Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance
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Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeylanicum on postprandial concentrations of plasma glucose, insulin, glycaemic index (GI) and insulinaemic index (GII) in subjects with impaired glucose tolerance (IGT). A total of ten subjects with IGT were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with placebo or C. zeylanicum capsules. Finger-prick capillary blood samples were taken for glucose measurements and venous blood for insulin measurements, before and at 15, 30, 45, 60, 90, 120, 150 and 180 min after the start of the OGTT. The ingestion of 6 g C. zeylanicum had no significant effect on glucose level, insulin response, GI or GII. Ingestion of C. zeylanicum does not affect postprandial plasma glucose or insulin levels in human subjects. The Federal Institute for Risk Assessment in Europe has suggested the replacement of C. cassia by C. zeylanicum or the use of aqueous extracts of C. cassia to lower coumarin exposure. However, the positive effects seen with C. cassia in subjects with poor glycaemic control would then be lost.
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The available literature on the acute effect of cinnamon on postprandial glycemia is quite puzzling.
“Regarding the acute effect of cinnamon on postprandial glycemia, the available literature is quite puzzling.”
Some published clinical studies have assessed the acute effect of raw cinnamon powder from different cinnamon species on postprandial glycemia.
“As illustrated by all of the above, some published clinical studies have assessed the acute effect of raw cinnamon powder from different cinnamon species on postprandial glycemia.”
No effect on glycemic response was observed with Ceylon cinnamon in human clinical trials [28,29].
“No effect was observed with Ceylon cinnamon [28, 29]”
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- Authors
- Wickenberg, J., Lindstedt, S., Berntorp, K., Nilsson, J., & Hlebowicz, J.
- Affiliations
- Lund University (SE)
- Corresponding author
- Hlebowicz, Joanna
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-09-20
- Volume
- 107
- Issue
- 12
- Pages
- 1845-1849
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2145680002
- Cited by
- 34
- References
- 35
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 7 · 2015: 1 · 2014: 5 · 2012: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- Fondation pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- Cinnamomum zeylanicum, cinnamon, Cinnamomum cassia, impaired glucose tolerance, postprandial blood glucose, insulin response, glycemic index, coumarins
- MeSH terms
- Adult, Aged, Blood Glucose, Capillaries, Capsules, Cinnamomum zeylanicum, Coumarins, Female, Glucose Tolerance Test, Humans, Insulin, Male, Phytotherapy, Middle Aged, Veins, Glucose Intolerance, Cross-Over Studies, Postprandial Period, Plant Preparations, Cinnamomum aromaticum
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