Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study

Gutierrez‐Mariscal, Francisco M.; Cardelo, Magdalena P.; de la Cruz, Silvia; Alcala‐Diaz, Juan F.; Roncero‐Ramos, Irene; Guler, Ipek; Vals‐Delgado, Cristina; López‐Moreno, Alejandro; Luque, Raul M.; Delgado‐Lista, Javier; Perez‐Martinez, Pablo; Yubero‐Serrano, Elena M.; Lopez‐Miranda, Jose

doi:10.1002/mnfr.201901290

Cited by 61Advanced Glycation End Products researchNutritional Studies and DietDiabetes Treatment and Management

Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study

Open access

Gutierrez‐Mariscal, Francisco M., Cardelo, Magdalena P., de la Cruz, Silvia, Alcala‐Diaz, Juan F., Roncero‐Ramos, Irene, Guler, Ipek, Vals‐Delgado, Cristina, López‐Moreno, Alejandro +5 more·2021·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.201901290

Open this paper in CoChat — free account Open PDF

Abstract

Scope: It is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets. Methods and Results: Patients from CORDIOPREV study, all with previous cardiovascular events, with T2DM at the beginning of the study are included. Patients are randomized to a Mediterranean or a low‐fat diet for five years. No different diabetes remission rates are found among diets. Serum methylglioxal (MG) and carboximethyllysine (CML), levels dietary AGE, as well as gene expression of AGER1 and RAGE are measured. Serum MG decreases only after the consumption of the Mediterranean diet. Moreover, a COX regression analysis shows that each SD decrease in the MG, occurring after the Mediterranean diet, increases the probability of T2DM remission with HR:2.56(1.02–6.25) and p = 0.046 and each SD increase in disposition index at baseline increases the probability of remission with HR:1.94(1.32–2.87) and p = 0.001. Conclusions: It is demonstrated that the reduction of serum AGEs levels and the modulation of its metabolism, occurring after the consumption of a Mediterranean diet, might be involved in the molecular mechanism underlying the T2DM remission of newly diagnosed patients with coronary heart disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/mnfr.201901290

