On‐line CE/ESI/MS interfacing: Recent developments and applications in proteomics

Krenkova, Jana; Foret, Frantisek

doi:10.1002/pmic.201200140

Cited by 44Mass Spectrometry Techniques and ApplicationsMicrofluidic and Capillary Electrophoresis ApplicationsAdvanced Proteomics Techniques and Applications

On‐line CE/ESI/MS interfacing: Recent developments and applications in proteomics

Krenkova, Jana, Foret, Frantisek·2012·PROTEOMICS

DOI 10.1002/pmic.201200140

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Abstract

After shining as the ultimate separation – sequencing technique used for the successful completion of the Human Genome Project, in the early 2000s CE experienced lowered popularity among separation scientists. The renewed interest in recent years relates to the separation needs, especially in proteomics, metabolomics, and glycomics, where CE complements liquid chromatography techniques. This interest is further boosted by the regulators requiring additional separation techniques for characterization of newly developed pharmaceuticals. This paper gives a short overview of recent developments in the on‐line interfacing of CE separation techniques with electrospray ionization/mass spectrometric analysis. Both the instrumentation and selected CE/ESI/MS applications including analyses of peptides, proteins, and glycans are discussed with the stress on research published in the past 3 years. Techniques related to the proteomic and glycomic analyses such as sample preconcentration, on‐line protein digestion, and analyte derivatization prior CE/ESI/MS analysis are also included.

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On-line mass spectrometric detection for capillary zone electrophoresis
Olivares, J. A., Nhung, N. T., Yonker, C. R., & Smith, R. D. (1987) · Analytical Chemistry · doi:10.1021/ac00135a034 · Cited by 635 · see citing works
Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry
Smith, R. D., Barinaga, C. J., & Udseth, H. R. (1988) · Analytical Chemistry · doi:10.1021/ac00169a022 · Cited by 534 · see citing works
Glycan labeling strategies and their use in identification and quantification
Ruhaak, L. R., Zauner, G., Hühn, C., Bruggink, C., Deelder, A. M., & Wuhrer, M. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3532-z · Cited by 481 · see citing works
Capillary zone electrophoresis-mass spectrometry using an electrospray ionization interface
Smith, R. D., Olivares, J. A., Nhung, N. T., & Udseth, H. R. (1988) · Analytical Chemistry · doi:10.1021/ac00156a013 · Cited by 393 · see citing works
Mechanism of electrospray mass spectrometry. Electrospray as an electrolysis cell
Blades, A. T., Ikonomou, M. G., & Kebarle, P. (1991) · Analytical Chemistry · doi:10.1021/ac00019a009 · Cited by 365 · see citing works
Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry
Soga, T., Igarashi, K., Ito, C., Mizobuchi, K., Zimmermann, H.-P., & Tomita, M. (2009) · Analytical Chemistry · doi:10.1021/ac900675k · Cited by 331 · see citing works
Simplifying CE−MS Operation. 2. Interfacing Low-Flow Separation Techniques to Mass Spectrometry Using a Porous Tip
Moini, M. (2007) · Analytical Chemistry · doi:10.1021/ac0704560 · Cited by 322 · see citing works
On-column transient and coupled column isotachophoretic preconcentration of protein samples in capillary zone electrophoresis
Foret, F., Szökő, É., & Karger, B. L. (1992) · Journal of Chromatography A · doi:10.1016/0021-9673(92)87100-m · Cited by 262 · see citing works
Self-citation
Simplified capillary electrophoresis nanospray sheath‐flow interface for high efficiency and sensitive peptide analysis
Wojcik, R., Dada, O. O., Sadilek, M., & Dovichi, N. J. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4672 · Cited by 234 · see citing works
On-line capillary zone electrophoresis-ion spray tandem mass spectrometry for the determination of dynorphins
Lee, E. D., Mück, W. M., Henion, J. D., & Covey, T. R. (1988) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)90575-2 · Cited by 209 · see citing works
A decade of microfluidic analysis coupled with electrospray mass spectrometry: An overview
Koster, S., & Verpoorte, E. M. J. (2007) · Lab on a Chip · doi:10.1039/b709706a · Cited by 204 · see citing works
