Artifacts in Cell Culture: Rapid Generation of Hydrogen Peroxide on Addition of (−)-Epigallocatechin, (−)-Epigallocatechin Gallate, (+)-Catechin, and Quercetin to Commonly Used Cell Culture Media

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Structure-antioxidant activity relationships of flavonoids and phenolic acids

Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085 · see citing works

Free Radicals in Biology and Medicine

Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

Burdon, R. H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00198-s · Cited by 1,166 · see citing works

Principal Phenolic Phytochemicals in Selected California Wines and Their Antioxidant Activity in Inhibiting Oxidation of Human Low-Density Lipoproteins

Frankel, E. N., Waterhouse, A. L., & Teissèdre, P. (1995) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00052a008 · Cited by 873 · see citing works

Flavonoids in Health and Disease

Rice-Evans, C. A., & Packer, L. (2003) · CRC Press eBooks · doi:10.1201/9780367803681 · Cited by 691 · see citing works

Measurement of Plasma Hydroperoxide Concentrations by the Ferrous Oxidation-Xylenol Orange Assay in Conjunction with Triphenylphosphine

Nourooz‐Zadeh, J., TAJADDINI-SARMADI, J., & Wolff, S. P. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1357 · Cited by 676 · see citing works

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

Hampton, M. B., & Orrenius, S. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01068-5 · Cited by 663 · see citing works

Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin

Laughton, M. J., Halliwell, B. B., Evans, P., Robin, J., & Hoult, S. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90442-5 · Cited by 559 · see citing works

Flavonoids in Health and Disease

Rucker, R. B. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.891a · Cited by 555 · see citing works

Repression of gene expression by oxidative stress

Morel, Y., & Barouki, R. (1999) · Biochemical Journal · doi:10.1042/bj3420481 · Cited by 543 · see citing works

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

Chen, Q. M., Bartholomew, J. C., Campisi, J., Acosta, M., REAGAN, J. D., & Ames, B. N. (1998) · Biochemical Journal · doi:10.1042/bj3320043 · Cited by 442 · see citing works

Antioxidants in tea

Wiseman, S. A., Balentine, D. A., & Frei, B. B. (1997) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399709527798 · Cited by 429 · see citing works

The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute?

Paganga, G., Miller, N., & Rice-Evans, C. A. (1999) · Free Radical Research · doi:10.1080/10715769900300161 · Cited by 391 · see citing works

Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts

Chen, Z. P., Schell, J. B., Ho, C., & Chen, K. Y. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00108-6 · Cited by 381 · see citing works

Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

Dong, Z., Ma, W., Huang, C., & Yang, C. S. (1997) · PubMed · Cited by 352 · see citing works

Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review).

Roebuck, K. A. (1999) · International Journal of Molecular Medicine · doi:10.3892/ijmm.4.3.223 · Cited by 326 · see citing works

Induction of apoptosis in prostate cancer cell lines by the green tea component, (−)-epigallocatechin-3-gallate

Paschka, A. G., Butler, R., & Young, C. Y. F. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00084-6 · Cited by 290 · see citing works

Dietary flavonoids and cancer risk in the Zutphen elderly study

Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M., & Kromhout, D. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514342 · Cited by 277 · see citing works

Health Effects and Bioavailability of Dietary Flavonols

Hollman, P. C. H., & Katan, M. (1999) · Free Radical Research · doi:10.1080/10715769900301351 · Cited by 276 · see citing works

Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.

Chung, J. Y., Huang, C., Meng, X., Dong, Z., & Yang, C. S. (1999) · PubMed · Cited by 262 · see citing works

Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9.