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Some studies subdivided results as previously proposed by Buse et al.
“Some studies [54–57] subdivided results as previously proposed by Buse et al. [58].”
From Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission (2022) · cites this paper as [54]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32279-7 · Cited by 13,867 · see citing works
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974 · see citing works
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)33102-1 · Cited by 2,095 · see citing works
Prevention and management of type 2 diabetes: dietary components and nutritional strategies
Ley, S. H., Hamdy, O., Mohan, V., & Hu, F. B. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60613-9 · Cited by 1,301 · see citing works
Advanced glycation end products in foods and a practical guide to their reduction in the diet
Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., & Vlassara, H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.03.018 · Cited by 1,289 · see citing works
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
Lim, E. L., Hollingsworth, K. G., Aribisala, B. S., Chen, M. J., Mathers, J. C., & Taylor, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2204-7 · Cited by 1,164 · see citing works
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works
How do we define cure of diabetes?
Buse, J. B., Caprio, S., Cefalu, W. T., Ceriello, A., Del Prato, S., Inzucchi, S. E., McLaughlin, S., Phillips, G. L., Robertson, R. P., Rubino, F., et al. (2009) · Diabetes Care · doi:10.2337/dc09-9036 · Cited by 1,003 · see citing works
The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
Goh, S.-Y., & Cooper, M. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1817 · Cited by 987 · see citing works
Clinical Relevance of Biomarkers of Oxidative Stress
Frijhoff, J., Winyard, P. G., Žarković, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E., Oettrich, J., Ruskovska, T., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6317 · Cited by 918 · see citing works
Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes
Ajala, O., English, P., & Pinkney, J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042457 · Cited by 821 · see citing works
Behavioral and Dietary Risk Factors for Noncommunicable Diseases
Ezzati, M., & Ríboli, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1203528 · Cited by 744 · see citing works
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
Kolb, H., & Martin, S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0901-x · Cited by 735 · see citing works
Oxidative stress and the etiology of insulin resistance and type 2 diabetes
Henriksen, E. J., Diamond-Stanic, M. K., & Marchionne, E. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.005 · Cited by 600 · see citing works
Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?
Vlassara, H., & Uribarri, J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0453-1 · Cited by 594 · see citing works
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-A role in pathogenesis and antiproliferative chemotherapy
Thornalley, P. J. (1996) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(95)02054-3 · Cited by 591 · see citing works
Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS)
(DPS), F. T. F. D. P. S., Lindström, J., Peltonen, M., Eriksson, J. G., Ilanne-Parikka, P., Aunola, S., Keinänen-Kiukaanniemi, S., Uusitupa, M., & Tuomilehto, J. (2013) · Diabetologia · doi:10.1007/s00125-012-2752-5 · Cited by 551 · see citing works
Pathogenesis of Type 2 Diabetes Mellitus
Leahy, J. L. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.01.003 · Cited by 469 · see citing works
Diet‐Derived Advanced Glycation End Products Are Major Contributors to the Body's AGE Pool and Induce Inflammation in Healthy Subjects
Uribarri, J., Cai, W., Sandu, O. A., Peppa, Μ., Goldberg, T., & Vlassara, H. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.052 · Cited by 423 · see citing works
Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders
Steven, S., Hollingsworth, K. G., Al-Mrabeh, A., Avery, L., Aribisala, B., Caslake, M., & Taylor, R. (2016) · Diabetes Care · doi:10.2337/dc15-1942 · Cited by 418 · see citing works
Nutrition and Cardiovascular Health
Casas, R. M., Castro‐Barquero, S., Estruch, R., & Sacanella, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123988 · Cited by 344 · see citing works
Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1
Cai, W., Ramdas, M., Zhu, L., Chen, X., Striker, G. E., & Vlassara, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205847109 · Cited by 330 · see citing works
Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes
Uribarri, J., Cai, W., Ramdas, M., Goodman, S., Pyzik, R., Chen, X., Zhu, L., Striker, G. E., & Vlassara, H. (2011) · Diabetes Care · doi:10.2337/dc11-0091 · Cited by 320 · see citing works
Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging
Fournet, M., Bonté, F., & Desmoulière, A. (2018) · Aging and Disease · doi:10.14336/ad.2017.1121 · Cited by 300 · see citing works
New IDF clinical practice recommendations for managing type 2 diabetes in primary care
Aschner, P. J. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.09.002 · Cited by 276 · see citing works
Oxidative Stress-Inducing Carbonyl Compounds From Common Foods: Novel Mediators of Cellular Dysfunction
Cai, W., Gao, Q.-D., Zhu, L., Peppa, Μ., He, C., & Vlassara, H. (2002) · Molecular Medicine · doi:10.1007/bf03402014 · Cited by 235 · see citing works
Protection against Loss of Innate Defenses in Adulthood by Low Advanced Glycation End Products (AGE) Intake: Role of the Antiinflammatory AGE Receptor-1
Vlassara, H., Cai, W., Goodman, S., Pyzik, R., Yong, A., Chen, X., Zhu, L., Neade, T., Beeri, M. S., Silverman, J. M., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0089 · Cited by 226 · see citing works
The effects of a Mediterranean diet on the need for diabetes drugs and remission of newly diagnosed type 2 diabetes: follow-up of a randomized trial
Esposito, K., Maiorino, M. I., Petrizzo, M., Bellastella, G., & Giugliano, D. (2014) · Diabetes Care · doi:10.2337/dc13-2899 · Cited by 205 · see citing works
Impact of Different Bariatric Surgical Procedures on Insulin Action and β-Cell Function in Type 2 Diabetes
Ferrannini, E., & Mingrone, G. (2009) · Diabetes Care · doi:10.2337/dc08-1762 · Cited by 191 · see citing works
CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (the CORDIOPREV study): Rationale, methods, and baseline characteristics
Delgado‐Lista, J., Pérez‐Martínez, P., García‐Ríos, A., Alcala-Diaz, J. F., Pérez-Caballero, A. I., Gómez-Delgado, F., Fuentes, F. J., Quintana‐Navarro, G. M., Lopez‐Segura, F., Ortiz-Morales, A. M., et al. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.04.011 · Cited by 177 · see citing works
Self-citation
Mediterranean diet for type 2 diabetes: cardiometabolic benefits
Esposito, K., Maiorino, M. I., Bellastella, G., Panagiotakos, D. B., & Giugliano, D. (2016) · Endocrine · doi:10.1007/s12020-016-1018-2 · Cited by 132 · see citing works
Prevention of Type 2 Diabetes by Dietary Patterns: A Systematic Review of Prospective Studies and Meta-Analysis
Esposito, K., Kastorini, C.-M., Panagiotakos, D. B., & Giugliano, D. (2010) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2010.0009 · Cited by 127 · see citing works
Serum advanced glycation end products (AGEs) are associated with insulin resistance
Tan, K. C. B., Shiu, S. W. M., Wong, Y., & Tam, X. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1188 · Cited by 111 · see citing works
Review: The epidemiology of lifestyle and risk for type 2 diabetes
van Dam, R. M. (2003) · European Journal of Epidemiology · doi:10.1023/b:ejep.0000006612.70245.24 · Cited by 102 · see citing works
The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial
Blanco-Rojo, R., Alcala-Diaz, J. F., Wopereis, S., Pérez‐Martínez, P., Quintana‐Navarro, G. M., Marı́n, C., Ordovás, J. M., van Ommen, B., Pérez‐Jiménez, F., Delgado‐Lista, J., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3776-4 · Cited by 100 · see citing works
Self-citation
Advanced glycation end-products and skin autofluorescence in end-stage renal disease: a review
Arsov, S., Graaff, R., van Oeveren, W., Stegmayr, B. G., Sikole, A., Rakhorst, G., & Smit, A. J. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0832 · Cited by 94 · see citing works
Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery
Taylor, R., Al-Mrabeh, A. H., Zhyzhneuskaya, S. V., Peters, C. A., Barnes, A. C., Aribisala, B. S., Hollingsworth, K. G., Mathers, J. C., Sattar, N. A., & Lean, M. E. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.010 · Cited by 71 · see citing works
Reversal of type 2 diabetes after bariatric surgery is determined by the degree of achieved weight loss in both short- and long-duration diabetes
Steven, S., Carey, P. E., Small, P. K., & Taylor, R. (2015) · Diabetic Medicine · doi:10.1111/dme.12567 · Cited by 55 · see citing works
Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial
López-Moreno, J., Quintana‐Navarro, G. M., Delgado‐Lista, J., García‐Ríos, A., Delgado‐Casado, N., Camargo, A., Pérez‐Martínez, P., Striker, G. E., Tinahones, F. J., Pérez‐Jiménez, F., et al. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14062 · Cited by 48 · see citing works
Self-citation
Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo
Cheng, A.-S., Cheng, Y.-H., Lee, C., Chung, C.-Y., & Chang, W.-C. (2015) · Nutrients · doi:10.3390/nu7042850 · Cited by 45 · see citing works
Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome
Lopez‐Moreno, J., Quintana‐Navarro, G. M., Camargo, A., Jimenez‐Lucena, R., Delgado‐Lista, J., Marin, C., Tinahones, F. J., Striker, G. E., Roche, H. M., Perez‐Martinez, P., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201601029 · Cited by 41 · see citing works
Self-citation
Advanced Glycation End Products Impair Glucose-Stimulated Insulin Secretion of a Pancreatic<i>β</i>-Cell Line INS-1-3 by Disturbance of Microtubule Cytoskeleton via p38/MAPK Activation
You, J., Wang, Z., Xu, S., Zhang, W., Fang, Q., Liu, H., Peng, L., Deng, T., & Lou, J. (2016) · Journal of Diabetes Research · doi:10.1155/2016/9073037 · Cited by 18 · see citing works
Remission of type 2 diabetes: mission not impossible
Uusitupa, M. I. J. (2017) · The Lancet · doi:10.1016/s0140-6736(17)33100-8 · Cited by 18 · see citing works
Alpha cell function interacts with diet to modulate prediabetes and Type 2 diabetes
Roncero‐Ramos, I., Jiménez-Lucena, R., Alcala-Diaz, J. F., Vals‐Delgado, C., Larriva, A. P. A.-D., Rangel-Zúñiga, O. A., Leon‐Acuña, A., Malagón, M. M., Delgado‐Lista, J., Pérez‐Martínez, P., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.08.012 · Cited by 16 · see citing works
Self-citation

