Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies
Open accessAbstract
Background We conducted a meta-analysis of studies comparing cytokine concentrations between patients with bipolar disorder (BD) and healthy control subjects (HCs).Methods We searched ISI Web of Science, MEDLINE, BIOSIS Previews, Scopus, Current Contents Connect, and Biological Abstracts for relevant studies. Based on heterogeneity status, we used fixed-effect or restricted maximal likelihood model to perform meta-analysis.Results Thirty studies with a total of 2599 participants (1351 BD and 1248 HCs) were eligible for the analysis. Concentrations of interleukin (IL)-4 (p = .008), IL-6 (p = .073), IL-10 (p = .013), soluble IL-2 receptor (sIL-2R; p < .001), sIL-6R (p = .021), tumor necrosis factor (TNF)-α (p = .010), soluble TNF receptor-1 (sTNFR1; p < .001), and IL-1 receptor antagonist (p value in mania < .001 and euthymia = .021) were significantly elevated in patients compared with HCs. Moreover, IL-1β (p = .059), and IL-6 (p = .073) tended to show higher values in patients. Levels of IL-2 (p = .156), interferon (INF)-γ (p = .741), C-C motif ligand 2 (p = .624), and IL-8 (p = .952) did not significantly differ between patients and HCs. Subgroup analysis based on mitogen stimulation status partially or completely resolved heterogeneity for most of the cytokines. Concentrations of IL-2, IL-4, sIL-6R, and INF-γ were unrelated to medication status. Phasic difference was present for TNF-α, sTNFR1, sIL-2R, IL-6, and IL-1RA, whereas it was absent for IL-4 and IL-10.Conclusions This meta-analysis provides evidence for significant elevation of proinflammatory, anti-inflammatory, and regulatory cytokines in BD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
sIL-2R and sTNF-R1 were significantly elevated consistently in BD.
“For example, sIL-2R and sTNF-R1 were significantly elevated consistently in BD32–34.”
From Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses (2019) · cites this paper as [33]
Cites
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
Estimating the mean and variance from the median, range, and the size of a sample
Hozo, S. P., Djulbegovic, B., & Hozo, I. (2005) · BMC Medical Research Methodology · doi:10.1186/1471-2288-5-13 · Cited by 9,062 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197 · see citing works
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Fontenot, J. D., Rasmussen, J. P., Gavin, M. A., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1263 · Cited by 1,819 · see citing works
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742 · see citing works
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178 · see citing works
Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review
Potvin, S., Stip, É., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, É. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.024 · Cited by 989 · see citing works
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794 · see citing works
Blood Pressure and Inflammation in Apparently Healthy Men
Chae, C. U., Lee, R. T., Rifai, N., & Ridker, P. M. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.399 · Cited by 716 · see citing works
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
Jones, S. A., Horiuchi, S., Topley, N., Yamamoto, N., & Fuller, G. M. (2001) · The FASEB Journal · doi:10.1096/fj.99-1003rev · Cited by 684 · see citing works
Effect of alcohol consumption on systemic markers of inflammation
Imhof, A., Froehlich, M., Brenner, H., Boeing, H., Pepys, M. B., & Koenig, W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04170-2 · Cited by 559 · see citing works
IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage
O’Garra, A., Vieira, P. L., Vieira, P., & Goldfeld, A. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23215 · Cited by 530 · see citing works
Inflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder
Goldstein, B. I., Kemp, D. E., Soczynska, J. K., & McIntyre, R. S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04505 · Cited by 510 · see citing works
Kauer‐Sant’Anna, M., Kapczinski, F. P., Andreazza, A. C., Bond, D. J., Lam, R. W. M., Young, L. T., & Yatham, L. N. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009310 · Cited by 434 · see citing works
Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
Brietzke, E., Stertz, L., Fernandes, B. S., Kauer-Sant’Anna, M., Mascarenhas, M., Escosteguy Vargas, A., Chies, J. A., & Kapczinski, F. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.12.001 · Cited by 423 · see citing works
Self-citationOswald, I. P., Gazzinelli, R. T., Sher, A., & James, S. L. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.11.3578 · Cited by 412 · see citing works
Maes, M. H. J., Bosmans, E., Calabrese, J. R., Smith, R. S., & Meltzer, H. Y. (1995) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)00049-w · Cited by 385 · see citing works
Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder
Kim, Y.-K., Jung, H.-G., Myint, A.-M., Kim, H., & Park, S.-H. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.02.018 · Cited by 375 · see citing works
Mental Disorders and Asthma in the Community
Goodwin, R. D., Jacobi, F., & Thefeld, W. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.11.1125 · Cited by 347 · see citing works
Abbasi, S.-H., Hosseini, F., Modabbernia, A., Ashrafi, M., & Akhondzadeh, S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.033 · Cited by 344 · see citing works
Self-citationAcute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs
Maes, M. H. J., Delange, J., Ranjan, R., Meltzer, H. Y., Desnyder, R., Cooremans, W., & Scharpé, S. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(96)02915-0 · Cited by 341 · see citing works
Padmos, R. C., Hillegers, M. H. J., Knijff, E. M., Vonk, R., Bouvy, A., Staal, F. J. T., de Ridder, D., Kupka, R. W., Nolen, W. A., & Drexhage, H. A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.395 · Cited by 336 · see citing works
Haack, M., Hinze‐Selch, D., Fenzel, T., Kraus, T., Kühn, M., Schuld, A., & Pollmächer, T. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00021-7 · Cited by 329 · see citing works
Nery, F. G., Monkul, E. S., Hatch, J. P., Fonseca, M., Zunta‐Soares, G. B., Frey, B. N., Bowden, C. L., & Soares, J. C. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.912 · Cited by 298 · see citing works
Cytokine profiles in bipolar affective disorder: focus on acutely ill patients.
O'Brien, S. M., Scully, P., Scott, L. V., & Dinan, T. G. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.11.015 · Cited by 285 · see citing works
Beissert, S., Schwarz, A., & Schwarz, T. (2005) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700004 · Cited by 256 · see citing works
Cytokines in bipolar disorder: A systematic review and meta-analysis
Munkholm, K., Vinberg, M., & Vedel Kessing, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.010 · Cited by 256 · see citing works
Jones, S. A., & Rose‐John, S. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00319-1 · Cited by 256 · see citing works
Immune variations in bipolar disorder: phasic differences
Ortiz‐Domínguez, A., Hernández, M. E., Berlanga, C., Gutiérrez‐Mora, D., Moreno, J., Heinze, G., & Pavón, L. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00493.x · Cited by 255 · see citing works
Α Review on the Acute Phase Response in Major Depression
Maes, M. (1993) · Reviews in the Neurosciences · doi:10.1515/revneuro.1993.4.4.407 · Cited by 239 · see citing works
Peripheral biomarkers and illness activity in bipolar disorder
Kapczinski, F. P., Dal‐Pizzol, F., Teixeira, A. L., Magalhães, P. V. D. S., Kauer‐Sant’Anna, M., Klamt, F., Moreira, J. C. F., Pasquali, M. A. D. B., Fries, G. R., Quevedo, J., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.015 · Cited by 236 · see citing works
Kim, Y.-K., Suh, I.-B., Kim, H., Han, C.-S., Lim, C.-S., Choi, S.-H., & Licinio, J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001084 · Cited by 224 · see citing works
Cigarette Smoking Influences Cytokine Production and Antioxidant Defences
Tappia, P. S., Troughton, K. L., Langley‐Evans, S. C., & Grimble, R. F. (1995) · Clinical Science · doi:10.1042/cs0880485 · Cited by 222 · see citing works
Localization of estrogen receptor ?-immunoreactivity in astrocytes of the adult rat brain
Azcoitia, Í., Sierra, A., & García‐Segura, L. M. (1999) · Glia · doi:10.1002/(sici)1098-1136(199905)26:3 · Cited by 222 · see citing works
McIntyre, R. S., Konarski, J. Z., Soczynska, J. K., Wilkins, K., Panjwani, G., Bouffard, B., Bottas, A., & Kennedy, S. H. (2006) · Psychiatric Services · doi:10.1176/appi.ps.57.8.1140 · Cited by 198 · see citing works
Kunz, M., Ceresér, K. M. M., Goi, P. D., Fries, G. R., Teixeira, A. L., Fernandes, B. S., Belmonte-de-Abreu, P. S., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Gama, C. S. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000300010 · Cited by 189 · see citing works
The activation of monocyte and T cell networks in patients with bipolar disorder
Drexhage, R. C., Hoogenboezem, T., Versnel, M. A., Berghout, A., Nolen, W. A., & Drexhage, H. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.013 · Cited by 172 · see citing works
The potential use of biomarkers as an adjunctive tool for staging bipolar disorder
Kapczinski, F. P., Dias, V. V., Kauer‐Sant’Anna, M., Brietzke, E. M., Vázquez, G. H., Vieta, E., & Berk, M. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.027 · Cited by 167 · see citing works
Self-citationHope, S., Dieset, I., Agartz, I., Steen, N. E., Ueland, T., Melle, I., Aukrust, P., & Andreassen, O. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.08.003 · Cited by 164 · cited 4× · see citing works
“Analysis of three studies (163 patients and 292 HCs) showed no difference between the two groups (Table 1) (22,43,44).”
