Antidiabetic effect ofCinnamomum cassia andCinnamomum zeylanicum In vivo andIn vitro
Abstract
Rats were given Cinnamomum cassia bark or extracts from Cinnamomum cassia and zeylanicum to evaluate blood glucose and plasma insulin levels in rats under various conditions. The cassia extract was superior to the zeylanicum extract. The cassia extract was slightly more efficacious than the equivalent amount of Cassia bark. A decrease in blood glucose levels was observed in a glucose tolerance test (GTT), whereas it was not obvious in rats that were not challenged by a glucose load. The elevation in plasma insulin was direct since a stimulatory in vitro effect of insulin release from INS-1 cells (an insulin secreting cell line) was observed. Thus the cassia extract has a direct antidiabetic potency.
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A study found that rats pretreated with cinnamon had lower blood glucose after a glucose tolerance test.
“A new study shows that rats given cinnamon and then administered a glucose tolerance test had decreased blood glucose concentrations (12).”
From Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects (2007) · cites this paper as [12]
The same study reported that cinnamon acts directly against diabetes in rats by raising plasma insulin.
“The same study shows that cinnamon has a direct antidiabetic effect by increasing insulin concentrations in plasma (12).”
From Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects (2007) · cites this paper as [12]
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- Authors
- Verspohl, E. J., Bauer, K., & Neddermann, E.
- Affiliations
- University of Münster (DE)
- Corresponding author
- Verspohl, Eugen J.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2005
- Volume
- 19
- Issue
- 3
- Pages
- 203-206
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1795126892
- Cited by
- 172
- References
- 11
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 14 · 2021: 14 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 11 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 15 · 2012: 10
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- Cinnamomum cassia, Cinnamomum zeylanicum, cinnamon bark extract, antidiabetic effect, blood glucose, plasma insulin, glucose tolerance, insulin secretion, INS-1 cells, herbal medicine
- MeSH terms
- Animals, Blood Glucose, Cinnamomum zeylanicum, Diabetes Mellitus, Type 1, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Glucose Tolerance Test, Hypoglycemic Agents, Insulin, Male, Phytotherapy, Plant Extracts, Rats, Wistar, Cinnamomum aromaticum, Rats
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