A framework for developing sex-specific engineered heart models

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551 · see citing works

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305 · see citing works

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650 · see citing works

X-inactivation profile reveals extensive variability in X-linked gene expression in females

Carrel, L., & Willard, H. F. (2005) · Nature · doi:10.1038/nature03479 · Cited by 2,097 · see citing works

Sex and gender: modifiers of health, disease, and medicine

Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001 · see citing works

RNA sequencing: the teenage years

Stark, R., Grzelak, M., & Hadfield, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0150-2 · Cited by 1,906 · see citing works

Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

Pati, F., Jang, J., Ha, D.-H., Won Kim, S., Rhie, J.-W., Shim, J.-H., Kim, D.-H., & Cho, D.-W. (2014) · Nature Communications · doi:10.1038/ncomms4935 · Cited by 1,904 · see citing works

3D bioprinting of collagen to rebuild components of the human heart

Lee, A., Hudson, A. R., Shiwarski, D. J., Tashman, J. W., Hinton, T. J., Yerneni, S., Bliley, J. M., Campbell, P. G., & Feinberg, A. W. (2019) · Science · doi:10.1126/science.aav9051 · Cited by 1,782 · see citing works

Cells of the adult human heart

Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C. L., Lindberg, E. L., Kanda, M., Polanski, K., Heinig, M., Lee, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2797-4 · Cited by 1,729 · see citing works

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

Ronaldson-Bouchard, K., Ma, S. P., Yeager, K., Chen, T., Song, L., Sirabella, D., Morikawa, K., Teles, D., Yazawa, M., & Vunjak-Novakovic, G. (2018) · Nature · doi:10.1038/s41586-018-0016-3 · Cited by 1,272 · see citing works

Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association

Mehta, L. S., Beckie, T. M., DeVon, H. A., Grines, C. L., Krumholz, H. M., Johnson, M. N., Lindley, K. J., Vaccarino, V., Wang, T. Y., Watson, K. E., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000351 · Cited by 1,244 · see citing works

An in vivo model of functional and vascularized human brain organoids

Mansour, A. A., Gonçalves, J. T., Bloyd, C. W., Li, H., Fernandes, S., Quang, D., Johnston, S., Parylak, S. L., Jin, X., & Gage, F. H. (2018) · Nature Biotechnology · doi:10.1038/nbt.4127 · Cited by 1,211 · see citing works

Landscape of X chromosome inactivation across human tissues

GTEx Consortium, Tukiainen, T., Villani, A.-C., Yen, A., Rivas, M. A., Marshall, J. L., Satija, R., Aguirre, M., Gauthier, L., Fleharty, M., et al. (2017) · Nature · doi:10.1038/nature24265 · Cited by 1,138 · see citing works

3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

Noor, N., Shapira, A., Edri, R., Gal, I., Wertheim, L., & Dvir, T. (2019) · Advanced Science · doi:10.1002/advs.201900344 · Cited by 1,042 · see citing works

Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs

Makkar, R. (1993) · JAMA · doi:10.1001/jama.270.21.2590 · Cited by 972 · see citing works

Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels

Skylar‐Scott, M. A., Uzel, S. G. M., Nam, L. L., Ahrens, J. H., Truby, R. L., Damaraju, S., & Lewis, J. A. (2019) · Science Advances · doi:10.1126/sciadv.aaw2459 · Cited by 953 · see citing works

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

Nunes, S. S., Miklas, J. W., Liu, J., Aschar-Sobbi, R., Xiao, Y., Zhang, B., Jiang, J., Massé, S., Gagliardi, M., Hsieh, A., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2524 · Cited by 952 · see citing works

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

Channappanavar, R., Fett, C., Mack, M., Eyck, P. T., Meyerholz, D. K., & Perlman, S. M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601896 · Cited by 896 · see citing works

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861 · see citing works

Accordion-like honeycombs for tissue engineering of cardiac anisotropy

Engelmayr, G. C., Cheng, M., Bettinger, C. J., Borenstein, J. T., Langer, R., & Freed, L. E. (2008) · Nature Materials · doi:10.1038/nmat2316 · Cited by 848 · see citing works

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Wang, G., McCain, M. L., Yang, L., He, A., Pasqualini, F. S., Agarwal, A., Yuan, H., Jiang, D., Zhang, D., Zangi, L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3545 · Cited by 837 · see citing works

Sex differences in heart failure

Lam, C. S. P., Arnott, C. G., Beale, A. L., Chandramouli, C., Hilfiker‐Kleiner, D., Kaye, D. M., Ky, B., Santema, B. T., Sliwa, K. S., & Voors, A. A. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz835 · Cited by 832 · see citing works

Biological markers of oxidative stress: Applications to cardiovascular research and practice

Ho, E. C., Galougahi, K. K., Liu, C., Bhindi, R., & Figtree, G. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.006 · Cited by 812 · see citing works

Sex differences in pharmacokinetics predict adverse drug reactions in women

Zucker, I., & Prendergast, B. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00308-5 · Cited by 777 · see citing works

Nanowired three-dimensional cardiac patches

Dvir, T., Timko, B. P., Brigham, M. D., Naik, S. R., Karajanagi, S. S., Levy, O., Jin, H., Parker, K. K., Langer, R., & Kohane, D. S. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.160 · Cited by 763 · see citing works

Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes

Regitz‐Zagrosek, V., Oertelt‐Prigione, S., Prescott, E., Franconi, F., Gerdts, E., Foryst‐Ludwig, A., Maas, A. H. E. M., Kautzky‐Willer, A., Knappe-Wegner, D., Kintscher, U., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv598 · Cited by 744 · see citing works

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy

Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003552 · Cited by 696 · see citing works

The impact of sex on gene expression across human tissues

Oliva, M., Muñoz-Aguirre, M., Kim-Hellmuth, S., Wucher, V., Gewirtz, A. D., Cotter, D. J., Parsana, P., Kasela, S., Balliu, B., Viñuela, A., et al. (2020) · Science · doi:10.1126/science.aba3066 · Cited by 679 · see citing works

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair

Tiburcy, M., Hudson, J. E., Balfanz, P., Schlick, S. F., Meyer, T., Liao, M.-L. C., Levent, E., Raad, F. S., Zeidler, S., Wingender, E., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024145 · Cited by 650 · see citing works

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

Hinson, J. T., Chopra, A., Nafissi, N., Polacheck, W. J., Benson, C. C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C. C., et al. (2015) · Science · doi:10.1126/science.aaa5458 · Cited by 638 · see citing works

The extracellular matrix protein agrin promotes heart regeneration in mice

Bassat, E., Mutlak, Y. E., Genzelinakh, A., Shadrin, I. Y., Umansky, K. B., Yifa, O., Kain, D., Rajchman, D., Leach, J. P., Riabov-Bassat, D., et al. (2017) · Nature · doi:10.1038/nature22978 · Cited by 637 · see citing works

Sex differences in the evolution of the electrocardiographic QT interval with age.