BackgroundInfluentialMood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus
Soczynska, J. K., Kennedy, S. H., Woldeyohannes, H. O., Liauw, S. S. L., Alsuwaidan, M. T., Yim, C. Y., & McIntyre, R. S. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8140-8 · Cited by 162 · see citing works
Dickerson, F., Stallings, C. R., Origoni, A. E., Boronow, J. J., & Yolken, R. H. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.018 · Cited by 157 · see citing works
Sepanjnia, K., Modabbernia, A., Ashrafi, M., Modabbernia, M.-J., & Akhondzadeh, S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.58 · Cited by 153 · see citing works
Self-citationHope, S., Melle, I. S., Aukrust, P., Steen, N. E., Birkenaes, A. B., Lorentzen, S., Agartz, I., Ueland, T., & Andreassen, O. A. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00757.x · Cited by 152 · see citing works
Breunis, M. N., Kupka, R., Nolen, W. A., Suppes, T. M., Denicoff, K. D., Leverich, G. S., Post, R. M., & Drexhage, H. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01452-x · Cited by 149 · see citing works
Knijff, E. M., Breunis, M. N., Kupka, R., de Wit, H. J., Ruwhof, C., Akkerhuis, G. W., Nolen, W. A., & Drexhage, H. A. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00444.x · Cited by 146 · see citing works
Hope, S., Ueland, T., Steen, N. E., Dieset, I., Lorentzen, S., Berg, A. O., Agartz, I., Aukrust, P., & Andreassen, O. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.12.023 · Cited by 131 · see citing works
Cytokine production in bipolar affective disorder patients under lithium treatment
Boufidou, F., Nikolaou, C., Alevizos, B., Liappas, I. A., & Christodoulou, G. N. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.01.007 · Cited by 130 · see citing works
do Prado, C. H., Rizzo, L. B., Wieck, A., Lopes, R. P., Teixeira, A. L., Grassi‐Oliveira, R., & Bauer, M. E. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.005 · Cited by 127 · see citing works
Abnormalities in serum chemokine levels in euthymic patients with Bipolar Disorder
Brietzke, E. M., Kauer‐Sant’Anna, M., Teixeira, A. L., & Kapczinski, F. P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.008 · Cited by 127 · see citing works
Self-citationRole of oxidative stress in the pathophysiology of bipolar disorder
Steckert, A. V., Valvassori, S. S., Moretti, M., Dal‐Pizzol, F., & Quevedo, J. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0195-2 · Cited by 125 · see citing works
Barbosa, I. G., Rocha, N. P., Huguet, R. B., Ferreira, R. A., Salgado, J. V., de Carvalho, L. A., Pariante, C. M., & Teixeira, A. L. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.034 · Cited by 121 · see citing works
Immunologic variables in acute mania of bipolar disorder
Liu, H., Yang, Y., Chou, Y.-M., Chen, K.-P., Shen, W. W., & Leu, S. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.006 · Cited by 118 · see citing works
Jerrell, J. M., McIntyre, R. S., & Tripathi, A. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05585ora · Cited by 111 · see citing works
Activation of indices of cell-mediated immunity in bipolar mania
Tsai, S., Chen, K.-P., Yang, Y., Chen, C., Lee, J.-C., Singh, V. K., & Leu, S.-J. C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00159-0 · Cited by 111 · see citing works
Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder.
