Potential contributors to variation in weight‐loss response to liraglutide
Abstract
Summary: Obesity treatment requires a chronic state of negative energy balance. Obesity medications can help with this, increasing long‐term dietary compliance by promoting satiety or reducing hunger. However, efficacy and safety of obesity medications vary for individuals. Early identification of non‐responders to obesity medications may limit drug exposure while optimizing benefits for responders. This review summarizes factors that impact weight‐loss response to liraglutide. Factors linked to greater weight loss on liraglutide include being female, not having diabetes, having relatively high baseline weight, and losing at least 4% of initial weight after 16 weeks of treatment. Other covariates that may predict treatment response but require further confirmation include central effects, nausea, gastric emptying of solids, and genotype. Baseline body mass index, race, and age seem less relevant for predicting weight‐loss response to liraglutide. Lesser known and harder‐to‐measure factors such as cerebral blood flow, food cue reactivity, gut hormone levels, and dietary adherence possibly impact variability of response to liraglutide. This information should assist healthcare providers with establishing realistic weight‐loss probability for individual patients. Future research should improve the ability to identify responders to liraglutide. Importantly, this review may provide a framework to identify responders to other obesity medications.
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Female gender, not having diabetes, greater baseline BW and weight loss in the first 16 weeks are potential predictors of better response to treatment.
“Female gender, not having diabetes, greater baseline BW and weight loss in the first 16 weeks are potential predictors of better response to treatment112.”
From Incretin-based therapies for the treatment of obesity-related diseases (2024) · cites this paper as [112]
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Incretin-based therapies for the treatment of obesity-related diseases
Caruso, I., Cignarelli, A., Sorice, G. P., Perrini, S., & Giorgino, F. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00030-5 · Cited by 48 · see citing works
- Authors
- Webster, C. M., Mittal, N., Dhurandhar, E. J., & Dhurandhar, N. V.
- Affiliations
- Texas Tech University (US)
- Obthera, Inc Lubbock Texas USA
- Corresponding author
- Dhurandhar, Nikhil V.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2023-04-17
- Volume
- 24
- Issue
- 7
- Pages
- e13568-e13568
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W4366085339
- Cited by
- 19
- References
- 119
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 4 · 2023: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- liraglutide, weight loss response, anti-obesity drugs, predictors of treatment response, non-responders, GLP-1 receptor agonists, sex differences, diabetes mellitus, nausea, gastric emptying, genotypes, gastrointestinal hormones, food cue reactivity, cerebral blood flow, dietary adherence, satiety
- MeSH terms
- Liraglutide, Body Weight, Female, Humans, Hypoglycemic Agents, Male, Obesity, Weight Loss, Body Mass Index, Overweight
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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