, K. K., Monisha, J., Arfuso, F., Sethi, G., Mishra, S., Kumar, A. P., & Kunnumakkara, A. B. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.04.021 · Cited by 148 · see citing works
Garcia-Muñoz, C., & Vaillant, F. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.644643 · Cited by 133 · see citing works
Garcı́a-Villalba, R., Espı́n, J. C., & Tomás-Barberán, F. A. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.08.044 · Cited by 132 · see citing works
Self-citationPhase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells
González‐Sarrías, A., Giménez‐Bastida, J. A., Núñez‐Sánchez, M. Á., Larrosa, M., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0589-4 · Cited by 132 · see citing works
Self-citationSaha, P., Yeoh, B. S., Singh, R., Chandrasekar, B., Vemula, P. K., Haribabu, B., Vijay‐Kumar, M., & Jala, V. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156811 · Cited by 121 · see citing works
Heilman, J. M., Andreux, P. A., Tran, N. L., Rinsch, C., & Blanco-Bose, W. E. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.07.050 · Cited by 122 · see citing works
Prebiotic nut compounds and human microbiota
Lamuel-Raventos, R. M., & St‐Onge, M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1096763 · Cited by 121 · see citing works
González‐Sarrías, A., Tomé‐Carneiro, J., Bellesia, A., Tomás-Barberán, F. A., & Espı́n, J. C. (2015) · Food & Function · doi:10.1039/c5fo00120j · Cited by 119 · see citing works
Self-citationGarcı́a-Villalba, R., Vissenaekens, H., Pitart, J., Romo‐Vaquero, M., Espı́n, J. C., Grootaert, C., Selma, M. V., Raes, K., Smagghe, G. J., Possemiers, S., et al. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02049 · Cited by 119 · see citing works
Self-citationMetabolites of the Ellagitannin Geraniin and Their Antioxidant Activities
Ito, H. (2011) · Planta Medica · doi:10.1055/s-0030-1270749 · Cited by 114 · see citing works
Piwowarski, J. P., Granica, S., Zwierzyńska, M., Stefańska, J., Schopohl, P., Melzig, M. F., & Kiss, A. K. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.06.032 · Cited by 107 · see citing works
Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
Al‐Harbi, S. A., Abdulrahman, A. O., Zamzami, M. A., & Khan, M. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.647582 · Cited by 104 · see citing works
Pomegranate Extracts and Cancer Prevention: Molecular and Cellular Activities
Syed, D. N., Chamcheu, J. C., Adhami, V. M., & Mukhtar, H. (2013) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520611313080003 · Cited by 107 · see citing works
Tulipani, S., Llorach, R., Jáuregui, O., López-Uriarte, P. J., Garcia‐Aloy, M., Bulló, M., Salas‐Salvadó, J., & Andrés‐Lacueva, C. (2011) · Journal of Proteome Research · doi:10.1021/pr200514h · Cited by 103 · see citing works
González‐Sarrías, A., Miguel, V., Merino, G., Lucas, R., Morales, J. C., Tomás-Barberán, F. A., Álvarez, A. I., & Espı́n, J. C. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4007505 · Cited by 101 · see citing works
Self-citationTherapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials
Eghbali, S., Askari, S. F., Avan, R., & Sahebkar, A. (2021) · Journal of Nutrition and Metabolism · doi:10.1155/2021/5297162 · Cited by 101 · see citing works
Mechanisms of gut bacterial metabolism of dietary polyphenols into bioactive compounds
Alqudah, S., & Claesen, J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2426614 · Cited by 100 · see citing works
Truchado, P., Larrosa, M., García‐Conesa, M., Cerdá, B., Vidal-Guevara, M. L., Tomás-Barberán, F. A., & Espı́n, J. C. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203641r · Cited by 98 · see citing works
Self-citationLi, Y., Zhuang, Q., Tao, L., Zheng, K., Chen, S., Yang, Y., Feng, C., Wang, Z., Shi, H., Shi, J., et al. (2022) · Cell Proliferation · doi:10.1111/cpr.13291 · Cited by 96 · see citing works
