Cited by 40Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systemsbiodegradable polymer synthesis and properties

Synthesis, self‐assembly, drug‐release behavior, and cytotoxicity of triblock and pentablock copolymers composed of poly(ε‐caprolactone), poly( L ‐lactide), and poly(ethylene glycol)

Sun, Lin, Shen, Lin‐Jing, Zhu, Ming‐Qiang, Dong, Chang‐Ming, Wei, Yen·2010·Journal of Polymer Science Part A: Polymer Chemistry

Abstract

Biocompatible and biodegradable ABC and ABCBA triblock and pentablock copolymers composed of poly(ε‐caprolactone) (PCL), poly( L ‐lactide) (PLA), and poly(ethylene glycol) (PEO) with controlled molecular weights and low polydispersities were synthesized by a click conjugation between alkyne‐terminated PCL‐ b ‐PLA and azide‐terminated PEO. Their molecular structures, physicochemical and self‐assembly properties were thoroughly characterized by means of FT‐IR, 1 H‐NMR, gel permeation chromatography, differential scanning calorimetry, wide‐angle X‐ray diffraction, dynamic light scattering, and transmission electron microscopy. These copolymers formed microphase‐separated crystalline materials in solid state, where the crystallization of PCL block was greatly restricted by both PEO and PLA blocks. These copolymers self‐assembled into starlike and flowerlike micelles with a spherical morphology, and the micelles were stable over 27 days in aqueous solution at 37 °C. The doxorubicin (DOX) drug‐loaded nanoparticles showed a bigger size with a similar spherical morphology compared to blank nanoparticles, demonstrating a biphasic drug‐release profile in buffer solution and at 37 °C. Moreover, the DOX‐loaded nanoparticles fabricated from the pentablock copolymer sustained a longer drug‐release period (25 days) at pH 7.4 than those of the triblock copolymer. The blank nanoparticles showed good cell viability, whereas the DOX‐loaded nanoparticles killed fewer cells than free DOX, suggesting a controlled drug‐release effect. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010

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Crossref · 10.1002/pola.24255

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Authors
Sun, L., Shen, L., Zhu, M., Dong, C., & Wei, Y.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Hunan University (CN)
Corresponding author
Dong, Chang‐Ming
Venue
Journal of Polymer Science Part A: Polymer Chemistry
Publisher
Wiley
Published
2010-09-02
Volume
48
Issue
20
Pages
4583-4593
ISSN
  • 0887-624X (ISSN-L)
  • 1099-0518
OpenAlex
W2135843462
Cited by
40
References
43
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2021: 3 · 2019: 2 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 4
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Locations
Journal of Polymer Science Part A Polymer Chemistry (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
polycaprolactone, poly(L-lactic acid), polyethylene glycol, triblock copolymers, pentablock copolymers, self-assembly, micelles, doxorubicin, drug delivery nanoparticles, controlled drug release, pH-responsive drug release, cytotoxicity, biodegradable polymers, microphase separation

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