The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western‐style diet in C57/BL6J mice
Abstract
Scope: To determine the effect of consumption of a quercetin‐rich diet on obesity and dysregulated hepatic gene expression. Methods and results: C56BL/6J mice were fed for 20 wk on AIN93G (control) or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Triglyceride levels in plasma, thiobarbituric acid‐reactive substances (oxidative stress marker) and glutathione levels and peroxisome proliferator‐activated receptor α expression in livers of mice fed with the Western diet were all improved after 8 wk feeding with quercetin. After 20 wk, further reductions of visceral and liver fat accumulation and improved hyperglycemia, hyperinsulinemia, dyslipidemia and plasma adiponectin and TNFα levels in these mice fed with quercetin were observed. The expression of hepatic genes related to steatosis, such as peroxisome proliferator‐activated receptor γ and sterol regulatory element‐binding protein‐1c was also normalized by quercetin. In mice fed with the control diet, quercetin did not affect body weight but reduces the plasma TNFα and hepatic thiobarbituric acid‐reactive substance levels. Conclusion: In mice fed with a Western diet, chronic dietary intake of quercetin reduces liver fat accumulation and improves systemic parameters related to metabolic syndrome, probably mainly through decreasing oxidative stress and reducing PPARα expression, and the subsequent reduced expression in the liver of genes related to steatosis.
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Cites
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Reactive oxygen species have a causal role in multiple forms of insulin resistance
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“At the same time, increased secretion of TNFa from adipose tissue has been shown to induce insulin resistance [46, 48, 49].”
BackgroundRoles of PPARs in health and disease
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Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
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Cited by
Tsuchida, T., Lee, Y. A., Fujiwara, N., Ybanez, M., Allen, B., Martins, S., Fiel, M. I., Goossens, N., Chou, H.-I., Hoshida, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.011 · Cited by 583
Quercetin and metabolic syndrome: A review
Hosseini, A., Razavi, B. M., Banach, M., & Hosseinzadeh, H. (2021) · Phytotherapy Research · doi:10.1002/ptr.7144 · Cited by 386
Jeong, S.-M., Kang, M.-J., Choi, H.-N., Kim, J.-H., & Kim, J.-I. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.3.201 · Cited by 265
Jung, C. H., Cho, I., Ahn, J., Jeon, T., & Ha, T. (2013) · Phytotherapy Research · doi:10.1002/ptr.4687 · Cited by 265
Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy
Le, N. H., Kim, C.-S., Park, T., Park, J. H. Y., Sung, M.-K., Lee, D. G., Hong, S.-M., Choe, S.-Y., Goto, T., Kawada, T., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/834294 · Cited by 167
Metadata
- Authors
- Kobori, M., Masumoto, S., Akimoto, Y., & Oike, H.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-12-15
- Volume
- 55
- Issue
- 4
- Pages
- 530-540
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1996154370
- Cited by
- 256
- References
- 11
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kobori, M., Masumoto, S., Akimoto, Y., & Oike, H. (2011). Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western‐style diet in C57/BL6J mice. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.201000392
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