Twenty years of interface development for capillary electrophoresis–electrospray ionization–mass spectrometry
Maxwell, E. J., & Chen, D. D. Y. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.06.034 · Cited by 197 · see citing works
Relevance and use of capillary coatings in capillary electrophoresis–mass spectrometry
Hühn, C., Ramautar, R., Wuhrer, M., & Somsen, G. W. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-3193-y · Cited by 196 · see citing works
Capillary electrophoresis–mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: An update of recent developments
Mischak, H., Coon, J. J., Novak, J., Weissinger, E. M., Schanstra, J. P., & Dominiczak, A. F. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20205 · Cited by 193 · see citing works
Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics
Lapainis, T., Rubakhin, S. S., & Sweedler, J. V. (2009) · Analytical Chemistry · doi:10.1021/ac900936g · Cited by 191 · see citing works
High Capacity Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry: Coupling a Porous Sheathless Interface with Transient-Isotachophoresis
Busnel, J., Schoenmaker, B., Ramautar, R., Carrasco‐Pancorbo, A., Ratnayake, C. K., Feitelson, J. S., Chapman, J. D., Deelder, A. M., & Mayboroda, O. A. (2010) · Analytical Chemistry · doi:10.1021/ac102159d · Cited by 165 · see citing works
Nanoelectrospray emitters: Trends and perspective
Gibson, G. T. T., Mugo, S. M., & Oleschuk, R. D. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20248 · Cited by 158 · see citing works
Optimization and Evaluation of a Sheathless Capillary Electrophoresis–Electrospray Ionization Mass Spectrometry Platform for Peptide Analysis: Comparison to Liquid Chromatography–Electrospray Ionization Mass Spectrometry
Faserl, K., Sarg, B., Kremser, L., & Lindner, H. H. (2011) · Analytical Chemistry · doi:10.1021/ac2010372 · Cited by 153 · see citing works
CE‐MS for metabolomics: Developments and applications in the period 2008–2010
Ramautar, R., Mayboroda, O. A., Somsen, G. W., & de Jong, G. J. (2010) · Electrophoresis · doi:10.1002/elps.201000378 · Cited by 152 · see citing works
Decoupling CE and ESI for a more robust interface with MS
Maxwell, E. J., Zhong, X., Zhang, H., van Zeijl, N., & Chen, D. D. Y. (2010) · Electrophoresis · doi:10.1002/elps.200900517 · Cited by 150 · see citing works
Metabolic Differentiation of Neuronal Phenotypes by Single-cell Capillary Electrophoresis–Electrospray Ionization-Mass Spectrometry
Nemes, P., Knolhoff, A. M., Rubakhin, S. S., & Sweedler, J. V. (2011) · Analytical Chemistry · doi:10.1021/ac2015855 · Cited by 137 · see citing works
Microfabricated devices: A new sample introduction approach to mass spectrometry
Lazar, I. M., Grym, J., & Foret, F. (2006) · Mass Spectrometry Reviews · doi:10.1002/mas.20081 · Cited by 136 · see citing works
Self-citation
Capillary Zone Electrophoresis-Electrospray Ionization-Tandem Mass Spectrometry as an Alternative Proteomics Platform to Ultraperformance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry for Samples of Intermediate Complexity
Li, Y., Champion, M. M., Sun, L., Champion, P. A. D., Wojcik, R., & Dovichi, N. J. (2012) · Analytical Chemistry · doi:10.1021/ac202899p · Cited by 128 · see citing works
Microchip technology in mass spectrometry
Sikanen, T. M., Franssila, S., Kauppila, T. J., Kostiainen, R. K., Kotiaho, T., & Ketola, R. A. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20238 · Cited by 115 · see citing works
Capillary electrophoresis–mass spectrometry for the analysis of intact proteins 2007–2010
Haselberg, R., de Jong, G. J., & Somsen, G. W. (2010) · Electrophoresis · doi:10.1002/elps.201000364 · Cited by 110 · see citing works
Performance of a sheathless porous tip sprayer for capillary electrophoresis–electrospray ionization-mass spectrometry of intact proteins
Haselberg, R., Ratnayake, C. K., de Jong, G. J., & Somsen, G. W. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.10.006 · Cited by 109 · see citing works
Glycomic analysis by capillary electrophoresis–mass spectrometry
Mechref, Y., & Novotny, M. V. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20196 · Cited by 105 · cited 4× · see citing works
“[9] Mechref, Y., Novotny, M. V., Glycomic analysis by capillary electrophoresis-mass spectrometry.”