Barbosa, I. G., Huguet, R. B., Mendonça, V. A., Sousa, L. P., Neves, F. S., Bauer, M. E., & Teixeira, A. L. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-010-0116-z · Cited by 108 · see citing works
Tryptophan breakdown pathway in bipolar mania
Myint, A.-M., Kim, Y., Verkerk, R. M., Park, S. H., Scharpé, S., Steinbusch, H. W. M., & Leonard, B. E. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.12.008 · Cited by 106 · see citing works
Díez, J. J., Hernánz, Á., Medina, S., et al. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01629.x · Cited by 106 · see citing works
Activation of gp 130 by IL‐6/soluble IL‐6 receptor induces neuronal differentiation
März, P., Herget, T., Lang, E., Otter, U., & Rose‐John, S. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01705.x · Cited by 103 · see citing works
Tsai, S., Chung, K., Wu, J.-Y., Kuo, C., Lee, H., & Huang, S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.022 · Cited by 102 · see citing works
Cytokine levels in euthymic bipolar patients
Guloksuz, S., Aktas Cetin, E., Cetin, T., Deniz, G., Oral, E. T., & Nutt, D. J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.027 · Cited by 102 · see citing works
Towards a multifactorial approach for prediction of bipolar disorder in at risk populations
Brietzke, E. M., Mansur, R. B., Soczynska, J. K., Kapczinski, F. P., Bressan, R. A., & McIntyre, R. S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.016 · Cited by 101 · see citing works
Self-citationT-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients.
Kim, Y.-K., Myint, A.-M., Lee, B.-H., Han, C.-S., Lee, S.-W., Leonard, B. E., & Steinbusch, H. W. M. (2004) · Psychiatry Research · doi:10.1016/j.psychres.2004.08.005 · Cited by 100 · see citing works
A high prevalence of organ-specific autoimmunity in patients with bipolar disorder
Padmos, R. C., Bekris, L. M., Knijff, E. M., Tiemeier, H. W., Kupka, R., Cohen, D., Nolen, W. A., Lernmark, Å., & Drexhage, H. A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.003 · Cited by 100 · see citing works
Immune parameters in rapid cycling bipolar patients before and after lithium treatment
Rapaport, M. H. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00007-2 · Cited by 99 · see citing works
Goldstein, B. I., Collinger, K. A., Lotrich, F. E., Marsland, A. L., Gill, M., Axelson, D., & Birmaher, B. B. (2011) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0009 · Cited by 97 · see citing works
From neuroprogression to neuroprotection: implications for clinical care.
Berk, M., Conus, P., Kapczinski, F. P., Andreazza, A. C., Yücel, M., Wood, S. J., Pantelis, C., Malhi, G. S., Dodd, S., Bechdolf, A., et al. (2010) · PubMed · Cited by 96 · see citing works
Reduced antioxidant defense systems in schizophrenia and bipolar I disorder
Raffa, M., Barhoumi, S., Atig, F., Fendri, C., Kerkeni, A., & Mechri, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.013 · Cited by 95 · see citing works
Tsai, S., Yang, Y.-Y., Kuo, C.-J., Chen, C., & Leu, S.-J. C. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00252-4 · Cited by 95 · see citing works
The effector T helper cell triade.
Fietta, P., & Delsante, G. (2009) · PubMed · Cited by 92 · see citing works
Maes, M. H. J. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00058-x · Cited by 86 · see citing works
Increased levels of adipokines in bipolar disorder
Barbosa, I. G., Rocha, N. P., de Miranda, A. S., Magalhães, P. V. D. S., Huguet, R. B., de Souza, L. P., Kapczinski, F. P., & Teixeira, A. L. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.11.010 · Cited by 83 · see citing works
Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder
Papiol, S., Rosa, A., Gutiérrez, B., Martín, B., Salgado, P., Catalán, R., Arias, B., & Fañanás, L. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.012914 · Cited by 80 · see citing works
Hung, Y., Hsieh, C., Chen, Y., Pei, D., Kuo, S., Shen, D., Sheu, W. H., & Chen, Y. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02963.x · Cited by 79 · see citing works