Suganuma, M., Okabe, S., Kai, Y., Sueoka, N., Sueoka, E., & Fujiki, H. (1999) · PubMed · Cited by 236 · see citing works

Prooxidant toxicity of polyphenolic antioxidants to HL‐60 cells: description of quantitative structure‐activity relationships

Sergedien≐, E., Jönsson, K., Szymusiak, H., Tyrakowska, B., Rietjens, I. M. C. M., & Č≐nas, N. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01561-6 · Cited by 234 · see citing works

Hydrogen Peroxide in Human Urine: Implications for Antioxidant Defense and Redox Regulation

Long, L. H., Evans, P. J., & Halliwell, B. B. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1263 · Cited by 211 · see citing works

Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu

Clement, M., Ponton, A., & Pervaiz, S. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01410-0 · Cited by 202 · see citing works

Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway

Kobuchi, H., Roy, S., Sen, C. K., Nguyen, H. G., & Packer, L. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.3.c403 · Cited by 197 · see citing works

Cancer inhibition by green tea

Fujiki, H., Suganuma, M., Okabe, S., Sueoka, N., Komori, A., Sueoka, E., Kozu, T., Tada, Y., Suga, K., Imai, K., et al. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00310-2 · Cited by 188 · see citing works

Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF‐α secretion, and NF‐κB‐dependent gene expression in RAW 264.7 macrophages

Park, Y. C., Rimbach, G. H., Saliou, C., Valacchi, G., & Packer, L. (2000) · FEBS Letters · doi:10.1016/s0014-5793(99)01735-4 · Cited by 185 · see citing works

Insulin Signaling Is Inhibited by Micromolar Concentrations of H2O2

Hansen, L. L., Ikeda, Y., Olsen, G. S., Busch, A. K., & Mosthaf, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.25078 · Cited by 181 · see citing works

Epigallocathechin-3 Gallate Selectively Inhibits the PDGF-BB–induced Intracellular Signaling Transduction Pathway in Vascular Smooth Muscle Cells and Inhibits Transformation ofsis-transfected NIH 3T3 Fibroblasts and Human Glioblastoma Cells (A172)

Ahn, H. Y., Hadizadeh, K. R., Seul, C., Yun, Y., Vetter, H., & Sachinidis, A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.1093 · Cited by 173 · see citing works

Quercetin-Induced Apoptosis in Colorectal Tumor Cells: Possible Role of EGF Receptor Signaling

Richter, M., Ebermann, R., & Marian, B. (1999) · Nutrition and Cancer · doi:10.1207/s15327914nc340113 · Cited by 162 · see citing works

Reactive oxygen intermediates regulate cellular response to apoptotic stimuli: An hypothesis

Clement, M., & Pervaiz, S. (1999) · Free Radical Research · doi:10.1080/10715769900300271 · Cited by 161 · see citing works

Redox regulation of signal transduction in mammalian cells

Herrlich, P. A., & Böhmer, F. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00298-1 · Cited by 158 · see citing works

Glutathione-Dependent Generation of Reactive Oxygen Species by the Peroxidase-Catalyzed Redox Cycling of Flavonoids

Galati, G., Chan, T. S., Wu, B., & O'Brien, P. J. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980271b · Cited by 148 · see citing works

Inhibition of ultraviolet B-induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (-)-epigallocatechin gallate in a human keratinocyte cell line

Chen, W., Dong, Z., Valcic, S., Timmermann, B. N., & Bowden, G. T. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199902)24:2 · Cited by 131 · see citing works

Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase.

Gupta, S., Ahmad, N., Mohan, R. R., Husain, M. M., & Mukhtar, H. (1999) · PubMed · Cited by 125 · see citing works

Effect of green and black tea supplementation on lipids, lipid oxidation and fibrinogen in the hamster: mechanisms for the epidemiological benefits of tea drinking

Vinson, J. A., & Dabbagh, Y. A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00880-1 · Cited by 120 · see citing works

Green tea catechins such as (−)‐epicatechin and (−)‐epigallocatechin accelerate Cu2+‐induced low density lipoprotein oxidation in propagation phase

Yamanaka, N., Oda, O., & Nagao, S. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01455-x · Cited by 118 · see citing works

Involvement of intracellular Ca2+ in oxidant‐induced NF‐κB activation

Sen, C. K., Roy, S., & Packer, L. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00346-8 · Cited by 102 · see citing works

Induction of C-Fos and C-Jun Proto-Oncogenes in Target Cells of the Lung and Pleura by Carcinogenic Fibers

Janssen-Heininger, Y. M. W., Heintz, N. H., Marsh, J. P., Borm, P. J. A., & Mossman, B. T. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.11.5.7946382 · Cited by 98 · see citing works

Generation of hydrogen peroxide by “Antioxidant” beverages and the effect of milk addition. Is cocoa the best beverage?