Flagged first, then by citations

3 of the 49 references couldn’t be matched to a known paper.

Research works printed but not linked: 46

S. L. James, D. Abate, K. H. Abate, S. M. Abay, C. Abbafati, N. Abbasi, H. Abbastabar, F. Abd-Allah, J. Abdela, A. Abdelalim, I. Abdollahpour, R. S. Abdulkader, Z. Abebe, S. F. Abera, O. Z. Abil, H. N. Abraha, L. J. Abu-Raddad, N. M. E. Abu-Rmeileh, M. M. K. Accrombessi, D. Acharya, P. Acharya, I. N. Ackerman, A. A. Adamu, O. M. Adebayo, V. Adekanmbi, O. O. Adetokunboh, M. G. Adib, J. C. Adsuar, K. A. Afanvi, M. Afarideh, et al., Lancet 2018, 392, 1789.
M. Ezzati, E. Riboli, N. Engl. J. Med. 2013, 369, 954.
H. Kolb, S. Martin, BMC Med. 2017, 15, 131.
R. M. van Dam, Eur. J. Epidemiol. 2003, 18, 1115.
K. Esposito, C. M. Kastorini, D. B. Panagiotakos, D. Giugliano, Metab. Syndr. Relat. Disord. 2010, 8, 471.
S. H. Ley, O. Hamdy, V. Mohan, F. B. Hu, Lancet 2014, 383, 1999.
O. Ajala, P. English, J. Pinkney, Am. J. Clin. Nutr. 2013, 97, 505.
R. Casas, S. Castro-Barquero, R. Estruch, E. Sacanella, Int. J. Mol. Sci. 2018, 19, 3988.
E. L. Lim, K. G. Hollingsworth, B. S. Aribisala, M. J. Chen, J. C. Math- ers, R. Taylor, Diabetologia 2011, 54, 2506.
S. Steven, K. G. Hollingsworth, A. Al-Mrabeh, L. Avery, B. Aribisala, M. Caslake, R. Taylor, Diabetes Care 2016, 39, 808.
K. Esposito, M. I. Maiorino, M. Petrizzo, G. Bellastella, D. Giugliano, Diabetes Care 2014, 37, 1824.
K. Esposito, M. I. Maiorino, G. Bellastella, D. B. Panagiotakos, D. Giugliano, Endocrine 2017, 56, 27.
K. Nowotny, T. Jung, A. Hohn, D. Weber, T. Grune, Biomolecules 2015, 5, 194.
M. Fournet, F. Bonte, A. Desmouliere, Aging Dis. 2018, 9, 880.
S. Y. Goh, M. E. Cooper, J. Clin. Endocrinol. Metab. 2008, 93, 1143.
J. Uribarri, W. Cai, O. Sandu, M. Peppa, T. Goldberg, H. Vlassara, Ann. N. Y. Acad. Sci. 2005, 1043, 461.
J. Uribarri, S. Woodruff, S. Goodman, W. Cai, X. Chen, R. Pyzik, A. Yong, G. E. Striker, H. Vlassara, J. Am. Dietetic Assoc. 2010, 110, 911.
J. Uribarri, W. Cai, M. Ramdas, S. Goodman, R. Pyzik, X. Chen, L. Zhu, G. E. Striker, H. Vlassara, Diabetes Care 2011, 34, 1610.
J. Lopez-Moreno, G. M. Quintana-Navarro, A. Camargo, R. Jimenez- Lucena, J. Delgado-Lista, C. Marin, F. J. Tinahones, G. E. Striker, H. M. Roche, P. Perez-Martinez, J. Lopez-Miranda, E. M. Yubero-Serrano, Mol. Nutr. Food Res. 2017, 61, 1601029.
J. Lopez-Moreno, G. M. Quintana-Navarro, J. Delgado-Lista, A. Garcia-Rios, N. Delgado-Casado, A. Camargo, P. Perez-Martinez, G. E. Striker, F. J. Tinahones, F. Perez-Jimenez, J. Lopez-Miranda, E. M. Yubero-Serrano, J. Am. Geriat. Soc. 2016, 64, 901.
R. Taylor, A. Al-Mrabeh, S. Zhyzhneuskaya, C. Peters, A. C. Barnes, B. S. Aribisala, K. G. Hollingsworth, J. C. Mathers, N. Sattar, M. E. J. Lean, Cell Metab. 2018, 28, 667.
S. Steven, P. E. Carey, P. K. Small, R. Taylor, Diabet. Med. 2015, 32, 47.
M. E. Lean, W. S. Leslie, A. C. Barnes, N. Brosnahan, G. Thom, L. McCombie, C. Peters, S. Zhyzhneuskaya, A. Al-Mrabeh, K. G. Hollingsworth, A. M. Rodrigues, L. Rehackova, A. J. Adamson, F. F. Sniehotta, J. C. Mathers, H. M. Ross, Y. McIlvenna, R. Stefanetti, M. Trenell, P. Welsh, S. Kean, I. Ford, A. McConnachie, N. Sattar, R. Tay- lor, Lancet 2018, 391, 541.
E. Ferrannini, G. Mingrone, Diabetes Care 2009, 32, 514.
M. Uusitupa, Lancet 2018, 391, 515.
J. Lindstrom, M. Peltonen, J. G. Eriksson, P. Ilanne-Parikka, S. Aunola, S. Keinanen-Kiukaanniemi, M. Uusitupa, J. Tuomilehto, Diabetologia 2013, 56, 284.
J. Frijhoff, P. G. Winyard, N. Zarkovic, S. S. Davies, R. Stocker, D. Cheng, A. R. Knight, E. L. Taylor, J. Oettrich, T. Ruskovska, A. C. Gasparovic, A. Cuadrado, D. Weber, H. E. Poulsen, T. Grune, H. H. Schmidt, P. Ghezzi, Antioxid. Redox Signaling 2015, 23, 1144.
F. Giacco, M. Brownlee, Circ. Res. 2010, 107, 1058.
E. J. Henriksen, M. K. Diamond-Stanic, E. M. Marchionne, Free Rad. Biol. Med. 2011, 51, 993.
J. L. Leahy, Arch. Med. Res. 2005, 36, 197.
H. Vlassara, J. Uribarri, Curr. Diabetes Rep. 2014, 14, 453.
K. C. Tan, S. W. Shiu, Y. Wong, X. Tam, Diabetes/Metab. Res. Rev. 2011, 27, 488.
A. S. Cheng, Y. H. Cheng, C. Y. Lee, C. Y. Chung, W. C. Chang, Nutrients 2015, 7, 2850.
J. You, Z. Wang, S. Xu, W. Zhang, Q. Fang, H. Liu, L. Peng, T. Deng, J. Lou, J. Diabetes Res. 2016, 2016, 9073037.
R. Blanco-Rojo, J. F. Alcala-Diaz, S. Wopereis, P. Perez-Martinez, G. M. Quintana-Navarro, C. Marin, J. M. Ordovas, B. van Ommen, F. Perez-Jimenez, J. Delgado-Lista, J. Lopez-Miranda, Diabetologia 2016, 59, 67.
J. Delgado-Lista, P. Perez-Martinez, A. Garcia-Rios, J. F. Alcala-Diaz, A. I. Perez-Caballero, F. Gomez-Delgado, F. Fuentes, G. Quintana- Navarro, F. Lopez-Segura, A. M. Ortiz-Morales, N. Delgado-Casado, E. M. Yubero-Serrano, A. Camargo, C. Marin, F. Rodriguez-Cantalejo, P. Gomez-Luna, J. M. Ordovas, J. Lopez-Miranda, F. Perez-Jimenez, Am. Heart J. 2016, 177, 42.
American Diabetes Association, Diabetes Care 2014, 37, S81.
P. Aschner, Diabetes Res. Clin. Pract. 2017, 132, 169.
J. B. Buse, S. Caprio, W. T. Cefalu, A. Ceriello, S. Del Prato, S. E. In- zucchi, S. McLaughlin, G. L. Phillips, 2nd, R. P. Robertson, F. Rubino, R. Kahn, M. S. Kirkman, Diabetes Care 2009, 32, 2133.
M. Matsuda, R. A. DeFronzo, Diabetes Care 1999, 22, 1462.
I. Roncero-Ramos, R. Jimenez-Lucena, J. F. Alcala-Diaz, C. Vals- Delgado, A. P. Arenas-Larriva, O. A. Rangel-Zuniga, A. Leon-Acuna, M. M. Malagon, J. Delgado-Lista, P. Perez-Martinez, J. M. Ordovas, A. Camargo, J. Lopez-Miranda, J. Nutr. Biochem. 2018, 62, 247.
P. J. Thornalley, General Pharmacol. Vascul. Syst. 1996, 27, 565.
S. Arsov, R. Graaff, W. van Oeveren, B. Stegmayr, A. Sikole, G. Rakhorst, A. J. Smit, Clin. Chem. Lab. Med. 2014, 52, 11.
W. Cai, Q. D. Gao, L. Zhu, M. Peppa, C. He, H. Vlassara, Mol. Med. 2002, 8, 337.
W. Cai, M. Ramdas, L. Zhu, X. Chen, G. E. Striker, H. Vlassara, Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 15888.
H. Vlassara, W. Cai, S. Goodman, R. Pyzik, A. Yong, X. Chen, L. Zhu, T. Neade, M. Beeri, J. M. Silverman, L. Ferrucci, L. Tansman, G. E. Striker, J. Uribarri, J. Clin. Endocrinol. Metab. 2009, 94, 4483.