BackgroundMethodInfluential
CE‐MS in biomarker discovery, validation, and clinical application
Mischak, H., & Schanstra, J. P. (2010) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201000058 · Cited by 102 · see citing works
Ionization techniques in capillary electrophoresis‐mass spectrometry: Principles, design, and application
Hommerson, P., Khan, A. M., de Jong, G. J., & Somsen, G. W. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20313 · Cited by 99 · see citing works
Improved sample preparation method for glycan analysis of glycoproteins by CE‐LIF and CE‐MS
Szabó, Z., Guttman, A., Rejtar, T., & Karger, B. L. (2010) · Electrophoresis · doi:10.1002/elps.201000037 · Cited by 97 · see citing works
Capillary electrophoresis applied to proteomic analysis
Fonslow, B. R., & Yates III, J. R. (2009) · Journal of Separation Science · doi:10.1002/jssc.200800592 · Cited by 92 · see citing works
CE with MS detection: A rapidly developing hyphenated technique
Klampfl, C. W. (2009) · Electrophoresis · doi:10.1002/elps.200900088 · Cited by 90 · see citing works
Capillary electrophoresis-mass spectrometry using noncovalently coated capillaries for the analysis of biopharmaceuticals
Haselberg, R., Brinks, V., Hawe, A., de Jong, G. J., & Somsen, G. W. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4738-4 · Cited by 83 · see citing works
Technical, bioinformatical and statistical aspects of liquid chromatography–mass spectrometry (LC–MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment☆
Dakna, M., He, Z., Yu, W., Mischak, H., & Kölch, W. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.10.048 · Cited by 81 · see citing works
Chiral CE‐MS
Simó, C., García‐Cañas, V., & Cifuentes, A. (2010) · Electrophoresis · doi:10.1002/elps.200900673 · Cited by 80 · see citing works
A replaceable microreactor for on-line protein digestion in a two-dimensional capillary electrophoresis system with tandem mass spectrometry detection
Li, Y., Wojcik, R., & Dovic̀hi, N. J. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.10.013 · Cited by 78 · see citing works
Design and applications of a self-aligning liquid junction-electrospray interface for capillary electrophoresis-mass spectrometry
Wachs, T., Sheppard, R. L., & Henion, J. D. (1996) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(96)00176-4 · Cited by 72 · see citing works
Capillary electrophoresis‐mass spectrometry for the analysis of amino acids
Desiderio, C., Iavarone, F., Rossetti, D. V., Messana, I., & Castagnola, M. (2010) · Journal of Separation Science · doi:10.1002/jssc.201000171 · Cited by 72 · see citing works
Capillary electrophoresis mass spectrometry coupling with immobilized enzyme electrospray capillaries
Křenková, J., Klepárnı́k, K., & Foret, F. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.02.095 · Cited by 70 · see citing works
Self-citation
Mass Transport in a Micro Flow-Through Vial of a Junction-at-the-Tip Capillary Electrophoresis-Mass Spectrometry Interface
Zhong, X., Maxwell, E. J., & Chen, D. D. Y. (2011) · Analytical Chemistry · doi:10.1021/ac200636y · Cited by 70 · see citing works
Profiling the Glycoforms of the Intact α Subunit of Recombinant Human Chorionic Gonadotropin by High-Resolution Capillary Electrophoresis−Mass Spectrometry
Thakur, D., Rejtar, T., Karger, B. L., Washburn, N., Bosques, C. J., Günay, N. S., Shriver, Z. H., & Venkataraman, G. (2009) · Analytical Chemistry · doi:10.1021/ac901506p · Cited by 69 · see citing works
Electrolyte systems for on‐line CE–MS: Detection requirements and separation possibilities
Pantůčková, P., Gebauer, P., Boček, P., & Křivánková, L. (2009) · Electrophoresis · doi:10.1002/elps.200800262 · Cited by 68 · see citing works
Flow-Through Microvial Facilitating Interface of Capillary Isoelectric Focusing and Electrospray Ionization Mass Spectrometry
Zhong, X., Maxwell, E. J., Ratnayake, C. K., Mack, S., & Chen, D. D. Y. (2011) · Analytical Chemistry · doi:10.1021/ac202130f · Cited by 66 · see citing works
CE‐TOF/MS: Fundamental concepts, instrumental considerations and applications
Staub, A., Schappler, J., Rudaz, S. L., & Veuthey, J. (2009) · Electrophoresis · doi:10.1002/elps.200800782 · Cited by 65 · see citing works
On‐line CE‐MS using pressurized liquid junction nanoflow electrospray interface and surface‐coated capillaries
Fanali, S., D’Orazio, G., Foret, F., Klepárnı́k, K., & Aturki, Z. (2006) · Electrophoresis · doi:10.1002/elps.200600322 · Cited by 55 · see citing works
Self-citation
Labeling of oligosaccharides for quantitative mass spectrometry
