Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: A transcriptomic approach to disease prevention

Azorín-Ortuño, María; Yáñez-Gascón, María J.; González-Sarrías, Antonio; Larrosa, Mar; Vallejo, Fernando; Pallarés, Francisco J.; Lucas, Ricardo; Morales, Juan C.; Tomás-Barberán, Francisco A.; García-Conesa, María-Teresa; Espín, Juan C.

doi:10.1016/j.jnutbio.2011.04.007

Cited by 49Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesNutrition, Genetics, and Disease

Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: A transcriptomic approach to disease prevention

Azorín-Ortuño, María, Yáñez-Gascón, María J., González-Sarrías, Antonio, Larrosa, Mar, Vallejo, Fernando, Pallarés, Francisco J., Lucas, Ricardo, Morales, Juan C. +3 more·2012·The Journal of Nutritional Biochemistry

DOI 10.1016/j.jnutbio.2011.04.007

Open this paper in CoChat — free account

Abstract

Metabolic and cardiovascular diseases (CVDs) have risen to alarming proportions, and there is a need for therapeutic and preventive measures. The polyphenol resveratrol (RES) protects against CVDs, but in vivo molecular mechanisms responsible for protection are not yet understood. Peripheral blood mononuclear cells (PBMNCs) are involved in the development of atherosclerosis and metabolic disorders. The identification of PBMNCs genes responding to dietary compounds might help to understand the mechanisms underlying the effects of polyphenols. We determined gene expression differences between PBMNCs from pigs fed a high-fat diet manifesting a mild increase of cholesterol and pigs fed a high-fat diet containing low doses of RES. Although the consumption of RES did not modify the levels of cholesterol, microarray analyses indicated that some of the differentially expressed genes, collagens (COL1A, COL3A), lipoprotein lipase (LPL) and fatty-acid binding proteins (FABPs) involved in CVDs and lipid metabolism were up-regulated by the high-fat diet and down-regulated by RES. Reverse transcriptase polymerase chain reaction confirmed that RES and RES-containing grape extract prevented the induction of FABP4 in PBMNCs in female pigs fed a high-fat diet. Low micromolar concentrations of RES and its metabolite dihydroresveratrol exerted a minor but significant reducing effect on the induction of FABP4 expression in human macrophages treated with oxidized low-density lipoprotein. Our results show that the consumption of low doses of RES modulates the expression of genes related to lipid metabolism and metabolic disorders that are affected by a high-fat diet and suggest that some of the circulating RES metabolites may contribute to these effects.

Integrity signals

Registry

Crossref · 10.1016/j.jnutbio.2011.04.007

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Daily administration of resveratrol at 0.11 mg/kg body weight for 12 months significantly downregulated lipoprotein lipase mRNA in PBMC of pigs.
“Consistent with this, another study reported significant downregulation of lipoprotein lipase mRNA in peripheral blood mononuclear cells (PBMC) of pigs after daily administration of resveratrol at a dose of 0.11 mg/kg of body weight for 12 months [19].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [19]