Luteolin, ellagic acid and punicic acid are natural products that inhibit prostate cancer metastasis
Wang, L., Li, W., Lin, M., Garcia, M., Mulholland, D. J., Lilly, M. B., & Martins‐Green, M. M. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu145 · Cited by 93 · see citing works
Scott, M. B., Styring, A., & McCullagh, J. (2022) · Pathogens · doi:10.3390/pathogens11070770 · Cited by 94 · see citing works
Giménez‐Bastida, J. A., Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.06.014 · Cited by 91 · see citing works
Self-citationRanjha, M. M. A. N., Shafique, B., Wang, L., Irfan, S., Safdar, M. N., Murtaza, M. A., Nadeem, M., Mahmood, S., Mueen‐ud‐Din, G., & Nadeem, H. R. (2021) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-021-00566-7 · Cited by 95 · see citing works
Zhang, X., Sandhu, A. K., Edirisinghe, I., & Burton‐Freeman, B. M. (2017) · Food & Function · doi:10.1039/c7fo00893g · Cited by 89 · see citing works
Ghosh, S., Singh, R., Vanwinkle, Z. M., Guo, H., Vemula, P. K., Goel, A., Haribabu, B., & Jala, V. R. (2022) · Theranostics · doi:10.7150/thno.70754 · Cited by 86 · see citing works
Biomarkers of food intake for nuts and vegetable oils: an extensive literature search
Garcia‐Aloy, M., Hulshof, P. J. M., Estruel‐Amades, S., Osté, M. C. J., Lankinen, M. A., Geleijnse, J. M., de Goede, J., Ulaszewska, M., Mattivi, F., Bakker, S. J. L., et al. (2019) · Genes & Nutrition · doi:10.1186/s12263-019-0628-8 · Cited by 82 · see citing works
Garcı́a-Villalba, R., Tomás-Barberán, F. A., Iglesias‐Aguirre, C. E., Giménez‐Bastida, J. A., González‐Sarrías, A., Selma, M. V., & Espı́n, J. C. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101109 · Cited by 84 · see citing works
Self-citationGonzález‐Sarrías, A., Núñez‐Sánchez, M. Á., Tomé‐Carneiro, J., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500780 · Cited by 84 · see citing works
Self-citationmuthukumaran, S., Tranchant, C. C., Shi, J., Ye, X., & Xue, S. J. (2017) · Food Quality and Safety · doi:10.1093/fqsafe/fyx023 · Cited by 85 · see citing works
Freedland, S. J., Carducci, M., Kroeger, N., Partin, A. W., Rao, J.-Y., Jin, Y., Kerkoutian, S., Wu, H., Li, Y., Creel, P. A., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0423 · Cited by 83 · see citing works
Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults
Sandhu, A. K., Miller, M. G., Thangthaeng, N., Scott, T. M., Shukitt‐Hale, B., Edirisinghe, I., & Burton‐Freeman, B. M. (2017) · Food & Function · doi:10.1039/c7fo01843f · Cited by 80 · see citing works
Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals
Haddad, E. H., Gaban‐Chong, N., Oda, K., & Sabaté, J. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-4 · Cited by 80 · see citing works
Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice
Gu, J., Thomas‐Ahner, J. M., Riedl, K. M., Bailey, M. T., Vodovotz, Y., Schwartz, S. J., & Clinton, S. K. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800636 · Cited by 80 · see citing works
Giménez‐Bastida, J. A., González‐Sarrías, A., Laparra, J. M., Schneider, C. G., & Espı́n, J. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157937 · Cited by 79 · see citing works
Self-citationDe Camargo, A. C., Schwember, A. R., Parada, R., Garcia, S., Maróstica Júnior, M. R., Franchin, M., Regitano-d’Arce, M. A. B., & Shahidi, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113498 · Cited by 75 · see citing works
Wong, T. L., Strandberg, K. R., Croley, C. R., Fraser, S., Venkata, K. C. N., Fimognari, C., Sethi, G., & Bishayee, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.01.006 · Cited by 74 · see citing works
Giménez‐Bastida, J. A., Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111260 · Cited by 73 · see citing works
