Cited by 596Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesAlcohol Consumption and Health Effects

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Resveratrol and health—A comprehensive review of human clinical trials

Smoliga, James M., Baur, Joseph A., Hausenblas, Heather A.·2011·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.201100143

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Abstract

In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes, cultured cells, and laboratory animals have suggested that resveratrol has anti‐aging, anti‐carcinogenic, anti‐inflammatory, and anti‐oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans. The limited number of human clinical trials that are available has largely described various aspects of resveratrol's safety and bioavailability, reaching a consensus that it is generally well‐tolerated, but have poor bioavailability. Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.

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See all 596

Authors: Smoliga, J. M., Baur, J. A., & Hausenblas, H. A.
Affiliations: Marywood University (US)
University of Pennsylvania (US)
University of Florida (US)
Corresponding author: Smoliga, James M.
ORCID: Smoliga, James M.
Baur, Joseph A.
Hausenblas, Heather A.
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2011-06-20
Volume: 55
Issue: 8
Pages: 1129-1141
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.201100143
OpenAlex: W2031213396
Cited by: 594
References: 87
Citations by year: 2026: 21 · 2025: 37 · 2024: 22 · 2023: 23 · 2022: 29 · 2021: 30 · 2020: 36 · 2019: 41 · 2018: 51 · 2017: 40 · 2016: 37 · 2015: 43 · 2014: 60 · 2013: 69 · 2012: 47
FWCI: 4.86
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: resveratrol, polyphenols, bioavailability, safety, anti-aging, anti-carcinogenic effects, anti-inflammatory activity, antioxidant activity, chronic disease prevention, longevity, dietary supplementation
MeSH terms: Resveratrol, Animals, Biological Availability, Cardiovascular Diseases, Clinical Trials as Topic, Diabetes Mellitus, Humans, Liver, Obesity, Stilbenes, Wine, Oxidative Stress, Dietary Supplements

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Resveratrol and health—A comprehensive review of human clinical trials

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