The effect of obesity on health outcomes
Dixon, J. B. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.008 · Cited by 797 · see citing works
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
Furuhashi, M., Tuncman, G., Görgün, C. Z., Makowski, L., Atsumi, G., Vaillancourt, E., Kono, K., Babaev, V. R., Fazio, S., Linton, M. F., et al. (2007) · Nature · doi:10.1038/nature05844 · Cited by 724 · see citing works
Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis
Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2364 · Cited by 691 · see citing works
Resveratrol bioavailability and toxicity in humans
Cottart, C., Nivet‐Antoine, V., Laguillier, C., & Beaudeux, J. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900437 · Cited by 592 · see citing works
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works
Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol
Stivala, L. A., Savio, M., Carafoli, F., Perucca, P., Bianchi, L. C., Maga, G., Forti, L., PAGNONI, U. M., Albini, A., Prosperi, E., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101846200 · Cited by 492 · see citing works
On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles
Kendziorski, C. M., Newton, M. A., Lan, H., & Gould, M. N. (2003) · Statistics in Medicine · doi:10.1002/sim.1548 · Cited by 370 · see citing works
Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model
Larrosa, M., Yañéz-Gascón, M. J., Selma, M. V., González-Sarrías, A., Toti, S., Cerón, J. J., Tomás-Barberán, F., Dolara, P., & Espín, J. C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803638d · Cited by 365 · see citing works
Self-citation
Resveratrol, obesity and diabetes
Szkudelska, K., & Szkudelski, T. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.02.054 · Cited by 342 · see citing works
Diabetes-Induced Accelerated Atherosclerosis in Swine
Gerrity, R. G., Natarajan, R. D., Nadler, J. L., & Kimsey, T. F. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1654 · Cited by 270 · see citing works
[Obesity and diabetes].
Aria Vallejo, E. (2000) · PubMed · Cited by 253 · see citing works
Biogenesis and function of fibrillin assemblies
Ramirez, F., & Sakai, L. Y. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0822-x · Cited by 216 · see citing works
Green Tea (–)-Epigallocatechin-3-Gallate Reduces Body Weight with Regulation of Multiple Genes Expression in Adipose Tissue of Diet-Induced Obese Mice
Lee, M.-S., Kim, C., & Kim, Y. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000214834 · Cited by 215 · see citing works
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
Smith, J. J., Kenney, R. D., Gagne, D. J., Frushour, B. P., Ladd, W., Galonek, H. L., Israelian, K., Song, J. J., Razvadauskaite, G., Lynch, A. V., et al. (2009) · BMC Systems Biology · doi:10.1186/1752-0509-3-31 · Cited by 210 · see citing works
Resveratrol (Trans-3,5,4′-trihydroxystilbene) Induces Silent Mating Type Information Regulation-1 and Down-Regulates Nuclear Transcription Factor-κB Activation to Abrogate Dextran Sulfate Sodium-Induced Colitis
Singh, U. P., Singh, N. P., Singh, B., Hofseth, L. J., Price, R. L., Nagarkatti, M., & Nagarkatti, P. S. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.160838 · Cited by 206 · see citing works
Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites
Hoshino, J., Park, E., Kondratyuk, T. P., Marler, L., Pezzuto, J. M., van Breemen, R. B., Mo, S., Li, Y., & Cushman, M. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100274c · Cited by 202 · see citing works
Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic β‐cell dysfunction in streptozotocin‐nicotinamide‐induced diabetic rats
Periyasamy, P., & Subramanian, S. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22138 · Cited by 199 · see citing works
Polyphenols and Aging
Queen, B., & Tollefsbol, T. O. (2010) · Current Aging Science · doi:10.2174/1874609811003010034 · Cited by 178 · see citing works
Pleiotropic mechanisms facilitated by resveratrol and its metabolites
Calamini, B., Ratia, K. M., Malkowski, M. G., Cuendet, M., Pezzuto, J. M., Santarsiero, B. D., & Mesecar, A. D. (2010) · Biochemical Journal · doi:10.1042/bj20091857 · Cited by 176 · see citing works
Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet
Ahn, J., Cho, I., Kim, S., Kwon, D., & Ha, T. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.08.012 · Cited by 173 · see citing works
Postharvest Induction Modeling Method Using UV Irradiation Pulses for Obtaining Resveratrol-Enriched Table Grapes: A New “Functional” Fruit?
Cantos‐Villar, E., Espı́n, J. C., & Tomás-Barberán, F. A. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010366a · Cited by 170 · see citing works
Self-citation
Sexually dimorphic gene expression in the heart of mice and men
Isensee, J., Witt, H., Pregla, R., Hetzer, R., Regitz‐Zagrosek, V., & Ruíz, P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0240-z · Cited by 149 · see citing works
Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets
Rocha, K. K. R., Souza, G. A., Ebaid, G., Seiva, F. R. F., Cataneo, A. C., & Novelli, E. L. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.03.010 · Cited by 144 · see citing works
Metabolic diseases and associated complications: sex and gender matter
Kautzky‐Willer, A., & Handisurya, A. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02161.x · Cited by 138 · see citing works
Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells
Tribolo, S., Lodi, F., Connor, C., Suri, S., Wilson, V. G., Taylor, M. A., Needs, P. W., Kroon, P. A., & Hughes, D. A. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.07.040 · Cited by 131 · see citing works