Cytokines and Neurotrophins Interact in Normal and Diseased States
Otten, U., März, P., Heese, K., Hock, C., KUNZ, D., & Rose‐John, S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05398.x · Cited by 75 · see citing works
A Simple Method for Obtaining Original Data from Published Graphs and Plots
Sistrom, C. L., & Mergo, P. J. (2000) · American Journal of Roentgenology · doi:10.2214/ajr.174.5.1741241 · Cited by 63 · see citing works
Immune parameters in euthymic bipolar patients and normal volunteers
Rapaport, M. H. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90012-4 · Cited by 62 · see citing works
Impaired nerve growth factor homeostasis in patients with bipolar disorder
Barbosa, I. G., Huguet, R. B., Neves, F. S., Reis, H. J., Bauer, M. E., Janka, Z., Palotás, A., & Teixeira, A. L. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.518629 · Cited by 61 · see citing works
Papiol, S., Molina, V., Desco, M., Rosa, A., Reig, S., Sanz, J., Palomo, T., & Fañanás, L. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00421.x · Cited by 59 · see citing works
Brietzke, E., Stabellini, R., Grassi-Oliveira, R., & Lafer, B. (2011) · CNS Spectrums · doi:10.1017/s1092852912000338 · Cited by 57 · see citing works
Self-citationEvidence for an association between tumor necrosis factor-alpha levels and lithium response
Gülöksüz, S., Altınbaş, K., Çetin, E. A., Kenis, G., Gazioğlu, S. B., Deniz, G., Oral, E., & van Os, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.044 · Cited by 55 · see citing works
Dickerson, F., Origoni, A. E., Stallings, C. R., Khushalani, S., Dickinson, D., & Medoff, D. R. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00784.x · Cited by 53 · see citing works
Su, K., Leu, S.-J. C., Yang, Y., Shen, W. W., Chou, Y.-M., & Tsai, S. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00369-x · Cited by 53 · see citing works
A relative resistance of T cells to dexamethasone in bipolar disorder
Knijff, E. M., Breunis, M. N., Geest, M. C. V., Kupka, R., Ruwhof, C., de Wit, H. J., Nolen, W. A., & Drexhage, H. A. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00359.x · Cited by 52 · see citing works
Postolache, T. T., Lapidus, M., Sander, E. R., LANGENBERG, P. W., Hamilton, R. G., Soriano, J. J., McDonald, J. S., Furst, N., Bai, J., Scrandis, D. A., et al. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.286 · Cited by 51 · see citing works
Su, S., Sun, M.-T., Wen, M.-J., Lin, C.-J., Chen, Y.-C., & Hung, Y. (2011) · The International Journal of Psychiatry in Medicine · doi:10.2190/pm.42.3.a · Cited by 50 · see citing works
A random effects variance shift model for detecting and accommodating outliers in meta-analysis
Gumedze, F. N., & Jackson, D. (2011) · BMC Medical Research Methodology · doi:10.1186/1471-2288-11-19 · Cited by 48 · see citing works
Selected Cytokine Profiles during Remission in Bipolar Patients
Remlinger-Molenda, A., Wójciak, P., Michalak, M., Karczewski, J., & RYBAKOWSKI, J. K. (2012) · Neuropsychobiology · doi:10.1159/000339949 · Cited by 46 · see citing works
Dieset, I., Hope, S., Ueland, T., Bjella, T. D., Agartz, I., Melle, I. S., Aukrust, P., Røssberg, J. I., & Andreassen, O. A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.040 · Cited by 43 · see citing works
Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder
Kim, S. J., Lee, H. J., Koo, H. G., Kim, J. W., Song, J. Y., Kim, M. K., Shin, D. H., Jin, S. Y., Hong, M. S., Park, H. J., et al. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200409000-00009 · Cited by 40 · see citing works
Therapeutic potential of interleukin-6 antagonism in bipolar disorder
Brietzke, E. M., Scheinberg, M. A., & Lafer, B. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.08.021 · Cited by 38 · see citing works
Self-citation[Activity of selected cytokines in bipolar patients during manic and depressive episodes].