Long, L. H., Lan, A., Hsuan, F. T. Y., & Halliwell, B. B. (1999) · Free Radical Research · doi:10.1080/10715769900300611 · Cited by 98 · see citing works

H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation

Péus, D., Meves, A., Vasa, R. A., Beyerle, A., O’Brien, T., & Pittelkow, M. R. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00198-7 · Cited by 85 · see citing works

Quercetin and anti‐CD95(Fas/Apo1) enhance apoptosis in HPB‐ALL cell line

Russo, M., Palumbo, R., Tedesco, I., Mazzarella, G., Russo, P., Iacomino, G., & Russo, G. L. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01544-6 · Cited by 83 · see citing works

Insulin-like growth factor-I-mediated survival from Anoikis: Role of cell aggregation and focal adhesion kinase

Valentinis, B., Krzysztof Reiss, F., & Baserga, R. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199809)176:3 · Cited by 78 · see citing works

Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c‐jun and JNK

Lu, L., Lee, S., & Huang, H. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701912 · Cited by 56 · see citing works

Growth Stimulation Versus Induction of Cell Quiescence by Hydrogen Peroxide in Prostate Tumor Spheroids Is Encoded by the Duration of the Ca2+ Response

Wartenberg, M., Diedershagen, H., Hescheler, J., & Sauer, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27759 · Cited by 56 · see citing works

Hydrogen Peroxide Suppresses U937 Cell Death by Two Different Mechanisms Depending on Its Concentration

Lee, B. R., & Um, H. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4409 · Cited by 51 · see citing works

Apoptosis-inducing Activity of Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma U937 Cells

Saeki, K., Sano, M., Miyase, T., Nakamura, Y., Hara, Y., Aoyagi, Y., & Isemura, M. (1999) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.63.585 · Cited by 39 · see citing works

Measuring reactive species and oxidative damage <i>in vivo</i> and in cell culture: how should you do it and what do the results mean?

Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238 · see citing works

Biochemistry of oxidative stress

Halliwell, B. B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351147 · Cited by 1,546 · see citing works

Oxidative stress and cancer: Have we moved forward?

Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302 · see citing works

(–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans

Schroeter, H., Heiss, C., Balzer, J., Kleinbongard, P., Keen, C. L., Hollenberg, N. K., Sies, H., Kwik-Uribe, C., Schmitz, H. H., & Kelm, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510168103 · Cited by 1,052 · see citing works

Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry Extracts Inhibit Growth and Stimulate Apoptosis of Human Cancer Cells in Vitro

Seeram, N. P., Adams, L. S., Zhang, Y., Lee, R., Sand, D., Scheuller, H. S., & Heber, D. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061750g · Cited by 770 · see citing works

Redox regulation of FoxO transcription factors

Klotz, L.-O., Sánchez-Ramos, C., Prieto-Arroyo, I., Urbánek, P., Steinbrenner, H., & Monsalve, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.019 · Cited by 747 · see citing works

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

Halliwell, B. B. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.028 · Cited by 767 · see citing works

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

Surh, Y., Kundu, J. K., & Na, H. (2008) · Planta Medica · doi:10.1055/s-0028-1088302 · Cited by 759 · see citing works

Cocoa Has More Phenolic Phytochemicals and a Higher Antioxidant Capacity than Teas and Red Wine

Lee, K. W., Kim, Y. J., Lee, H. J., & Lee, C. Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0344385 · Cited by 748 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Dietary polyphenols: Good, bad, or indifferent for your health?

Halliwell, B. B. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.004 · Cited by 558 · see citing works

Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?

Halliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711 · see citing works

Polyphenolic phytochemicals – just antioxidants or much more?

Stevenson, D. E., & Hurst, R. D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7237-1 · Cited by 551 · see citing works

Oxidative stress in cell culture: an under‐appreciated problem?

Halliwell, B. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00235-7 · Cited by 534 · see citing works

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG

Na, H., & Surh, Y. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.10.006 · Cited by 486 · see citing works

The wanderings of a free radical

Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467 · see citing works

Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells.