Sorted by citations

Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission
Churuangsuk, C., Hall, J., Reynolds, A., Griffin, S. J., Combet, E., & Lean, M. E. J. (2022) · Diabetologia · doi:10.1007/s00125-021-05577-2 · Cited by 204 · see citing works
Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney?
Fotheringham, A. K., Gallo, L. A., Borg, D. J., & Forbes, J. M. (2022) · Nutrients · doi:10.3390/nu14132675 · Cited by 112 · see citing works
Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials
Jing, T., Zhang, S., Bai, M., Chen, Z., Gao, S., Li, S., & Zhang, J. (2023) · Nutrients · doi:10.3390/nu15143156 · Cited by 113 · see citing works
The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies
Wang, L., Jiang, Y., & Zhao, C. (2024) · Experimental Dermatology · doi:10.1111/exd.15065 · Cited by 85 · see citing works
Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial
Podadera-Herreros, A., Alcala-Diaz, J. F., Gutierrez-Mariscal, F. M., Jiménez-Torres, J., de la Cruz, S., Larriva, A. P. A.-D., Cardelo, M. P., Torres-Peña, J. D., Luque, R. M., Ordovás, J. M., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2021.12.041 · Cited by 83 · see citing works
Self-citation
Dietary interventions to treat type 2 diabetes in adults with a goal of remission: an expert consensus statement from the American College of Lifestyle Medicine
Rosenfeld, R. M., Kelly, J. H., Agarwal, M., Aspry, K., Barnett, T., Davis, B. C., Fields, D., Gaillard, T., Gulati, M., Guthrie, G. E., et al. (2022) · American Journal of Lifestyle Medicine · doi:10.1177/15598276221087624 · Cited by 71 · see citing works
Mediterranean dietary pattern and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis of prospective cohort studies
Zeraattalab-Motlagh, S., Jayedi, A., & Shab‐Bidar, S. (2022) · European Journal of Nutrition · doi:10.1007/s00394-021-02761-3 · Cited by 66 · see citing works
Recent Advances in the Treatment of Insulin Resistance Targeting Molecular and Metabolic Pathways: Fighting a Losing Battle?
Wołosowicz, M., Prokopiuk, S., & Kaminski, T. W. (2022) · Medicina · doi:10.3390/medicina58040472 · Cited by 58 · see citing works
Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging
Portero‐Otín, M., de la Maza, M. P., & Uribarri, J. (2023) · Cells · doi:10.3390/cells12131684 · Cited by 46 · see citing works
AGEs-Induced and Endoplasmic Reticulum Stress/Inflammation-Mediated Regulation of GLUT4 Expression and Atherogenesis in Diabetes Mellitus
Passarelli, M., & Machado, U. F. (2021) · Cells · doi:10.3390/cells11010104 · Cited by 44 · see citing works
Mediterranean diet as a strategy for preserving kidney function in patients with coronary heart disease with type 2 diabetes and obesity: a secondary analysis of CORDIOPREV randomized controlled trial
Podadera-Herreros, A., Larriva, A. P. A.-D., Gutierrez-Mariscal, F. M., Alcala-Diaz, J. F., Ojeda‐Rodríguez, A., Rodríguez-Cantalejo, F., Cardelo, M. P., Rodríguez-Cano, D., Torres-Peña, J. D., Luque, R. M., et al. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00285-3 · Cited by 38 · see citing works
Self-citation
Investigating oral and systemic pathways between unhealthy and healthy dietary patterns to periodontitis in adolescents: A population‐based study
Costa, S. A., Nascimento, G. G., Colins, P. M. G., Alves, C. M. C., Thomaz, É. B. A. F., Souza, S. D. F. C., da Sílva, A. A. M., & Ribeiro, C. C. C. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13625 · Cited by 38 · see citing works
Methylglyoxal and Advanced Glycation End Products (AGEs): Targets for the Prevention and Treatment of Diabetes-Associated Bladder Dysfunction?
de Oliveira, A. L., de Oliveira, M. G., Mónica, F. Z., & Antunes, E. (2024) · Biomedicines · doi:10.3390/biomedicines12050939 · Cited by 37 · see citing works
Amyloid-β and heart failure in Alzheimer’s disease: the new vistas
Al-kuraishy, H., Sulaiman, G., Mohammed, H. A., Mohammed, S. G., Al-Gareeb, A., Albuhadily, A. K., Dawood, R. A., Ali, A. A., & Abu-Alghayth, M. H. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1494101 · Cited by 43 · see citing works
Yearly attained adherence to Mediterranean diet and incidence of diabetes in a large randomized trial
Martínez‐González, M. Á., Montero, P., Ruiz‐Canela, M., Toledo, E., Estruch, R., Gómez‐Gracia, E., Li, J., Ros, E., Arós, F., Hernáez, Á., et al. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01994-2 · Cited by 31 · see citing works
The Role of Advanced Glycation End Products on Dyslipidemia
Vekić, J., Vujčić, S., Bufan, B., Bojanin, D., Al-Hashmi, K., Al‐Rasadi, K., Stoian, A. P., Zeljković, A., & Rizzo, M. (2023) · Metabolites · doi:10.3390/metabo13010077 · Cited by 30 · see citing works
The Remarkable Roles of the Receptor for Advanced Glycation End Products (RAGE) and Its Soluble Isoforms in COVID-19: The Importance of RAGE Pathway in the Lung Injuries
Salehi, M., Amiri, S., Ilghari, D., Hasham, L. F. A., & Piri, H. (2022) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-022-01081-5 · Cited by 25 · see citing works
Flexible multielectrode arrays based electrochemical aptasensor for glycated human serum albumin detection
Zhou, L., Miranda, G. F., Chen, S., Neis, M., Hu, Z., Zhu, R., Li, Y., Prömpers, M., Offenhäusser, A., & Mayer, D. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.133730 · Cited by 23 · see citing works
Reduction of circulating methylglyoxal levels by a Mediterranean diet is associated with preserved kidney function in patients with type 2 diabetes and coronary heart disease: From the CORDIOPREV randomized controlled trial
Gutierrez-Mariscal, F. M., Podadera-Herreros, A., Alcala-Diaz, J. F., Cardelo, M. P., Larriva, A. P. A.-D., de la Cruz, S., Torres-Peña, J. D., Luque, R. M., Pérez‐Martínez, P., Delgado‐Lista, J., et al. (2023) · Diabetes & Metabolism · doi:10.1016/j.diabet.2023.101503 · Cited by 19 · see citing works
Self-citation
Methylglyoxal Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via RAGE-Induced ROS Generation: Protective Effects of Metformin
Medeiros, M. L., de Oliveira, A. L., de Oliveira, M. G., Mónica, F. Z., & Antunes, E. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s337115 · Cited by 17 · see citing works