Remlinger-Molenda, A., Wójciak, P., Michalak, M., & RYBAKOWSKI, J. K. (2012) · PubMed · Cited by 30 · see citing works
Cetin, T., Gülöksüz, S., Çetin, E. A., Gazioğlu, S. B., Deniz, G., Oral, E., & van Os, J. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-158 · Cited by 30 · see citing works
Knijff, E. M., Kupka, R., Ruwhof, C., et al. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00214.x · Cited by 18 · see citing works
Tsai, S., Lee, H., Chen, C., & Lee, C.-H. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00103-6 · Cited by 17 · see citing works
Brietzke, E. M., & Teixeira, A. L. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00822.x · Cited by 14 · see citing works
Self-citationAlbrecht, E. A., Dhanasekaran, S. M., & Tomlins, S. A. (2010) · Inflammation Research · doi:10.1007/s00011-010-0286-1 · Cited by 9 · see citing works
P.2.e.024 Cytokine profiles in bipolar affective disorder during acute episodes and in remission
Remlinger-Molenda, A., Wójciak, P., Kostrzewa, A., Karczewski, J., Wiktorowicz, K., & RYBAKOWSKI, J. K. (2010) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(10)70597-6 · Cited by 4 · see citing works
Tsai, S., Chung, K., & Huang, S. H. (2010) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(10)70603-9 · Cited by 3 · see citing works
P.2.e.024 The effect of mania on cytokine status in bipolar illness
Remlinger-Molenda, A., Wójciak, P., Karczewski, J., Kostrzewa, A., Wiktorowicz, K., & RYBAKOWSKI, J. K. (2009) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(09)70723-0 · Cited by 2 · see citing works
Kunz, M., Ceresér, K., Fries, G., Teixeira, A. A. D. S., Fernandes, B. S., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Gama, C. (2010) · Figshare · Cited by 2 · see citing works
Peripheral biomarkers in bipolar disorder: a population-based study in young adults
da Silva, P. V. (2012) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2012000100020 · Cited by 1 · see citing works
P.1.007 Th1, Th2 and Th3 cytokine alterations in bipolar disorder: Effects of mood stabilizers
Kim, Y. K., Myint, A.-M., Han, C. S., et al. (2004) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(04)80096-8 · Cited by 1 · see citing works
Su, K., Leu, S.-J. C., Yang, Y., et al. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00364-6 · Cited by 1 · see citing works
Lee, H. C., Tsai, S., Leu, S., et al. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)80157-1 · Cited by 1 · see citing works
Comparison of cytokine levels in depressed, manic, and euthymic patients with bipolar disorder
Brietzke, E. M., Stertz, L., Fernandes, B. S., Kauer‐Sant’Anna, M., Mascarenhas, M. Á., Vargas, A., Chies, J. A. B., & Kapczinski, F. P. (2010) · Figshare · Cited by 1 · see citing works
Self-citation(2005) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(05)81184-8 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Goldsmith, D. R., Rapaport, M. H., & Miller, B. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.3 · Cited by 1,683 · see citing works
So depression is an inflammatory disease, but where does the inflammation come from?
Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423 · see citing works
Passos, I. C., Vasconcelos-Moreno, M. P., Costa, L. G., Kunz, M., Brietzke, E., Quevedo, J., Salum, G., Magalhães, P. V., Kapczinski, F., & Kauer-Sant'Anna, M. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00309-0 · Cited by 743 · see citing works
Self-citationInflammation in psychiatric disorders: what comes first?
Bauer, M. E., & Teixeira, A. L. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13712 · Cited by 500 · see citing works
Childhood maltreatment and inflammatory markers: a systematic review.
Coelho, R., Viola, T. W., Walss‐Bass, C., Brietzke, E., & Grassi‐Oliveira, R. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12217 · Cited by 426 · see citing works
Self-citationYuan, N., Chen, Y., Xia, Y., Dai, J., & Liu, C. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0570-y · Cited by 428 · see citing works
Cytokines in bipolar disorder vs. healthy control subjects: A systematic review and meta-analysis
Munkholm, K., Braüner, J. V., Kessing, L. V., & Vinberg, M. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.018 · Cited by 402 · see citing works
Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?
Danese, A., & J Lewis, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.198 · Cited by 393 · see citing works
Cytokine Research in Depression: Principles, Challenges, and Open Questions
Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313 · see citing works
The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder
Maes, M., & Carvalho, A. F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1016-x · Cited by 306 · see citing works
Hidden wounds? inflammatory links between childhood trauma and psychopathology
Danese, A., & Baldwin, J. R. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044208 · Cited by 286 · see citing works