Unterieser, I., & Mischnick, P. (2010) · Carbohydrate Research · doi:10.1016/j.carres.2010.11.001 · Cited by 55 · see citing works
Recent advances in CE‐MS: Synergy of wet chemistry and instrumentation innovations
Pantůčková, P., Gebauer, P., Boček, P., & Křivánková, L. (2010) · Electrophoresis · doi:10.1002/elps.201000382 · Cited by 54 · see citing works
The role of capillary electrophoresis–mass spectrometry to proteome analysis and biomarker discovery
Ahmed, F. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.05.023 · Cited by 53 · see citing works
Use of organic solvent to prevent protein adsorption in CE‐MS experiments
Staub, A., Comte, S., Rudaz, S. L., Veuthey, J., & Schappler, J. (2010) · Electrophoresis · doi:10.1002/elps.201000245 · Cited by 48 · see citing works
Isoform differentiation of intact AGP from human serum by capillary electrophoresis–mass spectrometry
Ongay, S., & Neusüβ, C. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3948-5 · Cited by 48 · see citing works
Capillary electrophoresis–mass spectrometry: Recent trends in clinical proteomics
Desiderio, C., Rossetti, D. V., Iavarone, F., Messana, I., & Castagnola, M. (2010) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2010.06.035 · Cited by 47 · see citing works
New insight into suction and dilution effects in CE coupled to MS <i>via</i> an ESI interface. II – Dilution effect
Mokaddem, M., Gareil, P., Belgaied, J., & Varenne, A. (2009) · ELECTROPHORESIS · doi:10.1002/elps.200800480 · Cited by 45 · see citing works
Recent progress in microchip electrophoresis–mass spectrometry
Kitagawa, F., & Otsuka, K. (2010) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2010.11.013 · Cited by 45 · see citing works
Characterization of drug-lysozyme conjugates by sheathless capillary electrophoresis–time-of-flight mass spectrometry
Haselberg, R., Harmsen, S., Dolman, M. E. M., de Jong, G. J., Kok, R. J., & Somsen, G. W. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.04.050 · Cited by 43 · see citing works
High resolution TOF MS coupled to CE for the analysis of isotopically resolved intact proteins
Taichrib, A., Pelzing, M., Pellegrino, C., Rossi, M., & Neusüß, C. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.01.006 · Cited by 41 · see citing works
Capillary electrophoresis–mass spectrometry in urinary proteome analysis: current applications and future developments
Metzger, J., Schanstra, J. P., & Mischak, H. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2309-0 · Cited by 41 · see citing works
Transient isotachophoresis in on‐line solid phase extraction capillary electrophoresis time‐of‐flight‐mass spectrometry for peptide analysis in human plasma
Medina‐Casanellas, S., Benavente, F., Barbosa, J., & Sanz‐Nebot, V. (2011) · Electrophoresis · doi:10.1002/elps.201100017 · Cited by 40 · see citing works
Multifunctional protein processing chip with integrated digestion, solid‐phase extraction, separation and electrospray
Wang, C., Jemere, A. B., & Harrison, D. J. (2010) · Electrophoresis · doi:10.1002/elps.201000317 · Cited by 38 · see citing works
On-line coupling of electrokinetic chromatography and mass spectrometry
Somsen, G. W., Mol, R., & de Jong, G. J. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.01.026 · Cited by 37 · see citing works
Capillary electrophoresis time‐of‐flight mass spectrometry for a confident elucidation of a glycopeptide map of recombinant human erythropoietin
Giménez, E., Ramos‐Hernan, R., Benavente, F., Barbosa, J., & Sanz‐Nebot, V. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5114 · Cited by 36 · see citing works
Multiple injection technique for the determination and quantitation of insulin formulations by capillary electrophoresis and time-of-flight mass spectrometry
Staub, A., Rudaz, S. L., Veuthey, J., & Schappler, J. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.08.076 · Cited by 36 · see citing works
Online CIEF‐ESI‐MS in glycerol–water media with a view to hydrophobic protein applications
Mokaddem, M., Gareil, P., & Varenne, A. (2009) · Electrophoresis · doi:10.1002/elps.200900091 · Cited by 35 · see citing works
Proteomic reactors and their applications in biology
Zhou, H., Ning, Z., Wang, F., Seebun, D., & Figeys, D. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08292.x · Cited by 34 · see citing works
Chip‐CE/MS using a flat low‐sheath‐flow interface
Li, F., Huang, J., & Her, G. (2008) · Electrophoresis · doi:10.1002/elps.200800271 · Cited by 34 · see citing works
Optimization of a pressurized liquid junction nanoelectrospray interface between CE and MS for reliable proteomic analysis