Hong, J., Lu, H., Meng, X., Ryu, J., Hara, Y., & Yang, C. S. (2002) · PubMed · Cited by 400 · see citing works

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works

Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells

Sreelatha, S., Jeyachitra, A., & Padma, P. R. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.03.006 · Cited by 333 · see citing works

Green tea extract and (−)‐epigallocatechin‐3‐gallate, the major tea catechin, exert oxidant but lack antioxidant activities

Elbling, L., Weiss, R.-M., Teufelhofer, O., Uhl, M., Knasmüller, S., Schulte‐Hermann, R., Berger, W., & Micksche, M. (2005) · The FASEB Journal · doi:10.1096/fj.04-2915fje · Cited by 313 · see citing works

Use of spectroscopic probes for detection of reactive oxygen species

Bartosz, G. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.039 · Cited by 300 · see citing works

Cancer Chemopreventive Potential of Apples, Apple Juice, and Apple Components

Gerhäuser, C. (2008) · Planta Medica · doi:10.1055/s-0028-1088300 · Cited by 288 · see citing works

Production of Hydrogen Peroxide by Polyphenols and Polyphenol-rich Beverages under Quasi -physiological Conditions

Akagawa, M., Shigemitsu, T., & Suyama, K. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.2632 · Cited by 280 · see citing works

(−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells

Na, H., Kim, E., Jung, J., Lee, H., Hyun, J. W., & Surh, Y. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.04.003 · Cited by 268 · see citing works

Flavonoid Inhibition of Sodium-dependent Vitamin C Transporter 1 (SVCT1) and Glucose Transporter Isoform 2 (GLUT2), Intestinal Transporters for Vitamin C and Glucose

Song, J., Kwon, O., Chen, S., Daruwala, R., Eck, P., Park, J. B., & Levine, M. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110496200 · Cited by 262 · see citing works

Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity

Mladěnka, P., Zatloukalová, L., Filipský, T., & Hrdina, R. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.010 · Cited by 249 · see citing works

Oxidative breakage of cellular DNA by plant polyphenols: A putative mechanism for anticancer properties

Hadi, S. M., Bhat, H. S., Azmi, A. S., Hanif, S., Shamim, U., & ULLAH, M. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.04.002 · Cited by 249 · see citing works

Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate

Nakagawa, H. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh168 · Cited by 249 · see citing works

The In Vitro Cytotoxicity of Ascorbate Depends on the Culture Medium Used to Perform the Assay and Involves Hydrogen Peroxide

Clement, M., Ramalingam, J. K., Long, L. H., & Halliwell, B. B. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100687 · Cited by 230 · see citing works

Stability of (−)-epigallocatechin gallate and its activity in liquid formulations and delivery systems

Krupkova, O., Ferguson, S. J., & Wuertz‐Kozak, K. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.01.002 · Cited by 229 · see citing works

Cell culture, oxidative stress, and antioxidants: Avoiding pitfalls

Halliwell, B. B. (2014) · Biomedical Journal · doi:10.4103/2319-4170.128725 · Cited by 222 · see citing works

Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

Boettler, U., Sommerfeld, K., Volz, N., Pahlke, G., Teller, N., Somoza, V., Lang, R., Hofmann, T. F., & Marko, D. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.03.011 · Cited by 222 · see citing works

Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2

Wagner, A. E., Boesch, C., Breckwoldt, D., Schrader, C., Schmelzer, C., Döring, F., Hashida, K., Hori, O., Matsugo, S., & Rimbach, G. H. (2011) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-11-1 · Cited by 221 · see citing works

Structure–activity relationships for inhibition of human 5α-reductases by polyphenols

Hiipakka, R. A., Zhang, H., Dai, W. H., Dai, Q., & Liao, S. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)00848-1 · Cited by 216 · see citing works

Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation11G. Loo, K. Takahashi, A. Powolny, R.A. Hopkins, Induction of GADD45 gene expression by phenylethyl isothiocyanate in HCT-116 human colon adenocarcinoma cells, FASEB J 16 (2002) A264-A265 (abstract #216.15). Also, unpublished data. (review)