Resveratrol and cardiovascular health
Das, M., & Das, D. K. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.001 · Cited by 121 · see citing works
Annotation of the Affymetrix1 porcine genome microarray
Tsai, S. Q., Cassady, J. P., Freking, B. A., Nonneman, D., Rohrer, G. A., & Piedrahita, J. A. (2006) · Animal Genetics · doi:10.1111/j.1365-2052.2006.01460.x · Cited by 114 · see citing works
Cardiac extracellular matrix remodeling: Fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC)
McCurdy, S. M., Baicu, C. F., Heymans, S. R. B., & Bradshaw, A. D. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.06.018 · Cited by 112 · see citing works
Catechin reduces atherosclerotic lesion development in apo E-deficient mice: A transcriptomic study
Auclair, S., Milenković, D., Besson, C., Chauvet, S., Gueux, E., Morand, C., Mazur, A., & Scalbert, A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.007 · Cited by 106 · see citing works
Resveratrol and liver disease: from bench to bedside and community
Bishayee, A., Darvesh, A. S., Politis, T., & McGory, R. W. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02295.x · Cited by 104 · see citing works
Expression of Follistatin-Related Genes Is Altered in Heart Failure
Lara‐Pezzi, E., Felkin, L. E., Birks, E. J., Sarathchandra, P., Panse, K. D., George, R. S., Hall, J. L., Yacoub, M. H., Rosenthal, N. A., & Barton, P. J. R. (2008) · Endocrinology · doi:10.1210/en.2008-0151 · Cited by 93 · see citing works
In Vitro Biomarker Discovery for Atherosclerosis by Proteomics
Fach, E. M., Garulacan, L. A., Gao, J., Xiao, Q., Storm, S. M., Dubaquié, Y., Hefta, S. A., & Opiteck, G. J. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400160-mcp200 · Cited by 92 · see citing works
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart
Barger, J. L., Kayo, T., Pugh, T. D., Prolla, T. A., & Weindruch, R. H. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.013 · Cited by 89 · see citing works
Lipoprotein lipase and atherosclerosis
Stein, Y. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00014-5 · Cited by 83 · see citing works
Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: An exploratory nutrigenomics study
Khymenets, O., Fitó, M., Covas, M.-I., Farré, M., Pujadas, M.-A., Muñoz, D., Konstantinidou, V., & Torre, R. D. L. (2009) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2008.0079 · Cited by 68 · see citing works
Transcriptome architecture across tissues in the pig
Ferraz, A. A., Ojeda, A., López‐Béjar, M., Fernandes, L. T., Castelló, A., Folch, J. M., & Miguel Pérez-enciso, A. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-173 · Cited by 61 · see citing works
A concise synthesis of glucuronide metabolites of urolithin-B, resveratrol, and hydroxytyrosol
Lucas, R., Alcántara, D., & Morales, J. C. (2009) · Carbohydrate Research · doi:10.1016/j.carres.2009.05.016 · Cited by 60 · see citing works
Self-citation
Proteoglycan mediated lipoprotein retention: A mechanism of diabetic atherosclerosis
Tannock, L. R., & King, V. L. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9078-0 · Cited by 57 · see citing works
Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects
Ma, J., Dempsey, A. A., Stamatiou, D., Marshall, K. W., & Liew, C. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.032 · Cited by 55 · see citing works
High‐Fat High‐Energy Feeding Impairs Fasting Glucose and Increases Fasting Insulin Levels in the Göttingen Minipig
Larsen, M. O., Rolin, B. C., WILKEN, M., Carr, R. D., & Svendsen, O. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04297.x · Cited by 52 · see citing works
Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome
Robich, M. P., Chu, L. M., Chaudray, M., Nezafat, R., Han, Y., Clements, R., Laham, R. J., Manning, W. J., Coady, M. A., & Sellke, F. W. (2010) · Surgery · doi:10.1016/j.surg.2010.04.013 · Cited by 46 · see citing works
Pharmacokinetic Study of trans-Resveratrol in Adult Pigs
Azorín‐Ortuño, M., Yáñez-Gascón, M. J., Pallarés, F. J., Vallejo, F., Larrosa, M., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102799m · Cited by 42 · see citing works
Self-citation
Upregulation of collagens detected by gene array in a model of flow-induced pulmonary vascular remodeling
Medhora, M. M., Bousamra, M., Zhu, D., Somberg, L. B., & Jacobs, E. R. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2001 · Cited by 41 · see citing works
Determination of Dihydroresveratrol in Rat Plasma by HPLC
Juan, M. E., Alfaras, I., & Planas, J. M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100836j · Cited by 37 · see citing works
DNA microarrays to define and search for genes associated with obesity
Kim, Y., & Park, T. (2009) · Biotechnology Journal · doi:10.1002/biot.200900228 · Cited by 36 · see citing works
Regulatory role of Sirt1 on the gene expression of fatty acid‐binding protein 3 in cultured porcine adipocytes
Shan, T., Ren, Y., Wu, T., Liu, C. X., & Wang, Y. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22203 · Cited by 24 · see citing works
Effects of vitamin E on serum enzymes and electrolytes in hypercholesterolemia
Prasad, K. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0243-x · Cited by 15 · see citing works
Initial studies of the cytoplasmic FABP superfamily
Teruo, O. N. O., & Odani, S. (2010) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.86.220 · Cited by 14 · see citing works
Evaluation of canine γ‐crystallin C (CRYGC) with hereditary cataracts in Entlebucher mountain dogs
Müller, C., Wöhlke, A., & Distl, O. (2006) · Animal Genetics · doi:10.1111/j.1365-2052.2006.01469.x · Cited by 11 · see citing works

