A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes
Abstract
OBJECTIVES: These studies investigated the ability of a hydroxychalcone from cinnamon to function as an insulin mimetic in 3T3-LI adipocytes. METHODS: Comparative experiments were performed with the cinnamon methylhydroxychalcone polymer and insulin with regard to glucose uptake, glycogen synthesis. phosphatidylinositol-3-kinase dependency, glycogen synthase activation and glycogen synthase kinase-3beta activity. The phosphorylation state of the insulin receptor was also investigated. RESULTS: MHCP treatment stimulated glucose uptake and glycogen synthesis to a similar level as insulin. Glycogen synthesis was inhibited by both wortmannin and LY294002, inhibitors directed against the PI-3-kinase. In addition, MHCP treatment activated glycogen synthase and inhibited glycogen synthase kinase-3beta activities, known effects of insulin treatment. Analysis of the insulin receptor demonstrated that the receptor was phosphorylated upon exposure to the MHCP. This supports that the insulin cascade was triggered by MHCP. Along with comparing MHCP to insulin, experiments were done with MHCP and insulin combined. The responses observed using the dual treatment were greater than additive, indicating synergism between the two compounds. CONCLUSION: Together, these results demonstrate that the MHCP is an effective mimetic of insulin. MHCP may be useful in the treatment of insulin resistance and in the study of the pathways leading to glucose utilization in cells.
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Both in vitro and in vivo animal studies have shown insulin-enhancing or insulin-like effects after cinnamon administration.
“Both in vitro and in vivo animal studies have shown insulin-enhancing or insulin-like effects after cinnamon administration [365,366,367].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [366]
Cites
Thomas, J. A., Schlender, K. K., & Larner, J. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90127-9 · Cited by 1,198 · see citing works
Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway
Pap, M., & Cooper, G. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.19929 · Cited by 1,046 · see citing works
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953 · see citing works
Chromium occurrence and function in biological systems.
Mertz, W. (1969) · Physiological Reviews · doi:10.1152/physrev.1969.49.2.163 · Cited by 820 · see citing works
Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410404 · Cited by 675 · see citing works
Frost, S. C., & Lane, M. D. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89409-1 · Cited by 513 · see citing works
Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice
Zhang, B., Salituro, G., Szalkowski, D., Li, Z., Zhang, Y., Royo, I., Vilella, D., Dı́ez, M. T., Peláez, F., Ruby, C., et al. (1999) · Science · doi:10.1126/science.284.5416.974 · Cited by 456 · see citing works
Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance
Kahn, B. B. (1998) · Cell · doi:10.1016/s0092-8674(00)81125-3 · Cited by 426 · see citing works
Lazar, D. F., Wiese, R. J., Brady, M. J., Mastick, C. C., Waters, S. B., Yamauchi, K., Pessin, J. E., Cuatrecasas, P., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20801 · Cited by 396 · see citing works
Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action
Eldar-Finkelman, H., & Krebs, E. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9660 · Cited by 319 · see citing works
The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism
Summers, S. A., Kao, A. W., Kohn, A. D., Backus, G. S., Roth, R. A., Pessin, J. E., & Birnbaum, M. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17934 · Cited by 214 · see citing works
Ceresa, B. P., Kao, A. W., Santeler, S. R., & Pessin, J. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3862 · Cited by 214 · see citing works
