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Cited by 444

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Prediction of early, intermediate and late pre‐eclampsia from maternal factors, biophysical and biochemical markers at 11–13 weeks

Open access
Akolekar, Ranjit, Syngelaki, Argyro, Sarquis, Rita, Zvanca, Mona, Nicolaides, Kypros H.·2011·Prenatal Diagnosis

Abstract

Objective: To develop models for prediction of pre‐eclampsia (PE) based on maternal factors and biophysical and biochemical markers at 11–13 weeks' gestation. Methods: Screening study of singleton pregnancies at 11–13 weeks including 752 (2.2%) that subsequently developed PE and 32 850 that were unaffected by PE. Models were developed for the prediction of early PE, requiring delivery before 34 weeks, intermediate PE with delivery at 34–37 weeks and late PE delivering after 37 weeks. The data used for the models were firstly, maternal characteristics and history, uterine artery pulsatility index, mean arterial pressure and serum pregnancy‐associated plasma protein‐A obtained from the screening study and secondly, maternal serum or plasma concentration of placental growth factor, placental protein‐13, inhibin‐A, activin‐A, soluble endoglin, pentraxin‐3 and P‐selectin obtained from case‐control studies. Results: In screening for PE by maternal factors only at a fixed false positive rate of 5%, the estimated detection rates were 33.0% for early PE, 27.8% for intermediate PE and 24.5% for late PE. The respective detection rates in screening by a combination of maternal factors, biophysical and biochemical markers were 91.0, 79.4 and 60.9%. Conclusions: Effective prediction of PE can be achieved at 11–13 weeks' gestation. Copyright © 2011 John Wiley & Sons, Ltd.

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Metadata

Authors
Akolekar, R., Syngelaki, A., Sarquis, R., Zvanca, M., & Nicolaides, K. H.
Venue
Prenatal Diagnosis
Publisher
Wiley
Published
2011-01
Volume
31
Issue
1
Pages
66-74
ISSN
  • 0197-3851 (ISSN-L)
  • 1097-0223
OpenAlex
W1996307378
Cited by
444
References
39
FWCI
58.93
Type
journal article
Language
en
Open access
bronze

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