Rosenblat, J., & McIntyre, R. (2017) · Brain Sciences · doi:10.3390/brainsci7110144 · Cited by 258 · see citing works
Fernandes, B. S., Steiner, J., Molendijk, M. L., Dodd, S., Nardin, P., Gonçalves, C.-A., Jacka, F., Köhler, C. A., Karmakar, C., Carvalho, A. F., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30370-4 · Cited by 247 · see citing works
Tylee, D. S., Sun, J., Hess, J. L., Tahir, M. A., Sharma, E., Malik, R., Worrall, B. B., Levine, A. J., Martinson, J. J., Nejentsev, S., et al. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32652 · Cited by 219 · see citing works
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis
Tursich, M., Neufeld, R. W. J., Frewen, P. A., Harricharan, S., Kibler, J. L., Rhind, S. G., & Lanius, R. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.56 · Cited by 204 · see citing works
Rosenblat, J. D., Kakar, R., Berk, M., Kessing, L. V., Vinberg, M., Baune, B. T., Mansur, R. B., Brietzke, E., Goldstein, B. I., & McIntyre, R. S. (2016) · Bipolar Disorders · doi:10.1111/bdi.12373 · Cited by 199 · see citing works
Self-citationPsycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health
Raony, Í., de Figueiredo, C. S., Pandolfo, P., Giestal-de-Araujo, E., Oliveira-Silva Bomfim, P., & Savino, W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01170 · Cited by 185 · see citing works
Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers
Muneer, A. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.1.18 · Cited by 187 · see citing works
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works
Rosenblat, J. D., Brietzke, E., Mansur, R. B., Maruschak, N. A., Lee, Y., & McIntyre, R. S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.058 · Cited by 172 · see citing works
Self-citationNeuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165 · see citing works
Cytokines as biomarkers in depressive disorder: current standing and prospects
Lichtblau, N., Schmidt, F. M., Schumann, R., Kirkby, K. C., & Himmerich, H. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.813442 · Cited by 155 · see citing works
Neuroinflammation in suicide: Toward a comprehensive model
Courtet, P., Giner, L., Seneque, M., Guillaume, S., Olie, E., & Ducasse, D. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1054879 · Cited by 146 · see citing works
Baumeister, D., Russell, A., Pariante, C. M., & Mondelli, V. (2014) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-014-0887-z · Cited by 142 · see citing works
Horn, S. R., Long, M. M., Nelson, B. W., Allen, N. B., Fisher, P. A., & Byrne, M. L. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.016 · Cited by 129 · see citing works
Mapping inflammation onto mood: inflammatory mediators of anhedonia
Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.017 · Cited by 125 · see citing works
A meta-analysis of cytokines in suicidal behavior
Ducasse, D., Olié, E., Guillaume, S., Artéro, S., & Courtet, P. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.02.004 · Cited by 119 · see citing works
Pinto, J. V., Moulin, T. C., & Amaral, O. B. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.001 · Cited by 103 · see citing works
Sowa-Kućma, M., Styczeń, K., Siwek, M., Misztak, P., Nowak, R. J., Dudek, D., Rybakowski, J. K., Nowak, G., & Maes, M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.024 · Cited by 104 · see citing works
Barbosa, I. G., Rocha, N. P., Assis, F., Vieira, E. L. M., Soares, J. C., Bauer, M. E., & Teixeira (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu021 · Cited by 101 · see citing works
Brambilla, P., Bellani, M., Isola, M., Bergami, A., Marinelli, V, Dusi, N., Rambaldelli, G., Tansella, M., Maria Finardi, A., Martino, G., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.46 · Cited by 86 · see citing works
Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder
Pfaffenseller, B., Fries, G. R., Wollenhaupt-Aguiar, B., Colpo, G. D., Stertz, L., Panizzutti, B., Magalhães, P. V., & Kapczinski, F. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.811981 · Cited by 68 · see citing works
Siwek, M., Sowa-Kućma, M., Styczeń, K., Misztak, P., Nowak, R. J., Szewczyk, B., Dudek, D., Rybakowski, J. K., Nowak, G., & Maes, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0124-8 · Cited by 65 · see citing works
Inflammation-Related Changes in Mood Disorders and the Immunomodulatory Role of Lithium
Sakrajda, K., & Szczepankiewicz, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041532 · Cited by 65 · see citing works
Bias in emerging biomarkers for bipolar disorder
Carvalho, A. F., Köhler, C. A., Fernandes, B. S., Quevedo, J., Miskowiak, K. W., Brunoni, A. R., Machado-Vieira, R., Maes, M., Vieta, E., & Berk, M. (2016) · Psychological Medicine · doi:10.1017/s0033291716000957 · Cited by 63 · see citing works
Markers of inflammation in schizophrenia: association vs. causation