Loo, G. T. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00251-6 · Cited by 215 · see citing works

Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease

Rossi, L. C., Mazzitelli, S., Arciello, M., Capo, C. R., & Rotilio, G. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9696-7 · Cited by 216 · see citing works

In vitro biological properties of flavonoid conjugates found in vivo

Williamson, G., Barron, D., Shimoi, K., & Terao, J. (2005) · Free Radical Research · doi:10.1080/10715760500053610 · Cited by 212 · see citing works

Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries

Stoner, G. D., Wang, L., & Casto, B. C. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn142 · Cited by 207 · see citing works

Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation.

Lamy, S., Gingras, D., & Béliveau, R. (2002) · PubMed · Cited by 203 · see citing works

Hydrogen Peroxide. Ubiquitous in Cell Culture and In vivo?

Halliwell, B. B., Clement, M., Ramalingam, J., & Long, L. H. (2000) · IUBMB Life · doi:10.1080/713803727 · Cited by 198 · see citing works

Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties

Azmi, A. S., Bhat, S. H., Hanif, S., & Hadi, S. M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.12.059 · Cited by 190 · see citing works

A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells

Crespo, I., García‐Mediavilla, M. V., Gutiérrez, B., Sánchez‐Campos, S., Tuñón, M. J., & González‐Gallego, J. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508966083 · Cited by 188 · see citing works

The roles of polyphenols in cancer chemoprevention

Lee, K. W., & Lee, H. J. (2006) · BioFactors · doi:10.1002/biof.5520260202 · Cited by 185 · see citing works

Red wine polyphenols‐induced, endothelium‐dependent NO‐mediated relaxation is due to the redox‐sensitive PI3‐kinase/Akt‐dependent phosphorylation of endothelial NO‐synthase in the isolated porcine coronary artery

Ndiaye, M., Chataigneau, M., Lobysheva, I. I., Chataigneau, T., & Schini‐Kerth, V. B. (2004) · The FASEB Journal · doi:10.1096/fj.04-2146fje · Cited by 185 · see citing works

Interactions of quercetin with iron and copper ions: Complexation and autoxidation

Hajji, H. E., Nkhili, E., Tomao, V., & Dangles, O. (2006) · Free Radical Research · doi:10.1080/10715760500484351 · Cited by 177 · see citing works

Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)

Salucci, M., Stivala, L. A., Maiani, G., Bugianesi, R., & Vannini, V. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600295 · Cited by 175 · see citing works

Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen

Šarić, A., Balog, T., Sobočanec, S., Kušić, B., Šverko, V., Rusak, G., Likić, S., Bubalo, D., Pinto, B., Reali, D., et al. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.12.007 · Cited by 173 · see citing works

(‐)Epicatechin stimulates ERK‐dependent cyclic AMP response element activity and up‐regulates GluR2 in cortical neurons

Schroeter, H., Bahia, P. K., Spencer, J. P. E., Sheppard, O., Rattray, M., Cadenas, E., Rice-Evans, C. A., & Williams, R. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04434.x · Cited by 173 · see citing works

Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells

Kang, K. A., Lee, K. H., Chae, S., Zhang, R., Jung, M. S., Lee, Y., Kim, S. Y., Kim, H. S., Joo, H. G., Park, J. W., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.008 · Cited by 173 · see citing works

Chemistry of Secondary Polyphenols Produced during Processing of Tea and Selected Foods

Tanaka, T., Matsuo, Y., & Kouno, I. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms11010014 · Cited by 171 · see citing works

The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives

Issa, A., Volate, S. R., & Wargovich, M. J. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2006.02.009 · Cited by 169 · see citing works

Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation

Kang, K. A., Lee, K. H., Chae, S., Zhang, R., Jung, M. S., Ham, Y., Baik, J. S., Lee, N. H., & Hyun, J. W. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20668 · Cited by 168 · see citing works

Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells

Jaganathan, S. K. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i43.7726 · Cited by 163 · see citing works

In vitro Cytotoxicity of Epigallocatechin Gallate and Tea Extracts to Cancerous and Normal Cells from the Human Oral Cavity

