The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
Abstract
Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti‐inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) and human T‐cell leukemia/lymphoma virus‐I (HTLV‐I) signaling pathways, suppresses protein expression of epithelial‐mesenchymal transition (EMT)‐related markers including N‐cadherin, E‐cadherin, Slug, and Snail, and metastasis‐related markers such as matrix metallopeptidase 2 (MMP‐2). Accordingly, the aim of the present review is to collect information pertaining to the effective role of kaempferol against various degenerative disorders, summarize the antioxidant, anti‐inflammatory, anticancer, antidiabetic, and antiaging effects of kaempferol and to review the progress of recent research and available data on kaempferol as a protective and chemotherapeutic agent against several ailments.
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Cites
1 retracted
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RetractedFlavonoid antioxidants: chemistry, metabolism and structure-activity relationships
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Dietary Intake and Bioavailability of Polyphenols
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Polyphenols and disease risk in epidemiologic studies
Arts, I. C., & Hollman, P. C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.317s · Cited by 1,916
The Role of Oxidative Stress in Carcinogenesis
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A Review on the Dietary Flavonoid Kaempferol
M. Calderon-Montano, J., Burgos-Moron, E., Perez-Guerrero, C., & Lopez-Lazaro, M. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711795305335 · Cited by 1,383
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Inhibitory kinetics and mechanism of kaempferol on α-glucosidase
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Distinctive Antioxidant and Antiinflammatory Effects of Flavonols
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Cited by
Important Flavonoids and Their Role as a Therapeutic Agent
Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A.-H., & Jaremko, M. (2020) · Molecules · doi:10.3390/molecules25225243 · Cited by 1,696
Loh, C.-Y., Chai, J., Tang, T., Wong, W., Sethi, G., Shanmugam, M., Chong, P., & Looi, C. (2019) · Cells · doi:10.3390/cells8101118 · Cited by 1,315
Flavonoids as Anticancer Agents
Kopustinskiene, D. M., Jakstas, V., Savickas, A., & Bernatoniene, J. (2020) · Nutrients · doi:10.3390/nu12020457 · Cited by 1,295
Kaempferol: A Key Emphasis to Its Anticancer Potential
Imran, M., Salehi, B., Sharifi-Rad, J., Aslam Gondal, T., Saeed, F., Imran, A., Shahbaz, M., Tsouh Fokou, P. V., Umair Arshad, M., Khan, H., et al. (2019) · Molecules · doi:10.3390/molecules24122277 · Cited by 819
Self-citationPolyphenols: A concise overview on the chemistry, occurrence, and human health
Durazzo, A., Lucarini, M., Souto, E. B., Cicala, C., Caiazzo, E., Izzo, A. A., Novellino, E., & Santini, A. (2019) · Phytotherapy Research · doi:10.1002/ptr.6419 · Cited by 802
Metadata
- Authors
- Imran, M., Rauf, A., Shah, Z. A., Saeed, F., Imran, A., Arshad, M. U., Ahmad, B., Bawazeer, S., Atif, M., Peters, D. G., & Mubarak, M. S.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2018-11-07
- Volume
- 33
- Issue
- 2
- Pages
- 263-275
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2900436168
- Cited by
- 339
- References
- 90
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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