The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Resveratrol bioavailability and toxicity in humans
Abstract
Numerous data are now available on the beneficial properties of the polyphenolic compound resveratrol including its anti‐inflammatory and antitumor effects. However, few studies have been performed with resveratrol in humans, and the results of these studies appear fragmentary and sometimes contradictory due to variations in conditions of administration, protocols and methods of assessment. This review article presents the results of recent studies investigating the pharmacokinetics, bioavailability, and toxicity of resveratrol in humans. Resveratrol is well absorbed, rapidly metabolized, mainly into sulfo and glucuronides conjugates which are eliminated in urine. Resveratrol seems to be well tolerated and no marked toxicity was reported. These data are important in the context of human efficacy studies, and they provide further support for the use of resveratrol as a pharmacological drug in human medicine.
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Cites
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Potential Adverse Effects of Resveratrol: A Literature Review
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Antibacterial and antifungal properties of resveratrol
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Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1
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Pilot study of resveratrol in older adults with impaired glucose tolerance
Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., & Barzilai, N. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr235 · Cited by 281
Resveratrol as an active ingredient for cosmetic and dermatological applications: a review
Ratz-Łyko, A., & Arct, J. (2019) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764172.2018.1469767 · Cited by 216
Subedi, L., Lee, T. H., Wahedi, H. M., Baek, S.-H., & Kim, S. Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8379539 · Cited by 174
The Role of Inflammation in Colon Cancer
Janakiram, N. B., & Rao, C. V. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-0348-0837-8_2 · Cited by 151
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Growth inhibitory effect of grape phenolics against wine spoilage yeasts and acetic acid bacteria
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The synergistic antifungal activity of resveratrol with azoles against Candida albicans
Wang, J., Zhang, X., Gao, L., Wang, L., Song, F., Zhang, L., & Wan, Y. (2021) · Letters in Applied Microbiology · doi:10.1111/lam.13458 · Cited by 29
Resveratrol: A Promising Antiaging Agent for Cosmetic Skin Treatments
Fidalgo, J., Novo Barros, A., & Casas, A. (2024) · Resveratrol - Recent Advances, Application, and Therapeutic Potential · doi:10.5772/intechopen.107860 · Cited by 3
Metadata
- Authors
- Cottart, C., Nivet‐Antoine, V., Laguillier‐Morizot, C., & Beaudeux, J.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 54
- Issue
- 1
- Pages
- 7-16
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2094292815
- Cited by
- 592
- References
- 4
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- closed
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