Mid-adulthood cardiometabolic risk factor profiles of sarcopenic obesity
Open accessAbstract
Objective: Midlife and contemporaneous cardiometabolic risk factors associated with sarcopenic obesity were examined. Methods: Utilizing BMI and sex‐specific 24‐h urinary creatinine excretion, 1,019 participants from the Framingham cohorts were categorized as non‐sarcopenia non‐obese (NSNO), non‐obese sarcopenia, non‐sarcopenic obesity, and sarcopenic obesity. Cardiometabolic risk factors were quantified by standard laboratory assessment cross‐sectionally and 10, 20, and 30 years before sarcopenic obesity assessment. Results: NSNO, sarcopenia, obesity, and sarcopenic obesity accounted for 30.0%, 39.6%, 20.0%, and 10.4% of study participants, respectively. Cross‐sectionally, participants with sarcopenic obesity had a higher proportion of hypertension, metabolic syndrome, and type 2 diabetes than those with NSNO or sarcopenia (all P < 0.03). Similar patterns were observed retrospectively at 10, 20, and 30 years. Compared with NSNO or sarcopenia, sarcopenic obesity was associated with a higher prevalence of type 2 diabetes at 10 years and hypertension and metabolic syndrome at all three time points before baseline (all P < 0.03). Individuals with sarcopenic obesity had more type 2 diabetes than those with obesity alone at baseline and 10 years prior (all P < 0.001). Conclusions: Older adults with sarcopenic obesity had more adverse midlife cardiometabolic risks, particularly diabetes 10 years earlier, which suggests the importance of early identification of risk factors associated with sarcopenic obesity.
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Compared to obesity alone, sarcopenic obesity is associated with a heightened risk of adverse health outcomes, such as disability or impairment, cardiometabolic diseases, other comorbidities, and mortality.
“Compared to obesity alone, sarcopenic obesity is associated with a heightened risk of adverse health outcomes, such as disability or impairment, cardiometabolic diseases, other comorbidities, and mortality [4,5,6,7].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [5]
Sarcopenic obesity appears to be a more severe condition than obesity alone, as it is associated with higher risk of cardiovascular disease, reduced bone mineral density, and all-cause mortality.
“Sarcopenic obesity appears to be a more severe condition than obesity alone, as it is associated with a higher risk of several disorders such as cardiovascular disease, reduced bone mineral density, and all-cause mortality (16–18).”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [16]
Sarcopenic obesity is associated with frailty, fractures, cardiovascular disease, cancer, dementia, increased hospitalization, and increased all-cause mortality.
“This condition is currently a major concern as it is associated with frailty and disabilities such as cardiovascular disease, fractures, dementia, cancer, and increased all-cause mortality.”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [16]
Sarcopenic obesity significantly increases risk of cardiovascular risk factors including insulin resistance, metabolic syndrome, and adverse glycolipid metabolism, even in context of divergent comorbidities such as cancer and peritoneal dialysis.
“Sarcopenic obesity significantly increases the risk of cardiovascular risk factors including insulin resistance (IR), metabolic syndrome, and adverse glycolipid metabolism (16, 42–44), even in the context of divergent comorbidities such as cancer and peritoneal dialysis (45, 46).”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [16]
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- Authors
- Ma, J., Hwang, S., McMahon, G. M., Curhan, G. C., Mclean, R. R., Murabito, J. M., & Fox, C. S.
- Affiliations
- Framingham Heart Study (US)
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Boston University (US)
- Corresponding author
- Fox, Caroline S.
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2016-01-27
- Volume
- 24
- Issue
- 2
- Pages
- 526-534
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2297738515
- Cited by
- 68
- References
- 38
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 1
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- School of Medicine, Boston University (N01-HC25195)
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (HC25195, N01‐HC25195, N01-HC)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- sarcopenic obesity, cardiometabolic risk factors, midlife, type 2 diabetes, hypertension, metabolic syndrome, sarcopenia, older adults, Framingham cohort, urinary creatinine
- MeSH terms
- Aged, Creatinine, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Hypertension, Male, Middle Aged, Obesity, Retrospective Studies, Risk Factors, Body Mass Index, Prevalence, Risk Assessment, Metabolic Syndrome, Sarcopenia
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