Randomized trial reveals that physical activity and energy expenditure are associated with weight and body composition after RYGB
Open accessAbstract
Objective: This study investigated the associations of both physical activity time (PA) and energy expenditure (EE) with weight and fat mass (FM) loss in patients following Roux‐en‐Y gastric bypass (RYGB) surgery. Methods: Ninety‐six nondiabetic patients were included in this analysis. Post‐RYGB patients were randomized in one of two treatments: A 6‐month exercise training program (RYBG+EX) or lifestyle educational classes (RYGB). Body composition was assessed by dual‐energy X‐ray absorptiometry and computed tomography. Components of PA and EE were quantified by a multisensory device. Dose‐response relationships of both PA and EE with weight loss and body composition were explored according to quartiles of change in steps per day. Results: Patients in the highest quartiles of steps per day change lost more FM (3rd = −19.5 kg and 4th = −22.7 kg, P < 0.05) and abdominal adipose tissue (4th = −313 cm 2, P < 0.05), maintained skeletal muscle mass (3rd = −3.1 cm 2 and 4th = −4.5 cm 2, P < 0.05), and had greater reductions in resting metabolic rate. Decreases in sedentary EE and increases in light EE and age were significant predictors of both Δweight and ΔFM (R 2 = 73.8% and R 2 = 70.6%, respectively). Conclusions: Nondiabetic patients who perform higher, yet still modest, amounts of PA following RYGB have greater energy deficits and lose more weight and FM, while maintaining higher skeletal muscle mass.
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In an observational analysis of Roux-en-Y gastric bypass patients, the greatest increase in walking was associated with the best preservation of skeletal muscle measured at the thigh and with less loss of total body mean mass.
“In an observational analysis of Roux-en-Y gastric bypass patients (from a randomized trial), the greatest increase in walking was associated with the best preservation of skeletal muscle, measured at the thigh, and with less loss of total body mean mass [97].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [97]
When added to weight loss resulting from Roux-en-Y gastric bypass, walking enhanced muscle quality.
“When added to weight loss resulting from Roux-en-Y gastric bypass, walking also enhanced muscle quality [97].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [97]
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Cites
Energy balance and its components: implications for body weight regulation
Hall, K. D., Heymsfield, S. B., Kemnitz, J. W., Klein, S., Schoeller, D. A., & Speakman, J. R. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.036350 · Cited by 721 · see citing works
Physical activity and resting metabolic rate
Speakman, J. R., & Selman, C. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003282 · Cited by 441 · see citing works
Bariatric Surgery: Risks and Rewards
Pories, W. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1641 · Cited by 405 · see citing works
Metabolic Slowing with Massive Weight Loss despite Preservation of Fat-Free Mass
Johannsen, D. L., Knuth, N. D., Huizenga, R., Rood, J. C., Ravussin, E., & Hall, K. D. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1444 · Cited by 254 · see citing works
Exercise Following Bariatric Surgery: Systematic Review
Livhits, M., Mercado, C., Yermilov, I., Parikh, J. A., Dutson, E., Mehran, A., Ko, C. Y., & Gibbons, M. M. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0096-0 · Cited by 197 · see citing works
Bond, D. S., Jakicic, J. M., Unick, J. L., Vithiananthan, S., Pohl, D., Roye, G. D., Ryder, B. A., Sax, H. C., & Wing, R. R. (2010) · Obesity · doi:10.1038/oby.2010.88 · Cited by 192 · see citing works
Self-citationDas, S. K., Roberts, S. B., Kehayias, J. J., Wang, J., Hsu, L. K. G., Shikora, S. A., Saltzman, E., & McCrory, M. A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00185.2002 · Cited by 183 · see citing works
Stubbs, R. J., Hughes, D. A., Johnstone, A. M., Whybrow, S., Horgan, G. W., King, N. A., & Blundell, J. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00196.2003 · Cited by 169 · see citing works
Resistance to Exercise-Induced Weight Loss
Melanson, E. L., Keadle, S. K., Donnelly, J. E., Braun, B., & King, N. A. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31828ba942 · Cited by 156 · see citing works
