The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Comparison of blood oxygenattion and cerebral blood flow effect in fMRI: Estimation of relative oxygen consumption change
Abstract
The most widely‐used functional magnetic resonance imaging (fMRI) technique is based on the blood oxygenation level dependent (BOLD) effect, which requires at least partial uncoupling between cerebral blood flow (CBF) and oxygen consumption changes during increased mental activity. To compare BOLD and CBF effects during tasking, BOLD and flowsensitive alternating inversion recovery (FAIR) images were acquired during visual stimulation with red goggles at a frequency of 8 Hz in an inteerleaved fashion. With the FAIR technique, absolute and relative CBF changes were determined. Relative oxygen consumption changes cdan be estimated using the BOLD and relative CBF changes. In gray matter areas in the visual cortex, absolute and relative CBF changes in humans during photic stimulation were 31 ± 11 SD ml/100 g tissue/min and 43 ± 16 SD % (n =12), respectively, while the relative oxygen consumption change was close to zero. These findings agree extremely well with previouse results using positron emission tomography. The BOLD signal change is not linearly correlated with the relative CBF increase across subjects and negatively correlates with the oxygen consumption change. Caution should be exercised when interpreting the BOLD percent change as a quantitative index of the CBF change, especially in inter‐subject comparisons.
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Cited by
What we can do and what we cannot do with fMRI
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What does fMRI tell us about neuronal activity?
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Behind the scenes of functional brain imaging: A historical and physiological perspective
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Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
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Self-citationMethodology of brain perfusion imaging
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Metadata
- Authors
- Kim Cmrr, S., & Uĝurbil, K.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1997-07
- Volume
- 38
- Issue
- 1
- Pages
- 59-65
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2014594668
- Cited by
- 220
- References
- 9
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- closed
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