Cited by 95Neuroscience and Neuropharmacology ResearchStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

The enduring effects of an adolescent social stressor on synaptic density, part II: Poststress reversal of synaptic loss in the cortex by adinazolam and MK‐801

Leussis, Melanie P., Lawson, Katherine, Stone, Kimberly, Andersen, Susan L.·2008·Synapse

Abstract

Experience programs synaptic development to match the needs of the environment. This process depends on the nature and timing of the experience. Exposure to stress during adolescence selectively reduces synaptic density in the prefrontal cortex (a later maturing region), while sparing hippocampal synapses (an earlier maturing region). To determine whether the anatomical effects of an adolescent social stressor in rats endures into adulthood and are reversible, male subjects were isolation or group housed between days 30 and 35 and then treated with vehicle, adinazolam, MK-801, or tianeptine between days 40 and 55. At day 60, immunohistochemistry revealed a 13.5% +/- 5.3% reduction in synaptophysin in the infralimbic cortex and cingulate gyrus in isolation-housed subjects. MK-801 and adinazolam restored cortical synaptic density to within 2% of group-housed values, suggesting that the synaptic loss induced by stress during adolescence is modulated through reduced glutamatergic activity directly by NMDA antagonism or indirectly by enhancing GABAergic activity. Tianeptine did not modulate adolescent stress effects in the prefrontal cortex. None of these drugs increased cortical synaptophysin in group-housed controls. Increased synaptophysin was observed in the group-housed condition in the hippocampus, striatum, and nucleus accumbens following drug exposure. Although stress did not decrease synaptic density in these regions, drug exposure failed to increase synaptic density when…

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Crossref · 10.1002/syn.20483

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Authors
Leussis, M. P., Lawson, K., Stone, K., & Andersen, S. L.
Affiliations
Harvard University (US)
Corresponding author
Andersen, Susan L.
Venue
Synapse
Publisher
Wiley
Published
2007-12-14
Volume
62
Issue
3
Pages
185-192
ISSN
  • 0887-4476 (ISSN-L)
  • 1098-2396
OpenAlex
W2124453851
Cited by
95
References
42
Citations by year
2025: 6 · 2024: 2 · 2023: 4 · 2022: 11 · 2021: 5 · 2020: 9 · 2019: 1 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
1.19
Type
journal article
Language
en
Open access
closed
Locations
  • Synapse (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
isolation stress, synaptic density, prefrontal cortex, synaptophysin, adinazolam, MK-801, tianeptine, NMDA receptor antagonism, GABAergic activity, glutamatergic activity, hippocampus, striatum, nucleus accumbens, synapse maturation
MeSH terms
Age Factors, Animals, Animals, Newborn, Behavior, Animal, Benzodiazepines, Brain, Disease Models, Animal, Male, Random Allocation, Social Isolation, Stress, Physiological, Synapses, Dizocilpine Maleate, Synaptophysin, Rats, Sprague-Dawley, Gene Expression Regulation, Developmental, Excitatory Amino Acid Antagonists, Rats

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