The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Resveratrol and health—A comprehensive review of human clinical trials
Abstract
In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes, cultured cells, and laboratory animals have suggested that resveratrol has anti‐aging, anti‐carcinogenic, anti‐inflammatory, and anti‐oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans. The limited number of human clinical trials that are available has largely described various aspects of resveratrol's safety and bioavailability, reaching a consensus that it is generally well‐tolerated, but have poor bioavailability. Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.
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In the citing paper
“This polyphenol has anticancer and antioxidant properties and cytoprotective and anti-inflammatory effects.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
In the citing paper
“This polyphenol also has anti-inflammatory effects. In fact, it inhibits cyclooxygenase-2 (COX-2), nuclear factor-kB (NF-kB), and other molecules involved in inflammatory processes [6,8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
In the citing paper
“In fact, it inhibits cyclooxygenase-2 (COX-2), nuclear factor-kB (NF-kB), and other molecules involved in inflammatory processes [6,8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
In the citing paper
“Resveratrol also has cytoprotective effects and antioxidant properties, and modulates anti- and pro-apoptotic mediators, protecting cells from DNA damage.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
In the citing paper
“As reported for other polyphenols, resveratrol has a low bioavailability [8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
In the citing paper
“Multiple daily doses increase the Cmax of resveratrol and it appears that this polyphenol and its metabolites accumulate in human cells in a dose-dependent and tissue-specific manner [8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
In the citing paper
“However, there are inter-individual variations in its bioavailability and, to date, the exact role of its metabolites is unclear [8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
Citations
Cites
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“Resveratrol further inhibits cyclooxygenases [19], and could therefore act through some of the same mechanisms as aspirin.”
BackgroundResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
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Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Self-citationTranscriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
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HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000885 · Cited by 1,893
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Self-citationBrachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults
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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896
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Research works printed but not linked: 9
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Sorted by citations
Phytoalexins in defense against pathogens
Ahuja, I., Kissen, R., & Bones, A. M. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.11.002 · Cited by 1,146
Interventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
Hubbard, B. P., & Sinclair, D. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.12.004 · Cited by 588
Huang, C., Ju, D., Chang, C.-F., Reddy, P. M., & Velmurugan, B. K. (2017) · Biomedicine · doi:10.1051/bmdcn/2017070423 · Cited by 483
Antibacterial and antifungal properties of resveratrol
Vestergaard, M., & Ingmer, H. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.02.015 · Cited by 482
Metadata
- Authors
- Smoliga, J. M., Baur, J. A., & Hausenblas, H. A.
- Affiliations
- Marywood University (US)
- University of Pennsylvania (US)
- University of Florida (US)
- Corresponding author
- Smoliga, James M.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2011-06-20
- Volume
- 55
- Issue
- 8
- Pages
- 1129-1141
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2031213396
- Cited by
- 594
- References
- 87
- Citations by year
- 2026: 21 · 2025: 37 · 2024: 22 · 2023: 23 · 2022: 29 · 2021: 30 · 2020: 36 · 2019: 41 · 2018: 51 · 2017: 40 · 2016: 37 · 2015: 43 · 2014: 60 · 2013: 69 · 2012: 47
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, polyphenols, bioavailability, safety, anti-aging, anti-carcinogenic effects, anti-inflammatory activity, antioxidant activity, chronic disease prevention, longevity, dietary supplementation
- MeSH terms
- Resveratrol, Animals, Biological Availability, Cardiovascular Diseases, Clinical Trials as Topic, Diabetes Mellitus, Humans, Liver, Obesity, Stilbenes, Wine, Oxidative Stress, Dietary Supplements
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