Rautaharju, P. M., Sh, Z., Wong, S., Hp, C., Berenson, G. S., Prineas, R., & Davignon, A. (1992) · PubMed · Cited by 635 · see citing works

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

Patsch, C., Meylan, L. C., Thoma, E., Urich, E., Heckel, T., O’Sullivan, J., Grainger, S. J., Kapp, F., Sun, L., Christensen, K., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3205 · Cited by 628 · see citing works

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H.-W., Seol, Y.-J., Shrike Zhang, Y., Shin, S.-R., Zhao, L., Aleman, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08879-x · Cited by 623 · see citing works

Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs

Kim, D.-H., Lipke, E. A., Kim, P., Cheong, R., Thompson, S., Delannoy, M., Suh, K.-Y., Tung, L., & Levchenko, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906504107 · Cited by 611 · see citing works

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

Zhao, Y., Rafatian, N., Feric, N. T., Cox, B. J., Aschar-Sobbi, R., Wang, E. Y., Aggarwal, P., Zhang, B., Conant, G., Ronaldson-Bouchard, K., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.042 · Cited by 610 · see citing works

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

Zhang, B., Montgomery, M., Chamberlain, M. D., Ogawa, S., Korolj, A., Pahnke, A., Wells, L. A., Massé, S., Kim, J., Reis, L., et al. (2016) · Nature Materials · doi:10.1038/nmat4570 · Cited by 593 · see citing works

Epigenetics and Lifestyle

Alegría-Torres, J. A., Baccarelli, A., & Bollati, V. (2011) · Epigenomics · doi:10.2217/epi.11.22 · Cited by 587 · see citing works

Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes

Zhang, D., Shadrin, I. Y., Lam, J., Xian, H.-Q., Snodgrass, H. R., & Bursac, N. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.026 · Cited by 565 · see citing works

Tissue engineering of vascularized cardiac muscle from human embryonic stem cells

Caspi, O., Lesman, A., Basevitch, Y., Gepstein, A., Arbel, G., Habib, I. H. M., Gepstein, L., & Levenberg, S. (2007) · Circulation Research · doi:10.1161/01.res.0000257776.05673.ff · Cited by 558 · see citing works

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

Musah, S., Mammoto, A., Ferrante, T. C., Jeanty, S. S. F., Hirano-Kobayashi, M., Mammoto, T., Roberts, K., Chung, S., Novak, R., Ingram, M., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0069 · Cited by 550 · see citing works

Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering

Singelyn, J. M., DeQuach, J. A., Seif-Naraghi, S. B., Littlefield, R. B., Schup-Magoffin, P. J., & Christman, K. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.045 · Cited by 535 · see citing works

Small molecule absorption by PDMS in the context of drug response bioassays

van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P., & Mummery, C. L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.062 · Cited by 502 · see citing works

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Edington, C. D., Chen, W. L. K., Geishecker, E., Kassis, T., Soenksen, L. R., Bhushan, B. M., Freake, D., Kirschner, J., Maass, C., Tsamandouras, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22749-0 · Cited by 487 · see citing works

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

Xiao, S., Coppeta, J. R., Rogers, H. B., Isenberg, B. C., Zhu, J., Olalekan, S. A., McKinnon, K. E., Đokić, D., Rashedi, A. S., Haisenleder, D. J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14584 · Cited by 485 · see citing works

Women’s involvement in clinical trials: historical perspective and future implications

Liu, K. A., & Mager, N. A. D. (2016) · Pharmacy Practice · doi:10.18549/pharmpract.2016.01.708 · Cited by 478 · see citing works

Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue

Ruan, J.-L., Tulloch, N. L., Razumova, M. V., Saiget, M., Muskheli, V., Pabon, L., Reinecke, H., Regnier, M., & Murry, C. E. (2016) · Circulation · doi:10.1161/circulationaha.114.014998 · Cited by 467 · see citing works

Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China

Deng, Q., Hu, B., Zhang, Y., Wang, H., Zhou, X., Hu, W., Cheng, Y., Yan, J., Ping, H., & Zhou, Q. T. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.03.087 · Cited by 451 · see citing works

Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues

Lopes‐Ramos, C. M., Chen, C.-Y., Kuijjer, M. L., Paulson, J. N., Sonawane, A. R., Fagny, M., Platig, J., Glass, K., Quackenbush, J. F., & DeMeo, D. L. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107795 · Cited by 446 · see citing works

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

Shadrin, I. Y., Allen, B. W., Qian, Y., Jackman, C. P., Carlson, A. L., Juhas, M. E., & Bursac, N. (2017) · Nature Communications · doi:10.1038/s41467-017-01946-x · Cited by 420 · see citing works

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations

Lee, J. H., Protze, S. I., Laksman, Z., Backx, P. H., & Keller, G. M. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.003 · Cited by 404 · see citing works

Gender differences in cardiovascular disease

Gao, Z., Chen, Z., Sun, A., & Deng, X. (2019) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2019.100025 · Cited by 393 · see citing works

Cardiovascular diseases in women: a statement from the policy conference of the European Society of Cardiology

Stramba‐Badiale, M., Fox, K. M., Priori, S. G., Collins, P. D., Daly, C., Graham, I. D., Jonsson, B., Schenck-Gustafsson, K. G., & Tendera, M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi819 · Cited by 391 · see citing works

Inclusion, Analysis, and Reporting of Sex and Race/Ethnicity in Clinical Trials: Have We Made Progress?

GELLER, S. E., Koch, A., Pellettieri, B. F., & Carnes, M. L. (2011) · Journal of Women s Health · doi:10.1089/jwh.2010.2469 · Cited by 373 · see citing works

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

Protze, S. I., Liu, J., Nussinovitch, U., Ohana, L., Backx, P. H., Gepstein, L., & Keller, G. M. (2017) · Nature Biotechnology · doi:10.1038/nbt.3745 · Cited by 366 · see citing works

Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: a review

Tallawi, M., Rosellini, E., Barbani, N., Cascone, M. G., Rai, R., Saint-Pierre, G., & Boccaccini, A. R. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.0254 · Cited by 365 · see citing works

Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation

Hirt, M. N., Boeddinghaus, J., Mitchell, A. N., Schaaf, S., Börnchen, C., Müller, C., Schulz, H., Hübner, N., Stenzig, J., Stoehr, A., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.05.009 · Cited by 355 · see citing works

Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Robertson, C., Tran, D., & George, S. C. (2013) · Stem Cells · doi:10.1002/stem.1331 · Cited by 354 · see citing works

Heart rate variability and heart rate in healthy volunteers. Is the female autonomic nervous system cardioprotective?

Ramaekers, D. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1084 · Cited by 345 · see citing works

Sex Differences in Drug Disposition

Soldin, O. P., Chung, S. H., & Mattison, D. R. (2011) · BioMed Research International · doi:10.1155/2011/187103 · Cited by 341 · see citing works

17β-Estradiol Reduces Cardiomyocyte Apoptosis In Vivo and In Vitro via Activation of Phospho-Inositide-3 Kinase/Akt Signaling

Patten, R. D., Pourati, I., Aronovitz, M. J., Baur, J., Celestin, F., Chen, X., Michael, A., Haq, S., Nuedling, S., Grohé, C., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000144126.57786.89 · Cited by 333 · see citing works

Cardiovascular Disease and the Female Disadvantage

Woodward, M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071165 · Cited by 329 · see citing works

Sex and Gender Differences in Myocarditis and Dilated Cardiomyopathy

Fairweather, D., Cooper, L. T., & Blauwet, L. A. (2013) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2012.07.003 · Cited by 325 · see citing works

Gender differences in the effects of cardiovascular drugs

Tamargo, J. L., Rosano, G. M. C., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K. P., Savarese, G., et al. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw042 · Cited by 319 · see citing works

The gestational foundation of sex differences in development and vulnerability

DiPietro, J. A., & Voegtline, K. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.068 · Cited by 316 · see citing works

Twenty years and still counting: including women as participants and studying sex and gender in biomedical research

Mazure, C. M., & Jones, D. P. (2015) · BMC Women s Health · doi:10.1186/s12905-015-0251-9 · Cited by 310 · see citing works

Gender and the renin–angiotensin–aldosterone system

Komukai, K., Mochizuki, S., & Yoshimura, M. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00854.x · Cited by 290 · see citing works

Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues

Herron, T. J., Lee, P., & Jalife, J. (2012) · Circulation Research · doi:10.1161/circresaha.111.247494 · Cited by 290 · see citing works

