Dynamic mapping of normal human hippocampal development
Abstract
The hippocampus, which plays an important role in memory functions and emotional responses, has distinct subregions subserving different functions. Because the volume and shape of the hippocampus are altered in many neuropsychiatric disorders, it is important to understand the trajectory of normal hippocampal development. We present the first dynamic maps to reveal the anatomical sequence of normal human hippocampal development. A novel hippocampal mapping technique was applied to a database of prospectively obtained brain magnetic resonance imaging (MRI) scans (100 scans in 31 children and adolescents), scanned every 2 yr for 6–10 yr between ages 4 and 25. Our results establish that the structural development of the human hippocampus is remarkably heterogeneous, with significant differences between posterior (increase over time) and anterior (loss over time) subregions. These distinct developmental trajectories of hippocampal subregions may parallel differences in their functional development. Published 2006 Wiley‐Liss, Inc.
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The neuroanatomic structures underlying skill learning mature quite early during development, within the first 3 years of life.
“Also, the neuroanatomic structures underlying skill learning mature quite early during development, i.e., within the first 3 years of life (180, 468).”
From About Sleep's Role in Memory (2013) · cites this paper as [468]
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Guillery-Girard, B., Martins, S., Deshayes, S., Hertz-Pannier, L., Chiron, C., Jambaqué, I., Landeau, B., Clochon, P., Chételat, G., & Eustache, F. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00126 · Cited by 53 · see citing works
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Aust, S., Stasch, J., Jentschke, S., Alkan Härtwig, E., Koelsch, S., Heuser, I., & Bajbouj, M. (2014) · Hippocampus · doi:10.1002/hipo.22293 · Cited by 22 · see citing works
- Authors
- Gogtay, N., Nugent, T. F., Herman, D. H., Ordonez, A., Greenstein, D., Hayashi, K. M., Clasen, L., Toga, A. W., Giedd, J. N., Rapoport, J. L., & Thompson, P. M.
- Affiliations
- National Institute of Mental Health (US)
- University of California, Los Angeles (US)
- Corresponding author
- Gogtay, Nitin
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2006-07-06
- Volume
- 16
- Issue
- 8
- Pages
- 664-672
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2108500173
- Cited by
- 426
- References
- 68
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 14 · 2023: 16 · 2022: 13 · 2021: 18 · 2020: 27 · 2019: 23 · 2018: 26 · 2017: 32 · 2016: 25 · 2015: 30 · 2014: 25 · 2013: 41 · 2012: 23
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG016570)
- National Institute of Mental Health (R25MH060482)
- National Institute of Biomedical Imaging and Bioengineering (R21 EB 01651)
- National Center for Research Resources (P41RR013642, R21RR019771, U54RR021813, P41 RR13642)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Keywords
- hippocampal development, hippocampal subfields, posterior hippocampus, anterior hippocampus, developmental trajectories, brain morphometry, longitudinal MRI, children and adolescents, functional development
- MeSH terms
- Adolescent, Adult, Brain Mapping, Child, Child, Preschool, Female, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Reproducibility of Results
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