Kusý, P., Klepárnı́k, K., Aturki, Z., Fanali, S., & Foret, F. (2007) · Electrophoresis · doi:10.1002/elps.200600640 · Cited by 34 · see citing works
Self-citation
A promising capillary electrophoresis–electrospray ionization–mass spectrometry method for carbohydrate analysis
Maxwell, E. J., Ratnayake, C. K., Jayo, R., Zhong, X., & Chen, D. D. Y. (2011) · Electrophoresis · doi:10.1002/elps.201100027 · Cited by 34 · see citing works
Statistical evaluation of CZE‐UV and CZE‐ESI‐MS data of intact α‐1‐acid glycoprotein isoforms for their use as potential biomarkers in bladder cancer
Ongay, S., Martín‐Álvarez, P. J., Neusüß, C., & de Frutos, M. (2010) · Electrophoresis · doi:10.1002/elps.201000244 · Cited by 34 · see citing works
Analysis of recombinant human erythropoietin and novel erythropoiesis stimulating protein digests by immunoaffinity capillary electrophoresis–mass spectrometry
Giménez, E., Benavente, F., de Bolós, C., Nicolás, E., Barbosa, J., & Sanz‐Nebot, V. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.01.057 · Cited by 33 · see citing works
Analysis of hemoglobin‐based oxygen carriers by CE‐UV/Vis and CE‐ESI‐TOF/MS
Staub, A., Rudaz, S. L., Saugy, M., Veuthey, J., & Schappler, J. (2010) · Electrophoresis · doi:10.1002/elps.200900513 · Cited by 32 · see citing works
Performance of different separation methods interfaced in the same MS‐reflection TOF detector: A comparison of performance between CE versus HPLC for biomarker analysis
Mullen, W., Albalat, A., Gonzalez, J., Zerefos, P. G., Siwy, J., Franke, J., & Mischak, H. (2012) · Electrophoresis · doi:10.1002/elps.201100415 · Cited by 32 · see citing works
Recent advances in capillary electrophoresis‐based proteomic techniques for biomarker discovery
Fang, X., Balgley, B. M., & Lee, C. S. (2009) · Electrophoresis · doi:10.1002/elps.200900219 · Cited by 32 · see citing works
Sensitivity enhancement of CE and CE‐MS for the analysis of peptides by a dynamic pH junction
Hasan, M. N., Park, S. H., Oh, E., Song, E. J., Ban, E., & Yoo, Y. S. (2010) · Journal of Separation Science · doi:10.1002/jssc.201000020 · Cited by 31 · see citing works
Simultaneous analysis of cocaine and its metabolites in urine by capillary electrophoresis–electrospray mass spectrometry using a pressurized liquid junction nanoflow interface
Hezinová, V., Aturki, Z., Klepárnı́k, K., D’Orazio, G., Foret, F., & Fanali, S. (2012) · Electrophoresis · doi:10.1002/elps.201100410 · Cited by 31 · see citing works
Self-citation
Fast capillary electrophoresis–time-of-flight mass spectrometry using capillaries with inner diameters ranging from 75 to 5 μm
Grundmann, M., & Matysik, F. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4719-7 · Cited by 28 · see citing works
CE‐ESI‐TOF/MS for human growth hormone analysis
Staub, A., Giraud, S., Saugy, M., Rudaz, S. L., Veuthey, J., & Schappler, J. (2009) · Electrophoresis · doi:10.1002/elps.200900315 · Cited by 28 · see citing works
Evaluation of the effect of the immunopurification‐based procedures on the CZE‐UV and CZE‐ESI‐TOF‐MS determination of isoforms of intact α‐1‐acid glycoprotein from human serum
Ongay, S., Neusüß, C., Vaas, S., Díez‐Masa, J. C., & de Frutos, M. (2010) · Electrophoresis · doi:10.1002/elps.200900680 · Cited by 28 · see citing works
Analysis of Phosphorus-containing Amino Acid-type Herbicides by Sheathless Capillary Electrophoresis/Electrospray Ionization-Mass Spectrometry Using a High Sensitivity Porous Sprayer
Kawai, M., Iwamuro, Y., Iio‐Ishimaru, R., Chinaka, S., Takayama, N., & Hayakawa, K. (2011) · Analytical Sciences · doi:10.2116/analsci.27.857 · Cited by 26 · see citing works
CE‐ESI‐MS coupled with dynamic pH junction online concentration for analysis of peptides in human urine samples
Ye, H., Xia, S., Lin, W., Yu, L., Xu, X., Zheng, C., Liu, X., & Chen, G. (2010) · Electrophoresis · doi:10.1002/elps.201000194 · Cited by 25 · see citing works
CE‐ESI‐MS/MS as a rapid screening tool for the comparison of protein–ligand interactions
Hoffmann, T., & Martin, M. M. (2010) · Electrophoresis · doi:10.1002/elps.200900585 · Cited by 24 · see citing works
Staggered multistep elution solid‐phase extraction capillary electrophoresis/tandem mass spectrometry: a high‐throughput approach in protein analysis
Lee, W., Wang, C., & Her, G. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5091 · Cited by 22 · see citing works
Evaluation of the potentiometric detection of acetylcholine and other neurotransmitters in capillary electrophoresis
Kappes, T., Schnierle, P., & Hauser, P. C. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000401)21:7 · Cited by 19 · see citing works