Weisburg, J. H., Weissman, D. B., Sedaghat, T., & Babich, H. (2004) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2004.pto_950407.x · Cited by 153 · see citing works

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity

Isbrucker, R. A., Bausch, J., Edwards, J. A., & Wolz, E. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.07.005 · Cited by 153 · see citing works

Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems

He, K., Nukada, H., Urakami, T., & Murphy, M. P. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01453-3 · Cited by 149 · see citing works

Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics

Veeriah, S., Kautenburger, T., Habermann, N., Sauer, J., Dietrich, H., Will, F., & Pool‐Zobel, B. L. (2005) · Molecular Carcinogenesis · doi:10.1002/mc.20158 · Cited by 148 · see citing works

Quercetin Increases Oxidative Stress Resistance and Longevity in Saccharomyces cerevisiae

Belinha, I., Amorim, M. A., Rodrigues, P., de Freitas, V. A. P., Moradas‐Ferreira, P., Mateus, N. F. D. C. B., & Costa, V. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf063302e · Cited by 145 · see citing works

Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media

Long, L. H., Hoi, A., & Halliwell, B. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.012 · Cited by 140 · see citing works

The cytotoxicity of dopamine may be an artefact of cell culture

Clement, M., Long, L. H., Ramalingam, J. K., & Halliwell, B. B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00802.x · Cited by 140 · see citing works

The Flavonoid Quercetin Inhibits Pancreatic Cancer Growth In Vitro and In Vivo

Angst, E., Park, J. L., Moro, A., Lu, Q., Lu, X., Li, G., King, J. C., Chen, M. F., Reber, H. A., Go, V. L. W., et al. (2012) · Pancreas · doi:10.1097/mpa.0b013e318264ccae · Cited by 138 · see citing works

Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells

Walle, T., Vincent, T. S., & Walle, U. K. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00151-5 · Cited by 138 · see citing works

Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones

Erlank, H., Elmann, A., Kohen, R., & Kanner, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.033 · Cited by 137 · see citing works

Differential in vitro cytotoxicity of (−)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity

Babich, H., Krupka, M. E., Nissim, H. A., & Zuckerbraun, H. L. (2004) · Toxicology in Vitro · doi:10.1016/j.tiv.2004.09.001 · Cited by 134 · see citing works

Toxicological effects of Camellia sinensis (green tea): A review

Bedrood, Z., Rameshrad, M., & Hosseinzadeh, H. (2018) · Phytotherapy Research · doi:10.1002/ptr.6063 · Cited by 134 · see citing works

Tea polyphenol epigallocatechin gallate inhibits Escherichia coli by increasing endogenous oxidative stress

Xiong, L., Chen, Y.-J., Tong, J., Huang, J., Li, J., Gong, Y., & Liu, Z. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.08.098 · Cited by 132 · see citing works

Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines

Chai, P. C., Long, L. H., & Halliwell, B. B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00655-7 · Cited by 132 · see citing works

Modulatory Effects of Polyphenols on Apoptosis Induction: Relevance for Cancer Prevention

D’Archivio, M., Santangelo, C., Scazzocchio, B., Varı́, R., Filesi, C., Masella, R., & Giovannini, C. (2008) · International Journal of Molecular Sciences · doi:10.3390/ijms9030213 · Cited by 130 · see citing works

Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS

Anselm, E., Chataigneau, M., NDIAYE, M., Chataigneau, T., & Schini‐Kerth, V. B. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.004 · Cited by 130 · see citing works

Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals

Babich, H., Schuck, A. G., Weisburg, J. H., & Zuckerbraun, H. L. (2011) · Journal of Toxicology · doi:10.1155/2011/467305 · Cited by 128 · see citing works

In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols

Ramı́rez-Mares, M. V., Chandra, S., & de Mejı́a, E. G. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.03.002 · Cited by 128 · see citing works

Inhibition of β-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H2O2 at physiologically relevant EGCG concentrations

Dashwood, W., Orner, G. A., & Dashwood, R. H. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00914-2 · Cited by 125 · see citing works

Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels

Khoo, N. K. H., White, C. R., Pozzo‐Miller, L. D., Zhou, F., Constance, C., Inoue, T., Patel, R. P., & Parks, D. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.022 · Cited by 123 · see citing works

The role of antioxidants in the Mediterranean diets: focus on cancer

Visioli, F., Grande, S., Bogani, P., & Galli, C. L. (2004) · European Journal of Cancer Prevention · doi:10.1097/01.cej.0000137513.71845.f6 · Cited by 122 · see citing works

Studies in Polyphenol Chemistry and Bioactivity. 4.1 Synthesis of Trimeric, Tetrameric, Pentameric, and Higher Oligomeric Epicatechin-Derived Procyanidins Having All-4β,8-Interflavan Connectivity and Their Inhibition of Cancer Cell Growth through Cell Cycle Arrest1

Kozikowski, A. P., Tückmantel, W., Böttcher, G., & Romanczyk, L. J. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo020393f · Cited by 122 · see citing works

Effects of Polyphenols on Brain Ageing and Alzheimer’s Disease: Focus on Mitochondria

Schaffer, S., Asseburg, H., Kuntz, S., Muller, W. E., & Eckert, G. P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8282-9 · Cited by 123 · see citing works

Catechins from Green Tea (Camellia sinensis) Inhibit Bovine and Human Cartilage Proteoglycan and Type II Collagen Degradation In Vitro

Adcocks, C., Buttle, D. J., & Collin, P. D. (2002) · Journal of Nutrition · doi:10.1093/jn/132.3.341 · Cited by 119 · see citing works

Black Tea Polyphenols, Theaflavins, Prevent Cellular DNA Damage by Inhibiting Oxidative Stress and Suppressing Cytochrome P450 1A1 in Cell Cultures

Feng, Q., Torii, Y., Uchida, K., Nakamura, Y., Hara, Y., & Osawa, T. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010875c · Cited by 115 · see citing works

Bactericidal Action of Photoirradiated Gallic Acid via Reactive Oxygen Species Formation

Nakamura, K., Yamada, Y., Ikai, H., Kanno, T., Sasaki, K., & Niwano, Y. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303177p · Cited by 113 · see citing works

Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments

Raza, H., & John, A. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.01.004 · Cited by 113 · see citing works

Artefacts in cell culture: Pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media

Long, L. H., & Halliwell, B. B. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.069 · Cited by 113 · see citing works

Generation of reactive oxygen species in cyanobacteria and green algae induced by allelochemicals of submerged macrophytes

Wang, J., Zhu, J., Liu, S., Liu, B., Gao, Y., & Wu, Z. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.06.076 · Cited by 113 · see citing works

Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle

Ueda, M., Nishiumi, S., Nagayasu, H., Fukuda, I., Yoshida, K., & Ashida, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.128 · Cited by 112 · see citing works

Triphlorethol-A fromEcklonia cavaprotects V79-4 lung fibroblast against hydrogen peroxide induced cell damage

Kang, K. A., Lee, K. H., Chae, S., Koh, Y. S., Yoo, B.-S., Kim, J. H., Ham, Y., Baik, J. S., Lee, N. H., & Hyun, J. W. (2005) · Free Radical Research · doi:10.1080/10715760500161165 · Cited by 111 · see citing works

Hydrogen Peroxide Effects on Natural-Sourced Polysacchrides: Free Radical Formation/Production, Degradation Process, and Reaction Mechanism—A Critical Synopsis

Ofoedu, C. E., You, L., Osuji, C. M., Iwouno, J. O., Kabuo, N. O., Ojukwu, M., Agunwah, I. M., Chacha, J. S., Muobike, O. P., Agunbiade, A. O., et al. (2021) · Foods · doi:10.3390/foods10040699 · Cited by 109 · see citing works

Dietary polyphenols as antioxidants and anticancer agents: more questions than answers.