High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy

McLellan, M. A., Skelly, D. A., Dona, M. S. I., Squiers, G. T., Farrugia, G. E., Gaynor, T. L., Cohen, C. D., Pandey, R., Diep, H., Vinh, A., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.045115 · Cited by 287 · see citing works

Estrogen accelerates the resolution of inflammation in macrophagic cells

Villa, A. M., Rizzi, N., Vegeto, E., Ciana, P., & Maggi, A. C. (2015) · Scientific Reports · doi:10.1038/srep15224 · Cited by 272 · see citing works

The landscape of sex-differential transcriptome and its consequent selection in human adults

Gershoni, M., & Pietrokovski, S. (2017) · BMC Biology · doi:10.1186/s12915-017-0352-z · Cited by 267 · see citing works

Social, behavioral, and biological factors, and sex differences in mortality

Rogers, R. G., Everett, B. G., Onge, J. M. S., & Krueger, P. M. (2010) · Demography · doi:10.1353/dem.0.0119 · Cited by 264 · see citing works

Early androgen exposure and human gender development

Hines, M., Constantinescu, M., & Spencer, D. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0022-1 · Cited by 263 · see citing works

Cardiovascular Disease Risk Factors and Myocardial Infarction in the Transgender Population

Alzahrani, T., Nguyen, T., Ryan, A., Dwairy, A., McCaffrey, J. A., Yunus, R. N., Forgione, J., Krepp, J. M., Nagy, C. D., Mazhari, R., et al. (2019) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.119.005597 · Cited by 260 · see citing works

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

Goldfracht, I., Protze, S. I., Shiti, A., Setter, N., Gruber, A., Shaheen, N., Nartiss, Y., Keller, G. M., & Gepstein, L. (2020) · Nature Communications · doi:10.1038/s41467-019-13868-x · Cited by 260 · see citing works

Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering

O’Neill, J. D., Anfang, R. R., Anandappa, A. J., Costa, J. A., Javidfar, J., Wobma, H., Singh, G., Freytes, D. O., Bacchetta, M. D., Sonett, J. R., et al. (2013) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2013.04.022 · Cited by 258 · see citing works

Composite scaffold provides a cell delivery platform for cardiovascular repair

Godier-Furnémont, A., Martens, T. P., Koeckert, M. S., Wan, L. Q., Parks, J. J., Arai, K., Zhang, G., Hudson, B. I., Homma, S., & Vunjak‐Novakovic, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104619108 · Cited by 257 · see citing works

Nontranscriptional Regulation of Cardiac Repolarization Currents by Testosterone

Bai, C., Kurokawa, J., Tamagawa, M., Nakaya, H., & Furukawa, T. (2005) · Circulation · doi:10.1161/circulationaha.104.523217 · Cited by 254 · see citing works

Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium

Garbern, J. C., Minami, E., Stayton, P. S., & Murry, C. E. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.075 · Cited by 253 · see citing works

The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization

Freeman, I., & Cohen, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.057 · Cited by 252 · see citing works

Women Have Higher Left Ventricular Ejection Fractions Than Men Independent of Differences in Left Ventricular Volume

Chung, A. K., Das, S. R., Leonard, D. S., Peshock, R. M., Kazi, F., Abdullah, S. M., Canham, R. M., Levine, B. D., & Drazner, M. H. (2006) · Circulation · doi:10.1161/circulationaha.105.574400 · Cited by 250 · see citing works

The Spectrum of Dilated Cardiomyopathy: The Johns Hopkins Experience with 1,278 Patients

Felker, G. M., Hu, W., Hare, J. M., Hruban, R. H., Baughman, K. L., & Kasper, E. K. (1999) · Medicine · doi:10.1097/00005792-199907000-00005 · Cited by 248 · see citing works

The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes

Mihic, A., Li, J., Miyagi, Y., Gagliardi, M., Li, S.-H., Zu, J., Weisel, R. D., Keller, G., & Li, R.-K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.052 · Cited by 248 · see citing works

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

Boese, A. C., Kim, S. C., Yin, K., Lee, J., & Hamblin, M. H. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00217.2016 · Cited by 241 · see citing works

Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture

Feinberg, A. W., Alford, P. W., Jin, H., Ripplinger, C. M., Werdich, A. A., Sheehy, S. P., Grosberg, A., & Parker, K. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.043 · Cited by 240 · see citing works

Visualization of spiral and scroll waves in simulated and experimental cardiac tissue

Cherry, E. M., & Fenton, F. H. (2008) · New Journal of Physics · doi:10.1088/1367-2630/10/12/125016 · Cited by 237 · see citing works

Sex Drives Dimorphic Immune Responses to Viral Infections

Ghosh, S., & Klein, R. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601166 · Cited by 232 · see citing works

Analysis of heart injury laboratory parameters in 273 COVID‐19 patients in one hospital in Wuhan, China

Han, H. W., Xie, L., Liu, R., Yang, J. W., Liu, F., Wu, K., Chen, L., Hou, W., Feng, Y., & Zhu, C. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25809 · Cited by 228 · see citing works

A tissue-engineered scale model of the heart ventricle

MacQueen, L. A., Sheehy, S. P., Chantre, C. O., Zimmerman, J. F., Pasqualini, F. S., Liu, X., Goss, J. A., Campbell, P. H., Gonzalez, G. M., Park, S.-J., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0271-5 · Cited by 227 · see citing works

Endocrinology of the Menopause

Hall, J. E. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.05.010 · Cited by 223 · see citing works

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Tsamandouras, N., Chen, W. L. K., Edington, C. D., Stokes, C. L., Griffith, L. G., & Cirit, M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0122-4 · Cited by 222 · see citing works

Cardiac Size and Sex-Matching in Heart Transplantation

Reed, R. M., Netzer, G., Hunsicker, L. G., Mitchell, B. D., Rajagopal, K., Scharf, S. M., & Eberlein, M. H. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.09.005 · Cited by 221 · see citing works

Engineering precision biomaterials for personalized medicine

Aguado, B. A., Grim, J. C., Rosales, A. M., Watson-Capps, J. J., & Anseth, K. S. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam8645 · Cited by 216 · see citing works

Growth factor delivery: Defining the next generation platforms for tissue engineering

Aguilar, L. M. C., Silva, S. M., & Moulton, S. E. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.05.028 · Cited by 211 · see citing works

Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults

Connelly, P. J., Freel, E. M., Perry, C. G., Ewan, J., Touyz, R. M., Currie, G. E., & Delles, C. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13080 · Cited by 205 · see citing works

Electrical Stimulation Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells

Chan, Y.-C., Ting, S., Lee, Y.-K., Ng, K., Zhang, J., Chen, Z., Siu, C., Oh, S. K. W., & Tse, H. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9510-z · Cited by 203 · see citing works

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

Fleischer, S., Tavakol, D. N., & Vunjak‐Novakovic, G. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910811 · Cited by 199 · see citing works

Cardiac Actions of Erythromycin

Drici, M., Knollmann, B. C., Wang, W.-X., & Woosley, R. L. (1998) · JAMA · doi:10.1001/jama.280.20.1774 · Cited by 197 · see citing works

Age-Gender Influence on the Rate-Corrected QT Interval and the QT-Heart Rate Relation in Families With Genotypically Characterized Long QT Syndrome

Lehmann, M. H., Timothy, K. W., Frankovich, D., Fromm, B. S., Keating, M. T., Locati, E. H., Taggart, R. T., Towbin, J. A., Moss, A. J., Schwartz, P. J., et al. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00454-8 · Cited by 192 · see citing works

Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

Leonard, A., Bertero, A., Powers, J. D., Beussman, K. M., Bhandari, S., Regnier, M., Murry, C. E., & Sniadecki, N. J. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.03.016 · Cited by 191 · see citing works