Imparl-Radosevich, J. M., Deas, S., Polansky, M. M., Baedke, D. A., Ingebritsen, T. S., Anderson, R. A., & Graves, D. J. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023270 · Cited by 205 · see citing works
Guinovart, J. J., Salavert, A., Massagué, J., Ciudad, C. J., Salsas, E., & Itarte, E. (1979) · FEBS Letters · doi:10.1016/0014-5793(79)80515-3 · Cited by 175 · see citing works
Insulin potentiating factor and chromium content of selected foods and spices
Khan, A., Bryden, N. A., Polansky, M. M., & Anderson, R. A. (1990) · Biological Trace Element Research · doi:10.1007/bf02917206 · Cited by 171 · see citing works
Nadiv, O., Shinitzky, M., Manu, H., Hecht, D., Roberts, C. T., LeRoith, D., & Zick, Y. (1994) · Biochemical Journal · doi:10.1042/bj2980443 · Cited by 169 · see citing works
Brady, M., Bourbonais, F., & Saltiel, A. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14063 · Cited by 123 · see citing works
Syndromes of Severe Insulin Resistance
Tritos, N. A., & Mantzoros, C. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5143 · Cited by 120 · see citing works
Offenbacher, E. G., & Pi-Sunyer, X. (1988) · Annual Review of Nutrition · doi:10.1146/annurev.nu.08.070188.002551 · Cited by 109 · see citing works
Chromium in foods in relation to biological activity
Toepfer, E. W., Mertz, W., Roginski, E. E., & Polansky, M. M. (1973) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60185a008 · Cited by 100 · see citing works
Takata, M., Ogawa, W., Kitamura, T., Hino, Y., Kuroda, S., Kotani, K., Klip, A., Gingras, A., Sonenberg, N., & Kasuga, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20611 · Cited by 99 · see citing works
Identification of Wortmannin-sensitive Targets in 3T3-L1 Adipocytes
Hausdorff, S. F., Fingar, D. C., Morioka, K., Garza, L. A., Whiteman, E. L., Summers, S. A., & Birnbaum, M. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24677 · Cited by 96 · see citing works
Begum, N., Sussman, K. E., & Draznin, B. (1991) · Diabetes · doi:10.2337/diab.40.12.1620 · Cited by 58 · see citing works
Convergence and Divergence of the Signaling Pathways for Insulin and Phosphoinositolglycans
Müller, G. A., Wied, S., Piossek, C., Bauer, A. S., Bauer, J., & Frick, W. (1998) · Molecular Medicine · doi:10.1007/bf03401738 · Cited by 46 · see citing works
Signalling pathways of an insulin-mimetic phosphoinositolglycan–peptide in muscle and adipose tissue
Kessler, A., Müller, G. A., Wied, S., Crecelius, A. C., & Eckel, J. (1998) · Biochemical Journal · doi:10.1042/bj3300277 · Cited by 42 · see citing works
Modan‐Moses, D., Janicot, M., McLenithan, J. C., Lane, M. D., & Casella, S. J. (1998) · Biochemical Journal · doi:10.1042/bj3330825 · Cited by 41 · see citing works
Donnelly, R., & Qu, X. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02181.x · Cited by 40 · see citing works
Begum, N., Sussman, K. E., & Draznin, B. (1991) · Diabetes · doi:10.2337/diabetes.40.12.1620 · Cited by 22 · see citing works
Use of pharmacological agents in elucidating the mechanism of insulin action
Srivastava, A. K. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01208-5 · Cited by 18 · see citing works
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Sorted by citations
Health benefits of herbs and spices: the past, the present, the future
Tapsell, L. C., Hemphill, I., Cobiac, L., SULLIVAN, D. R., Fenech, M. F., Patch, C. S., Roodenrys, S. J., Keogh, J. B., Clifton, P. M., Williams, P., et al. (2006) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2006.tb00548.x · Cited by 989 · see citing works
Cinnamon improves glucose and lipids of people with type 2 diabetes
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., & Anderson, R. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3215 · Cited by 981 · see citing works
Cinnamon: A Multifaceted Medicinal Plant
Pasupuleti, V. R., & Gan, S. H. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/642942 · Cited by 844 · see citing works
Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Khan, A., Flanagan, V. P., Schoene, N. W., & Graves, D. J. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034916b · Cited by 561 · see citing works
Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice
Kim, S. H., Hyun, S. H., & Choung, S. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.08.059 · Cited by 502 · see citing works
Natural Products for the Treatment of Type 2 Diabetes Mellitus
Rı́os, J. L., Francini, F., & Schinella, G. R. (2015) · Planta Medica · doi:10.1055/s-0035-1546131 · Cited by 447 · see citing works
Pinent, M., Blay, M., Bladé, C., Salvadó, M. J., Arola, L., & Ardèvol, A. (2004) · Endocrinology · doi:10.1210/en.2004-0764 · Cited by 363 · see citing works
Mang, B., Wolters, M., Schmitt, B., Kelb, K., Lichtinghagen, R., Stichtenoth, D. O., & Hahn, A. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01629.x · Cited by 354 · see citing works
Gruenwald, J., Freder, J., & Armbruester, N. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390902773052 · Cited by 356 · see citing works
Cinnamaldehyde and its derivatives, a novel class of antifungal agents
Shreaz, S., Wani, W. A., Behbehani, J. M., Raja, V., Irshad, M., Karched, M., Ali, I., Siddiqi, W. A., & Hun, L. T. (2016) · Fitoterapia · doi:10.1016/j.fitote.2016.05.016 · Cited by 348 · see citing works
The role of chalcones in suppression of NF-κB-mediated inflammation and cancer
Yadav, V. R., Prasad, S., Sung, B., & Aggarwal, B. B. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.12.006 · Cited by 342 · see citing works
Wang, R., Wang, R., & Yang, B. J. (2008) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2008.12.002 · Cited by 302 · see citing works
Qin, B., Nagasaki, M., Ren, M., Bajotto, G., Oshida, Y., & Sato, Y. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(03)00173-6 · Cited by 298 · see citing works
Animal models to test drugs with potential antidiabetic activity
Fröde, T. S., & Medeiros, Y. S. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.10.038 · Cited by 296 · see citing works
Cao, H., Polansky, M. M., & Anderson, R. A. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.12.034 · Cited by 272 · see citing works
Jung, E. H., Kim, S. R., Hwang, I. K., & Ha, T. Y. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0714463 · Cited by 264 · see citing works
Vanschoonbeek, K., Thomassen, B. J., Senden, J. M., Wodzig, W. K., & van Loon, L. J. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.4.977 · Cited by 241 · see citing works
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES
Baru, P. C. R. (2014) · ADVANCED SCIENCES INDEX · Cited by 236 · see citing works
Mechanism of action of natural products used in the treatment of diabetes mellitus
Prabhakar, P. K., & Doble, M. (2011) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-011-0810-3 · Cited by 240 · see citing works
Akilen, R., Tsiami, A., Devendra, D., & Robinson, N. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03079.x · Cited by 230 · see citing works
Viuda‐Martos, M., Ruiz‐Navajas, Y., Fernández‐López, J., & Pérez‐Álvarez, J. Á. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903044271 · Cited by 232 · see citing works
Ziegenfuss, T. N., Hofheins, J. E., Mendel, R. W., Landis, J. A., & Anderson, R. A. (2006) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-3-2-45 · Cited by 231 · see citing works
Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes
Blevins, S. M., Leyva, M. J., Brown, J., Wright, J., Scofield, R. H., & Aston, C. E. (2007) · Diabetes Care · doi:10.2337/dc07-0098 · Cited by 221 · see citing works
Qin, B., Panickar, K. S., & Anderson, R. A. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400324 · Cited by 220 · see citing works
Self-citationRevisiting an ancient spice with medicinal purposes: Cinnamon
Ribeiro‐Santos, R., Andrade, M. A., Madella, D. K. S. F., Martinazzo, A. P., Moura, L. D. A. G., de Melo, N. R., & Sanches-Silva, A. T. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.02.011 · Cited by 220 · see citing works