Hu, M. (2011) · PubMed · Cited by 108 · see citing works

Flavonoids from a grape seed extract interact with digestive secretions and intestinal cells as assessed in an in vitro digestion/Caco-2 cell culture model

Laurent, C., Besançon, P., & Caporiccio, B. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.10.016 · Cited by 105 · see citing works

(−)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization

Zhang, Y., Yang, N., Zhou, F., Shen, T., Duan, T., Zhou, J., Shi, Y., Zhu, X.-Q., & Shen, H.-M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046749 · Cited by 103 · see citing works

Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X‐ray structure at 2.1 Å resolution

Borbulevych, O. Y., Jankun, J., Selman, S. H., & Skrzypczak‐Jankun, E. (2003) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.10579 · Cited by 103 · see citing works

Prooxidant activity of melatonin promotes fas‐induced cell death in human leukemic Jurkat cells

Wölfler, A., Caluba, H.-C., Abuja, P. M., Dohr, G., Schauenstein, K., & Liebmann, P. M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02680-1 · Cited by 103 · see citing works

Chemico-biological aspects of (−)- epigallocatechin- 3 -gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects

Sahadevan, R., Singh, S. K., Binoy, A., & Sadhukhan, S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2068500 · Cited by 103 · see citing works

Nanoencapsulation Enhances Epigallocatechin-3-gallate Stability and Its Antiatherogenic Bioactivities in Macrophages

Zhang, J., Nie, S., & Wang, S. F. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4023004 · Cited by 99 · see citing works

Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts

Chan, W. (2007) · Biochemical Journal · doi:10.1042/bj20061875 · Cited by 99 · see citing works

Biphasic effects of dietary antioxidants on oxidative stress-mediated carcinogenesis

Lee, K. W., & Lee, H. J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.021 · Cited by 99 · see citing works

Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress

Plauth, A., Geikowski, A., Cichon, S., Wowro, S. J., Liedgens, L., Rousseau, M., Weidner, C., Fuhr, L., Kliem, M., Jenkins, G., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.006 · Cited by 98 · see citing works

Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells

Chisholm, K. A., Bray, B. J., & Rosengren, R. J. (2004) · Anti-Cancer Drugs · doi:10.1097/00001813-200410000-00010 · Cited by 98 · see citing works

Radical chemistry of epigallocatechin gallate and its relevance to protein damage

Hagerman, A. E., Dean, R. T., & Davies, M. J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00158-9 · Cited by 98 · see citing works

Up-regulation of tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 in human colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice

BERMUDEZSOTO, M., Larrosa, M., García‐Cantalejo, J., Espı́n, J. C., Tomás-Barberán, F. A., & García‐Conesa, M. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.05.003 · Cited by 97 · see citing works

Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide

Knickle, A. F., Fernando, W., Greenshields, A. L., Rupasinghe, H. P. V., & Hoskin, D. W. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.05.005 · Cited by 94 · see citing works

Artefacts in cell culture: α-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media

Long, L. H., & Halliwell, B. B. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.01.091 · Cited by 94 · see citing works

EFFECTS OF HYPOXIA ON MNSOD EXPRESSION AND SUBSEQUENT EPIGALLOCATECHIN GALLATE INDUCED PROSTATE CANCER CELL APOPTOSIS

O'Neill, A., Morrissey, C., Cunningham, K., Taylor, C. T., Fitzpatrick, J. M., & Watson, R. W. G. (2006) · European Urology Supplements · doi:10.1016/s1569-9056(06)61291-8

Hydrogen Peroxide Generation in Caco-2 Cell Culture Medium by Addition of Phenolic Compounds: Effect of Ascorbic Acid

Roques, S. C., Landrault, N., Teissèdre, P., Laurent, C., Besançon, P., Rouanet, J., & Caporiccio, B. (2002) · Free Radical Research · doi:10.1080/10715760290025979 · Cited by 45 · see citing works

Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media

Long, L. H., Hoi, A., & Halliwell, B. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.012 · Cited by 140 · see citing works

The effects of oxaloacetate on hydrogen peroxide generation from ascorbate and epigallocatechin gallate in cell culture media: Potential for altering cell metabolism

Long, L. H., & Halliwell, B. B. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.136 · Cited by 27 · see citing works

Dietary antioxidants as a source of hydrogen peroxide

Grzesik, M., Bartosz, G., Stefaniuk, I., Pichla, M., Namieśnik, J., & Sadowska‐Bartosz, I. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.11.109 · Cited by 90 · see citing works