Self-citationGasmi, J., & Sanderson, J. T. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103306k · Cited by 75 · see citing works
Spilmont, M., Léotoing, L., Davicco, M.-J., Lebecque, P., Miot-Noirault, É., Pilet, P., Rios, L. Y., Wittrant, Y., & Coxam, V. (2015) · Nutrients · doi:10.3390/nu7115465 · Cited by 72 · see citing works
González‐Sarrías, A., Núñez‐Sánchez, M. Á., Garcı́a-Villalba, R., Tomás-Barberán, F. A., & Espı́n, J. C. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1131-7 · Cited by 72 · see citing works
Self-citationTulipani, S., Urpí-Sardà, M., Garcı́a-Villalba, R., Rabassa, M., López-Uriarte, P. J., Bulló, M., Jáuregui, O., Tomás-Barberán, F. A., Salas‐Salvadó, J., Espı́n, J. C., et al. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301509w · Cited by 71 · see citing works
Self-citationAntiatherogenic effects of ellagic acid and urolithins in vitro
Mele, L., Mena, P. R., Piemontese, A., Marino, V., López-Gutiérrez, N., Bernini, F., Brighenti, F., Zanotti, I., & Rio, D. D. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.02.017 · Cited by 70 · see citing works
Natural Products to Fight Cancer: A Focus on Juglans regia
Catanzaro, E., Greco, G., Potenza, L., Calcabrini, C., & Fimognari, C. (2018) · Toxins · doi:10.3390/toxins10110469 · Cited by 68 · see citing works
Sánchez‐González, C., Ciudad, C. J., Noé, V., & Izquierdo-Pulido, M. (2014) · Food & Function · doi:10.1039/c4fo00542b · Cited by 66 · see citing works
Bobowska, A., Granica, S., Filipek, A., Melzig, M. F., Moeslinger, T., Zentek, J., Kruk, A., & Piwowarski, J. P. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02386-y · Cited by 65 · see citing works
Piwowarski, J. P., Stanisławska, I. J., Granica, S., Stefańska, J., & Kiss, A. K. (2017) · Drug Metabolism and Disposition · doi:10.1124/dmd.117.075200 · Cited by 65 · see citing works
Yisimayili, Z., & Chao, Z. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133600 · Cited by 64 · see citing works
Zhang, W., Chen, J., Aguilera‐Barrantes, I., Shiau, C., Sheng, X., Wang, L., Stoner, G. D., & Huang, Y. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600048 · Cited by 64 · see citing works
Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation
Ávila-Gálvez, M. A., Giménez‐Bastida, J. A., González‐Sarrías, A., & Espı́n, J. C. (2019) · Food & Function · doi:10.1039/c9fo00298g · Cited by 63 · see citing works
Self-citationDifferences in Metabolism of Ellagitannins by Human Gut Microbiota ex Vivo Cultures
Piwowarski, J. P., Granica, S., Stefańska, J., & Kiss, A. K. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00602 · Cited by 62 · see citing works
Chaves, F. M., Pavan, I. C. B., da Silva, L. G. S., Freitas, L., Rostagno, M. A., Antunes, A. E. C., Bezerra, R. M. N., & Simabuco, F. M. (2019) · Plant Foods for Human Nutrition · doi:10.1007/s11130-019-00776-0 · Cited by 59 · see citing works
An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate
Benedetti, G., Zabini, F., Tagliavento, L., Meneguzzo, F., Calderone, V., & Testai, L. (2023) · Antioxidants · doi:10.3390/antiox12071351 · Cited by 58 · see citing works
Urolithin A causes p21 up-regulation in prostate cancer cells
Sánchez‐González, C., Ciudad, C. J., Izquierdo-Pulido, M., & Noé, V. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0924-z · Cited by 58 · see citing works
Hasheminezhad, S. H., Boozari, M., Iranshahi, M., Yazarlu, O., Sahebkar, A., Hasanpour, M., & Iranshahy, M. (2021) · Phytotherapy Research · doi:10.1002/ptr.7290 · Cited by 57 · see citing works
Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03100 · Cited by 55 · see citing works
Self-citationMetabolomics reveals diet-derived plant polyphenols accumulate in physiological bone