Validation of an Armband to Measure Daily Energy Expenditure in Older Adults
Mackey, D. C., Manini, T. M., Schoeller, D. A., Koster, A., Glynn, N. W., Goodpaster, B. H., Satterfield, S., Newman, A. B., Harris, T. B., Cummings, S. R., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr101 · Cited by 153 · see citing works
Self-citationClinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity
Coen, P. M., Tanner, C. J., Helbling, N. L., Dubis, G. S., Hames, K. C., Xie, H., Eid, G. M., Stefanović-Račić, M., Toledo, F. G. S., Jakicic, J. M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci78016 · Cited by 152 · see citing works
Self-citationBehavioral Factors Associated with Successful Weight Loss after Gastric Bypass
Livhits, M. J., Mercado, C., Yermilov, I., Parikh, J., Dutson, E., Mehran, A., Ko, C. Y., & Gibbons, M. (2010) · The American surgeon · doi:10.1177/000313481007601027 · Cited by 151 · see citing works
Weight loss, weight maintenance, and adaptive thermogenesis
Camps, S. G., Verhoef, S. P. M., & Westerterp, K. R. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.050310 · Cited by 143 · see citing works
Relative changes in resting energy expenditure during weight loss: a systematic review
Schwartz, A., & Doucet, É. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00654.x · Cited by 132 · see citing works
Energy balance during an 8-wk energy-restricted diet with and without exercise in obese women
Kempen, K. P., Saris, W. H. M., & Westerterp, K. R. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.4.722 · Cited by 129 · see citing works
Rosenkilde, M., Auerbach, P., Reichkendler, M. H., Ploug, T., Stallknecht, B. M., & Sjödin, A. M. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00141.2012 · Cited by 121 · see citing works
Multidimensional Physical Activity
Thompson, D., Peacock, O. J., Western, M. J., & Batterham, A. M. (2015) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000039 · Cited by 120 · see citing works
King, W. C., Chen, J., Bond, D. S., Belle, S. H., Courcoulas, A. P., Patterson, E. J., Mitchell, J. E., Inabnet, W. B., Dakin, G. F., Flum, D. R., et al. (2015) · Obesity · doi:10.1002/oby.21106 · Cited by 119 · see citing works
Dulloo, A. G., Jacquet, J., Montani, J., & Schutz, Y. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01041.x · Cited by 116 · see citing works
de Jonge, L., DeLany, J. P., Nguyen, T., Howard, J., Hadley, E. C., Redman, L. M., & Ravussin, É. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.73 · Cited by 110 · see citing works
Patterns of Weight Loss Response Following Gastric Bypass and Sleeve Gastrectomy
de Hollanda, A., Ruiz, T., Jiménez, A., Flores, L., Lacy, A. M., & Vidal, J. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1512-7 · Cited by 102 · see citing works
Yates, T. E., Henson, J. J., Edwardson, C. L., Dunstan, D. W., Bodicoat, D. H., Khunti, K. K., & Davies, M. J. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.04.005 · Cited by 81 · see citing works
A role for exercise after bariatric surgery?
Coen, P. M., & Goodpaster, B. H. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12545 · Cited by 79 · see citing works
Self-citationvan Gemert, W. G., Westerterp, K. R., van Acker, B. A. C., Wagenmakers, A. J. M., Halliday, D., Greve, J.-W. M., & Soeters, P. B. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801230 · Cited by 72 · see citing works
Dose response of exercise training following roux‐en‐Y gastric bypass surgery: A randomized trial
Woodlief, T., Carnero, E. Á., Standley, R. A., Distéfano, G., Anthony, S. J., Dubis, G., Jakicic, J. M., Houmard, J. A., Coen, P. M., & Goodpaster, B. H. (2015) · Obesity · doi:10.1002/oby.21332 · Cited by 72 · see citing works
Self-citationCreel, D. B., Schuh, L. M., Reed, C., Gomez, A., Hurst, L. A., Stote, J. J., & Cacucci, B. M. (2016) · Obesity · doi:10.1002/oby.21548 · Cited by 64 · see citing works
DeLany, J. P., Kelley, D. E., Hames, K. C., Jakicic, J. M., & Goodpaster, B. H. (2014) · Obesity · doi:10.1002/oby.20525 · Cited by 60 · see citing works
Self-citationHerrmann, S. D., Willis, E. A., Honas, J. J., Lee, J., Washburn, R. A., & Donnelly, J. E. (2015) · Obesity · doi:10.1002/oby.21073 · Cited by 58 · see citing works
Towards Integrated Physical Activity Profiling
Thompson, D., & Batterham, A. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056427 · Cited by 53 · see citing works