Flagged first, then by citations

Sorted by citations

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence
Tomé‐Carneiro, J., Larrosa, M., González‐Sarrías, A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990407 · Cited by 451 · see citing works
Self-citation
Resveratrol: French Paradox Revisited
Catalgol, B., Batirel, S., Taga, Y., & Ozer, N. K. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00141 · Cited by 449 · see citing works
A review study of (bio)sensor systems based on conducting polymers
Ateş, M. (2013) · Materials Science and Engineering C · doi:10.1016/j.msec.2013.01.035 · Cited by 432 · see citing works
One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease
Tomé‐Carneiro, J., Larrosa, M., Yáñez-Gascón, M. J., Dávalos, A., Gil‐Zamorano, J., Gonzálvez, M., García‐Almagro, F. J., Ros, J. A. R., Tomás-Barberán, F. A., Espı́n, J. C., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.03.011 · Cited by 378 · see citing works
Self-citation
Buckwheat as a Functional Food and Its Effects on Health
Giménez‐Bastida, J. A., & Zieliński, H. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02498 · Cited by 306 · see citing works
The pharmacology of resveratrol in animals and humans
Park, E.-J., & Pezzuto, J. M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.014 · Cited by 302 · see citing works
Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis
Potì, F., Santi, D., Spaggiari, G., Zimetti, F., & Zanotti, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020351 · Cited by 256 · see citing works
Resveratrol, Metabolic Syndrome, and Gut Microbiota
Chaplin, A. M. L., Carpéné, C., & Mercader, J. (2018) · Nutrients · doi:10.3390/nu10111651 · Cited by 248 · see citing works
Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease
Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6427-8 · Cited by 241 · see citing works
Self-citation
Resveratrol: Anti-Obesity Mechanisms of Action
Aguirre, L., Fernández-Quintela, A., Arias, N., & Portillo, M. (2014) · Molecules · doi:10.3390/molecules191118632 · Cited by 205 · see citing works
Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: Systematic review and meta-analysis
Zhu, X., Wu, C., Qiu, S., Yuan, X., & Li, L. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0217-z · Cited by 196 · see citing works
Nutritional and bioactive characteristics of buckwheat, and its potential for developing gluten‐free products: An updated overview
Sofi, S. A., Ahmed, N., Farooq, A., Rafiq, S., Zargar, S. M., Kamran, F., Dar, T. A., Mir, S. A., Dar, B. N., & Khaneghah, A. M. (2022) · Food Science & Nutrition · doi:10.1002/fsn3.3166 · Cited by 179 · see citing works
Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolism
Zanotti, I., Dall’Asta, M., Mena, P. R., Mele, L., Bruni, R., Ray, S., & Rio, D. D. (2014) · Food & Function · doi:10.1039/c4fo00670d · Cited by 158 · see citing works
Inhibition of Quorum Sensing (QS) in Yersinia enterocolitica by an Orange Extract Rich in Glycosylated Flavanones
Truchado, P., Giménez‐Bastida, J. A., Larrosa, M., Castro-Ibáñez, I., Espı́n, J. C., Tomás-Barberán, F. A., García‐Conesa, M., & Allende, A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301365a · Cited by 153 · see citing works
Self-citation
Recent Advances in Natural Polyphenol Research
Dini, I., & Grumetto, L. (2022) · Molecules · doi:10.3390/molecules27248777 · Cited by 144 · see citing works
Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective
Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12150 · Cited by 88 · see citing works
Self-citation
Resveratrol and cardiovascular health – Promising therapeutic or hopeless illusion?
Tang, P. C., Ng, Y.-F., Ho, S., Gyda, M., & Chan, S. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.08.001 · Cited by 87 · see citing works
The Role of Resveratrol Administration in Human Obesity
Mongioì, L. M., La Vignera, S., Cannarella, R., Cimino, L., Compagnone, M., Condorelli, R. A., & Calogero, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094362 · Cited by 71 · see citing works
Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters
Giménez‐Bastida, J. A., Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900629 · Cited by 68 · see citing works
Self-citation
Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health‐Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action
Navarro, G., Martínez‐Pinilla, E., Ortiz, R., Noé, V., Ciudad, C. J., & Franco, R. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12359 · Cited by 63 · see citing works
Physiological Relevance of the Antiproliferative and Estrogenic Effects of Dietary Polyphenol Aglycones versus Their Phase-II Metabolites on Breast Cancer Cells: A Call of Caution
Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03100 · Cited by 55 · see citing works
Self-citation
The Influence of Polyphenols on Atherosclerosis Development
Ziółkiewicz, A., Kasprzak‐Drozd, K., Rusinek, R., Markut–Miotła, E., & Oniszczuk, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087146 · Cited by 45 · see citing works
Plant polyphenols in the treatment of age‐associated diseases: Revealing the pleiotropic effects of icariin by network analysis
Schluesener, J. K., & Schluesener, H. J. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300409 · Cited by 39 · see citing works
Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
Zhou, Q., Wang, Y., Han, X., Fu, S., Zhu, C., & Chen, Q. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.795980 · Cited by 37 · see citing works
An update on the role of nutrigenomic modulations in mediating the cardiovascular protective effect of fruit polyphenols
Krga, I., Milenković, D., Morand, C., & Monfoulet, L. (2016) · Food & Function · doi:10.1039/c6fo00596a · Cited by 36 · see citing works
Evidence for the Analgesic Activity of Resveratrol in Acute Models of Nociception in Mice
Bazzo, K. O., Souto, A. A., Lopes, T. G., Zanin, R. F., Gomez, M. V., de Souza, A. H., & Campos, M. M. (2012) · Journal of Natural Products · doi:10.1021/np300529x · Cited by 29 · see citing works
Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa
O’Croinin, C., Garcia Guerra, A., Doschak, M. R., Löbenberg, R., & Davies, N. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071941 · Cited by 25 · see citing works
A Dietary Resveratrol-Rich Grape Extract Prevents the Developing of Atherosclerotic Lesions in the Aorta of Pigs Fed an Atherogenic Diet
