Markers of inflammation in schizophrenia: association vs. causation
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Emerging evidence suggests that SMI and T2DM share some pathophysiological features, including hypothalamic-pituitary-adrenal and mitochondrial dysfunction, neuro-inflammation, common genetic links and epigenetic interactions.
“Emerging evidence 48 suggests that SMI and T2DM share some pathophysiological features, including hypothalamic-pituitary-adrenal and mitochondrial dysfunction, neuro-inflammation, common genetic links and epigenetic interactions.”
From Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016) · cites this paper as [48]
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Cites
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742 · see citing works
Ouchi, N., Kihara, S., Arita, Y., Okamoto, Y., Maeda, K., Kuriyama, H., Hotta, K., Nishida, M., Takahashi, M., Muraguchi, M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.11.1296 · Cited by 1,730 · see citing works
Hannestad, J., DellaGioia, N., & Bloch, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.132 · Cited by 914 · see citing works
Type 1/Type 2 Immunity in Infectious Diseases
Spellberg, B. J., & Edwards, J. E. (2001) · Clinical Infectious Diseases · doi:10.1086/317537 · Cited by 904 · see citing works
Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies
Modabbernia, A., Taslimi, S., Brietzke, E., & Ashrafi, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.007 · Cited by 596 · see citing works
Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works
Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression
Jernås, M., Palming, J., Sjöholm, K., Jennische, E., Svensson, P.-A., Gabrielsson, B. G., Levin, M., Sjögren, A., Rudemo, M., Lystig, T. C., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5678fje · Cited by 454 · see citing works
Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease
Matsuzawa, Y. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0380 · Cited by 434 · see citing works
Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update
Sommer, I. E., van Westrhenen, R., Begemann, M., de Witte, L. D., Leucht, S., & Kahn, R. S. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt139 · Cited by 342 · see citing works
Inflammation and Schizophrenia
Kirkpatrick, B. W., & Miller, B. J. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt141 · Cited by 318 · see citing works
The macrophage-T-lymphocyte theory of schizophrenia: Additional evidence
Smith, R. S., & Maes, M. H. J. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90062-4 · Cited by 222 · see citing works
Hiles, S. A., Baker, A., de Malmanche, T., & Attia, J. (2012) · Psychological Medicine · doi:10.1017/s0033291712000128 · Cited by 218 · see citing works
Howick, J., Glasziou, P., & Aronson, J. K. (2009) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2009.090020 · Cited by 217 · see citing works
Nitta, M., Kishimoto, T., Müller, N., Weiser, M., Davidson, M., Kane, J. M., & Correll, C. U. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt070 · Cited by 204 · see citing works
Self-citationBusse, S., Busse, M., Schiltz, K., Bielau, H., Gos, T., Brisch, R., Mawrin, C., Schmitt, A., Jordan, W., Müller, U., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.005 · Cited by 195 · see citing works
Benros, M. E., Pedersen, M. G., Rasmussen, H., Eaton, W. W., Nordentoft, M., & Mortensen, P. B. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13010086 · Cited by 192 · see citing works
Na, K., Lee, K. J., Lee, J. S., Cho, Y. S., & Jung, H. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.006 · Cited by 178 · see citing works
Brydon, L., Walker, C., Wawrzyniak, A., Whitehead, D., Okamura, H., Yajima, J., Tsuda, A., & Steptoe, A. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.007 · Cited by 164 · see citing works
Schwarz, M., Müller, N., Riedel, M. J., & Ackenheil, M. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1203 · Cited by 153 · see citing works
The role of inflammatory cytokines in suicidal behavior: A systematic review
Serafini, G., Pompili, M., Elena Seretti, M., Stefani, H., Palermo, M., Coryell, W., & Girardi, P. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.06.002 · Cited by 151 · see citing works
Wager‐Smith, K., & Markou, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.010 · Cited by 150 · see citing works
The Cytokine Model of Schizophrenia: Emerging Therapeutic Strategies
Girgis, R. R., Kumar, S. S., & Brown, A. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.002 · Cited by 135 · see citing works
Hope, S., Ueland, T., Steen, N. E., Dieset, I., Lorentzen, S., Berg, A. O., Agartz, I., Aukrust, P., & Andreassen, O. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.12.023 · Cited by 131 · see citing works
Leonard, B. E. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.018 · Cited by 129 · see citing works