Manu, P., Correll, C. U., Wampers, M., Mitchell, A. J., Probst, M., Vancampfort, D., & De Hert, M. (2014) · World Psychiatry · doi:10.1002/wps.20117 · Cited by 59 · see citing works
Quidé, Y., Bortolasci, C. C., Spolding, B., Kidnapillai, S., Watkeys, O. J., Cohen-Woods, S., Carr, V. J., Berk, M., Walder, K., & Green, M. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110013 · Cited by 44 · see citing works
Enrichment pathway analysis. The inflammatory genetic background in Bipolar Disorder
Drago, A., Crisafulli, C., Calabrò, M., & Serretti, A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.032 · Cited by 47 · see citing works
Overlapping evidence of innate immune dysfunction in psychotic and affective disorders
Hughes, H. K., & Ashwood, P. (2020) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2020.100038 · Cited by 39 · see citing works
Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology
Data-Franco, J., Singh, A., Popovic, D., Ashton, M., Berk, M., Vieta, E., Figueira, M. L., & Dean, O. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.004 · Cited by 38 · see citing works
Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study
Kao, L.-T., Lin, H.-C., & Lee, H.-C. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.01.014 · Cited by 36 · see citing works
Korkmaz, Ş. A., & Kızgın, S. (2023) · Current Medical Research and Opinion · doi:10.1080/03007995.2023.2260302 · Cited by 33 · see citing works
Elevated lipids are associated with reduced regional brain structure in youth with bipolar disorder
Kennedy, K. G., Islam, A. H., Grigorian, A., Fiksenbaum, L., Mitchell, R. H. B., McCrindle, B. W., MacIntosh, B. J., & Goldstein, B. I. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13278 · Cited by 33 · see citing works
Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation
Howerton, A. R., Roland, A. V., & Bale, T. L. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0118-14.2014 · Cited by 33 · see citing works
Mechanisms Underpinning the Polypharmacy Effects of Medications in Psychiatry
Bortolasci, C. C., Spolding, B., Callaly, E., Martin, S., Panizzutti, B., Kidnapillai, S., Connor, T., Hasebe, K., Mohebbi, M., Dean, O. M., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy014 · Cited by 25 · see citing works
Torsvik, A., Brattbakk, H.-R., Trentani, A., Holdhus, R., Stansberg, C., Bartz-Johannessen, C. A., Hughes, T., Steen, N. E., Melle, I., Djurovic, S., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02442-1 · Cited by 21 · see citing works
Wang, T.-Y., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Wang, L.-J., Chen, P. S., Chen, S.-H., Chu, C.-H., Huang, S.-Y., Tzeng, N.-S., et al. (2016) · Scientific Reports · doi:10.1038/srep27431 · Cited by 21 · see citing works
Wu, X., Chen, Z., Liao, Y., Yang, Z., Liang, X., Guan, N., & Gan, Z. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1063479 · Cited by 23 · see citing works
Immune abnormalities across psychiatric disorders: clinical relevance
Mondelli, V., Dazzan, P., & Pariante, C. M. (2015) · BJPsych Advances · doi:10.1192/apt.bp.114.012872 · Cited by 17 · see citing works
The lipid paradox in neuroprogressive disorders: Causes and consequences
Morris, G., Berk, M., Walder, K., O’Neil, A., Maes, M., & Puri, B. K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.017 · Cited by 17 · see citing works
Sanchez-Autet, M., Arranz, B., Sierra, P., Safont, G., Garcia-Blanco, A., de la Fuente, L., Garriga, M., Marín, L., & García-Portilla, M. P. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.2013089 · Cited by 15 · see citing works
Slyepchenko, A., Brunoni, A. R., McIntyre, R. S., Quevedo, J., & Carvalho, A. F. (2016) · Current Molecular Medicine · doi:10.2174/1566524016666160126144601 · Cited by 14 · see citing works
Wang, Z., Wang, X., Zhao, X., Hu, Z., Sun, D., Wu, D., & Xing, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.970933 · Cited by 10 · see citing works
- Authors
- Modabbernia, A., Taslimi, S., Brietzke, E., & Ashrafi, M.
- Affiliations
- Roozbeh Hospital (IR)
- Universidade Federal de São Paulo (BR)
- Shariati Hospital (IR)
- Corresponding author
- Modabbernia, Amirhossein
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 74
- Issue
- 1
- Pages
- 15-25
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2082279387
- Cited by
- 596
- References
- 110
- Citations by year
- 2026: 27 · 2025: 27 · 2024: 39 · 2023: 39 · 2022: 43 · 2021: 53 · 2020: 57 · 2019: 54 · 2018: 52 · 2017: 46 · 2016: 57 · 2015: 49 · 2014: 39 · 2013: 14
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- bipolar disorder, cytokines, interleukin-6, IL-4, IL-10, TNF-α, soluble TNF receptor 1, soluble interleukin-2 receptor, soluble IL-6 receptor, interleukin-1 receptor antagonist, inflammatory cytokines, anti-inflammatory cytokines, regulatory cytokines, mania, euthymia, mitogen stimulation, interferon-gamma, interleukin-2
- MeSH terms
- Bipolar Disorder, Humans, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review