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BMP Type II Receptor Is Required for Gastrulation and Early Development of Mouse Embryos
Open accessAbstract
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta superfamily, play a variety of roles during mouse development. BMP type II receptor (BMPR-II) is a type II serine/threonine kinase receptor, which transduces signals for BMPs through heteromeric complexes with type I receptors, including activin receptor-like kinase 2 (ALK2), ALK3/BMPR-IA, and ALK6/BMPR-IB. To elucidate the function of BMPR-II in mammalian development, we generated BMPR-II mutant mice by gene targeting. Homozygous mutant embryos were arrested at the egg cylinder stage and could not be recovered at 9.5 days postcoitum. Histological analysis revealed that homozygous mutant embryos failed to form organized structure and lacked mesoderm. The BMPR-II mutant embryos are morphologically very similar to the ALK3/BMPR-IA mutant embryos, suggesting that BMPR-II is important for transducing BMP signals during early mouse development. Moreover, the epiblast of the BMPR-II mutant embryo exhibited an undifferentiated character, although the expression of tissue-specific genes for the visceral endoderm was essentially normal. Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development.
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Citations
Cites
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,556
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C.-H., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,696
Self-citationBone morphogenetic proteins: multifunctional regulators of vertebrate development.
Hogan, B. L. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,962
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
Winnier, G., Blessing, M., Labosky, P. A., & Hogan, B. L. (1995) · Genes & Development · doi:10.1101/gad.9.17.2105 · Cited by 1,788
Bmp4 is required for the generation of primordial germ cells in the mouse embryo
Lawson, K. A., Dunn, N. R., Roelen, B. A. J., Zeinstra, L. M., Davis, A. M., Wright, C. V. E., Korving, J. P. W. F. M., & Hogan, B. L. M. (1999) · Genes & Development · doi:10.1101/gad.13.4.424 · Cited by 1,310
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
Zhang, H., & Bradley, A. (1996) · Development · doi:10.1242/dev.122.10.2977 · Cited by 983
Expression pattern of the mouse T gene and its role in mesoderm formation
Wilkinson, D. G., Bhatt, S., & Herrmann, B. G. (1990) · Nature · doi:10.1038/343657a0 · Cited by 855
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839
Mishina, Y., Suzuki, A., Ueno, N., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.24.3027 · Cited by 776
Axis Development and Early Asymmetry in Mammals
Beddington, R. S. P., & Robertson, E. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80560-7 · Cited by 756
Expression cloning of an activin receptor, a predicted transmembrane serine kinase
Mathews, L. S., & Vale, W. W. (1991) · Cell · doi:10.1016/0092-8674(91)90549-e · Cited by 738
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C. H., & Miyazono, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32506-1 · Cited by 730
Self-citationMADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
Hoodless, P. A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M. B., Attisano, L., & Wrana, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81250-7 · Cited by 696
Sasaki, H., & Hogan, B. L. M. (1993) · Development · doi:10.1242/dev.118.1.47 · Cited by 667
Liu, F., Ventura, F., Doody, J., & Massagué, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3479 · Cited by 593
Different phenotypes for mice deficient in either activins or activin receptor type II
Matzuk, M. M., Kumar, T. R., & Bradley, A. (1995) · Nature · doi:10.1038/374356a0 · Cited by 589
Characterization of Type I Receptors for Transforming Growth Factor-β and Activin
ten Dijke, P., Yamashita, H., Ichijo, H., Franzén, P., Laiho, M., Miyazono, K., & Heldin, C.-H. (1994) · Science · doi:10.1126/science.8140412 · Cited by 551
Self-citationCloning and characterization of a human type II receptor for bone morphogenetic proteins.
Rosenzweig, B. L., Imamura, T., Okadome, T., Cox, G. N., Yamashita, H., ten Dijke, P., Heldin, C. H., & Miyazono, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7632 · Cited by 550
Self-citationSaitou, M., Fujimoto, K., Doi, Y., Itoh, M., Fujimoto, T., Furuse, M., Takano, H., Noda, T., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.397 · Cited by 547
Self-citationThomas, P. Q., Brown, A., & Beddington, R. S. P. (1998) · Development · doi:10.1242/dev.125.1.85 · Cited by 528
Signal transduction by bone morphogenetic proteins
Kawabata, M. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00036-1 · Cited by 528
Self-citationSirard, C., de la Pompa, J. L., Elia, A., Itie, A., Mirtsos, C., Cheung, A., Hahn, S., Wakeham, A., Schwartz, L., Kern, S. E., et al. (1998) · Genes & Development · doi:10.1101/gad.12.1.107 · Cited by 502
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T. K., Andries, M., Smith, J. C., Heldin, C. H., & Miyazono, K. (1995) · The Journal of cell biology · doi:10.1083/jcb.130.1.217 · Cited by 496
Self-citationCripto is required for correct orientation of the anterior–posterior axis in the mouse embryo
Ding, J., Yang, L., Yan, Y.-T., Chen, A., Desai, N., Wynshaw-Boris, A., & Shen, M. M. (1998) · Nature · doi:10.1038/27215 · Cited by 481
Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2
Macı́as-Silva, M., Hoodless, P. A., Tang, S. J., Buchwald, M., & Wrana, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25628 · Cited by 476
Attisano, L., Wrana, J. L., Cheifetz, S., & Massague, J. (1992) · Cell · doi:10.1016/0092-8674(92)90209-u · Cited by 474
Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90409-x · Cited by 451
Suzuki, A., Thies, R. S., Yamaji, N., Song, J. J., Wozney, J. M., Murakami, K., & Ueno, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10255 · Cited by 447
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
Chang, H., Huylebroeck, D., Verschueren, K., Guo, Q., Matzuk, M. M., & Zwijsen, A. (1999) · Development · doi:10.1242/dev.126.8.1631 · Cited by 435
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily
Graff, J. M., Bansal, A., & Melton, D. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81249-0 · Cited by 424
Fujii, M., Takeda, K., Imamura, T., Aoki, H., Sampath, T. K., Enomoto, S., Kawabata, M., Kato, M., Ichijo, H., & Miyazono, K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3801 · Cited by 415
Self-citationAngiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
Yang, X., Castilla, L. H., Xu, X., Li, C., Gotay, J., Weinstein, M., Liu, P. P., & Deng, C.-X. (1999) · Development · doi:10.1242/dev.126.8.1571 · Cited by 388
Oh, S. P., & Li, E. (1997) · Genes & Development · doi:10.1101/gad.11.14.1812 · Cited by 379
Bone Morphogenetic Proteins: From Basic Studies to Clinical Approaches
Sakou, T. (1998) · Bone · doi:10.1016/s8756-3282(98)00053-2 · Cited by 367
Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells
Koenig, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5961 · Cited by 366
Wholemount in situ hybridization of vertebrate embryos
Wilkinson, D. G. (1992) · Cited by 366
Yang, X., Li, C., Xu, X., & Deng, C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3667 · Cited by 361
Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S., & Miyazono, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.35.21345 · Cited by 328
Self-citationCharacterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation
Ebisawa, T., Tada, K., Kitajima, I., Tojo, K., Sampath, T. K., Kawabata, M., Miyazono, K., & Imamura, T. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.20.3519 · Cited by 317
Self-citationDuncan, S. A., Nagy, A., & Chan, W. (1997) · Development · doi:10.1242/dev.124.2.279 · Cited by 291
Gu, Z., Reynolds, E. M., Song, J., Lei, H., Feijen, A., Yu, L., He, W., MacLaughlin, D. T., Raaij, J. V. D. E.-V., Donahoe, P. K., et al. (1999) · Development · doi:10.1242/dev.126.11.2551 · Cited by 245
Yagi, T., Ikawa, Y., Yoshida, K., Shigetani, Y., Takeda, N., Mabuchi, I., Yamamoto, T., & Aizawa, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9918 · Cited by 239
Nohno, T., Ishikawa, T., Saito, T., Hosokawa, K., Noji, S., Wolsing, D. H., & Rosenbaum, J. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22522 · Cited by 234
Song, J., Oh, S. P., Schrewe, H., Nomura, M., Lei, H., Okano, M., Gridley, T., & Li, E. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9370 · Cited by 193
Kawabata, M., Chytil, A., & Moses, H. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5625 · Cited by 189
Self-citationThomsen, G. H. (1996) · Development · doi:10.1242/dev.122.8.2359 · Cited by 171
Multiple Roles for Activin-Like Kinase-2 Signaling during Mouse Embryogenesis
Mishina, Y., Crombie, R., Bradley, A., & Behringer, R. R. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9378 · Cited by 169
Smad5 Induces Ventral Fates inXenopusEmbryo
Suzuki, A., Chang, C., Yingling, J. M., Wang, X.-F., & Hemmati‐Brivanlou, A. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8548 · Cited by 153
Mesodern-inducing factors and mesodermal patterning
Smith, J. C. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80070-0 · Cited by 111
Tang, S. J., Hoodless, P. A., Lü, Z., Breitman, M. L., McInnes, R. R., Wrana, J. L., & Buchwald, M. (1998) · Development · doi:10.1242/dev.125.10.1877 · Cited by 104
Differential expression of BMP receptors in early mouse development
Roelen, B. A. J., Goumans, M., van Rooijen, M., & Mummery, C. L. (1997) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9303341 · Cited by 57
Truncated Type II Receptor for BMP-4 Induces Secondary Axial Structures in Xenopus Embryos
Ishikawa, T., Yoshioka, H., Ohuchi, H., Noji, S., & Nohno, T. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2587 · Cited by 46
Manova, K., Leon, V. D., Angeles, M., Kalantry, S., Giarrè, M., Attisano, L., Wrana, J. L., & Bachvarova, R. F. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00295-x · Cited by 45
Cited by
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,385
Deng, Z., Morse, J. H., Slager, S. L., Cuervo, N., Moore, K. J., Venetos, G., Kalachikov, S., Cayanis, E., Fischer, S. G., Barst, R. J., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/303059 · Cited by 1,206
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
Morrell, N. W., Adnot, S., Archer, S. L., Dupuis, J., Lloyd Jones, P., MacLean, M. R., McMurtry, I. F., Stenmark, K. R., Thistlethwaite, P. A., Weissmann, N., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.018 · Cited by 819
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
Chang, H., Brown, C. W., & Matzuk, M. M. (2002) · Endocrine Reviews · doi:10.1210/er.2002-0003 · Cited by 787
Wilson, T., Wu, X.-Y., Juengel, J. L., Ross, I. K., Lumsden, J. M., Lord, E. A., Dodds, K. G., Walling, G. A., McEwan, J. C., O’Connell, A. R., et al. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.4.1225 · Cited by 548
Metadata
- Authors
- Beppu, H., Kawabata, M., Hamamoto, T., Chytil, A., Minowa, O., Noda, T., & Miyazono, K.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 221
- Issue
- 1
- Pages
- 249-258
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2014751423
- Cited by
- 421
- References
- 54
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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