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

Mastikhina, O., Moon, B., Williams, K., Hatkar, R., Gustafson, D., Mourad, O., Sun, X., Koo, M., Lam, A. Y. L., Sun, Y., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119741 · Cited by 190 · see citing works

Generation of Quiescent Cardiac Fibroblasts From Human Induced Pluripotent Stem Cells for In Vitro Modeling of Cardiac Fibrosis

Zhang, H., Tian, L., Shen, M., Tu, C., Wu, H., Gu, M., Paik, D. T., & Wu, J. C. (2019) · Circulation Research · doi:10.1161/circresaha.119.315491 · Cited by 187 · see citing works

A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq

Li, B., Qing, T., Zhu, J., Wen, Z., Yu, Y., Fukumura, R., Zheng, Y., Gondo, Y., & Shi, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-04520-z · Cited by 184 · see citing works

Sex-Dependent Regulation of Fibrosis and Inflammation in Human Left Ventricular Remodelling Under Pressure Overload

Kararigas, G., Dworatzek, E., Petrov, G., Summer, H., Schulze, T. M., Baczkó, I., Knosalla, C., Gölz, S., Hetzer, R., & Regitz‐Zagrosek, V. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.171 · Cited by 180 · see citing works

Sex-chromosome dosage effects on gene expression in humans

Raznahan, A., Parikshak, N. N., Chandran, V., Blumenthal, J. D., Clasen, L. S., Alexander-Bloch, A. F., Zinn, A. R., Wangsa, D., Wise, J., Murphy, D. G. M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802889115 · Cited by 179 · see citing works

Wavelength‐Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins

Azagarsamy, M. A., & Anseth, K. S. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201308174 · Cited by 176 · see citing works

Estrogen-related mechanisms in sex differences of hypertension and target organ damage

Sabbatini, A. R., & Kararigas, G. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00306-7 · Cited by 176 · see citing works

Engineering a perfusable 3D human liver platform from iPS cells

Schepers, A. G., Li, C. Y., Chhabra, A., Tschudy-Seney, B., & Bhatia, S. N. (2016) · Lab on a Chip · doi:10.1039/c6lc00598e · Cited by 174 · see citing works

Menopause-Related Estrogen Decrease and the Pathogenesis of HFpEF

Sabbatini, A. R., & Kararigas, G. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.049 · Cited by 173 · see citing works

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Matsa, E., Burridge, P. W., Yu, K.-H., Ahrens, J. H., Termglinchan, V., Wu, H., Liu, C., Shukla, P., Sayed, N., Churko, J. M., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.07.006 · Cited by 164 · see citing works

Influence of donor and recipient sex mismatch on heart transplant outcomes: Analysis of the International Society for Heart and Lung Transplantation Registry

Khush, K. K., Kubo, J. T., & Desai, M. (2012) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2012.02.005 · Cited by 163 · see citing works

Moldable elastomeric polyester-carbon nanotube scaffolds for cardiac tissue engineering

Ahadian, S., Huyer, L. D., Estili, M., Yee, B., Smith, N., Xu, Z., Sun, Y., & Radisic, M. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.12.009 · Cited by 163 · see citing works

X Inactivation and Escape: Epigenetic and Structural Features

Fang, H., Distèche, C. M., & Berletch, J. B. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00219 · Cited by 162 · see citing works

Sex Differences in Circulating Biomarkers of Cardiovascular Disease

Lau, E. S., Paniagua, S. M., Guseh, J. S., Bhambhani, V., Zanni, M. V., Courchesne, P. L., Lyass, A., Larson, M. G., Levy, D. A., & Ho, J. E. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.06.077 · Cited by 159 · see citing works

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells

van den Berg, C. W., Okawa, S., Lopes, S. M. C. D. S., van Iperen, L., Passier, R. C., Braam, S. R., Tertoolen, L. G. J., del Sol, A., Davis, R. P., & Mummery, C. L. (2015) · Development · doi:10.1242/dev.123810 · Cited by 158 · see citing works

Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation

Godier-Furnémont, A., Tiburcy, M., Wagner, E., Dewenter, M., Lämmle, S., El‐Armouche, A., Lehnart, S. E., Vunjak‐Novakovic, G., & Zimmermann, W. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.055 · Cited by 157 · see citing works

Can We Engineer a Human Cardiac Patch for Therapy?

Zhang, J. J., Zhu, W., Radisic, M., & Vunjak‐Novakovic, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.311213 · Cited by 156 · see citing works

Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium

Lemme, M., Ulmer, B. M., Lemoine, M. D., Zech, A. T. L., Flenner, F., Ravens, U., Reichenspurner, H. C., Rol-Garcia, M., Smith, G. L., Hansen, A., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.10.008 · Cited by 156 · see citing works

Increased afterload induces pathological cardiac hypertrophy: a new in vitro model

Hirt, M. N., Sörensen, N. A., Bartholdt, L. M., Boeddinghaus, J., Schaaf, S., Eder, A., Vollert, I., Stöhr, A., Schulze, T., Witten, A., et al. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0307-z · Cited by 154 · see citing works

Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ros homeostasis in young mouse heart and brain

Khalifa, A. R. M., Abdel‐Rahman, E. A., Mahmoud, A. M., Ali, M. H., Noureldin, M., Saber, S. H., Mohsen, M., & Ali, S. S. (2017) · Physiological Reports · doi:10.14814/phy2.13125 · Cited by 154 · see citing works

The Impact of Donor-Recipient Sex Matching on Survival After Orthotopic Heart Transplantation

Weiss, E. S., Allen, J. G., Patel, N., Russell, S. D., Baumgartner, W. A., Shah, A. S., & Conte, J. V. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.844183 · Cited by 153 · see citing works

Sex Differences in the Biology and Pathology of the Aging Heart

Keller, K. M., & Howlett, S. E. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.03.017 · Cited by 152 · see citing works

In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits

Liu, X. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00673-9 · Cited by 150 · see citing works

Sex Differences and the Influence of Sex Hormones on Cognition through Adulthood and the Aging Process

Gurvich, C., Hoy, K., Thomas, N., & Kulkarni, J. (2018) · Brain Sciences · doi:10.3390/brainsci8090163 · Cited by 150 · see citing works

Modular assembly of thick multifunctional cardiac patches

Fleischer, S., Shapira, A., Feiner, R., & Dvir, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615728114 · Cited by 149 · see citing works

Sex differences in mechanisms of cardiac excitation–contraction coupling

Parks, R. J., & Howlett, S. E. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1233-0 · Cited by 148 · see citing works

Sex-Related Differences in Heart Failure With Preserved Ejection Fraction

Dewan, P., Rørth, R., Raparelli, V., Campbell, R. T., Shen, L., Jhund, P. S., Petrie, M. C., Anand, I. S., Carson, P. E., Desai, A. S., et al. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006539 · Cited by 146 · see citing works

Gender-related differences in lifestyle may affect health status.

