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Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Open accessAbstract
Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of advantages over previous cardiac models, however, questions of their immaturity complicate their adoption as a new in vitro model. hPS-CM differ from adult cardiomyocytes with respect to structure, proliferation, metabolism and electrophysiology, better approximating fetal cardiomyocytes. Time in culture appears to significantly impact phenotype, leading to what can be referred to as early and late hPS-CM. This work surveys the phenotype of hPS-CM, including structure, bioenergetics, sensitivity to damage, gene expression, and electrophysiology, including action potential, ion channels, and intracellular calcium stores, while contrasting fetal and adult CM with hPS-CM at early and late time points after onset of differentiation.
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Cites
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Transient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science · doi:10.1126/science.1200708 · Cited by 2,545
Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
Moretti, A., Bellin, M., Welling, A., Jung, C. B., Lam, J. T., Bott-Flügel, L., Dorn, T., Goedel, A., Höhnke, C., Hofmann, F., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908679 · Cited by 1,251
Modelling the long QT syndrome with induced pluripotent stem cells
Itzhaki, I., Maizels, L., Huber, I., Zwi-Dantsis, L., Caspi, O., Winterstern, A., Feldman, O., Gepstein, A., Arbel, G., Hammerman, H., et al. (2011) · Nature · doi:10.1038/nature09747 · Cited by 1,049
He, J.-Q., Ma, Y., Lee, Y., Thomson, J. A., & Kamp, T. J. (2003) · Circulation Research · doi:10.1161/01.res.0000080317.92718.99 · Cited by 800
Lopaschuk, G. D., & Jaswal, J. S. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181e74a14 · Cited by 636
Xue, T., Cho, H. C., Akar, F. G., Tsang, S.-Y., Jones, S. P., Marbán, E., Tomaselli, G. F., & Li, R. A. (2005) · Circulation · doi:10.1161/01.cir.0000151313.18547.a2 · Cited by 480
Zhu, W.-Z., Xie, Y., Moyes, K. W., Gold, J. D., Askari, B., & Laflamme, M. A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223917 · Cited by 228
Liu, J., Fu, J. D., Siu, C. W., & Li, R. A. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0549 · Cited by 186
Cited by
Guidelines for experimental models of myocardial ischemia and infarction
Lindsey, M. L., Bolli, R., Canty, J. M., Du, X.-J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2017 · Cited by 526
Evolution of strategies to improve preclinical cardiac safety testing
Gintant, G., Sager, P. T., & Stockbridge, N. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.34 · Cited by 407
Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., et al. (2016) · SLAS Discovery · doi:10.1177/1087057115594589 · Cited by 302
Chal, J., Al Tanoury, Z., Hestin, M., Gobert, B., Aivio, S., Hick, A., Cherrier, T., Nesmith, A. P., Parker, K. K., & Pourquié, O. (2016) · Nature Protocols · doi:10.1038/nprot.2016.110 · Cited by 299
Herron, T. J., Rocha, A. M. D., Campbell, K. F., Ponce-Balbuena, D., Willis, B. C., Guerrero-Serna, G., Liu, Q., Klos, M., Musa, H., Zarzoso, M., et al. (2016) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.113.003638 · Cited by 257
Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues
Feric, N. T., & Radisic, M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.019 · Cited by 247
Cardiovascular disease models: A game changing paradigm in drug discovery and screening
Savoji, H., Mohammadi, M. H., Rafatian, N., Toroghi, M. K., Wang, E. Y., Zhao, Y., Korolj, A., Ahadian, S., & Radisic, M. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.036 · Cited by 223
Induced pluripotent stem cells: at the heart of cardiovascular precision medicine
Chen, I. Y., Matsa, E., & Wu, J. C. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.36 · Cited by 191
In vitro cardiac tissue models: Current status and future prospects
Mathur, A., Ma, Z., Loskill, P., Jeeawoody, S., & Healy, K. E. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.011 · Cited by 187
Yoshida, S., Miyagawa, S., Fukushima, S., Kawamura, T., Kashiyama, N., Ohashi, F., Toyofuku, T., Toda, K., & Sawa, Y. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.08.012 · Cited by 178
Guidance Document on Good In Vitro Method Practices (GIVIMP)
OECD (2018) · OECD Series on Testing and Assessment · doi:10.1787/9789264304796-en · Cited by 161
Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype
Ronaldson-Bouchard, K., Yeager, K., Teles, D., Chen, T., Ma, S., Song, L., Morikawa, K., Wobma, H. M., Vasciaveo, A., Ruiz, E. C., et al. (2019) · Nature Protocols · doi:10.1038/s41596-019-0189-8 · Cited by 144
Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes
Zhu, R., Blazeski, A., Poon, E., Costa, K. D., Tung, L., & Boheler, K. R. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt507 · Cited by 110
Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy
Sommariva, E., Brambilla, S., Carbucicchio, C., Gambini, E., Meraviglia, V., Dello Russo, A., Farina, F. M., Casella, M., Catto, V., Pontone, G., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv579 · Cited by 101
Kerscher, P., Turnbull, I. C., Hodge, A. J., Kim, J., Seliktar, D., Easley, C. J., Costa, K. D., & Lipke, E. A. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.011 · Cited by 88
Zhuang, R. Z., Lock, R., Liu, B., & Vunjak-Novakovic, G. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00885-3 · Cited by 84
Keung, W., Boheler, K. R., & Li, R. A. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt406 · Cited by 87
Titmarsh, D. M., Glass, N. R., Mills, R. J., Hidalgo, A., Wolvetang, E. J., Porrello, E. R., Hudson, J. E., & Cooper-White, J. J. (2016) · Scientific Reports · doi:10.1038/srep24637 · Cited by 59
A framework for developing sex-specific engineered heart models
Lock, R., Al Asafen, H., Fleischer, S., Tamargo, M., Zhao, Y., Radisic, M., & Vunjak-Novakovic, G. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00381-1 · Cited by 50
Substrate stiffness modulates the maturation of human pluripotent stem-cell-derived hepatocytes
Mittal, N., Tasnim, F., Yue, C., Qu, Y., Phan, D., Choudhury, Y., Tan, M.-H., & Yu, H. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00475 · Cited by 25
Ashwood, C., Waas, M., Weerasekera, R., & Gundry, R. L. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.12.012 · Cited by 25
Zhou, Y., Zhou, R., Huang, W., Wang, J., Jiang, C., Li, A., Huang, C., & Zhang, Y. (2024) · Biologics: Targets and Therapy · doi:10.2147/btt.s448054 · Cited by 4
Abi-Gerges, N., McMahon, C., Vargas, H., Sager, P., Chui, R., Stevens, D., Davila, J., Schaub, J. R., Wu, J. C., del Rio, C., et al. (2019) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2019.106582 · Cited by 3
Metadata
- Authors
- Robertson, C., Tran, D. D., & George, S. C.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04-24
- Volume
- 31
- Issue
- 5
- Pages
- 829-837
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2016157842
- Cited by
- 354
- References
- 14
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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