Self-citation
The development of a two‐leveled two cross interface for on‐line coupling solid‐phase extraction and capillary electrophoresis‐mass spectrometry
Lee, W., & Her, G. (2009) · Electrophoresis · doi:10.1002/elps.200800709 · Cited by 19 · see citing works
Development of a CE‐MS method to analyze components of the potential biomarker vascular endothelial growth factor 165
Puerta, Á., & Bergquist, J. (2009) · Electrophoresis · doi:10.1002/elps.200800738 · Cited by 18 · see citing works
Analyte transport in liquid junction nano‐electrospray interface between capillary electrophoresis and mass spectrometry
Klepárnı́k, K., & Otevrel, M. (2010) · Electrophoresis · doi:10.1002/elps.200900544 · Cited by 17 · see citing works
Electrochemical Reactions and Ionization Processes
Girault, H. H., Liu, B., Qiao, L., Bi, H., Prudent, M., Lion, N., & Abonnenc, M. (2010) · European Journal of Mass Spectrometry · doi:10.1255/ejms.1081 · Cited by 15 · see citing works
A liquid-junction/low-flow interface for sensitivity improvement in micelle electrokinetic chromatography–electrospray ionization-mass spectrometry
Liu, Y., Wang, N.-H., Li, F., & Her, G. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.10.049 · Cited by 12 · see citing works
Sequential injection setup for capillary isoelectric focusing combined with MS detection
Páger, C., Dörnyei, Á., & Kilár, F. (2011) · Electrophoresis · doi:10.1002/elps.201100012 · Cited by 10 · see citing works
Analysis of low molecular weight acids by monolithic immobilized pH gradient‐based capillary isoelectric focusing coupled with mass spectrometry
Wang, T., Fekete, Á., Gaspar, A., Ma, J., Liang, Z., Yuan, H., Zhang, L., Schmitt‐Kopplin, P., & Zhang, Y. (2011) · Journal of Separation Science · doi:10.1002/jssc.201000720 · Cited by 8 · see citing works
Untitled work
Heller (2001) · doi:10.1002/1522-2683(200102)22:4

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Gomes, F. P., & Yates, J. R. (2019) · Mass Spectrometry Reviews · doi:10.1002/mas.21599 · Cited by 112 · see citing works
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Ibáñez, C., Simó, C., García‐Cañas, V., Cifuentes, A., & Castro‐Puyana, M. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.07.042 · Cited by 109 · see citing works
Preventive and therapeutic potential of peptides from cereals against cancer
Ortiz-Martinez, M., Winkler, R., & García-Lara, S. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.03.044 · Cited by 100 · see citing works
Metabolome analysis based on capillary electrophoresis-mass spectrometry
Hirayama, A., Wakayama, M., & Soga, T. (2014) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2014.05.005 · Cited by 91 · see citing works
Recent advances in coupling capillary electrophoresis‐based separation techniques to ESI and MALDI‐MS
Zhong, X., Zhang, Z., Jiang, S., & Li, L. (2013) · Electrophoresis · doi:10.1002/elps.201300451 · Cited by 74 · see citing works
Recent developments and applications of capillary and microchip electrophoresis in proteomic and peptidomic analyses
Štěpánová, S., & Kašička, V. (2015) · Journal of Separation Science · doi:10.1002/jssc.201500973 · Cited by 70 · see citing works
Capillary zone electrophoresis-mass spectrometry for bottom-up proteomics
Zhang, Z., Qu, Y., & Dovichi, N. J. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.08.008 · Cited by 61 · see citing works
Unraveling the Glyco-Puzzle: Glycan Structure Identification by Capillary Electrophoresis
Mittermayr, S., Bones, J., & Guttman, A. (2013) · Analytical Chemistry · doi:10.1021/ac4006099 · Cited by 61 · see citing works
Solvent-Assisted Electrospray Ionization for Direct Analysis of Various Compounds (Complex) from Low/Nonpolar Solvents and Eluents
Zhang, J.-T., Wang, H., Zhu, W., Cai, T., & Guo, Y. (2014) · Analytical Chemistry · doi:10.1021/ac502656a · Cited by 52 · see citing works
Capillary Isotachophoresis-Nanoelectrospray Ionization-Selected Reaction Monitoring MS via a Novel Sheathless Interface for High Sensitivity Sample Quantification
Wang, C., Lee, C. S., Smith, R. D., & Tang, K. (2013) · Analytical Chemistry · doi:10.1021/ac401202c · Cited by 46 · see citing works
Capillary Electrophoresis Coupled to Electrospray Ionization Tandem Mass Spectrometry for Ultra-Sensitive Proteomic Analysis of Limited Samples
Johnson, K. R., Greguš, M., Kostas, J. C., & Ivanov, A. R. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02929 · Cited by 44 · see citing works
Capillary electrophoresis-mass spectrometry for intact protein analysis: Pharmaceutical and biomedical applications (2018-March 2023).