Varı́, R., Scazzocchio, B., d’Amore, A., Giovannini, C., Gessani, S., & Masella, R. (2016) · Annali dell Istituto Superiore di Sanità · doi:10.4415/ann_16_02_06 · Cited by 143 · see citing works

Sex- and Age-Based Differences in the Natural History and Outcome of Dilated Cardiomyopathy

Halliday, B. P., Gulati, A., Ali, A., Newsome, S., Lota, A. S., Tayal, U., Vassiliou, V. S., Aržanauskaitė, M., İzgi, C., Krishnathasan, K., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1216 · Cited by 143 · see citing works

Sex Chromosome Effects Unmasked in Angiotensin II–Induced Hypertension

Ji, H., Zheng, W. H., Wu, X., Liu, J., ECELBARGER, C. A., Watkins, R., Arnold, A. P., & Sandberg, K. L. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.144949 · Cited by 142 · see citing works

Aging and sex hormones in males

Decaroli, M. C., & Rochira, V. (2016) · Virulence · doi:10.1080/21505594.2016.1259053 · Cited by 141 · see citing works

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Fong, A. H., Romero-López, M., Heylman, C. M., Keating, M., Tran, D. D., Sobrino, A., Tran, A. Q., Pham, H. H., Fimbres, C., Gershon, P. D., et al. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0027 · Cited by 140 · see citing works

Large Scale Gene Expression Meta-Analysis Reveals Tissue-Specific, Sex-Biased Gene Expression in Humans

Mayne, B. T., Bianco-Miotto, T., Buckberry, S., Breen, J., Clifton, V., Shoubridge, C., & Roberts, C. T. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00183 · Cited by 140 · see citing works

Bioengineered uterine tissue supports pregnancy in a rat model

Hellström, M., Moreno-Moya, J. M., Bandstein, S., Bom, E., Akouri, R., Miyazaki, K., Maruyama, T., & Brännström, M. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.03.048 · Cited by 138 · see citing works

Biowire Model of Interstitial and Focal Cardiac Fibrosis

Wang, E. Y., Rafatian, N., Zhao, Y., Lee, A., Lai, B. F. L., Lu, R. X. Z., Jekic, D., Huyer, L. D., Knee‐Walden, E. J., Bhattacharya, S., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b00052 · Cited by 128 · see citing works

Sex-Steroid Hormones and Electrocardiographic QT-Interval Duration: Findings From the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis

Zhang, Y., Ouyang, P., Post, W. S., Dalal, D., Vaidya, D. M., Blasco‐Colmenares, E., Soliman, E. Z., Tomaselli, G. F., & Güallar, E. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr172 · Cited by 127 · see citing works

I-Wire Heart-on-a-Chip I: Three-dimensional cardiac tissue constructs for physiology and pharmacology

Sidorov, V. Y., Samson, P. C., Sidorova, T. N., Davidson, J. M., Lim, C. C., & Wikswo, J. P. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.009 · Cited by 127 · see citing works

Sex-Related Differences in the Extent of Myocardial Fibrosis in Patients With Aortic Valve Stenosis

Tastet, L. L., Kwieciński, J., Pîbarot, P., Capoulade, R., Everett, R. J., Newby, D. E., Shen, M., Guzzetti, E., Arsenault, M., Bédard, É., et al. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.06.014 · Cited by 124 · see citing works

Biohybrid cardiac ECM-based hydrogels improve long term cardiac function post myocardial infarction

Efraim, Y., Sarig, H., Anavy, N. C., Sarig, U., de-Berardinis, E., Chaw, S. Y., Krishnamoorthi, M. K., Kalifa, J., Bogireddi, H., Duc, T. V., et al. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.12.015 · Cited by 123 · see citing works

Preparation of an Electrically Conductive Graphene Oxide/Chitosan Scaffold for Cardiac Tissue Engineering

Jiang, L., Chen, D., Wang, Z., Zhang, Z., Xia, Y., Xue, H., & Liu, Y. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-02967-6 · Cited by 123 · see citing works

Sex differences in the mechanisms underlying long QT syndrome

Salama, G., & Bett, G. C. L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00864.2013 · Cited by 120 · see citing works

Spring-like fibers for cardiac tissue engineering

Fleischer, S., Feiner, R., Shapira, A., Ji, J., Sui, X., Wagner, H. D., & Dvir, T. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.054 · Cited by 118 · see citing works

Gender‐Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans

KRECICSHEPARD, M., Barnas, C., SLIMKO, J., Jones, M. P., & Schwartz, J. B. (2000) · The Journal of Clinical Pharmacology · doi:10.1177/00912700022008883 · Cited by 116 · see citing works

Quantitative analysis of Y-Chromosome gene expression across 36 human tissuesPreprint

Godfrey, A. K., Naqvi, S., Chmátal, L., Chick, J. M., Mitchell, R. N., Gygi, S. P., Skaletsky, H., & Page, D. C. (2020) · Genome Research · doi:10.1101/gr.261248.120 · Cited by 116 · see citing works

Age and gender effects on the extent of myocardial involvement in acute myocarditis: a cardiovascular magnetic resonance study

Cocker, M. S., Abdel-Aty, H., Strohm, O., & Friedrich, M. G. (2009) · Heart · doi:10.1136/hrt.2008.164061 · Cited by 115 · see citing works

Gender Differences in the Pathophysiology, Clinical Presentation, and Outcomes of Ischemic Heart Failure

Dunlay, S. M., & Roger, V. L. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0107-7 · Cited by 113 · see citing works

Measuring mitochondrial function in intact cardiac myocytes

Dedkova, E. N., & Blatter, L. A. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.08.030 · Cited by 112 · see citing works

Timing and Duration of Menopausal Hormone Treatment May Affect Cardiovascular Outcomes

Harman, S. M., Vittinghoff, E., Brinton, E. A., Budoff, M. J., Cedars, M. I., Løbo, R. A., Merriam, G. R., Miller, V. M., Naftolin, F. N., Pal, L., et al. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.09.021 · Cited by 111 · see citing works

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

Norheim, F., Hasin-Brumshtein, Y., Vergnes, L., Krishnan, K. C., Pan, C., Seldin, M. M., Hui, S. T. Y., Mehrabian, M., Zhou, Z., Gupta, S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.013 · Cited by 111 · see citing works

Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

Mithal, A., Capilla, A., Heinze, D. M., Berical, A. C., Villacorta-Martín, C., Vedaie, M., Jacob, A., Abo, K. M., Szymaniak, A. D., Peasley, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13916-6 · Cited by 111 · see citing works

Biomaterializing the promise of cardiac tissue engineering

Pomeroy, J. E., Helfer, A., & Bursac, N. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.009 · Cited by 107 · see citing works

Sex Chromosome Effects on Male–Female Differences in Mammals

Snell, D. M., & Turner, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.09.018 · Cited by 106 · see citing works

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

Kawatou, M., Masumoto, H., Fukushima, H., Morinaga, G., Sakata, R., Ashihara, T., & Yamashita, J. K. (2017) · Nature Communications · doi:10.1038/s41467-017-01125-y · Cited by 105 · see citing works

Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy

Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., & Costa, K. D. (2016) · PLOS ONE · doi:10.1371/journal.pone.0146697 · Cited by 101 · see citing works

Effects of aging on cardiac extracellular matrix in men and women

Dworatzek, E., Baczkó, I., & Kararigas, G. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500031 · Cited by 99 · see citing works

Sex differences in the metabolic effects of the renin-angiotensin system

White, M., Fleeman, R. M., & Arnold, A. C. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0247-5 · Cited by 99 · see citing works

Gender Differences in Cardiovascular Pharmacotherapy—the Example of Hypertension: A Mini Review

Kalibala, J., Péchère-Bertschi, A., & Desmeules, J. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00564 · Cited by 99 · see citing works

Albumin fiber scaffolds for engineering functional cardiac tissues

Fleischer, S., Shapira, A., Regev, O., Nseir, N., Zussman, E., & Dvir, T. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25185 · Cited by 97 · see citing works

Sex Differences in Aging: Genomic Instability

Fischer, K. E., & Riddle, N. C. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx105 · Cited by 97 · see citing works

Genome Editing in Human Stem Cells

Byrne, S. M., Mali, P., & Church, G. M. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801185-0.00006-4 · Cited by 96 · see citing works

Donor–recipient size matching and mortality in heart transplantation: Influence of body mass index and gender