Roussel, A., Hininger‐Favier, I., Benaraba, R., Ziegenfuss, T. N., & Anderson, R. A. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719756 · Cited by 210 · see citing works
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199 · see citing works
Molecular targets and anticancer activity of quinoline–chalcone hybrids: literature review
Mohamed, M. F. A., & Abuo‐Rahma, G. E. A. (2020) · RSC Advances · doi:10.1039/d0ra05594h · Cited by 195 · see citing works
Wang, J. G., Anderson, R. A., Graham, G. M., Chu, M. C., Sauer, M. V., Guarnaccia, M. M., & Løbo, R. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.082 · Cited by 177 · see citing works
Adisakwattana, S., Lerdsuwankij, O., Poputtachai, U., Minipun, A., & Suparpprom, C. (2011) · Plant Foods for Human Nutrition · doi:10.1007/s11130-011-0226-4 · Cited by 171 · see citing works
Antidiabetic effect ofCinnamomum cassia andCinnamomum zeylanicum In vivo andIn vitro
Verspohl, E. J., Bauer, K., & Neddermann, E. (2005) · Phytotherapy Research · doi:10.1002/ptr.1643 · Cited by 172 · see citing works
Cinnamon extract inhibits tau aggregation associated with Alzheimer’s disease in vitro
Peterson, D. W., George, R. C., Scaramozzino, F., LaPointe, N. E., Anderson, R. A., Graves, D. J., & Lew, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1083 · Cited by 171 · see citing works
Lu, J., Zhang, K., Nam, S., Anderson, R. A., Jove, R., & Wen, W. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp292 · Cited by 168 · see citing works
Effect of Cinnamon on Glucose Control and Lipid Parameters
Baker, W. L., Gutierrez-Williams, G., White, C. M., Kluger, J., & Coleman, C. I. (2007) · Diabetes Care · doi:10.2337/dc07-1711 · Cited by 166 · see citing works
Advances in the Treatment of Type 2 Diabetes Mellitus
Israili, Z. H. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181afbf51 · Cited by 163 · see citing works
Chromium and polyphenols from cinnamon improve insulin sensitivity
Anderson, R. A. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006010 · Cited by 164 · see citing works
Cheng, D. M., Kuhn, P. E., Poulev, A., Rojo, L. E., Lila, M. A., & Raskin, I. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.06.117 · Cited by 160 · see citing works
Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose
Anderson, R. A., Zhan, Z., Luo, R., Guo, X., Guo, Q., Zhou, J. J., Kong, J., Davis, P. A., & Stoecker, B. J. (2015) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2015.03.005 · Cited by 151 · see citing works
Cao, H., Urban, J. F., & Anderson, R. A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.5.833 · Cited by 144 · see citing works
Complementary and alternative medicine for the treatment of type 2 diabetes.
Nahas, R., & Moher, M. (2009) · PubMed Central · Cited by 139 · see citing works
Dugoua, J.-J., Seely, D., Perri, D., Cooley, K., Forrelli, T., Mills, E. J., & Koren, G. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y07-080 · Cited by 139 · see citing works
Doshi, P. J., Adsule, P. G., Banerjee, K., & Oulkar, D. P. (2013) · Journal of Food Science and Technology · doi:10.1007/s13197-013-0991-1 · Cited by 134 · see citing works
Proanthocyanidins: Biological Activities Associated with Human Health
Beecher, G. R. (2004) · Archives of Physiology and Biochemistry · doi:10.3109/13880200490893474 · Cited by 143 · see citing works
Cinnamon in glycaemic control: Systematic review and meta analysis
Akilen, R., Tsiami, A., Devendra, D., & Robinson, N. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.04.003 · Cited by 124 · see citing works
The Effect of Cinnamon on A1C Among Adolescents With Type 1 Diabetes
Altschuler, J. A., Casella, S. J., MacKenzie, T. A., & Curtis, K. M. (2007) · Diabetes Care · doi:10.2337/dc06-1871 · Cited by 122 · see citing works
