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Micromanaging aging with miRNAs: New messages from the nuclear envelope
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Aging-associated transcriptional signatures affect non-coding RNAs, including a class of miRNAs (gero-miRs) that is associated with the aging process and influences lifespan by targeting components of longevity networks or by regulating stem cell behavior.
“These aging-associated transcriptional signatures also affect non-coding RNAs, including a class of miRNAs (gero-miRs) that is associated with the aging process and influences lifespan by targeting components of longevity networks or by regulating stem cell behavior (Boulias and Horvitz, 2012; Toledano et al., 2012; Ugalde et al., 2011).”
From The Hallmarks of Aging (2013) · cites this paper as Ugalde et al., 2011
In “The Growing Relevance of miRNAs in Aging,” the paper reports age-related changes in miRNA expression and lifespan effects through aging-related pathways in C. elegans. “GeromiRs, a New and Expanding Group of miRNAs” also describes miRNAs regulating stem-cell behavior, but does not establish that this regulation changes lifespan; it says miRNAs’ contribution to aging still requires further study. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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Self-citationPuzzles, promises and a cure for ageing
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microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age
Noren Hooten, N., Abdelmohsen, K., Gorospe, M., Ejiogu, N., Zonderman, A. B., & Evans, M. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010724 · Cited by 357
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“murine fibroblasts activates p19ARF and p16INKa and triggers cellular senescence,(49) whereas miR-24 decrease in senescent human fibroblasts is in part responsible for p16INKa up-modulation.(50) Similarly, the five members of the miR-106b family, including the aforementioned miR-20a, are downregulated in stressinduced…”
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
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Self-citationThe comparison of microRNA profile of the dermis between the young and elderly
Li, T., Yan, X., Jiang, M., & Xiang, L. (2016) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.01.005 · Cited by 34
Metadata
- Authors
- Ugalde, A. P., Español, Y., & López-Otín, C.
- Venue
- Nucleus
- Publisher
- Informa UK Limited
- Published
- 2011-11
- Volume
- 2
- Issue
- 6
- Pages
- 549-555
- ISSN
- 1949-1034
- 1949-1042
- Cited by
- 34
- References
- 9
- Language
- en
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