Changes in quantity plant-based protein intake on type 2 diabetes remission in coronary heart disease patients: from the CORDIOPREV study
Gutierrez-Mariscal, F. M., Alcala-Diaz, J. F., Quintana‐Navarro, G. M., de la Cruz, S., Torres-Peña, J. D., Cardelo, M. P., Larriva, A. P. A.-D., Malagón, M. M., Romero‐Cabrera, J. L., Ordovás, J. M., et al. (2023) · European Journal of Nutrition · doi:10.1007/s00394-022-03080-x · Cited by 15 · see citing works
Self-citation
Dietary Advanced Glycation End Products and Cardiovascular-Kidney-Metabolic Complications
Uribarri, J., & Tuttle, K. R. (2025) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000859 · Cited by 15 · see citing works
Metformin abrogates the voiding dysfunction induced by prolonged methylglyoxal intake
de Oliveira, A. L., de Oliveira, M. G., Medeiros, M. L., Mónica, F. Z., & Antunes, E. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174502 · Cited by 14 · see citing works
Pathological role of RAGE underlying progression of various diseases: its potential as biomarker and therapeutic target
Sarkar, S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03595-6 · Cited by 13 · see citing works
Does dietary fat affect advanced glycation end products and their receptors? A systematic review of clinical trials
Mendes, N. P., Ribeiro, P. V. D. M., & Alfenas, R. D. C. G. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab095 · Cited by 12 · see citing works
The potential role of the Mediterranean Diet for the treatment and management of Polycystic Ovary Syndrome: a review of the pathophysiological mechanisms and clinical evidence.
Scannell, N., Villani, A., Moran, L., & Mantzioris, E. (2025) · Proceedings of the Nutrition Society · doi:10.1017/s0029665124007584 · Cited by 12 · see citing works
“In sub-group analysis from the CORDIOPREV study, Gutierrez-Mariscal et al (117) reported that in newly diagnosed diabetic patients with coronary heart disease, long-term (5 years) consumption of a MedDiet intervention was associated with improved glycemic control and a higher probability of T2DM remission.”
Dietary advanced glycation end-products and their associations with body weight on a Mediterranean diet and low-fat vegan diet: a randomized, cross-over trial
Kahleová, H., Znayenko‐Miller, T., Motoa, G., Eng, E. M., Prevost, A., Uribarri, J., Holubkov, R., & Barnard, N. D. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1426642 · Cited by 10 · see citing works
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial
Gutierrez-Mariscal, F. M., Lopez-Moreno, A., Torres-Peña, J. D., Gómez-Luna, P., Larriva, A. P. A.-D., Romero‐Cabrera, J. L., Luque, R. M., Uribarri, J., Pérez‐Martínez, P., Delgado‐Lista, J., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02451-4 · Cited by 10 · see citing works
Self-citation
Antiviral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models
Dhanushkodi, N. R., Prakash, S., Quadiri, A., Zayou, L., Srivastava, R., Shaik, A. M., Suzer, B., Ibraim, I. C., Landucci, G., Tifrea, D. F., et al. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300392 · Cited by 10 · see citing works
MiRNAs as biomarkers of nutritional therapy to achieve T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
Alcala-Diaz, J. F., Camargo, A., Vals‐Delgado, C., Leon‐Acuña, A., García-Fernández, H., Larriva, A. P. A.-D., Cardelo, M. P., Mora-Ortiz, M., Pérez‐Martínez, P., Delgado‐Lista, J., et al. (2025) · Nutrition and Diabetes · doi:10.1038/s41387-025-00362-1 · Cited by 9 · see citing works
Self-citation
Effect of long-term Mediterranean versus low-fat diet on neutrophil count, and type 2 diabetes mellitus remission in patients with coronary heart disease: results from the CORDIOPREV study
Boughanem, H., Gutierrez-Mariscal, F. M., Larriva, A. P. A.-D., Torres-Peña, J. D., Romero‐Cabrera, J. L., Rangel-Zúñiga, O. A., García-Fernández, H., Podadera-Herreros, A., Rodríguez-Cantalejo, F., Soehnlein, O., et al. (2025) · Nutrition and Diabetes · doi:10.1038/s41387-025-00360-3 · Cited by 9 · see citing works
Self-citation
Glycation-induced Amyloid Formation in Proteins: An Emerging Perspective to Explore Diabetes Associated Onset of Neurodegenerative Symptoms
Banik, S. P. (2023) · Current Nutrition & Food Science · doi:10.2174/1573401319666230224094812 · Cited by 8 · see citing works
Diet and vascular risk
Gómez-Delgado, F., Romero‐Cabrera, J. L., & Pérez‐Martínez, P. (2022) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000960 · Cited by 8 · see citing works
Advanced Glycation End Products and Diabetes
Hadzi‐Petrushev, N., Angelovski, M., & Mladenov, M. I. (2023) · Contemporary Endocrinology · doi:10.1007/978-3-031-39721-9_5 · Cited by 6 · see citing works
A Mediterranean diet improves glycation markers in healthy people and in those with chronic diseases: a systematic review of clinical trials
Silva-e-Oliveira, J., da Silva, J. L., de Freitas, B. V. M., Alfenas, R. D. C. G., & Bressan, J. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae045 · Cited by 7 · see citing works
Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients
Radić, J., Vučković, M., Gelemanović, A., Kolak, E., Nenadić, D. B., Begović, M., & Radić, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191711060 · Cited by 6 · see citing works
The impact of food-based dietary strategies on achieving type 2 diabetes remission: A systematic review
Mozaffari, H., Civi, R. M., Askari, M., Lee, C., Wong, E., Wong, C., & Conklin, A. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.103096 · Cited by 5 · see citing works
Apolipoprotein A-IV of diabetic-foot patients upregulates tumor necrosis factor α expression in microfluidic arterial models
Ji, J. F., Zhao, X., Huang, J., Wu, X., Xie, F. X., Li, L., Wang, T., & Mi, S. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702221147562 · Cited by 4 · see citing works
Telomere Maintenance Is Associated with Type 2 Diabetes Remission in Response to a Long-Term Dietary Intervention without Non-Weight Loss in Patients with Coronary Heart Disease: From the CORDIOPREV Randomized Controlled Trial
Ojeda‐Rodríguez, A., Alcala-Diaz, J. F., Rangel-Zúñiga, O. A., Larriva, A. P. A.-D., Gutierrez-Mariscal, F. M., Torres-Peña, J. D., Mora-Ortiz, M., Romero‐Cabrera, J. L., Luque, R. M., Ordovás, J. M., et al. (2024) · Antioxidants · doi:10.3390/antiox13010125 · Cited by 4 · see citing works
