The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish
Open accessAbstract
In this study we describe a model system that allows continuous in vivo observation of the vertebrate embryonic vasculature. We find that the zebrafish fli1 promoter is able to drive expression of enhanced green fluorescent protein (EGFP) in all blood vessels throughout embryogenesis. We demonstrate the utility of vascular-specific transgenic zebrafish in conjunction with time-lapse multiphoton laser scanning microscopy by directly observing angiogenesis within the brain of developing embryos. Our images reveal that blood vessels undergoing active angiogenic growth display extensive filopodial activity and pathfinding behavior similar to that of neuronal growth cones. We further show, using the zebrafish mindbomb mutant as an example, that the expression of EGFP within developing blood vessels permits detailed analysis of vascular defects associated with genetic mutations. Thus, these transgenic lines allow detailed analysis of both wild type and mutant embryonic vasculature and, together with the ability to perform large scale forward-genetic screens in zebrafish, will facilitate identification of new mutants affecting vascular development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SEGREGATION ANALYSES AND GENE-CENTROMERE DISTANCES IN ZEBRAFISH
Streisinger, G., Singer, F., Walker, C., Knauber, D., & Dower, N. (1986) · Genetics · doi:10.1093/genetics/112.2.311 · Cited by 245
Cited by
Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S. W., & Ruhrberg, C. (2010) · Blood · doi:10.1182/blood-2009-12-257832 · Cited by 1,153
Genetic compensation triggered by mutant mRNA degradation
El-Brolosy, M. A., Kontarakis, Z., Rossi, A., Kuenne, C., Günther, S., Fukuda, N., Kikhi, K., Boezio, G. L. M., Takacs, C. M., Lai, S.-L., et al. (2019) · Nature · doi:10.1038/s41586-019-1064-z · Cited by 1,028
SIRT1 Controls Endothelial Angiogenic Functions During Vascular Growth
Potente, M., Ghaeni, L., Baldessari, D., Mostoslavsky, R., Rossig, L., Dequiedt, F., Haendeler, J., Mione, M., Dejana, E., Alt, F. W., et al. (2007) · Genes & Development · doi:10.1101/gad.435107 · Cited by 608
Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature
Torres-Vázquez, J., Gitler, A. D., Fraser, S. D., Berk, J. D., Pham, V. N., Fishman, M. C., Childs, S., Epstein, J. A., & Weinstein, B. M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.06.008 · Cited by 367
Self-citationAdult Zebrafish as a Model System for Cutaneous Wound-Healing Research
Richardson, R., Slanchev, K., Kraus, C., Knyphausen, P., Eming, S., & Hammerschmidt, M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.16 · Cited by 299
A global view of protein expression in human cells, tissues, and organs
Pontén, F., Gry, M., Fagerberg, L., Lundberg, E., Asplund, A., Berglund, L., Oksvold, P., Björling, E., Hober, S., Kampf, C., et al. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.93 · Cited by 222
Veneman, W. J., Spaink, H. P., Brun, N. R., Bosker, T., & Vijver, M. G. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.06.014 · Cited by 204
Connecting Vascular and Nervous System Development: Angiogenesis and the Blood-Brain Barrier
Tam, S. J., & Watts, R. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-152829 · Cited by 197
Isken, A., Golczak, M., Oberhauser, V., Hunzelmann, S., Driever, W., Imanishi, Y., Palczewski, K., & von Lintig, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.009 · Cited by 194
Control of angiogenesis by AIBP-mediated cholesterol efflux
Fang, L., Choi, S.-H., Baek, J. S., Liu, C., Almazan, F., Ulrich, F., Wiesner, P., Taleb, A., Deer, E., Pattison, J., et al. (2013) · Nature · doi:10.1038/nature12166 · Cited by 192
Guenebeaud, C., Goldschneider, D., Castets, M., Guix, C., Chazot, G., Delloye-Bourgeois, C., Eisenberg-Lerner, A., Shohat, G., Zhang, M., Laudet, V., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.021 · Cited by 137
A unique role for 6-O sulfation modification in zebrafish vascular development
Chen, E., Stringer, S. E., Rusch, M. A., Selleck, S. B., & Ekker, S. C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.032 · Cited by 88
Radial glia regulate vascular patterning around the developing spinal cord
Matsuoka, R. L., Marass, M., Avdesh, A., Helker, C. S., Maischein, H.-M., Grosse, A. S., Kaur, H., Lawson, N. D., Herzog, W., & Stainier, D. Y. (2016) · eLife · doi:10.7554/elife.20253 · Cited by 84
Self-citationVegf signaling promotes vascular endothelial differentiation by modulating etv2 expression
Casie Chetty, S., Rost, M. S., Enriquez, J. R., Schumacher, J. A., Baltrunaite, K., Rossi, A., Stainier, D. Y. R., & Sumanas, S. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.03.005 · Cited by 76
Lammert, E., & Axnick, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006619 · Cited by 75
EGFR is required for Wnt9a/Fzd9b signalling specificity in haematopoietic stem cells
Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C. H., Wozniak, J. M., Barahona, R., Kamei, C. N., Houston, J., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0330-5 · Cited by 60
Knight, R. D., Javidan, Y., Nelson, S., Zhang, T., & Schilling, T. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10494 · Cited by 65
Rissone, A., Weinacht, K. G., la Marca, G., Bishop, K., Giocaliere, E., Jagadeesh, J., Felgentreff, K., Dobbs, K., Al-Herz, W., Jones, M., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141286 · Cited by 63
Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P. P., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101723 · Cited by 54
Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
Ghersi, J. J., Baldissera, G., Hintzen, J., Luff, S. A., Cheng, S., Xia, I. F., Sturgeon, C. M., & Nicoli, S. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01187-9 · Cited by 32
Scherer, A. K., Blair, B. A., Park, J., Seman, B. G., Kelley, J. B., & Wheeler, R. T. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008414 · Cited by 30
Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis
Choudhry, P., Joshi, D., Funke, B., & Trede, N. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.006 · Cited by 13
Gence, L., Morello, E., Rastegar, S., Apalama, M. L., Meilhac, O., Bascands, J., & Diotel, N. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.16586 · Cited by 5
Pro-Angiogenetic Effects of Purified Extracts from Helix aspersa during Zebrafish Development
Zizioli, D., Mastinu, A., Muscò, A., Bonini, S. A., Finazzi, D., Avisani, R., Kron Morelli, G. B., Pecorelli, S., & Memo, M. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44080232 · Cited by 4
Metadata
- Authors
- Lawson, N. D., & Weinstein, B. M.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 248
- Issue
- 2
- Pages
- 307-318
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2091760375
- Cited by
- 2,151
- References
- 1
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