Azorín‐Ortuño, M., Yáñez-Gascón, M. J., Pallarés, F. J., Rivera, J., González‐Sarrías, A., Larrosa, M., Vallejo, F., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301154q · Cited by 24 · see citing works
Self-citation
Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes
Kühn, G., Pallauf, K., Schulz, C., Birringer, M., Diaz-Rica, B., de Pascual‐Teresa, S., & Rimbach, G. H. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00106 · Cited by 21 · see citing works
Resveratrol Functionalized Carboxymethyl-β-Cyclodextrin: Synthesis, Characterization, and Photostability
Cheng, J. G., Tian, B., Huang, Q., Ge, H. R., & Wang, Z. Z. (2018) · Journal of Chemistry · doi:10.1155/2018/6789076 · Cited by 19 · see citing works
A high-fat diet increases body fat mass and up-regulates expression of genes related to adipogenesis and inflammation in a genetically lean pig
Yang, X., Qiu, Y.-Q., Wang, L., Gao, K., & Jiang, Z. (2018) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1700507 · Cited by 19 · see citing works
Brain in situ hybridization maps as a source for reverse-engineering transcriptional regulatory networks: Alzheimer's disease insights
Acquaah-Mensah, G. K., & Taylor, R. C. (2016) · Gene · doi:10.1016/j.gene.2016.03.045 · Cited by 19 · see citing works
Natural Products from Mediterranean Diet: From Anti-hyperlipidemic Agents to Dietary Epigenetic Modulators
Deligiannidou, G.-E., Athina, S., Berghe, W. V., Christos, K., & Constantinides, T. K. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1573407215666190628150921 · Cited by 17 · see citing works
Effect of diets supplemented with linseed alone or combined with vitamin E and selenium or with plant extracts, on Longissimus thoracis transcriptome in growing-finishing Italian Large White pigs
Sirri, R., Vitali, M., Zambonelli, P., Giannini, G., Zappaterra, M., Fiego, D. P. L., Sami, D., & Davoli, R. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0297-2 · Cited by 16 · see citing works
Targeting microbiota-host interactions with resveratrol on cancer: Effects and potential mechanisms of action
Wang, P., Shang, R., Ma, Y., Wang, D., Zhao, W., Chen, F., Hu, X., & Zhao, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2106180 · Cited by 15 · see citing works
Enhanced brain delivery and antiproliferative activity of resveratrol using milk-derived exosomes
Ávila‐Gálvez, M. Á., Garay-Mayol, B., Giménez‐Bastida, J. A., Hazas, M. L. D. L., Mazarío‐Gárgoles, C., Brito, M. A., Dávalos, A., Espı́n, J. C., & González‐Sarrías, A. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101370 · Cited by 15 · see citing works
Self-citation
Prevention of Type 2 Diabetes by Polyphenols of Fruits
Rupasinghe, H. P. V., Balasuriya, N., & Wang, Y. (2017) · Springer eBooks · doi:10.1007/978-3-319-67625-8_17 · Cited by 15 · see citing works
Functional analysis finds differences on the muscle transcriptome of pigs fed an n-3 PUFA-enriched diet with or without antioxidant supplementations
Vitali, M., Sirri, R., Zappaterra, M., Zambonelli, P., Giannini, G., Fiego, D. P. L., & Davoli, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212449 · Cited by 12 · see citing works
Potential mechanisms and therapeutic effect of dietary resveratrol supplementation on the spleen organ of chicken in chronic unpredictable mild stress transcriptomic analysis
Laghari, F., Chang, Q., Zhang, H., Zhang, J., Pan, L., Pu, Z., Bao, J., & Zhang, R. (2025) · Poultry Science · doi:10.1016/j.psj.2025.104940 · Cited by 10 · see citing works
Resveratrol treatment improves plasma and blood glucose concentration and lipid metabolism in high-fat-fed C57BL/6J mice
Yu, Y., Zhang, N., Jiang, H., Xue, W., Guo, X., Xu, X., Fang, W., Wang, H., & Hua, E. (2016) · European Food Research and Technology · doi:10.1007/s00217-016-2684-2 · Cited by 10 · see citing works
Etiology of atherosclerosis informs choice of animal models and tissues for initial functional genomic studies of resveratrol
Huminiecki, Ł., Atanasov, A. G., & Horbańczuk, J. O. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104598 · Cited by 9 · see citing works
A molecular insight into the lipid changes of pig Longissimus thoracis muscle following dietary supplementation with functional ingredients
Rocchetti, G., Vitali, M., Zappaterra, M., Righetti, L., Sirri, R., Lucini, L., Dall’Asta, C., Davoli, R., & Galaverna, G. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264953 · Cited by 9 · see citing works
Effect of Knotweed in Diet on Physiological Changes in Pig
Maděra, P., Kovařová, M., Frantík, T., Filipčík, R., Novák, J., Vencl, Š., Maděrová, L., Rozkot, M., Kuchařová, S., Václavková, E., et al. (2021) · Agriculture · doi:10.3390/agriculture11020169 · Cited by 4 · see citing works
Key toxicological targets identification for atherosclerosis induced by environmental hazardous substance nicotine exposure and its antagonists screening from active components of Dendrobium officinale
Li, H. T., Zhang, Y., Wang, Q., Li, L., Zheng, G., Zheng, R., Wang, T., Yang, X., Shi, Z., Yang, F., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140799 · Cited by 1 · see citing works
The Complex Interplay between Botanical Supplements and the Human Gut Microbiome
Ponte, A. T., Liu, A., Acquah, K. S., & Balunas, M. J. (2026) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5c01493 · Cited by 1 · see citing works
Nutrigenômica/nutrigenética na elucidação das doenças crônicas
Valente, M. A. S., Barbosa, M. C. D. A., Velloso‐Rodrigues, C., Vieira, P. A. F., & Barbosa, M. D. O. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1 · see citing works
Resveratrol affects the lipid profile but not antioxidant enzymes gene expression in rats fed hypercholesterolaemic diet
Kopeć, A., Piątkowska, E., & Leszczyńska, T. (2013) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/66004/2013
Integrated Transcriptomic and Microbiota Analysis Reveals Gut Barrier-Digestion Trade-Offs Under Optimized Feeding Strategies in Marine-Cultured Nibea CoiborPreprint
Qu, Z., Li, R., Zhou, J., Min, Q., Yi, X., Zhuang, Z., Yuan, B., Ba, X., Zhao, N., & Zhang, B. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5265380
Integrated Transcriptomic and Microbiota Analyses Reveal Intestinal Remodeling Driven by Feeding Strategies in Nibea CoiborPreprint
Qu, Z., Li, R., Zhou, J., Min, Q., Yi, X., Zhuang, Z., Yuan, B., Ba, X., Zhao, N., & Zhang, B. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5272596