Self-citation
Oleic Acid Status Positively Correlates with the Soluble Receptor for Advanced Glycation End-Products (sRAGE) in Healthy Adults Who Are Homozygous for G Allele of RAGE G82S Polymorphism
Deo, P., Dhillon, V. S., Thomas, P., & Fenech, M. F. (2023) · Cells · doi:10.3390/cells12121662 · Cited by 3 · see citing works
Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider
Armando Rojas, R., Lindner, C., Schneider, I., González, I., & Morales, M. A. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i39.5679 · Cited by 3 · see citing works
Association between Mediterranean Diet and Advanced Glycation End Products in University Students: A Cross-Sectional Study
Polić, N., Matulić, V., Dragun, T., Matek, H., Marendić, M., Efendić, I. Ž., Russo, A., & Kolčić, I. (2024) · Nutrients · doi:10.3390/nu16152483 · Cited by 3 · see citing works
Differences in splicing factors may predict type 2 diabetes remission in the CORDIOPREV study
Ojeda‐Rodríguez, A., Torres-Peña, J. D., Larriva, A. P. A.-D., Rangel-Zúñiga, O. A., Podadera-Herreros, A., Boughanem, H., G-García, M. E., López-Moreno, A., Katsiki, N., Luque, R. M., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111527 · Cited by 2 · see citing works
Self-citation
A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming
Mercurio, G., Giacco, A., Troise, A. D., Ledbetter, M., Pascale, S. D., Scopigno, N., Vigliotti, M., Mazzola, M., Riccio, G., Scaloni, A., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70210 · Cited by 2 · see citing works
Digital Twin Intervention for Type 2 Diabetes: One-Year Outcomes of a Randomized TrialPreprint
Joshi, S., Shamanna, P., Dharmalingam, M., Vadavi, A., Keshavamurthy, A., Shah, L., KAUFMAN, F. R., Mittal, A., Bhagra, S., Liu, S., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4499693 · Cited by 2 · see citing works
The effects of major dietary patterns on patients with type 2 diabetes: Protocol for a systematic review and network meta-analysis
Chen, H., Wang, Y., Song, G., Li, W., Li, J., & Chen, W. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306336 · Cited by 1 · see citing works
Diet and Diabetes Remission (DIREM): Effects of Calorie-carbohydrate Restriction versus Intermittent Fasting for Type 2 Diabetes Remission: Study Protocol for a Randomized Controlled Trial
Badrooj, N., Esteghamati, A., Djafarian, K., Yekaninejad, M. S., Reyhan, S. K., Abbaszadeh, M., Emamgholipour, S., & Shab‐Bidar, S. (2025) · Asian Journal of Social Health and Behavior · doi:10.4103/shb.shb_184_25 · Cited by 1 · see citing works
Metabolic and Antioxidant Modulation by Artemisia indica Willd. Aqueous Extract in Glucose and Cholesterol Dysregulation
Tseng, C.-Y., Wong, Y. S., Chyau, C.-C., Liang, Y.-H. C., Lin, H., & Chen, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010297 · Cited by 1 · see citing works
Nutrition-induced remission of type 2 diabetes: mechanisms, clinical evidence, and future directions-a mini review
Pescari, D., Mihuta, S., Bena, A., Pui, R., Paul, C., & Stoian, D. L. (2026) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2026.1792614 · Cited by 2 · see citing works
The Role of Advanced Glycation End-Product Levels Measured by Skin Autofluorescence in the Development of Mitral Annular Calcification
Boyraz, B., & Peker, T. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10090406 · Cited by 1 · see citing works
Dietary Advanced Glycation End-Products (AGES) Induced Complications in Type 1 Diabetes Mellitus
Bhattacharyya, S., & Acharya, S. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1007016 · Cited by 1 · see citing works
The Mediterranean Diet
Yubero‐Serrano, E. M., Gutierrez-Mariscal, F. M., Ojeda‐Rodríguez, A., Pérez‐Martínez, P., & López‐Miranda, J. (2025) · Nutrition and health · doi:10.1007/978-3-031-87441-3_2 · Cited by 1 · see citing works
Self-citation
Dietary advanced glycation end products (AGE) and women's infertility
Çelik, E., & Akdevelıoğlu, Y. (2023) · Current Perspectives on Health Sciences · doi:10.58208/cphs.1355248
Determination of AGE-CML Level in Commercially Available Sports Bar in Italy
Cannataro, R., Elechi, J. O. G., Torre, C. L., Fazio, A., Abrego-Guandique, D. M., Caroleo, M. C., & Cione, E. (2024) · Recent Advances in Food Nutrition & Agriculture · doi:10.2174/012772574x300368240318051000
Clinical outcomes after the recognition and management of Sjögren’s syndrome in children: a Case Study
Rajeswari, S., Deepthi, P., Verma, S., Kumar, A., Dev, A., & Kaur, A. (2025) · Health Leadership and Quality of Life · doi:10.56294/hl2025614
The Impact of a Mediterranean Dietary on the Variables Linked to an increased likelihood of Cardiac Diseases
Yadav, K., Selvaraj, B. N. X., Mishra, R., Kumar, A., Bhushan, B., & Pandre, K. (2025) · Health Leadership and Quality of Life · doi:10.56294/hl2025613
A proposed model using glycation metrics and circulating biomarkers for the prevention of cardiovascular disease
Valk, T., & McMorrow, C. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1624682
Quinoa Improves Glucose Metabolism and Fluctuation Based on β-Cell Function in Early-Stage Type 2 Diabetes Mellitus: A Randomized Study
Zhang, J., Cong, R., Xu, L., Liu, H., Wei, W., Diao, Y., Hu, X., & Tang, K. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s584727
A randomized controlled trial protocol comparing low-calorie Mediterranean and low-carbohydrate diets for diabetes remission in individuals with type 2 diabetes in northern Lebanon: an intervention mapping–based approach
Ayoub, J. C., Haidar, S. A., Blaak, E. E., & de Ruijter, D. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1787980
Oleanolic Acid‐Enriched Olive Oil Attenuates Kidney Function Decline in Patients With Type 2 Diabetes: Results From the OLTRAD Randomised Controlled Trial
García‐González, A., Matamoros-Domínguez, A., Espinosa-Cabello, J. M., Perez-Muñoz, G., Aranda, M. J. L., Roque-Cuéllar, M. D. C., García-Rey, S., Jiménez‐Sánchez, A., Martínez-Ortega, A. J., Mangas-Cruz, M. Á., et al. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.71206
Self-citation
Type 2 Diabetes Remission and Role of Technology
Joshi, S., & Shamanna, P. (2026) · Springer eBooks · doi:10.1007/978-3-032-24854-1_13