Vafa, M., Mohammadi, F., Shidfar, F., Sormaghi, M. H. S., Heidari, I., Golestan, B., & Amiri, F. (2012) · PubMed Central · Cited by 121 · see citing works
Effects of short‐term cinnamon ingestion on in vivo glucose tolerance
Solomon, T. P. J., & Blannin, A. K. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00694.x · Cited by 119 · see citing works
Najafian, M. (2014) · Comparative Clinical Pathology · doi:10.1007/s00580-014-1967-x · Cited by 117 · see citing works
Gupta Jain, S., Puri, S., Misra, A., Gulati, S., & Mani, K. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0504-8 · Cited by 115 · see citing works
Schoene, N. W., Kelly, M. A., Polansky, M. M., & Anderson, R. A. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.12.039 · Cited by 115 · see citing works
Hajimonfarednejad, M., Nimrouzi, M., Heydari, M., Zarshenas, M. M., Raee, M. J., & Jahromi, B. N. (2017) · Phytotherapy Research · doi:10.1002/ptr.5970 · Cited by 114 · see citing works
Lu, Z., Jia, Q., Wang, R., Wu, X., Wu, Y., Huang, C., & Li, Y. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.08.008 · Cited by 113 · see citing works
Cao, H., Graves, D. J., & Anderson, R. A. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.03.023 · Cited by 112 · see citing works
Kort, D. H., & Lobo, R. A. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.05.009 · Cited by 111 · see citing works
Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review
Costello, R. B., Dwyer, J. T., Saldanha, L. G., Bailey, R. L., Merkel, J. M., & Wambogo, E. A. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.07.015 · Cited by 113 · see citing works
Wong, C. Y. J., Al‐Salami, H., & Dass, C. R. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13359 · Cited by 112 · see citing works
Antidiabetic effects of cinnamon oil in diabetic KK-A mice
Ping, H., Zhang, G., & Ren, G. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.05.069 · Cited by 110 · see citing works
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome
Noce, A., Lauro, M. D., Daniele, F. D., Zaitseva, A. P., Marrone, G., Borboni, P., & Daniele, N. D. (2021) · Nutrients · doi:10.3390/nu13020630 · Cited by 116 · see citing works
Hariri, M., & Ghiasvand, R. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41342-6_1 · Cited by 107 · see citing works
Khalifa, S. A. M., Yosri, N., El-Mallah, M. F., Ghonaim, R., Guo, Z., Musharraf, S. G., Du, M., Khatib, A., Xiao, J., Saeed, A., et al. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153311 · Cited by 104 · see citing works
Bioactivity of cinnamon with special emphasis on diabetes mellitus: A review
Bandara, T., Uluwaduge, I., & Jansz, E. R. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.627849 · Cited by 102 · see citing works
Jia, Q., Liu, X., Wu, X., Wang, R., Hu, X., Li, Y. H., & Huang, C. (2009) · Phytomedicine · doi:10.1016/j.phymed.2008.12.012 · Cited by 100 · see citing works
Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean.
McCue, P. P., Kwon, Y., & Shetty, K. (2005) · PubMed · Cited by 100 · see citing works
Kirkham, S., Akilen, R., Sharma, S., & Tsiami, A. (2009) · Diabetes, obesity and metabolism · doi:10.1111/j.1463-1326.2009.01094.x · Cited by 101 · see citing works
Preuss, H. G., Echard, B. W., Polansky, M. M., & Anderson, R. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719525 · Cited by 96 · see citing works
Rahmatullah, M., Jahan, R., Khatun, M. A., Jahan, F., Azad, A. K., Bashar, A. B. M. A., Miajee, Z. U. M. E. U., Ahsan, S., Nahar, N., Ahmad, I., et al. (2010) · AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE · Cited by 93 · see citing works
Silva, M. L., Bernardo, A., Singh, J., & de Mesquita, M. F. (2022) · Nutrients · doi:10.3390/nu14132773 · Cited by 96 · see citing works
Deyno, S., Eneyew, K., Seyfe, S., Tuyiringire, N., Peter, E. L., Muluye, R. A., Tolo, C. U., & Ogwang, P. E. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107815 · Cited by 95 · see citing works
ANTIOXIDANT ACTIVITY OF COMMON BEANS (PHASEOLUS VULGARIS L.)
