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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid Plaques

Wallace, Mark N., Geddes, Joan G., Farquhar, Duncan A., Masson, Margaret R.·1997·Experimental Neurology
DOI 10.1006/exnr.1996.6373
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Abstract

This study provides the first evidence that nitric oxide is released by astrocytes surrounding beta-amyloid plaques. Nitric oxide is involved in many neuropathological conditions and can have either a neuroprotective or a neurotoxic function depending on its concentration and the redox state of the tissue. It is produced by the enzyme nitric oxide synthase, which can be located by a simple histochemical technique for demonstrating NADPH diaphorase. Using this method we examined tissue from 10 brains where there were varying numbers of beta-amyloid plaques in the cerebral cortex. In the 6 brains with moderate or high densities of plaques, primitive and cored plaques were associated with between 1 and 10 reactive astrocytes that contained NADPH diaphorase or were immunoreactive for the inducible form of nitric oxide synthase. In the 4 brains which had only low densities of plaques, the plaques were not associated with diaphorase-containing astrocytes. The percentage of plaques associated with 1 or more NADPH diaphorase-containing astrocyte varied between 1 and 21% and was correlated with the density of plaques. Astrocytes were the only form of NADPH diaphorase-positive glial cell associated with the plaques. There was no evidence of any nitric oxide synthase occurring in microglia.

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Crossref · 10.1006/exnr.1996.6373

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  • Unregulated glial activation could potentially compromise neuronal health via the sustained secretion of pro-inflammatory cytokines and oxidative stress molecules.

    “Unregulated glial activation could potentially compromise neuronal health via the sustained secretion of pro-inflammatory cytokines and oxidative stress molecules (57,58).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [58]

Citations

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Research works printed but not linked: 31

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Metadata

Authors
Wallace, M. N., Geddes, J. G., Farquhar, D. A., & Masson, M. R.
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
1997-04
Volume
144
Issue
2
Pages
266-272
ISSN
0014-4886
DOI
10.1006/exnr.1996.6373
Cited by
145
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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