Bergenfeldt, H., Stehlik, J., Höglund, P., Andersson, B., & Nilsson, J. (2017) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2017.02.002 · Cited by 93 · see citing works

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function

Cook, C. D., Hill, A. S., Guo, M. G., Stockdale, L., Papps, J. P., Isaacson, K., Lauffenburger, D. A., & Griffith, L. G. (2017) · Integrative Biology · doi:10.1039/c6ib00245e · Cited by 93 · see citing works

Engineering Precision Medicine

Sun, W., Lee, J., Zhang, S., Benyshek, C., Dokmeci, M. R., & Khademhosseini, A. (2018) · Advanced Science · doi:10.1002/advs.201801039 · Cited by 93 · see citing works

Gender Differences in Patients with Takotsubo Cardiomyopathy: Multi-Center Registry from Tokyo CCU Network

Murakami, T., Yoshikawa, T., Maekawa, Y., Ueda, T., Isogai, T., Sakata, K., Nagao, K., Yamamoto, T., & Takayama, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136655 · Cited by 92 · see citing works

Sex differences in cardiovascular epigenetics—a systematic review

Hartman, R. J. G., Huisman, S. E., & den Ruijter, H. M. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0180-z · Cited by 92 · see citing works

Sex differences in SR Ca2+ release in murine ventricular myocytes are regulated by the cAMP/PKA pathway

Parks, R. J., Ray, G., Bienvenu, L. A., Rose, R. A., & Howlett, S. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.07.006 · Cited by 91 · see citing works

Age-associated changes in excitation-contraction coupling are more prominent in ventricular myocytes from male rats than in myocytes from female rats

Howlett, S. E. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00214.2009 · Cited by 91 · see citing works

Sex Differences in Drug Effects: Interaction with Sex Hormones in Adult Life

Spoletini, I., Vitale, C., Malorni, W., & Rosano, G. M. C. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_5 · Cited by 90 · see citing works

Significant role of estrogen in maintaining cardiac mitochondrial functions

Rattanasopa, C., Phungphong, S., Wattanapermpool, J., & Bupha‐Intr, T. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.009 · Cited by 88 · see citing works

Electrospun Extracellular Matrix: Paving the Way to Tailor‐Made Natural Scaffolds for Cardiac Tissue Regeneration

Schoen, B., Avrahami, R., Baruch, L., Efraim, Y., Goldfracht, I., Elul, O., Davidov, T., Gepstein, L., Zussman, E., & Machluf, M. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700427 · Cited by 88 · see citing works

Measurement of Estradiol—Challenges Ahead

Stanczyk, F. Z., & Clarke, N. J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2905 · Cited by 87 · see citing works

Comparison of clinical findings in idiopathic dilated cardiomyopathy in women versus men

Maria, R. D., Gavazzi, A., Recalcati, F., Baroldi, G., Vita, C. D., & Camerini, F. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90355-g · Cited by 85 · see citing works

Mitochondrial connexin 43 in sex-dependent myocardial responses and estrogen-mediated cardiac protection following acute ischemia/reperfusion injury

Wang, M., Smith, K., Yu, Q., Miller, C. A., Singh, K., & Sen, C. K. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0759-5 · Cited by 84 · see citing works

Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages

Vijay, V., Han, T., Moland, C. L., Kwekel, J. C., Fuscoe, J. C., & Desai, V. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117047 · Cited by 80 · see citing works

Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation

Rodrigues, I. C. P., Kaasi, A., Filho, R. M., Jardini, A. L., & Gabriel, L. P. (2018) · Einstein (São Paulo) · doi:10.1590/s1679-45082018rb4538 · Cited by 80 · see citing works

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Hartman, R. J. G., Kapteijn, D., Haitjema, S., Bekker, M. N., Mokrý, M., Pasterkamp, G., Civelek, M., & den Ruijter, H. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69451-8 · Cited by 79 · see citing works

Sex-Specific Characteristics of the Microcirculation

Huxley, V. H., & Kemp, S. S. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_20 · Cited by 77 · see citing works

Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population: Results from Kochi RYOMA study

Kubo, T., Kitaoka, H., Okawa, M., Hirota, T., Hayato, K., Yamasaki, N., Matsumura, Y., Yabe, T., & Doi, Y. (2010) · Journal of Cardiology · doi:10.1016/j.jjcc.2010.07.004 · Cited by 76 · see citing works

Decellularized liver scaffolds promote liver regeneration after partial hepatectomy

Shimoda, H., Yagi, H., Higashi, H., Tajima, K., Kuroda, K., Abe, Y., Kitago, M., Shinoda, M., & Kitagawa, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-48948-x · Cited by 76 · see citing works

Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format

Mannhardt, I., Saleem, U., Mosqueira, D., Loos, M., Ulmer, B. M., Lemoine, M. D., Larsson, C., Améen, C., de Korte, T., Vlaming, M. L. H., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.002 · Cited by 74 · see citing works

Development of a novel human recellularized endometrium that responds to a 28-day hormone treatment†

Olalekan, S. A., Burdette, J. E., Getsios, S., Woodruff, T. K., & Kim, J. J. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox039 · Cited by 73 · see citing works

Advances in understanding the renin-angiotensin-aldosterone system (RAAS) in blood pressure control and recent pivotal trials of RAAS blockade in heart failure and diabetic nephropathy

Ghazi, L., & Drawz, P. E. (2017) · F1000Research · doi:10.12688/f1000research.9692.1 · Cited by 71 · see citing works

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice

Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A. M., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.04.004 · Cited by 71 · see citing works

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krüger, M., Poggesi, C., Ho, C. Y., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004133 · Cited by 71 · see citing works

A Stretchable and Flexible Cardiac Tissue–Electronics Hybrid Enabling Multiple Drug Release, Sensing, and Stimulation

Feiner, R., Wertheim, L., Gazit, D., Kalish, O., Mishal, G., Shapira, A., & Dvir, T. (2019) · Small · doi:10.1002/smll.201805526 · Cited by 71 · see citing works

Oestrogen upregulates L‐type Ca2+channels via oestrogen‐receptor‐α by a regional genomic mechanism in female rabbit hearts

Yang, X., Chen, G., Papp, R., DeFranco, D. B., Zeng, F., & Salama, G. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.219501 · Cited by 69 · see citing works

Tissue-specific sex differences in human gene expression

Kassam, I., Wu, Y., Yang, J., Visscher, P. M., & McRae, A. F. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz090 · Cited by 69 · see citing works

Impact of Age and Sex on QT Prolongation in Patients Receiving Psychotropics

Rabkin, S. W. (2015) · The Canadian Journal of Psychiatry · doi:10.1177/070674371506000502 · Cited by 67 · see citing works

Gender differences in the etiology of heart failure: A systematic review

Azad, N. A., Anusha, K., Shabnam, M., Hébert, P. C., & Fergusson, D. A. (2011) · 老年心脏病学杂志：英文版 · doi:10.3724/sp.j.1263.2011.00015 · Cited by 67 · see citing works

Association of Estrogen Receptor β Gene Polymorphisms With Left Ventricular Mass and Wall Thickness in Women

Peter, I., Shearman, A. M., Vasan, R. S., Zucker, D. R., Schmid, C. H., Demissie, S., Cupples, L. A., Kuvin, J. T., Karas, R. H., & Mendelsohn, M. E. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.023 · Cited by 66 · see citing works

Female Sex as a Risk Factor for In-Hospital Mortality Among Children Undergoing Cardiac Surgery

Chang, R. R., Chen, A. Y., & Klitzner, T. S. (2002) · Circulation · doi:10.1161/01.cir.0000029104.94858.6f · Cited by 66 · see citing works

Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts

Heras-Bautista, C. O., Mikhael, N., Lam, J., Shinde, V., Katsen‐Globa, A., Dieluweit, S., Molčányi, M., Uvarov, V., Jütten, P., Sahito, R. G. A., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.03.017 · Cited by 66 · see citing works

Integrated Analysis of Contractile Kinetics, Force Generation, and Electrical Activity in Single Human Stem Cell-Derived Cardiomyocytes

Kijlstra, J. D., Hu, D., Mittal, N., Kausel, E., van der Meer, P., Garakani, A., & Domian, I. J. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.10.017 · Cited by 65 · see citing works

Sex Differences in the Long-term Prognosis of Dilated Cardiomyopathy

Cannata, A. N., Fabris, E., Merlo, M., Artico, J., Gentile, P., Gava, C. P. L. D., Ballaben, A., Ramani, F., Barbati, G., & Sinagra, G. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.05.031 · Cited by 63 · see citing works

Sex Differences in Heart Failure

Savarese, G., & D’Amario, D. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_32 · Cited by 61 · see citing works

Gender Disparities in Cardiac Cellular Electrophysiology and Arrhythmia Susceptibility in Human Failing Ventricular Myocytes

Verkerk, A. O., Wilders, R., Veldkamp, M. W., de Geringel, W., Kirkels, J. H., & Tan, H. L. (2005) · International Heart Journal · doi:10.1536/ihj.46.1105 · Cited by 60 · see citing works

Estrogen receptor beta signals to inhibition of cardiac fibrosis

Pedram, A., Razandi, M., Narayanan, R., & Levin, E. R. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.018 · Cited by 60 · see citing works

Human disease models in drug development

Loewa, A., Feng, J. J., & Hedtrich, S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00063-3 · Cited by 331 · see citing works

Sex differences in heart: from basics to clinics

Prajapati, C., Koivumäki, J. T., Pekkanen-Mattila, M., & Aalto‐Setälä, K. (2022) · European journal of medical research · doi:10.1186/s40001-022-00880-z · Cited by 92 · see citing works

Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics

Gil-Cabrerizo, P., Simón‐Yarza, T., Garbayo, E., & Blanco‐Prieto, M. J. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115302 · Cited by 51 · see citing works

Emerging technologies for cardiac tissue engineering and artificial hearts

Sun, L., Wang, Y., Xu, D., & Zhao, Y. (2023) · Smart Medicine · doi:10.1002/smmd.20220040 · Cited by 44 · see citing works

Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes

Raniga, K., Nasir, A., Vo, N. T. N., Vaidyanathan, R., Dickerson, S., Hilcove, S. A., Mosqueira, D., Mirams, G. R., Clements, P., Hicks, R., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.01.007 · Cited by 38 · see citing works

Hierarchical Design of Tissue‐Mimetic Fibrillar Hydrogel Scaffolds

Pardo, A., Gómez‐Florit, M., Davidson, M. D., Öztürk-Öncel, M. Ö., Domingues, R. M. A., Burdick, J. A., & Gomes, M. E. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303167 · Cited by 35 · see citing works

A Change of Heart: Human Cardiac Tissue Engineering as a Platform for Drug Development

Bremner, S. B., Gaffney, K. S., Sniadecki, N. J., & Mack, D. L. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01668-7 · Cited by 29 · see citing works

Biofabrication and biomanufacturing in Ireland and the UK

Murphy, J. F., Lavelle, M., Asciak, L., Burdis, R., Levis, H. J., Ligorio, C., McGuire, J., Polleres, M., Smith, P. O., Tullie, L., et al. (2024) · Bio-Design and Manufacturing · doi:10.1007/s42242-024-00316-z · Cited by 28 · see citing works

Engineering stem cell therapeutics for cardiac repair

Fang, J., Li, J. J., Zhong, X., Zhou, Y., Lee, R. J., Cheng, K., & Li, S. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.06.013 · Cited by 27 · see citing works

Sex in cardiovascular disease: Why this biological variable should be considered in in vitro models

McClain, A. K., Monteleone, P. P., & Zoldan, J. (2024) · Science Advances · doi:10.1126/sciadv.adn3510 · Cited by 25 · see citing works

Neglecting sex and gender in research is a public-health risk

Haupt, S., Carcel, C., & Norton, R. (2024) · Nature · doi:10.1038/d41586-024-01372-2 · Cited by 23 · see citing works

Female cardiovascular biology and resilience in the setting of physiological and pathological stress

Collins, H. E. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102747 · Cited by 22 · see citing works

Sex differences in radiation research

Taliaferro, L. P., Agarwal, R. K., Coleman, C. N., DiCarlo, A. L., Hofmeyer, K. A., Loelius, S. G., Molinar‐Inglis, O., Tedesco, D. C., & Satyamitra, M. M. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2283089 · Cited by 21 · see citing works

Myocardial infarction from a tissue engineering and regenerative medicine point of view: A comprehensive review on models and treatments

Basara, G., Bahçecioğlu, G., Ozcebe, S. G., Ellis, B. W., Ronan, G., & Zorlutuna, P. (2022) · Biophysics Reviews · doi:10.1063/5.0093399 · Cited by 19 · see citing works

Se(XY) matters: the importance of incorporating sex in microphysiological models

Kouthouridis, S., Robson, E., Hartung, A., Raha, S., & Zhang, B. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.04.005 · Cited by 16 · see citing works

Bridging the Gap in Ashby's Map for Soft Material Properties for Tissue Engineering.

Lou, L., Paolino, L., & Agarwal, A. (2023) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.3c04331 · Cited by 17 · see citing works

Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine

Allen, J. B., Ludtka, C., & James, B. D. (2023) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092222-030857 · Cited by 16 · see citing works

Biotechnological advances and applications of human pluripotent stem cell-derived heart models

Muniyandi, P., O’Hern, C., Popa, M. A., & Aguirre, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1214431 · Cited by 14 · see citing works

Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function

Veser, C., Carlier, A., Dubois, V., Mihaila, S. M., & Swapnasrita, S. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00662-8 · Cited by 18 · see citing works

Osteopontin activity modulates sex‐specific calcification in engineered valve tissue mimics

Schroeder, M. E., Batan, D., Rodriguez, A. G., Speckl, K. F., Peters, D. K., Kirkpatrick, B. E., Hach, G. K., Walker, C. J., Grim, J. C., Aguado, B. A., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10358 · Cited by 12 · see citing works

Advances in the design, generation, and application of tissue-engineered myocardial equivalents

Bernava, G., & Iop, L. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1247572 · Cited by 14 · see citing works

Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading

Zhao, Y., Godier-Furnémont, A., Bax, N. A. M., Bouten, C. V. C., Brown, L. M., Fine, B. M., & Vunjak‐Novakovic, G. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.02.003 · Cited by 12 · see citing works

Recent advances in cell-based in vitro models for predicting drug permeability across brain, intestinal, and pulmonary barriers

Eltanameli, B., Piñeiro-Llanes, J., & Cristofoletti, R. (2024) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2024.2366390 · Cited by 12 · see citing works

Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches

Chevalley, T., Dübi, M., Fumeaux, L., Merli, M. S., Sarre, A., Schaer, N., Siméoni, U., & Yzydorczyk, C. (2025) · Cells · doi:10.3390/cells14060467 · Cited by 11 · see citing works

Sex matters: the frequently overlooked importance of considering sex in computational models

Burrowes, K., Ruppage, M., Lowry, A., & Zhao, D. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1186646 · Cited by 11 · see citing works

Hypoxic–Normoxic Crosstalk Activates Pro‐Inflammatory Signaling in Human Cardiac Fibroblasts and Myocytes in a Post‐Infarct Myocardium on a Chip

Khalil, N. N., Rexius‐Hall, M. L., Gupta, D., McCarthy, L., Verma, R., Kellogg, A. C., Takamoto, K., Xu, M., Nejatpoor, T., Parker, S. J., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401478 · Cited by 11 · see citing works