Fedewa, M. V., Hathaway, E. D., Williams, T. D., & Schmidt, M. D. (2016) · Sports Medicine · doi:10.1007/s40279-016-0649-z · Cited by 53 · see citing works
Surgical Weight Loss: Impact on Energy Expenditure
Thivel, D., Brakoniecki, K., Duché, P., Morio, B., Boirie, Y., & Laferrère, B. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0839-1 · Cited by 52 · see citing works
Validation of the SenseWear Armband as a Measure of Sedentary Behavior and Light Activity
Reece, J. D., Barry, V., Fuller, D. K., & Caputo, J. L. (2014) · Journal of Physical Activity and Health · doi:10.1123/jpah.2014-0136 · Cited by 44 · see citing works
Wefers, J., Woodlief, T., Carnero, E. Á., Helbling, N. L., Anthony, S. J., Dubis, G. S., Jakicic, J. M., Houmard, J. A., Goodpaster, B. H., & Coen, P. M. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.08.493 · Cited by 44 · see citing works
Self-citationSpontaneous activity responses to exercise in males and females
McLaughlin, R., Malkova, D., & Nimmo, M. A. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602417 · Cited by 41 · see citing works
Bonomi, A. G., Soenen, S., Goris, A. H. C., & Westerterp, K. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059641 · Cited by 35 · see citing works
Browning, M. G., Franco, R. L., Cyrus, J. C., Celi, F., & Evans, R. K. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2184-2 · Cited by 33 · see citing works
Road Running After Gastric Bypass for Morbid Obesity: Rationale and Results of a New Protocol
Marchesi, F., Sario, G. D., Reggiani, V., Tartamella, F., Giammarresi, A., Cecchini, S., Costi, R., Guareschi, G., Beltrami, G., Panfilis, C. D., et al. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1517-2 · Cited by 31 · see citing works
Physical Activity in Obese Type 2 Diabetes After Gastric Bypass or Medical Management
Panosian, J., Ding, S.-A., Wewalka, M., Simonson, D. C., GOEBEL-FABBRI, A. E., Foster, K., Halperin, F., Vernon, A. H., & Goldfine, A. B. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.07.019 · Cited by 20 · see citing works
Suboc, T. M. B., Knabel, D. R., Strath, S. J., Dharmashankar, K., Coulliard, A., Malik, M. A., Haak, K., & Widlansky, M. E. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv063 · Cited by 18 · see citing works
Ott, M. T. (1992) · Archives of Surgery · doi:10.1001/archsurg.1992.01420090097014 · Cited by 11 · see citing works
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Bellicha, A., van Baak, M. A., Battista, F., Beaulieu, K., Blundell, J. E., Busetto, L., Carraça, E. V., Dicker, D., Encantado, J., Ermolao, A., et al. (2021) · Obesity Reviews · doi:10.1111/obr.13296 · Cited by 150 · see citing works
Wadden, T. A., Chao, A. M., Moore, M., Tronieri, J. S., Gilden, A., Amaro, A., Leonard, S., & Jakicic, J. M. (2023) · Current Obesity Reports · doi:10.1007/s13679-023-00534-z · Cited by 129 · see citing works
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Self-citation
- Authors
- Carnero, E. A., Dubis, G. S., Hames, K. C., Jakicic, J. M., Houmard, J. A., Coen, P. M., & Goodpaster, B. H.
- Affiliations
- Translational Research Institute for Metabolism and Diabetes, Florida Hospital Orlando Florida USA
- East Carolina University (US)
- University of Pittsburgh (US)
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2017-05-30
- Volume
- 25
- Issue
- 7
- Pages
- 1206-1216
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC5513190
- OpenAlex
- W2617866057
- Cited by
- 73
- References
- 40
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 9 · 2019: 6 · 2018: 11 · 2017: 1
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
- Funders
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK078192)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- Roux-en-Y gastric bypass, physical activity, energy expenditure, weight loss, body composition, fat loss, exercise training, lifestyle education, step count, light physical activity, resting metabolic rate, skeletal muscle mass, abdominal fat, bariatric surgery, non-diabetic patients
- MeSH terms
- Cardiorespiratory Fitness, Adult, Body Composition, Body Weight, Diet, Energy Metabolism, Female, Health Education, Humans, Life Style, Male, Middle Aged, Obesity, Gastric Bypass, Weight Loss, Exercise, Absorptiometry, Photon, Young Adult
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