Cited by 102Phytochemicals and Medicinal PlantsMedicinal Plants and NeuroprotectionMedicinal Plants and Bioactive Compounds

Neuroprotective Effects of Withania somnifera Dunn. in Hippocampal Sub‐regions of Female Albino Rat

Jain, Sushma, Shukla, Sunil Dutt, Sharma, Kanika, Bhatnagar, Maheep·2001·Phytotherapy Research

Abstract

The neuroprotective effects of W. somnifera were studied on stressed adult female Swiss albino rats. Experimental rats were subjected to immobilization stress for 14 h and were treated with a root powder extract of W. somnifera available as Stresscom capsules (Dabur India Ltd). Control rats were maintained in completely, non stressed conditions. Thionin stained serial coronal sections (7 microm) of brain passing through the hippocampal region of stressed rats (E(1) group) demonstrated 85% degenerating cells (dark cells and pyknotic cells) in the CA(2) and CA(3) sub-areas. Treatment with W. somnifera root powder extract significantly reduced (80%) the number of degenerating cells in both the areas. The study thus demonstrates the antistress neuroprotective effects of W. somnifera.

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Crossref · 10.1002/ptr.802

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Authors
Jain, S., Shukla, S. D., Sharma, K., & Bhatnagar, M.
Affiliations
Mohanlal Sukhadia University (IN)
Corresponding author
Bhatnagar, Maheep
Venue
Phytotherapy Research
Publisher
Wiley
Published
2001-07-26
Volume
15
Issue
6
Pages
544-548
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
OpenAlex
W2072592210
Cited by
101
References
15
Citations by year
2025: 5 · 2024: 2 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 9 · 2012: 4
FWCI
2.50
Type
journal article
Language
en
Open access
closed
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
Keywords
Withania somnifera, neuroprotection, restraint stress, hippocampus, neurodegeneration, anti-stress effects, female albino rats
MeSH terms
Animals, Ascorbic Acid, Central Nervous System Diseases, Female, Hippocampus, Immobilization, Phytotherapy, Neurons, Plant Extracts, Stress, Physiological, Plant Roots, Neuroprotective Agents, Solanaceae, Herbal Medicine, Rats

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