Cited by 596Bipolar Disorder and TreatmentTryptophan and brain disordersTreatment of Major Depression

Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies

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Modabbernia, Amirhossein, Taslimi, Shervin, Brietzke, Elisa, Ashrafi, Mandana·2013·Biological Psychiatry

Abstract

Background We conducted a meta-analysis of studies comparing cytokine concentrations between patients with bipolar disorder (BD) and healthy control subjects (HCs).Methods We searched ISI Web of Science, MEDLINE, BIOSIS Previews, Scopus, Current Contents Connect, and Biological Abstracts for relevant studies. Based on heterogeneity status, we used fixed-effect or restricted maximal likelihood model to perform meta-analysis.Results Thirty studies with a total of 2599 participants (1351 BD and 1248 HCs) were eligible for the analysis. Concentrations of interleukin (IL)-4 (p = .008), IL-6 (p = .073), IL-10 (p = .013), soluble IL-2 receptor (sIL-2R; p < .001), sIL-6R (p = .021), tumor necrosis factor (TNF)-α (p = .010), soluble TNF receptor-1 (sTNFR1; p < .001), and IL-1 receptor antagonist (p value in mania < .001 and euthymia = .021) were significantly elevated in patients compared with HCs. Moreover, IL-1β (p = .059), and IL-6 (p = .073) tended to show higher values in patients. Levels of IL-2 (p = .156), interferon (INF)-γ (p = .741), C-C motif ligand 2 (p = .624), and IL-8 (p = .952) did not significantly differ between patients and HCs. Subgroup analysis based on mitogen stimulation status partially or completely resolved heterogeneity for most of the cytokines. Concentrations of IL-2, IL-4, sIL-6R, and INF-γ were unrelated to medication status. Phasic difference was present for TNF-α, sTNFR1, sIL-2R, IL-6, and IL-1RA, whereas it was absent for IL-4 and IL-10.Conclusions This meta-analysis provides evidence for significant elevation of proinflammatory, anti-inflammatory, and regulatory cytokines in BD.

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Crossref · 10.1016/j.biopsych.2013.01.007

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Authors
Modabbernia, A., Taslimi, S., Brietzke, E., & Ashrafi, M.
Affiliations
  • Roozbeh Hospital (IR)
  • Universidade Federal de São Paulo (BR)
  • Shariati Hospital (IR)
Corresponding author
Modabbernia, Amirhossein
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2013-07
Volume
74
Issue
1
Pages
15-25
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2082279387
Cited by
596
References
110
Citations by year
2026: 27 · 2025: 27 · 2024: 39 · 2023: 39 · 2022: 43 · 2021: 53 · 2020: 57 · 2019: 54 · 2018: 52 · 2017: 46 · 2016: 57 · 2015: 49 · 2014: 39 · 2013: 14
FWCI
7.22
Type
journal article
Language
en
Open access
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
bipolar disorder, cytokines, interleukin-6, IL-4, IL-10, TNF-α, soluble TNF receptor 1, soluble interleukin-2 receptor, soluble IL-6 receptor, interleukin-1 receptor antagonist, inflammatory cytokines, anti-inflammatory cytokines, regulatory cytokines, mania, euthymia, mitogen stimulation, interferon-gamma, interleukin-2
MeSH terms
Bipolar Disorder, Humans, Cytokines

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