Distinct metabolic effects of resveratrol on lipogenesis markers in mice adipose tissue treated with high-polyunsaturated fat and high-protein diets
Mendes, K. L., de PINHO, L., Andrade, J. M. O., Paraíso, A. F., Lula, J. F., de Macêdo, S. M., Feltenberger, J. D., Guimarães, A. L. S., de Paula, A. M. B., & Santos, S. H. S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.04.014 · Cited by 24 · see citing works
Does exercise have a favorable effect on blood lipids and HDL-cholesterol in young turkish males?
Hergenç, G., & Ozsullu, T. T. (2001) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(01)80168-9
Resveratrol Protects Rabbits Against Cholesterol Diet-Induced\nHyperlipidaemia
Tanko, Y., Jimoh, A., Ahmed, A., Mohammed, A., & Ayo, J. O. (2016) · Bioline International (Bioline International)
Resveratrol Protects Rabbits Against Cholesterol Diet-Induced Hyperlipidaemia.
Tanko, Y., Jimoh, A., Ahmed, A., Mohammed, A., & Ayo, J. (2016) · Nigerian Journal of Physiological Sciences · Cited by 11 · see citing works
Long-term dietary resveratrol supplementation decreased serum lipids levels, improved intramuscular fat content, and changed the expression of several lipid metabolism-related miRNAs and genes in growing-finishing pigs1
Zhang, H. Z., Chen, D. W., He, J., Zheng, P., Yu, J., Mao, X., Huang, Z., Luo, Y., Luo, J., & Yu, B. (2019) · Journal of Animal Science · doi:10.1093/jas/skz057 · Cited by 46 · see citing works

