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UCSF ChimeraX: Tools for structure building and analysis

Open access
Meng, Elaine C., Goddard, Thomas D., Pettersen, Eric F., Couch, Greg S., Pearson, Zach J., Morris, John H., Ferrin, Thomas E.·2023·Protein Science

Abstract

Advances in computational tools for atomic model building are leading to accurate models of large molecular assemblies seen in electron microscopy, often at challenging resolutions of 3–4 Å. We describe new methods in the UCSF ChimeraX molecular modeling package that take advantage of machine‐learning structure predictions, provide likelihood‐based fitting in maps, and compute per‐residue scores to identify modeling errors. Additional model‐building tools assist analysis of mutations, post‐translational modifications, and interactions with ligands. We present the latest ChimeraX model‐building capabilities, including several community‐developed extensions. ChimeraX is available free of charge for noncommercial use at https://www.rbvi.ucsf.edu/chimerax.

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Items 101–122 of 122

Metadata

Authors
Meng, E. C., Goddard, T. D., Pettersen, E. F., Couch, G. S., Pearson, Z. J., Morris, J. H., & Ferrin, T. E.
Venue
Protein Science
Publisher
Wiley
Published
2023-10-20
Volume
32
Issue
11
Pages
e4792-e4792
ISSN
  • 0961-8368 (ISSN-L)
  • 1469-896X
OpenAlex
W4387164156
Cited by
4,442
References
7
FWCI
393.46
Type
journal article
Language
en
Open access
hybrid
Funders
  • National Institutes of Health (R24 GM141254, R01 GM129325)
  • Chan Zuckerberg Initiative (EOSS4‐0000000439)

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