The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
miRNAs in human cancer
Open accessAbstract
Mature microRNAs (miRNAs) are single‐stranded RNA molecules of 20–23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis and invasion. miRNA targeting is mostly achieved through specific base‐pairing interactions between the 5′ end (‘seed’ region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs; target sites in the 3′ UTR lead to more effective mRNA destabilization. Since miRNAs frequently target hundreds of mRNAs, miRNA regulatory pathways are complex. To provide a critical overview of miRNA dysregulation in cancer, we first discuss the methods currently available for studying the role of miRNAs in cancer and then review miRNA genomic organization, biogenesis and mechanism of target recognition, examining how these processes are altered in tumorigenesis. Given the critical role miRNAs play in tumorigenesis processes and their disease‐specific expression, they hold potential as therapeutic targets and novel biomarkers. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Self-citationThe widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
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The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679
MicroRNA regulation by RNA-binding proteins and its implications for cancer
van Kouwenhove, M., Kedde, M., & Agami, R. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3107 · Cited by 617
Silencing disease genes in the laboratory and the clinic
Watts, J. K., & Corey, D. R. (2012) · The Journal of Pathology · doi:10.1002/path.2993 · Cited by 470
Matoulkova, E., Michalova, E., Vojtesek, B., & Hrstka, R. (2012) · RNA Biology · doi:10.4161/rna.20231 · Cited by 357
MicroRNA-223 is neuroprotective by targeting glutamate receptors
Harraz, M. M., Eacker, S. M., Wang, X., Dawson, T. M., & Dawson, V. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121288109 · Cited by 283
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Liu, X., Abraham, J. M., Cheng, Y., Wang, Z., Wang, Z., Zhang, G., Ashktorab, H., Smoot, D. T., Cole, R. N., Boronina, T. N., et al. (2018) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2018.09.010 · Cited by 212
Kundu, P., Fabian, M. R., Sonenberg, N., Bhattacharyya, S. N., & Filipowicz, W. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks148 · Cited by 180
Ning, F.-L., Wang, F., Li, M.-L., Yu, Z.-S., Hao, Y.-Z., & Chen, S.-S. (2014) · Diagnostic Pathology · doi:10.1186/1746-1596-9-143 · Cited by 74
miR-199a-5p Regulates Urothelial Permeability and May Play a Role in Bladder Pain Syndrome
Monastyrskaya, K., Sánchez-Freire, V., Hashemi Gheinani, A., Klumpp, D. J., Babiychuk, E. B., Draeger, A., & Burkhard, F. C. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.10.020 · Cited by 59
Dijkstra, J. R., Mekenkamp, L. J. M., Teerenstra, S., De Krijger, I., & Nagtegaal, I. D. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01467.x · Cited by 53
Bourdon, J. A., Saber, A. T., Halappanavar, S., Jackson, P. A., Wu, D., Hougaard, K. S., Jacobsen, N. R., Williams, A., Vogel, U., Wallin, H., et al. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21706 · Cited by 51
Micromanaging aging with miRNAs: new messages from the nuclear envelope
Ugalde, A. P., Español, Y., & López-Otín, C. (2011) · Nucleus · doi:10.4161/nucl.2.6.17986 · Cited by 34
Habieb, A., Matboli, M., El-Tayeb, H., & El-Asmar, F. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04810-x · Cited by 29
Implementing biological markers as a tool to guide clinical care of patients with pancreatic cancer
Iovanna, J. (2021) · Translational Oncology · doi:10.1016/j.tranon.2020.100965 · Cited by 18
Cavallini, A., Rotelli, M. T., Lippolis, C., Piscitelli, D., Digennaro, R., Covelli, C., Carella, N., Accetturo, M., & Altomare, D. F. (2017) · Oncotarget · doi:10.18632/oncotarget.16383 · Cited by 17
Metadata
- Authors
- Farazi, T. A., Spitzer, J. I., Morozov, P., & Tuschl, T.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2010-11-18
- Volume
- 223
- Issue
- 2
- Pages
- 102-115
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W1970760326
- Cited by
- 895
- References
- 29
- FWCI
- 23.76
- Type
- journal article
- Language
- en
- Open access
- green
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