Maráková, K., Opetová, M., & Tomašovský, R. (2023) · Journal of Separation Science · doi:10.1002/jssc.202300244 · Cited by 39 · see citing works
Capillary zone electrophoresis for analysis of complex proteomes using an electrokinetically pumped sheath flow nanospray interface
Sun, L., Zhu, G., Yan, X., Champion, M. M., & Dovic̀hi, N. J. (2013) · PROTEOMICS · doi:10.1002/pmic.201300295 · Cited by 43 · see citing works
Capillary zone electrophoresis for bottom‐up analysis of complex proteomes
Sun, L., Zhu, G., Yan, X., Zhang, Z., Wojcik, R., Champion, M. M., & Dovichi, N. J. (2016) · PROTEOMICS · doi:10.1002/pmic.201500339 · Cited by 41 · see citing works
A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples
Nguyen, T. T. T. N., Petersen, N. J., & Rand, K. D. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.07.002 · Cited by 33 · see citing works
Evaluation of a new low sheath-flow interface for CE-MS
González‐Ruiz, V., Codesido, S., Far, J., Rudaz, S. L., & Schappler, J. (2016) · Electrophoresis · doi:10.1002/elps.201500523 · Cited by 33 · see citing works
Coupling High-Field Asymmetric Ion Mobility Spectrometry with Capillary Electrophoresis-Electrospray Ionization-Tandem Mass Spectrometry Improves Protein Identifications in Bottom-Up Proteomic Analysis of Low Nanogram Samples
Johnson, K. R., Greguš, M., & Ivanov, A. R. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00337 · Cited by 31 · see citing works
Derivatisation for separation and detection in capillary electrophoresis (2012–2015)
Wuethrich, A., & Quirino, J. P. (2015) · Electrophoresis · doi:10.1002/elps.201500290 · Cited by 29 · see citing works
Characterization of a Porous Nano-electrospray Capillary Emitter at Ultra-low Flow Rates
Járvás, G., Fonslow, B. R., Yates, J. R., Foret, F., & Guttman, A. (2016) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmw148 · Cited by 23 · see citing works
Self-citation
Single-cell proteomics in complex tissues using microprobe capillary electrophoresis mass spectrometry
Lombard‐Banek, C., Choi, S. B., & Nemes, P. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.07.001 · Cited by 23 · see citing works
On-Line Solid-Phase Extraction Capillary Electrophoresis Mass Spectrometry for Preconcentration and Clean-Up of Peptides and Proteins
Benavente, F., Medina‐Casanellas, S., Giménez, E., & Sanz‐Nebot, V. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-4014-1_6 · Cited by 20 · see citing works
Addition of reagents to the sheath liquid: A novel concept in capillary electrophoresis-mass spectrometry
Causon, T. J., Maringer, L., Buchberger, W. W., & Klampfl, C. W. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.04.002 · Cited by 18 · see citing works
Multiplexed electrokinetic sample fractionation, preconcentration and elution for proteomics
Hua, Y., Jemere, A. B., Dragoljic, J., & Harrison, D. J. (2013) · Lab on a Chip · doi:10.1039/c3lc50401h · Cited by 15 · see citing works
Separation, identification and quantification of associated impurities in cobratide using sheathless CE-MS and CE-UV
Liu, B., Wang, W., Gao, T., Huang, L., Fan, H., & Chen, H. (2021) · Analytical Methods · doi:10.1039/d1ay00717c · Cited by 15 · see citing works
Numerical modeling of capillary electrophoresis – electrospray mass spectrometry interface design
Járvás, G., Guttman, A., & Foret, F. (2014) · Mass Spectrometry Reviews · doi:10.1002/mas.21423 · Cited by 11 · see citing works
Self-citation
The Role of Proteomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools
Christians, U., McCrery, S., Klawitter, J., & Klawitter, J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375672-5.10004-0 · Cited by 7 · see citing works
Sheath Liquids in CE-MS: Role, Parameters, and Optimization
Klampfl, C. W., & Himmelsbach, M. (2016) · Wiley-VCH eBooks · doi:10.1002/9783527693801.ch3 · Cited by 5 · see citing works
Capillary Electrophoresis-Mass Spectrometry for Proteomics
Martelli, C., & Desiderio, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809375-7.00014-9 · Cited by 5 · see citing works
The Role of Proteomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools
Christians, U., Klawitter, J., Klepacki, J., & Klawitter, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803014-1.00004-2 · Cited by 5 · see citing works
Simulation‐based design of a microfabricated pneumatic electrospray nebulizer
Járvás, G., Grym, J., Foret, F., & Guttman, A. (2014) · Electrophoresis · doi:10.1002/elps.201400387 · Cited by 4 · see citing works
Self-citation
Precursor Resolution via Ion Z‐State Manipulation: A Tandem Mass Spectrometry Approach for the Analysis of Mixtures of Multiply‐Charged Ions
Pizzala, N. J., Chao, H., Faye, B., & McLuckey, S. A. (2025) · Journal of Mass Spectrometry · doi:10.1002/jms.5124 · Cited by 2 · see citing works
CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications
Hirayama, A., & Soga, T. (2018) · Royal Society of Chemistry eBooks · doi:10.1039/9781788012737-00134 · Cited by 2 · see citing works
Single-cell Metabolomics with Capillary Electrophoresis–Mass Spectrometry
Onjiko, R. M., Portero, E. P., & Nemes, P. (2018) · Royal Society of Chemistry eBooks · doi:10.1039/9781788012737-00209 · Cited by 2 · see citing works
Mass Spectrometric Detectors for Environmental Studies
Balcerzak, M. (2016) · Wiley eBooks · doi:10.1002/9781119085362.ch2 · Cited by 1 · see citing works
Trends in CE ‐ MS and Applications
Týčová, A., & Foret, F. (2015) · doi:10.1002/9783527678129.assep039
Self-citation
Microfabricated Liquid Junction Capillary Electrophoresis–Mass Spectrometry Interface
Křenková, J., & Foret, F. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2493-7_4
Self-citation
Spatiotemporal Proteomics: Unveiling Evolving Molecular Landscapes in Inflammatory Bowel Disease and Associated Colorectal Cancer
Zhang, P., Tang, X., Akanyibah, F. A., Du, S., & Mao, F. (2025) · Laboratory Investigation · doi:10.1016/j.labinv.2025.104256 · Cited by 1 · see citing works
Ultrasensitive CITP-MS based targeted proteomics technologies for protein identification and quantification
Wang, C. (2014) · University Libraries (University of Maryland)
Identification des ligands biologiques de l’uranium dans les gonades de Danio rerio. : Impact sur leur fonctionnalité.
Eb-Levadoux, Y. (2017) · doi:10.70675/923590c4z9f60z406dzb61dz2184c9d723e9
Développement d'un laboratoire sur puce pour la protéomique : focalisation isoélectrique-digestion électrochimique-détection par spectrométrie de masse
Frej, M. B. (2019) · doi:10.70675/80a369d2z496az4137zb74az51a9ac887223
From Columns to Clouds: Emerging Interfaces and Ion Sources for Coupling Analytical Separations With Mass Spectrometry
Raju, C. M., & Urban, P. L. (2026) · Journal of Separation Science · doi:10.1002/jssc.70411

Trends in CE-MS and its applications
Týčová, A. (., & Foret, F. (. (2016) · ASEP
Self-citation
Developments in Interfacing Designs for CE–MS: Towards Enabling Tools for Proteomics and Metabolomics
Lindenburg, P. W., Haselberg, R., Rozing, G. P., & Ramautar, R. (2014) · Chromatographia · doi:10.1007/s10337-014-2795-5 · Cited by 74 · see citing works
CE–MS for proteomics: Advances in interface development and application
Ramautar, R., Heemskerk, A. A. M., Hensbergen, P. J., Deelder, A. M., Busnel, J.-M., & Mayboroda, O. A. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.04.050 · Cited by 86 · see citing works
Highly Sensitive and Robust Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry: Interfaces, Preconcentration Techniques and Applications
Wu, H., & Tang, K. (2020) · Reviews in Analytical Chemistry · doi:10.1515/revac-2020-0112 · Cited by 34 · see citing works
A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples
Nguyen, T. T. T. N., Petersen, N. J., & Rand, K. D. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.07.002 · Cited by 33 · see citing works

Authors: Krenkova, J., & Foret, F.
Affiliations: Institute of Analytical Chemistry of the ASCR Brno Czech Republic
Venue: PROTEOMICS
Publisher: Wiley
Published: 2012-09-10
Volume: 12
Issue: 19-20
Pages: 2978-2990
ISSN: 1615-9853 (ISSN-L)
1615-9861
DOI: 10.1002/pmic.201200140
OpenAlex: W2157903154
Cited by: 44
References: 89
Citations by year: 2026: 1 · 2025: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 8 · 2015: 4 · 2014: 8 · 2013: 7
FWCI: 0.57
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: PROTEOMICS (publishedVersion)
PubMed (publishedVersion)
ASEP (submittedVersion, public-domain)
Funders: SoMoPro programme
European Community within the Seventh Framework Programme (229603)
South Moravian Region
Agency of the Czech Republic (P301/11/2055, P206/12/G014)
institutional support RVO (68081715)
Topics: Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords: capillary electrophoresis, electrospray ionization, glycomics, metabolomics, peptide analysis, protein analysis, glycan analysis, preconcentration, pharmaceutical characterization
MeSH terms: Humans, Peptides, Polysaccharides, Proteins, Systems Integration, Electrophoresis, Capillary, Spectrometry, Mass, Electrospray Ionization, Proteomics

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