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Cited by 266

The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.

The extracellular matrix – the under‐recognized element in lung disease?

Open access
Burgess, Janette K, Mauad, Thais, Tjin, Gavin, Karlsson, Jenny C, Westergren‐Thorsson, Gunilla·2016·The Journal of Pathology
DOI 10.1002/path.4808
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Abstract

The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM) contains the main building blocks of both components. The ECM provides physical support and stability to the lung, and as such it has in the past been regarded as an inert structure. More recent research has provided novel insights revealing that the ECM is also a bioactive environment that orchestrates the cellular responses in its environs. Changes in the ECM in the airway or parenchymal tissues are now recognized in the pathological profiles of many respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). Only recently have we begun to investigate whether these ECM changes result from the disease process, or whether they constitute a driving factor that orchestrates the pathological outcomes. This review summarizes our current knowledge of the alterations in the ECM in asthma, COPD, and IPF, and the contributions of these alterations to the pathologies. Emerging data suggest that alterations in the composition, folding or rigidity of ECM proteins may alter the functional responses of cells within their environs, and in so doing change the pathological outcomes. These characteristics highlight potential avenues for targeting lung pathologies in the future. This may ultimately contribute to a better understanding of chronic lung diseases, and novel approaches for finding therapeutic solutions. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

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Metadata

Authors
Burgess, J. K., Mauad, T., Tjin, G., Karlsson, J. C., & Westergren‐Thorsson, G.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2016-10-28
Volume
240
Issue
4
Pages
397-409
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.4808
OpenAlex
W2522881241
Cited by
266
References
104
FWCI
21.19
Type
journal article
Language
en
Open access
hybrid

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