The Emergence of Model Systems to Investigate the Link Between Traumatic Brain Injury and Alzheimer’s Disease

Srinivasan, G. R., & Brafman, D. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.813544 · Cited by 10 · see citing works

Addressing Sex as a Biological Variable in Preclinical Models of Lung Disease: An Official American Thoracic Society Research Statement

Lingappan, K., Sundar, I. K., Prakash, Y. S., Redente, E. F., Sin, D. D., Han, M. K., Lahm, T., Krymskaya, V. P., Kotton, D. N., Kulkarni, H. S., et al. (2025) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202506-1361st · Cited by 10 · see citing works

Emerging Trajectories for Next Generation Tissue Engineers

Tavakol, D. N., Fleischer, S., Falcucci, T., Graney, P. L., Halligan, S. P., Kaplan, D. L., & Vunjak‐Novakovic, G. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c01428 · Cited by 9 · see citing works

Developing sex-accurate cell culture environments

Borelli, A. N., & Masters, K. S. B. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00265-3 · Cited by 8 · see citing works

The Appropriateness of Medical Devices Is Strongly Influenced by Sex and Gender

Campesi, I., Franconi, F., & Serra, P. A. (2024) · Life · doi:10.3390/life14020234 · Cited by 8 · see citing works

Toward Sex-Specific Biomaterials Innovation: A Perspective

Koons, G. L. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00342 · Cited by 7 · see citing works

Estradiol and dihydrotestosterone exert sex-specific effects on human fibroblast and endothelial proliferation, bioenergetics, and vasculogenesis

Martier, A. T., Maurice, Y. V., Conrad, K. M., Carlino, D. A., Mauvais‐Jarvis, F., & Mondrinos, M. J. (2025) · Communications Biology · doi:10.1038/s42003-025-08822-1 · Cited by 13 · see citing works

Sex Influences the Safety and Therapeutic Efficacy of Cardiac Nanomedicine Technologies

Lin, Z., Jiwani, Z., Serpooshan, V., Aghaverdi, H., Yang, P. C.-M., Aguirre, A., Wu, J. C., & Mahmoudi, M. (2023) · Small · doi:10.1002/smll.202305940 · Cited by 5 · see citing works

Sex-Based Mechanisms of Cardiac Development and Function: Applications for Induced-Pluripotent Stem Cell Derived-Cardiomyocytes

Luo, Y., Safabakhsh, S., Palumbo, A., Fiset, C., Shen, C., Parker, J., Foster, L. J., & Laksman, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115964 · Cited by 5 · see citing works

Aldosterone’s impact on kidney health: exploring the benefits of mineralocorticoid receptor antagonists for renal protection

Liu, Z. (2024) · American Journal of Translational Research · doi:10.62347/nrgg6465 · Cited by 5 · see citing works

Directional dependence on concomitant pressure and volume increases during left ventricular filling

Lin, Y.-M., Paolino, L., Lou, L., Herrera, A., Pierre, E., Agarwal, A. K., & Ramaswamy, S. D. (2022) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2022.111129 · Cited by 5 · see citing works

Advancing 3D Engineered In Vitro Models for Heart Failure Research: Key Features and Considerations

van Doorn, E. C. H., Amesz, J. H., Manintveld, O. C., de Groot, N. M. S., Essers, J., Shin, S. R., & Taverne, Y. J. H. J. (2024) · Bioengineering · doi:10.3390/bioengineering11121220 · Cited by 4 · see citing works

Signals from the extracellular matrix: Region- and sex-specificity in cardiac aging

Ramli, M. F. H., Aguado, B. A., & Young, J. L. (2025) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102524 · Cited by 4 · see citing works

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

Givens, S. E., Andebrhan, A. A., Schmuck, E. G., Renaud, A., Xie, A., Ebrahimi‐Barough, S., Abrahante, J. E., Stanis, N., Dudley, S. C., Dutton, J. R., et al. (2025) · Stem Cells · doi:10.1093/stmcls/sxaf038 · Cited by 4 · see citing works

Engineering the cardiac tissue microenvironment

Ronan, G., Bahcecioglu, G., Aliyev, N., & Zorlutuna, P. (2024) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad0ea7 · Cited by 4 · see citing works

Guiding the spatial organization of engineered heart tissues

Beeghly, G. F., Shakeri, A., Mirzapourshafiyi, F., Dikyol, C., Offen, N., Alsaafin, A., Nuber, U. A., & Radisic, M. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115907 · Cited by 3 · see citing works

Estrogen elicits ferroptosis-related myocardial oxidative stress and dysfunction in male rats

Ahmed, S. A., & Abdel‐Rahman, A. A. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103690 · Cited by 2 · see citing works

Investigating nanoparticle distribution and tissue architecture in male and female human cardiac organoids

Grumelot, S., Mannering, F. L., Campbell, N., Ashokkumar, M. S., Howard, E., Serpooshan, V., Asgari, M., Latifi, N., Vali, H., Aguirre, A., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.172977 · Cited by 2 · see citing works

Design and Simulation of an Oxygen Gradient Generator for Heart-on-a-Chip

Mosayebzadeh, M., Fathi, S., & Mehrizi, A. A. (2023) · National and International Iranian Conference on Biomedical Engineering (ICBME) · doi:10.1109/icbme61513.2023.10488612 · Cited by 1 · see citing works

Reversible multiscale corneal sexual dimorphism orchestrates neuro-epithelial coupling and tear proteome compositionPreprint

Feret, N., Megido, A. C., Pernot, S., Girard, M., Decoudu, M., Fichter, L., Attina, A., Vialaret, J., David, A., Daïen, V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.02.680047

Human-Induced Pluripotent Stem Cell Models as Predictive Tools to Assess Sex Differences in Cardiovascular Drug Responses

Caudal, A., Hu, E., Chen, Y. M., & Wu, J. C. (2026) · Physiology in health and disease · doi:10.1007/978-3-032-26472-5_25

Sex Chromosome Effects on Cardiovascular Health and Disease

Huynh, D. T., Lai, J., Cornwell, H., & Nguyen, P. K. P. (2026) · Physiology in health and disease · doi:10.1007/978-3-032-26472-5_5

Cardiovascular Disease and Androgens: Clinical Trends, Potential Mechanisms, and Considerations for Engineering Solutions

Monroe, M. N., Curylo, A. L., Amirkhosravi, F., Huitron, E. I. G., Ezeokeke, G. I., Ojediran, I. G., Wang, J. K., Cremer, S. E., & Grande-Allen, K. J. (2026) · Cardiovascular Engineering and Technology · doi:10.1007/s13239-026-00859-5

Heart-on-a-chip

Wang, Y., Okhovatian, S., Zhao, Y., Wu, Q., Bodenstein, D. F., & Radisic, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-16110-0.00031-5

Matters of the heart: Cellular sex differences

Walker, C. J., Schroeder, M. E., Aguado, B. A., Anseth, K. S., & Leinwand, L. A. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.04.010 · Cited by 74 · see citing works

Sex-Based Mechanisms of Cardiac Development and Function: Applications for Induced-Pluripotent Stem Cell Derived-Cardiomyocytes

Luo, Y., Safabakhsh, S., Palumbo, A., Fiset, C., Shen, C., Parker, J., Foster, L. J., & Laksman, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115964 · Cited by 5 · see citing works

Hearts apart: sex differences in cardiac remodeling in health and disease

Martin, T. G., & Leinwand, L. A. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180074 · Cited by 75 · see citing works

Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine

Allen, J. B., Ludtka, C., & James, B. D. (2023) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092222-030857 · Cited by 16 · see citing works

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