Reduction of circulating levels of methylglyoxal by a Mediterranean diet is associated with preserved kidney function in type 2 diabetes patients with coronary heart disease
Yubero‐Serrano, E. M., Podadera-Herreros, A., Alcala-Diaz, J. F., Gutierrez-Mariscal, F. M., Cardelo, M. P., Larriva, A. P. A.-D., Torres-Peña, J. D., Pérez‐Martínez, P., Delgado‐Lista, J., & López‐Miranda, J. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.06.540 · Cited by 2 · see citing works
Self-citation
Dietary modulation of advanced glycation end products metabolism on carotid intima-media thickness in type 2 diabetes patients: From the CORDIOPREV study
Yubero‐Serrano, E. M., Gutierrez-Mariscal, F. M., Gómez-Luna, P., Alcala-Diaz, J. F., Pérez‐Martínez, P., & López‐Miranda, J. (2022) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2022.08.004 · Cited by 5 · see citing works
Self-citation
Reduction of circulating methylglyoxal levels by a Mediterranean diet is associated with preserved kidney function in patients with type 2 diabetes and coronary heart disease: From the CORDIOPREV randomized controlled trial
Gutierrez-Mariscal, F. M., Podadera-Herreros, A., Alcala-Diaz, J. F., Cardelo, M. P., Larriva, A. P. A.-D., de la Cruz, S., Torres-Peña, J. D., Luque, R. M., Pérez‐Martínez, P., Delgado‐Lista, J., et al. (2023) · Diabetes & Metabolism · doi:10.1016/j.diabet.2023.101503 · Cited by 19 · see citing works
Self-citation
The effect of a diet reduction in advanced glycation end products on metabolic markers in patients with chronic coronary artery disease and type 2 diabetes
Kuwabara, K. L., Faria, N. F. O., Freitas, R. A. M. S., Torres, E. A. F. S., Strunz, C. M. C., Maranhão, R. C., Cesar, L. A. M., & Mansur, A. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf784.3865
Type 2 diabetes remission by consumption of low-fat and Mediterranean diets: from CORDIOPREV study
Roncero‐Ramos, I., Vals‐Delgado, C., Quintana‐Navarro, G. M., Krylova, Y., Gomez‐Marin, B., Pozuelo-Sanchez, I., Delgado, F. G., Camargo, A., & Lopez-Miranda, J. (2019) · doi:10.13140/rg.2.2.32396.77441
Self-citation