Authors: Azorín-Ortuño, M., Yáñez-Gascón, M. J., González-Sarrías, A., Larrosa, M., Vallejo, F., Pallarés, F. J., Lucas, R., Morales, J. C., Tomás-Barberán, F. A., García-Conesa, M.-T., & Espín, J. C.
Affiliations: Centro de Edafología y Biología Aplicada del Segura (ES)
Universidad de Murcia (ES)
Consejo Superior de Investigaciones Científicas (ES)
ORCID: Larrosa, Mar
Vallejo, Fernando
Pallarés, Francisco J.
Lucas, Ricardo
Morales, Juan C.
Tomás-Barberán, Francisco A.
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2012-07
Volume: 23
Issue: 7
Pages: 829-837
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/j.jnutbio.2011.04.007
OpenAlex: W2082454497
Cited by: 49
References: 49
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 5
FWCI: 2.67
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: resveratrol, hypercholesterolemia, high-fat diet, peripheral blood mononuclear cells, FABP4, fatty acid binding protein, lipoprotein lipase, collagen genes, lipid metabolism, cardiovascular disease prevention, oxidized LDL, macrophages, grape extract, polyphenols, pigs
MeSH terms: Resveratrol, Animals, Cholesterol, Dietary Fats, Dose-Response Relationship, Drug, Female, Hypercholesterolemia, Leukocytes, Mononuclear, Lipoprotein Lipase, Lipoproteins, LDL, Male, Stilbenes, Swine, Down-Regulation, Up-Regulation, Microarray Analysis, Atherosclerosis, Lipid Metabolism, Fatty Acid-Binding Proteins, Diet, High-Fat, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: A transcriptomic approach to disease prevention

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks