Cited by 247Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and ApplicationsMachine Learning in Bioinformatics

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ProSight Lite: Graphical software to analyze top‐down mass spectrometry data

Fellers, Ryan T., Greer, Joseph B., Early, Bryan P., Yu, Xiang, LeDuc, Richard D., Kelleher, Neil L., Thomas, Paul M.·2015·PROTEOMICS

DOI 10.1002/pmic.201400313

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Abstract

Many top‐down proteomics experiments focus on identifying and localizing PTMs and other potential sources of “mass shift” on a known protein sequence. A simple application to match ion masses and facilitate the iterative hypothesis testing of PTM presence and location would assist with the data analysis in these experiments. ProSight Lite is a free software tool for matching a single candidate sequence against a set of mass spectrometric observations. Fixed or variable modifications, including both PTMs and a select number of glycosylations, can be applied to the amino acid sequence. The application reports multiple scores and a matching fragment list. Fragmentation maps can be exported for publication in either portable network graphic (PNG) or scalable vector graphic (SVG) format. ProSight Lite can be freely downloaded from http://prosightlite.northwestern.edu , installs and updates from the web, and requires Windows 7 or a higher version.

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Self-citation

Authors: Fellers, R. T., Greer, J. B., Early, B. P., Yu, X., LeDuc, R. D., Kelleher, N. L., & Thomas, P. M.
Affiliations: Northwestern University (US)
Corresponding author: Kelleher, Neil L.
Thomas, Paul M.
ORCID: Fellers, Ryan T.
Greer, Joseph B.
Yu, Xiang
LeDuc, Richard D.
Kelleher, Neil L.
Thomas, Paul M.
Venue: PROTEOMICS
Publisher: Wiley
Published: 2015-02-26
Volume: 15
Issue: 7
Pages: 1235-1238
ISSN: 1615-9853 (ISSN-L)
1615-9861
DOI: 10.1002/pmic.201400313
OpenAlex: W1983285663
Cited by: 247
References: 15
Citations by year: 2026: 6 · 2025: 21 · 2024: 22 · 2023: 18 · 2022: 21 · 2021: 36 · 2020: 19 · 2019: 27 · 2018: 20 · 2017: 28 · 2016: 18 · 2015: 10
FWCI: 7.99
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: PROTEOMICS (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (P30DA018310)
National Institute of General Medical Sciences (R01GM067193)
Topics: Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Machine Learning in Bioinformatics
Keywords: top-down mass spectrometry, post-translational modification, mass shift, glycosylation, graphics software, open source software
MeSH terms: Amino Acid Sequence, Humans, Molecular Weight, Protein Processing, Post-Translational, Software, Proteome, Databases, Protein, Proteomics, Tandem Mass Spectrometry, Molecular Sequence Annotation

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