Prenatal inflammation and neurodevelopment in schizophrenia: A review of human studies
Miller, B. J., Culpepper, N. H., Rapaport, M. H., & Buckley, P. F. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.010 · Cited by 124 · see citing works
A systematic, quantitative review of blood autoantibodies in schizophrenia
Ezeoke, A., Mellor, A. L., Buckley, P. F., & Miller, B. J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.029 · Cited by 115 · see citing works
Dimitrov, D. H., Lee, S., Yantis, J., Valdez, C., Paredes, R. M., Braida, N., Velligan, D. I., & Walss‐Bass, C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.10.019 · Cited by 114 · see citing works
A review of anti-inflammatory agents for symptoms of schizophrenia
Keller, W. R., Kum, L. M., Wehring, H. J., Koola, M. M., Buchanan, R. W., & Kelly, D. L. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112467089 · Cited by 107 · see citing works
Borovčanin, M., Jovanović, I., Radosavljevic, G. D., Dejanovic, S. D., Stefanović, V., Arsenijević, N., & Lukić, M. L. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.03.027 · Cited by 82 · see citing works
Autoimmunity in depression: increased antiphospholipid autoantibodies
Maes, M. H. J., Meltzer, H. Y., Jacobs, J., Suy, E., Calabrese, J. R., Minner, B., & Raus, J. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03349.x · Cited by 77 · see citing works
Acute stress effects on local Il-1β responses to pathogens in a human in vivo model
Deinzer, R., Granrath, N., Stuhl, H., Twork, L., Idel, H., Waschul, B., & Herforth, A. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.008 · Cited by 57 · see citing works
Production of interferon-gamma in families with multiple occurrence of schizophrenia
Arolt, V., Weitzsch, C., Wilke, I., et al. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(96)03023-5 · Cited by 49 · see citing works
Wampers, M., Hanssens, L., van Winkel, R., Heald, A. H., Collette, J., Peuskens, J., Reginster, J., Scheen, A. J., & Binder, M. D. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.03.010 · Cited by 46 · see citing works
Self-citationAltered immune function in unaffected first-degree biological relatives of schizophrenia patients
Martínez‐Gras, I., García-Sánchez, F., Guaza, C., Rodríguez–Jiménez, R., Andres, E. M., Palomo, T., Rubio, G., & Borrell, J. I. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.05.036 · Cited by 41 · see citing works
Hanssens, L. S., VANWINKEL, R., Wampers, M., VANEYCK, D., Scheen, A. J., Reginster, J., Collette, J., Peuskens, J., & DEHERT, M. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.09.008 · Cited by 40 · see citing works
Self-citationAutoantibody disturbances in affective disorders: a function of age and gender?
Hornig, M., Amsterdam, J. D., Kamoun, M., & Goodman, D. B. P. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00190-6 · Cited by 35 · see citing works
Soluble interleukin 2 receptor levels in families of people with schizophrenia
Gaughran, F., O'Neill, E., Sham, P. C., et al. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00275-4 · Cited by 30 · see citing works
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- [10]10. Keller WR, Kum LM, Wehring HJ et al. A review of antiinflammatory agents for symptoms of schizophrenia. J Psychopharmacol 2013;27:337-42.
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Self-citationVancampfort, D., Rosenbaum, S., Schuch, F. B., Ward, P. B., Probst, M., & Stubbs, B. (2016) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.11.008 · Cited by 225 · see citing works
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Self-citationVancampfort, D., Rosenbaum, S., Ward, P. B., & Stubbs, B. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.09.029 · Cited by 113 · see citing works
Self-citationLambert, M., Ruppelt, F., Siem, A.-K., Rohenkohl, A. C., Kraft, V., Luedecke, D., Sengutta, M., Schröter, R., Daubmann, A., Correll, C. U., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.036 · Cited by 29 · see citing works
- Authors
- Manu, P., Correll, C. U., Wampers, M., Mitchell, A. J., Probst, M., Vancampfort, D., & De Hert, M.
- Affiliations
- Albert Einstein College of Medicine (US)
- KU Leuven (BE)
- University of Leicester (GB)
- University Psychiatric Centre KU Leuven; Campus Kortenberg Kortenberg Belgium
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2014-06
- Volume
- 13
- Issue
- 2
- Pages
- 189-192
- ISSN
- 1723-8617 (ISSN-L)
- PMC
- PMC4102292
- OpenAlex
- W1984981264
- Cited by
- 59
- References
- 42
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 11 · 2015: 8 · 2014: 4
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- World Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Lirias (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- inflammation, inflammatory markers, schizophrenia, association versus causation, neuroinflammation
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