Reversal of type 2 diabetes after bariatric surgery is determined by the degree of achieved weight loss in both short- and long-duration diabetes
Open accessAbstract
AIM: To define the impact of duration of diabetes and extent of weight loss on the reversibility of Type 2 diabetes after bariatric surgery. METHODS: Complete data were collated from 89 individuals with Type 2 diabetes mellitus undergoing any bariatric surgical procedure in a specialist bariatric centre. People with a preoperative HbA1c < 43 mmol/mol (6.1%) were excluded. Diabetes duration was defined as: short, < 4 years; medium, 4-8 years; and long, > 8 years. RESULTS: An HbA1c of <43 mmol/mol (6.1%) was achieved by 62% of patients in the short-duration group and 26% of patients in the long-duration group. Normoglycaemia was rarely achieved in the long-duration group if weight loss was < 25 kg. In the whole cohort there was a clear relationship of greater weight loss with lower HbA1c levels (Rs = -0.53; P < 0.0001). CONCLUSIONS: The study shows that the degree of achieved weight loss is the major determinant of return to normal blood glucose levels after bariatric surgery. Normoglycaemia can be achieved in long-duration Type 2 diabetes, but a greater degree of weight loss is required than for short-duration diabetes.
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Accumulated evidence points to duration of diabetes with earlier age of onset and persistent elevation of HbA1c as the main drivers of the disabling and costly clinical complications of type 2 diabetes, in particular the vascular consequences of associated hypertension and dyslipidaemia.
“Accumulated evidence points to duration of diabetes with earlier age of onset and persistent elevation of HbA1c as the main drivers of the disabling and costly clinical complications of type 2 diabetes, in particular the vascular consequences of associated hypertension and dyslipidaemia. 27”
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- Authors
- Steven, S., Carey, P. E., Small, P. K., & Taylor, R.
- Affiliations
- Newcastle University (GB)
- Sunderland Royal Hospital (GB)
- Corresponding author
- Steven, S.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2014-09-12
- Volume
- 32
- Issue
- 1
- Pages
- 47-53
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2026423521
- Cited by
- 55
- References
- 29
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 3 · 2012: 1
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, bariatric surgery, diabetes remission, weight loss, diabetes duration, HbA1c, normoglycemia
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Remission Induction, Risk Factors, Time Factors, Weight Loss, Body Mass Index, Treatment Outcome, Patient Selection, Bariatric Surgery
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