Madhujith, T., Naczk, M., & Shahidi, F. (2004) · Journal of Food Lipids · doi:10.1111/j.1745-4522.2004.01134.x · Cited by 90 · see citing works
Shen, Y., Jia, L.-N., Honma, N., Hosono, T., ARIGA, T., & Seki, T. (2012) · Journal of Traditional and Complementary Medicine · doi:10.1016/s2225-4110(16)30067-0 · Cited by 90 · see citing works
Solomon, T. P. J., & Blannin, A. K. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-0986-9 · Cited by 89 · see citing works
Abdelwahab, S. İ., Mariod, A. A., Taha, M. M. E., Zaman, F. Q., Abdelmageed, A. H. A., Khamis, S., Sivasothy, Y., & Awang, K. (2014) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2014.02.001 · Cited by 88 · see citing works
Annunziata, G., Jiménez‐García, M., Capó, X., Moranta, D., Arnone, A., Tenore, G. C., Sureda, A., & Tejada, S. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111248 · Cited by 86 · see citing works
The physiological basis of complementary and alternative medicines for polycystic ovary syndrome
Raja-Khan, N. T., Stener‐Victorin, E., Wu, X., & Legro, R. S. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00667.2010 · Cited by 86 · see citing works
Dietary management of the metabolic syndrome beyond macronutrients
Minich, D. M., & Bland, J. S. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00075.x · Cited by 82 · see citing works
Przeor, M. (2022) · Pharmaceuticals · doi:10.3390/ph15010065 · Cited by 93 · see citing works
Takasao, N., Tsuji, K., Ishikura, S., Tamura, A., & Akagawa, M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2043357 · Cited by 81 · see citing works
Chen, L., Sun, P. G., Wang, T., Chen, K., Jia, Q., Wang, H., & Li, Y. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3024535 · Cited by 73 · see citing works
Controversies surrounding the clinical potential of cinnamon for the management of diabetes
Rafehi, H., Ververis, K., & Karagiannis, T. C. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01538.x · Cited by 72 · see citing works
Adisakwattana, S., Roengsamran, S., Hsu, W. H., & Yibchok‐anun, S. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.04.073 · Cited by 71 · see citing works
Ranasinghe, P. D., Gunatilake, M., Gunapala, N., Perera, P. K., Katulanda, P., Perera, S., Abeywardene, E., Premakumara, G. A. S., & Lokuhetty, D. (2012) · Pharmacognosy Research · doi:10.4103/0974-8490.94719 · Cited by 71 · see citing works
Anderson, R. A., Qin, B., Canini, F., Poulet, L., & Roussel, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083243 · Cited by 71 · see citing works
Akilen, R., Pimlott, Z., Tsiami, A. A., & Robinson, N. (2013) · Nutrition · doi:10.1016/j.nut.2013.03.007 · Cited by 70 · see citing works
The Effect of Cinnamon on Glucose of Type II Diabetes Patients
Hasanzade, F., Toliat, M., Emami, S. A., & Emamimoghaadam, Z. (2013) · Journal of Traditional and Complementary Medicine · doi:10.4103/2225-4110.114900 · Cited by 69 · see citing works
Roffey, B., Atwal, A. S., Johns, T., & Kubow, S. J. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.02.003 · Cited by 68 · see citing works
Markey, O., McClean, C. M., Medlow, P., Davison, G. W., Trinick, T. R., Duly, E., & Shafat, A. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-78 · Cited by 67 · see citing works
Cinnamon increases liver glycogen in an animal model of insulin resistance
Couturier, K., Qin, B., Batandier, C., Awada, M., Hininger‐Favier, I., Canini, F., Leverve, X. M., Roussel, A., & Anderson, R. A. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.016 · Cited by 66 · see citing works
The structural basis of action of vanadyl (VO2+) chelates in cells
Makinen, M. W., & Salehitazangi, M. (2014) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2014.07.003 · Cited by 63 · see citing works
Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57blks/j Db/db mice
Li, J., Liu, T., Wang, L., Guo, X., Xu, T., Wu, L., Qin, L., & Sun, W. (2012) · 中医杂志：英文版 · doi:10.1016/s0254-6272(13)60053-9 · Cited by 62 · see citing works
Lakshmi, B. S., Sujatha, S., Anand, S., Sangeetha, K. N., Narayanan, R. B., KATIYAR, C., Kanaujia, A., Duggar, R., Singh, Y. P., SRINIVAS, K., et al. (2009) · Journal of Diabetes · doi:10.1111/j.1753-0407.2009.00022.x · Cited by 60 · see citing works
Role of Diet, Nutrients, Spices and Natural Products in Diabetes Mellitus
Khan, A., & Safdar, M. (2002) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2003.1.12 · Cited by 59 · see citing works
Tzeng, Y., Chen, K., Rao, Y. K., & Lee, M. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.01.023 · Cited by 58 · see citing works
Roffey, B., Atwal, A., & Kubow, S. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500253 · Cited by 63 · see citing works
Magistrelli, A., & Chezem, J. C. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.07.037 · Cited by 56 · see citing works
Ranasinghe, P., Galappaththy, P., Constantine, G. R., Jayawardena, R., Weeratunga, H. D., Premakumara, S., & Katulanda, P. (2017) · Trials · doi:10.1186/s13063-017-2192-0 · Cited by 57 · see citing works
Kopp, C., SINGH, S. P., Regenhard, P., Müller, U., Sauerwein, H., & Mielenz, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022906 · Cited by 57 · see citing works
Functional foods for health: Focus on diabetes
Rudkowska, I. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.01.011 · Cited by 58 · see citing works
Culinary plants, herbs and spices – A rich source of PPARγ ligands
Mueller, M., & Jungbauer, A. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.04.063 · Cited by 57 · see citing works
Ibrahim, T. S., Almalki, A. J., Moustafa, A. H., Allam, R. M., Abuo‐Rahma, G. E. A., El‐Subbagh, H. I., & Mohamed, M. F. A. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104885 · Cited by 56 · see citing works
Cinnamon Supplementation in Patients with Type 2 Diabetes Mellitus
Pham, A. Q., Kourlas, H., & Pham, D. Q. (2007) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.4.595 · Cited by 56 · see citing works
- Authors
- Jarvill-Taylor, K. J., Anderson, R. A., & Graves, D. J.
- Affiliations
- Iowa State University (US)
- United States Department of Agriculture (US)
- Corresponding author
- Graves, Donald J.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2001-08
- Volume
- 20
- Issue
- 4
- Pages
- 327-336
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2078460365
- Cited by
- 324
- References
- 28
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 16 · 2021: 15 · 2020: 13 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 22 · 2015: 15 · 2014: 18 · 2013: 14 · 2012: 21
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American College of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Diabetes Action Research and Education Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- hydroxychalcones, cinnamon, insulin mimetics, insulin resistance, 3T3-L1 adipocytes, glucose uptake, glycogen synthesis, glycogen synthase, glycogen synthase kinase-3β, phosphatidylinositol 3-kinase, insulin receptor phosphorylation
- MeSH terms
- Wortmannin, Phosphoinositide-3 Kinase Inhibitors, Androstadienes, Animals, Chromones, Cinnamomum zeylanicum, Enzyme Activation, Enzyme Inhibitors, Glucose, Glycogen, Glycogen Synthase, Insulin, Morpholines, Phosphorylation, Polymers, Receptor, Insulin, 3T3 Cells, Adipocytes, Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Glycogen Synthase Kinases, Glycogen Synthase Kinase 3, Mice
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