The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
BOLD Based Functional MRI at 4 Tesla Includes a Capillary Bed Contribution: Echo‐Planar Imaging Correlates with Previous Optical Imaging Using Intrinsic Signals
Abstract
We show that the EPI time course in functional MR imaging at 4 Tesla displays a multiphasic response in response to photic stimulation. Focal areas of gray matter display an initial negative change in signal intensity that reaches a maximum of 1 % about 2 s after the onset of photic stimulation. This component then changes sign, reaching a positive maximum about 5 s after the onset of the stimulus. Other areas, including those where draining veins are visible, show only a positive signal change, reaching a maximum of about 6% after the onset of the visual stimulus. These time constants are in very good agreement with published data obtained with intrinsic optical mapping techniques, where a deoxygenation phase has been shown to occur in functionally specific cortical columns, followed by an increase in blood volume which is more distributed in nature. Thus, we believe there is strong evidence that a sensitivity to capillary oxygenation state is present in high S/N functional MR images obtained with EPI at 4 T.
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Cites
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483
Self-citationFox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Lai, S., Hopkins, A. L., Haacke, E. M., Li, D., Wasserman, B. A., Buckley, P., Friedman, L., Meltzer, H., Hedera, P., & Friedland, R. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300318 · Cited by 390
Functional magnetic resonance imaging of Brocaʼs area during internal speech
Hinke, R. M., Hu, X., Stillman, A. E., Kim, S.-G., Merkle, H., Salmi, R., & Ugurbil, K. (1993) · NeuroReport · doi:10.1097/00001756-199306000-00018 · Cited by 293
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Cited by
Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model
Buxton, R. B., Wong, E. C., & Frank, L. R. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390602 · Cited by 1,665
Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. K. (2006) · Nature Neuroscience · doi:10.1038/nn1675 · Cited by 898
Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
Kim, S.-G., & Ogawa, S. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.23 · Cited by 547
Self-citationLocalization of pain-related brain activation: A meta-analysis of neuroimaging data
Duerden, E. G., & Albanese, M. (2013) · Human Brain Mapping · doi:10.1002/hbm.21416 · Cited by 342
Giger, M. L., Chan, H., & Boone, J. (2008) · Medical Physics · doi:10.1118/1.3013555 · Cited by 311
Metadata
- Authors
- Menon, R. S., Ogawa, S., Hu, X., Strupp, J. P., Anderson, P., & Uǧurbil, K.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1995-03
- Volume
- 33
- Issue
- 3
- Pages
- 453-459
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W1997232604
- Cited by
- 421
- References
- 5
- FWCI
- 25.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: BOLD Based Functional MRI at 4 Tesla Includes a Capillary Bed Contribution: Echo‐Planar Imaging Correlates with Previous Optical Imaging Using Intrinsic Signals. https://app.cochat.ai/papers/10.1002/mrm.1910330323
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- Menon, R. S., Ogawa, S., Hu, X., Strupp, J. P., Anderson, P., & Uǧurbil, K. (1995). BOLD Based Functional MRI at 4 Tesla Includes a Capillary Bed Contribution: Echo‐Planar Imaging Correlates with Previous Optical Imaging Using Intrinsic Signals. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910330323
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