Alldritt, I., Whitham-Agut, B., Sipin, M., Studholme, J., Trentacoste, A., Tripp, J. A., Cappai, M. G., Ditchfield, P. W., Devièse, T., Hedges, R. E. M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44390-1 · Cited by 55 · see citing works
Chen, P., Guo, Z., Chen, F., Wu, Y., & Zhou, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.917266 · Cited by 54 · see citing works
Bioactivation of High-Molecular-Weight Polyphenols by the Gut Microbiome
Mena, P. R., Calani, L., Bruni, R., & Rio, D. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407825-3.00006-x · Cited by 50 · see citing works
Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet
Abdulrahman, A. O., Kuerban, A., Alshehri, Z. A., Abdulaal, W. H., Khan, J. A., & Khan, M. I. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s268146 · Cited by 50 · see citing works
Metabolism of Oak Leaf Ellagitannins and Urolithin Production in Beef Cattle
González‐Barrio, R., Truchado, P., Garcı́a-Villalba, R., Hervás, G., Frutos, P., Espı́n, J. C., & Tomás-Barberán, F. A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300718k · Cited by 49 · see citing works
Self-citationA Walnut-Enriched Diet Reduces the Growth of LNCaP Human Prostate Cancer Xenografts in Nude Mice
Reiter, R. J., Tan, D., Manchester, L. C., Korkmaz, A., Fuentes‐Broto, L., Hardman, W. E., Rosales‐Corral, S., & Qi, W. (2013) · Cancer Investigation · doi:10.3109/07357907.2013.800095 · Cited by 49 · see citing works
Liberal, J. M. T., do Carmo, A., Gomes, C. M. F., Cruz, M. T., & Batista, M. T. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0483-7 · Cited by 49 · see citing works
Pilot Walnut Intervention Study of Urolithin Bioavailability in Human Volunteers
Pfundstein, B., Haubner, R., Würtele, G., Gehres, N., Ulrich, C. M., & Owen, R. W. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5040652 · Cited by 47 · see citing works
AlMatar, M., Islam, M. R., Albarri, O., Var, İ., & Köksal, F. (2017) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557517666170419114722 · Cited by 46 · see citing works
- Authors
- González‐Sarrías, A., Giménez‐Bastida, J. A., García‐Conesa, M. T., Gómez‐Sánchez, M. B., García‐Talavera, N. V., Gil‐Izquierdo, A., Sánchez‐Álvarez, C., Fontana‐Compiano, L. O., Morga‐Egea, J. P., Pastor‐Quirante, F. A., Martínez‐Díaz, F., Tomás‐Barberán, F. A., & Espín, J. C.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Hospital Reina Sofía de Murcia (ES)
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 54
- Issue
- 3
- Pages
- 311-322
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2130994151
- Cited by
- 212
- References
- 40
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 16 · 2020: 16 · 2019: 12 · 2018: 16 · 2017: 17 · 2016: 14 · 2015: 15 · 2014: 11 · 2013: 16 · 2012: 7
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Hispana (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Funders
- Ministerio de Ciencia e Innovación (CSD2007-00063)
- Consejo Superior de Investigaciones Científicas (CSD2007-00063)
- Instituto de Salud Carlos III (CSD2007-00063)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Keywords
- urolithins, ellagitannins, ellagic acid, gut microbiota metabolites, pomegranate juice, Juglans regia, prostate cancer prevention, benign prostatic hyperplasia, cell proliferation markers, p21, Ki-67, c-Myc, dietary bioactive compounds
- MeSH terms
- Aged, Animals, Beverages, Coumarins, Ellagic Acid, Fruit, Humans, Intestines, Male, Middle Aged, Nuclear Proteins, Plant Extracts, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms, RNA, Messenger, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Rats, Sprague-Dawley, Glucuronides, Lythraceae, Juglans, Hydrolyzable Tannins, Intracellular Signaling Peptides and Proteins, Cyclin-Dependent Kinase Inhibitor p21, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review