Authors: Gutierrez‐Mariscal, F. M., Cardelo, M. P., de la Cruz, S., Alcala‐Diaz, J. F., Roncero‐Ramos, I., Guler, I., Vals‐Delgado, C., López‐Moreno, A., Luque, R. M., Delgado‐Lista, J., Perez‐Martinez, P., Yubero‐Serrano, E. M., & Lopez‐Miranda, J.
Affiliations: Maimonines Institute for Biomedical Research of Córdoba (IMIBIC) Córdoba 14004 Spain
Instituto de Salud Carlos III (ES)
Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
ORCID: Cardelo, Magdalena P.
Roncero‐Ramos, Irene
Guler, Ipek
Vals‐Delgado, Cristina
Luque, Raul M.
Delgado‐Lista, Javier
Yubero‐Serrano, Elena M.
Lopez‐Miranda, Jose
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2020-06-23
Volume: 65
Issue: 1
Pages: e1901290-e1901290
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.201901290
OpenAlex: W3034860513
Cited by: 60
References: 49
Citations by year: 2026: 5 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 10 · 2021: 5
FWCI: 4.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Universidad de Córdoba Insitutional Repository (Universidad de Córdoba) (submittedVersion, cc-by-nc-nd)
Funders: European Association of Social Psychology
Universidad de Córdoba
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
Instituto de Salud Carlos III (PI10/01041, PI13/00023, 00023, 2013-2016, PI18/01822, FIS PI13/00023)
European Regional Development Fund
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: advanced glycation end products, type 2 diabetes remission, Mediterranean diet, low-fat diet, methylglyoxal, carboxymethyllysine, RAGE, coronary artery disease, newly diagnosed type 2 diabetes, disposition index, dietary AGEs
MeSH terms: Receptor for Advanced Glycation End Products, Antigens, Neoplasm, Coronary Disease, Diabetes Mellitus, Type 2, Female, Gene Expression Regulation, Humans, Insulin Resistance, Male, Middle Aged, Pyruvaldehyde, Treatment Outcome, Glycation End Products, Advanced, Diet, Fat-Restricted, Mitogen-Activated Protein Kinases, Diet, Mediterranean, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks