The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer’s disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer’s disease?
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To investigate whether the observed association of intracellular neuronal calcium sensor (NCS) proteins with amyloid plaques and neurofibrillar tangles in Alzheimer brains is linked to a possible neuroprotective or neurotoxic activity of the protein, we performed cytotoxicity tests in PC12 cells transfected with the calcium sensor protein VILIP-1 (visinin-like protein) and the calcium buffer protein calbindin-D28K. Whereas VILIP-1 expression enhanced the neurotoxic effect of ionomycin already at low ionophore concentrations, calbindin-D28K protected against ionomycin-induced cytotoxicity only at high ionomycin and therefore calcium concentrations. However, in double-transfected cells calbindin-D28K rescued VILIP-1-mediated cytotoxicity at low ionomycin concentrations. Since VILIP-1 was found to be associated with fibrillar tangles in Alzheimer brains, we tested whether VILIP-1 has an influence on tau hyperphosphorylation. VILIP-1 expression enhanced hyperphosphorylation of tau protein compared to nontransfected or calbindin-D28K-transfected cells. These results raise the possibility that the observed reduction in VILIP-1-expressing cells may indicate a selective vulnerability of these neurons and that the calcium sensor protein is involved in the pathophysiology of Alzheimer's disease. The calcium sensor protein may influence tau phosphorylation and have a role in calcium-mediated neurotoxicity opposed to the previously discovered protective effect of calcium buffer proteins.
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VSNL1 is associated with neuropathologic lesions.
“the latter which is associated with neuropathologic lesions.52,79”
From Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements (2023) · cites this paper as [79]
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Greene, L., & Tischler, A. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2424 · Cited by 5,594 · see citing works
Calbindin D-28k and parvalbumin in the rat nervous system
Celio, M. R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90091-h · Cited by 2,086 · see citing works
The distribution of tau in the mammalian central nervous system.
Binder, L. I., Frankfurter, A., & Rebhun, L. I. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1371 · Cited by 1,588 · see citing works
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
Mattson, M. P. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1081 · Cited by 1,006 · cited 1× · see citing works
“Several lines of evidence point to distur- bances of calcium homeostasis and calcium signaling in neurodegenerative diseases such as Alzheimer’s disease (Heizmann & Braun, 1992; Mattson, 1997).”
BackgroundBrain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748 · see citing works
Self-citationTau protein pathology in neurodegenerative diseases
Spillantini, M. G., & Goedert, M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01337-x · Cited by 683 · see citing works
Calcium binding and conformational response in EF-hand proteins
Ikura, M. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(06)80021-6 · Cited by 664 · see citing works
Matsuo, E. S., Shin, R., Billingsley, M., de Voorde, A. V., O'Connor, M., Trojanowski, J., & Lee, V. (1994) · Neuron · doi:10.1016/0896-6273(94)90264-x · Cited by 588 · see citing works
Mattson, M. P., Rychlik, B., Chu, C., & Christakost, S. (1991) · Neuron · doi:10.1016/0896-6273(91)90120-o · Cited by 524 · see citing works
Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain
Siegel, G. J., & Chauhan, N. B. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00030-8 · Cited by 492 · see citing works
Changes in Ca2+-binding proteins in human neurodegenerative disorders
Heizmann, C. W., & Braun, K. A. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90067-i · Cited by 409 · see citing works
Sontag, E., Nunbhakdi‐Craig, V., Lee, G. S., Bloom, G. S., & Mumby, M. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80250-0 · Cited by 391 · see citing works
Iacopino, A. M., & Christakos, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4078 · Cited by 388 · see citing works
The cause of neuronal degeneration in Alzheimer’s disease
Vickers, J. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00023-4 · Cited by 254 · see citing works
Braunewell, K., & Gundelfinger, E. D. (1999) · Cell and Tissue Research · doi:10.1007/s004410051207 · Cited by 251 · see citing works
Self-citationFerreira, A., Lu, Q., Orecchio, L., & Kosik, K. S. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0615 · Cited by 178 · see citing works
Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's disease
Hof, P. R., Nimchinsky, E. A., Celio, M. R., Bouras, C., & Morrison, J. H. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90504-e · Cited by 172 · see citing works
Calcium binding and conformational response in EF-hand proteins
Ikura, M. (1996) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(96)80879-6 · Cited by 143 · see citing works
Hartigan, J. A., & Johnson, G. V. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21395 · Cited by 141 · see citing works
Alkon, D. L., Nelson, T. J., Zhao, W., & Cavallaro, S. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01277-6 · Cited by 132 · see citing works
Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments
Fraser, S. P., Suh, Y.-H., & Djamgoz, M. B. A. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10079-5 · Cited by 123 · see citing works
Lenz, S. E., Henschel, Y., Zopf, D., Voss, B., & Gundelfinger, E. D. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90160-d · Cited by 121 · see citing works
Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons
Gwag, B. J., Canzoniero, L. M. T., Sensi, S. L., Demaro, J. A., Koh, J., Goldberg, M. P., Jacquin, M., & Choi, D. W. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00508-9 · Cited by 116 · see citing works
Bernstein, H., Baumann, B., Dános, P., Diekmann, S., Bogerts, B., Gundelfinger, E. D., & Braunewell, K. (1999) · Journal of Neurocytology · doi:10.1023/a:1007056731551 · Cited by 113 · see citing works
Self-citationAltered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examplesa
Mattson, M. P., Rydel, R. E., Lieberburg, I. M., & Smith‐Swintosky, V. L. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb18285.x · Cited by 110 · see citing works
Mikkonen, M., Alafuzoff, I. I., Tapiola, T., Soininen, H. S., & Miettinen, R. A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00047-0 · Cited by 110 · see citing works
Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1.
Schaad, N., de Castro, E., Nef, S., Hegi, S., Hinrichsen, R. D., Martone, M. E., Ellisman, M. H., Sikkink, R. A., Rusnak, F. M., Sygush, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9253 · Cited by 105 · see citing works
Bernstein, H., Ansorge, S., Riederer, P. F., Reiser, M., Frölich, L., & Bogerts, B. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00135-4 · Cited by 101 · see citing works
Self-citationMolecular basis of Alzheimer's disease
Drouet, B., Pinçon‐Raymond, M., Chambaz, J., & Pillot, T. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050035 · Cited by 89 · see citing works
Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells
McMahon, A., Wong, B. S., Iacopino, A. M., Ng, M. C., Chi, S. N., & German, D. C. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00305-7 · Cited by 85 · see citing works
Hunziker, W. H., & Schrickel, S. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-5-465 · Cited by 82 · see citing works
Friedel, R. H., Schnürch, H., Stubbusch, J., & Barde, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12670 · Cited by 81 · see citing works
CALMODULIN AND CALBINDIN D28K IN ALZHEIMER DISEASE
McLachlan, D. R. C., Wong, L. J., Bergeron, C., & Baimbridge, K. G. (1987) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198701030-00009 · Cited by 81 · see citing works
Wernyj, R. P., Mattson, M. P., & Christakos, S. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00307-6 · Cited by 76 · see citing works
Sampson, V., Morrison, J. H., & Vickers, J. C. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6433 · Cited by 75 · see citing works
Braunewell, K. H., Riederer, P. F., Spilker, C., Gundelfinger, E. D., Bogerts, B., & Bernstein, H. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051244 · Cited by 73 · see citing works
Self-citationBraunewell, K., Spilker, C., Behnisch, T., & Gundelfinger, E. D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052129.x · Cited by 59 · see citing works
Self-citationSpilker, C., Richter, K., Smalla, K., Manahan‐Vaughan, D., Gundelfinger, E. D., & Braunewell, K. H. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00536-9 · Cited by 57 · see citing works
Self-citationIsolation and culture of bovine endothelial cells of endoneurial origin
Kanda, T., Iwasaki, T., Yamawaki, M., & Ikeda, K. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6 · Cited by 35 · see citing works
Maguire-Zeiss, K., Li, Z.-W., Shimodal, L. M. N., & Hamill, R. (1995) · Brain Research. Molecular Brain Research · doi:10.1016/0169-328x(95)00035-q · Cited by 26 · see citing works
Nishiyama, E., Ohwada, J., Iwamoto, N., & Arai, H. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90388-2 · Cited by 25 · see citing works
Spilker, C., Gundelfinger, E. D., & Braunewell, K. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00201-2 · Cited by 22 · see citing works
Self-citationShimohama, S., Chachin, M., Taniguchi, T., Hidaka, H., & Kimura, J. (1996) · Brain Research · doi:10.1016/0006-8993(96)00070-4 · Cited by 19 · see citing works
Reduced Proteins in Temporal Cortex in Alzheimer's Disease: An Electrophoretic Study
Borthwick, N. M., Yates, C. M., & Gordon, A. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb08780.x · Cited by 18 · see citing works
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Sorted by citations
Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer’s disease
Drummond, E., Nayak, S., Faustin, A., Pires, G., Hickman, R. A., Askenazi, M., Cohen, M., Haldiman, T., Kim, C., Han, X., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1691-0 · Cited by 239 · see citing works
Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function
Burgoyne, R. D., O'Callaghan, D. W., Hasdemir, B., Haynes, L. P., & Tepikin, A. V. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.01.010 · Cited by 200 · see citing works
Visinin‐like protein‐1: Diagnostic and prognostic biomarker in Alzheimer disease
Tarawneh, R. M., D’Angelo, G., Macy, E., Xiong, C., Carter, D. R., Cairns, N. J., Fagan, A. M., Head, D. M., Mintun, M. A., Ladenson, J. H., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22448 · Cited by 167 · see citing works
Gururaj Joshi, A., Aluise, C. D., Cole, M. P., Rukhsana Sultana, A., Pierce, W. M. J., Vore, M. E., Clair, D. K. S., & Butterfield, D. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.021 · Cited by 156 · see citing works
Kester, M. I., Teunissen, C. E., Sutphen, C., Herries, E. M., Ladenson, J. H., Xiong, C., Scheltens, P., van der Flier, W. M., Morris, J. C., Holtzman, D. M., et al. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0142-1 · Cited by 146 · see citing works
Ravetti, M. G., Rosso, O. A., Berretta, R. E., & Moscato, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010153 · Cited by 140 · see citing works
Braunewell, K., & Klein-Szanto, A. J. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0716-3 · Cited by 126 · see citing works
Self-citationDhiman, K., Blennow, K., Zetterberg, H., Martins, R. N., & Gupta, V. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03040-5 · Cited by 114 · see citing works
Alzheimer’s Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid
Huynh, R. A., & Mohan, C. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00102 · Cited by 109 · see citing works
CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease
Tarawneh, R. M., Lee, J., Ladenson, J. H., Morris, J. C., & Holtzman, D. M. (2012) · Neurology · doi:10.1212/wnl.0b013e318248e568 · Cited by 107 · see citing works
Biase, A. D., Knoblach, S. M., Giovanni, S. D., Fan, C., Molon, A., Hoffman, E. P., & Faden, A. I. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00081.2005 · Cited by 107 · see citing works
Biomarker-based dissection of neurodegenerative diseases
Olsson, B., Zetterberg, H., Hampel, H. J., & Blennow, K. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.006 · Cited by 96 · see citing works
Tarawneh, R. M., Head, D. M., Allison, S. L., Buckles, V., Fagan, A. M., Ladenson, J. H., Morris, J. C., & Holtzman, D. M. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0202 · Cited by 96 · see citing works
The Diversity of Calcium Sensor Proteins in the Regulation of Neuronal FunctionPreprint
McCue, H. V., Haynes, L. P., & Burgoyne, R. D. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004085 · Cited by 89 · see citing works
Calcium Sensors in Neuronal Function and DysfunctionPreprint
Burgoyne, R. D., Helassa, N., McCue, H. V., & Haynes, L. P. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035154 · Cited by 87 · see citing works
The darker side of Ca signaling by neuronal Ca-sensor proteins: from Alzheimer's disease to cancer
Braunewell, K. H. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.008 · Cited by 87 · see citing works
Self-citationAnderson, A. G., Rogers, B. B., Loupe, J. M., Rodriguez-Nunez, I., Roberts, S. C., White, L. M., Brazell, J. N., Bunney, W. E., Bunney, B. G., Watson, S. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100263 · Cited by 82 · see citing works
Brackmann, M., Schuchmann, S., Anand, R., & Braunewell, K. (2005) · Journal of Cell Science · doi:10.1242/jcs.02376 · Cited by 70 · see citing works
Self-citationZelaya, M. V., Pérez‐Valderrama, E., de Morentin, X. M., Tuñón, T., Ferrer, I., Luquín, M. R., Fernández‐Irigoyen, J., & Santamaría, E. (2015) · Oncotarget · doi:10.18632/oncotarget.6254 · Cited by 67 · see citing works
The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer’s disease—old wine in new bottles
Braunewell, K. H. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00020 · Cited by 66 · see citing works
Self-citationLuo, X., Hou, L., Shi, H., Zhong, X., Zhang, Y., Zheng, D., Tan, Y., Guoyan, H., Mu, N., Chan, J., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12331 · Cited by 65 · see citing works
The rat brain hippocampus proteome
Fountoulakis, M., Tsangaris, G. T., Maris, A., & Lübec, G. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.01.037 · Cited by 60 · see citing works
Leko, M. B., Borovečki, F., Dejanović, N., Hof, P. R., & Šimić, G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150705 · Cited by 56 · see citing works
The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer’s Disease
Groblewska, M., Muszyński, P., Wojtulewska-Supron, A., Kulczyńska‐Przybik, A., & Mroczko, B. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150060 · Cited by 51 · see citing works
Hartl, D., Schuldt, V., Forler, S., Zabel, C., Klose, J., & Rohe, M. (2012) · Journal of Proteome Research · doi:10.1021/pr300021e · Cited by 48 · see citing works
Schrenk-Siemens, K., Pérez‐Alcalá, S., Richter, J., Lacroix, E., Rahuel, J., Körte, M., Müller, U., Barde, Y., & Bibel, M. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0010 · Cited by 48 · see citing works
Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia
Bernstein, H., Braunewell, K., Spilker, C., Dános, P., Baumann, B., Funke, S., Diekmann, S., Gundelfinger, E. D., & Bogerts, B. (2002) · Neuroreport · doi:10.1097/00001756-200203250-00006 · Cited by 45 · see citing works
Self-citationProteomics analysis of the temporal changes in axonal proteins during maturation
Yamatani, H., Kawasaki, T., Mita, S., Inagaki, N., & Hirata, T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20794 · Cited by 43 · see citing works
Mroczko, B., Groblewska, M., Zboch, M., Muszyński, P., Zajkowska, A., Borawska, R., Szmitkowski, M., Kornhuber, J., & Lewczuk, P. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141050 · Cited by 42 · see citing works
Li, C., Pan, W., Braunewell, K. H., & Ames, J. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173724 · Cited by 40 · see citing works
Self-citationHalbgebauer, S., Steinacker, P., Riedel, D., Oeckl, P., Anderl‐Straub, S., Lombardi, J., Arnim, C. A. F. V., Nagl, M., Giese, A., Ludolph, A. C., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01122-4 · Cited by 40 · see citing works
Schindler, S. E., & Fagan, A. M. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00142 · Cited by 39 · see citing works
Arefin, A. S., Mathieson, L., Johnstone, D. M., Berretta, R. E., & Moscato, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045535 · Cited by 39 · see citing works
The Role of Vitamin D in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512473196 · Cited by 36 · see citing works
Reiser, G., & Bernstein, H. (2002) · Neuroreport · doi:10.1097/00001756-200212200-00008 · Cited by 37 · see citing works
Self-citationIdentification of EFHC2 as a quantitative trait locus for fear recognition in Turner syndrome
Weiss, L. A., Purcell, S., Waggoner, S. G., Lawrence, K., Spektor, D., Daly, M. J., Sklar, P. B., & Skuse, D. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl445 · Cited by 35 · see citing works
Lin, C., Chang, L., Tseng, G. C., Kirkwood, C. M., Sibille, E. L., & Sweet, R. A. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00030 · Cited by 34 · see citing works
Liebl, M. P., Kaya, A. M., Tenzer, S., Mittenzwei, R., Koziollek‐Drechsler, I., Schild, H., Moosmann, B., Behl, C., & Clement, A. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.008 · Cited by 26 · see citing works
Braunewell, K. H., Brackmann, M., & Manahan‐Vaughan, D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00051-0 · Cited by 25 · see citing works
Self-citationMavroudis, I. A., Petridis, F., Chatzikonstantinou, S., Karantali, E., & Kazis, D. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01458-2 · Cited by 24 · see citing works
Expression of the neuronal calcium sensor visinin-like protein-1 in the rat hippocampus
Zhao, C., & Braunewell, K. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.067 · Cited by 24 · see citing works
Self-citationNo diurnal variation of classical and candidate biomarkers of Alzheimer’s disease in CSF
Cicognola, C., Chiasserini, D., Eusebi, P., Andréasson, U., Vanderstichele, H., Zetterberg, H., Parnetti, L., & Blennow, K. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0130-3 · Cited by 23 · see citing works
Zhao, C., Anand, R., & Braunewell, K. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-008-9320-z · Cited by 22 · see citing works
Self-citationAn initial top-down proteomic analysis of the standard cuprizone mouse model of multiple sclerosis
Partridge, M. A., Gopinath, S., Myers, S. J., & Coorssen, J. R. (2015) · Journal of Chemical Biology · doi:10.1007/s12154-015-0138-0 · Cited by 22 · see citing works
Sensing change: the emerging role of calcium sensors in neuronal disease.
Seaton, G., Hogg, E. L., Jo, J., Whitcomb, D. J., & Cho, K. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.014 · Cited by 22 · see citing works
Moscato, P., Berretta, R. E., Hourani, M., Mendes, A. S., & Cotta, C. (2005) · Lecture notes in computer science · doi:10.1007/978-3-540-32003-6_9 · Cited by 20 · see citing works
Kirkwood, C. M., MacDonald, M. L., Schempf, T. A., Vatsavayi, A. V. V., Ikonomović, M. D., Koppel, J. L., Ding, Y., Sun, M., Kofler, J., López, O. L., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv018 · Cited by 18 · see citing works
Clinical biomarkers for Lewy body diseases
Abdelmoaty, M. M., Lu, E., Kadry, R., Foster, E. G., Bhattarai, S., Mosley, R. L., & Gendelman, H. E. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01152-x · Cited by 16 · see citing works
The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction
Kerrigan, T. L., Whitcomb, D. J., Regan, P. L., & Cho, K. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00057 · Cited by 16 · see citing works
Freitas, N. L., Deus, J. V. C., Sampaio, K., Gomes, Y. C. P., Torres, R. C., Brandão, C. O., Soares, C., Silva, M. T. T., & Espíndola, O. D. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-08632-9 · Cited by 13 · see citing works
Cho, S. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042211 · Cited by 12 · see citing works
Kawakami, M. (2013) · Brain Sciences · doi:10.3390/brainsci3031325 · Cited by 12 · see citing works
Novel CSF Biomarkers Tracking Autoimmune Inflammatory and Neurodegenerative Aspects of CNS Diseases
Kapaki, E. N., Vakrakou, A. G., & Boufidou, F. (2022) · Diagnostics · doi:10.3390/diagnostics13010073 · Cited by 11 · see citing works
Baksheeva, V. E., Tsvetkov, P. O., Zalevsky, A. O., Vladimirov, V. I., Gorokhovets, N. V., Zinchenko, D. V., Permyakov, S. E., Devred, F., & Zernii, E. Y. (2022) · Biomolecules · doi:10.3390/biom12070956 · Cited by 11 · see citing works
Effects of cyclosporin A administration on gene expression in rat brain
Kawakami, M., Yoshimoto, T., Nakagata, N., Yamamura, K., & Siesjö, B. K. (2011) · Brain Injury · doi:10.3109/02699052.2011.571229 · Cited by 9 · see citing works
Zhou, B., Yang, W., Ji, J., & Ru, B. (2003) · Journal of Proteome Research · doi:10.1021/pr034014q · Cited by 9 · see citing works
Proteins linked to spatial memory formation of CD1 mice in the multiple T‐maze
Patil, S. S., Li, K., Heo, S., Höger, H., & Lübec, G. (2011) · Hippocampus · doi:10.1002/hipo.20956 · Cited by 8 · see citing works
Cerebrospinal Fluid Biomarkers in the Evaluation of Alzheimer Disease
Verbeek, M. M., & Rikkert, M. G. M. O. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.113027 · Cited by 5 · see citing works
Calcium Regulation by EF-hand Protein in the Brain
Leclerc, E., Sturchler, E., & Heizmann, C. W. (2009) · Springer eBooks · doi:10.1007/978-0-387-30370-3_27 · Cited by 2 · see citing works
Some Notes on Visinin-Like Protein 1 and Alzheimer Disease
Bernstein, H., & Braunewell, K. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.116970 · Cited by 2 · see citing works
Self-citationDrebrin is a novel biomarker of cognitive deterioration in Alzheimer's disease
Shoji, M., Kawarabayashi, T., Nakamura, T., Sugawara, T., Ishizawa, K., Amari, M., Takahashi, R., Kasahara, H., Koganezawa, N., Higa, A., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877251404412 · Cited by 1 · see citing works
EF-Hand Proteins and Calcium Sensing: The Neuronal Calcium Sensors
Weiss, J. L., & Burgoyne, R. D. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50497-6 · Cited by 1 · see citing works
Gururaj Joshi, A. (2006) · UKnowledge (University of Kentucky)
Novel Genes in Mesodermal Development
Ola, R. (2012) · Työväentutkimus Vuosikirja
Genomic clues to secondary injury mechanisms in brain trauma
von Gertten, C. (2006) · Figshare
Enslen, B. (2025) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/81re-z060
Kirkwood, C. M. (2015) · D-Scholarship@Pitt (University of Pittsburgh)
Molecular Biomarkers for Diagnosis & Therapies of Alzheimer’s Disease
Potdar, P. D., & Shetti, A. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.4.433
The Search for Biomarkers in Alzheimer's Disease
Meiliana, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.107
EF-Hand Proteins and Calcium Sensing
Haynes, L. P., & Burgoyne, R. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00122-4
Braunewell, K. (2009) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a004095.01
Self-citationPerkovic, M. N., Leko, M. B., Erjavec, G. N., Milos, T., Vuic, B., Borovečki, F., Šimić, G., & Pivac, N. (2025) · Brain Mechanisms · doi:10.1016/j.bramec.2025.202495
Wang, Y., Yu, S., Zhang, M., Zhu, H., Chen, S., Zhou, Y., Zhou, X., Sun, Z., Yu, X., Zhu, X., et al. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251331000
Biomarkers as Outcome Measures in Clinical Trials of Alzheimer Disease
Tarawneh, R. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-80849-4_15
Halbgebauer, S., Steinacker, P., Riedel, D., Oeckl, P., Anderl-Straub, S., Lombardi, J., Arnim, C. A. F. V., Nagl, M., Giese, A., Ludolph, A. C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21622142
Figueiredo, G. E. (2009) · Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)
- Authors
- Schnurra, I., Bernstein, H.-G., Riederer, P., & Braunewell, K.-H.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Würzburg (DE)
- Humboldt-Universität zu Berlin (DE)
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 8
- Issue
- 5
- Pages
- 900-909
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2089804237
- Cited by
- 76
- References
- 46
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 4 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 2 · 2013: 3 · 2012: 6
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- College of Environmental Science and Forestry, State University of New York
- Deutsche Forschungsgemeinschaft (Br-1579/2-1, Br-1579/3-1)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- VILIP-1, neuronal calcium sensor proteins, Alzheimer's disease, amyloid plaques, neurofibrillary tangles, tau hyperphosphorylation, calbindin-D28k, ionomycin, PC12 cells, neuronal cell death
- MeSH terms
- Alzheimer Disease, Animals, Brain, Brain Chemistry, Calcium, Calcium-Binding Proteins, Humans, Ionophores, Nerve Tissue Proteins, Phosphorylation, Protein Processing, Post-Translational, Rabbits, Recombinant Fusion Proteins, Transfection, Ionomycin, PC12 Cells, Neurofibrillary Tangles, tau Proteins, Calcium Signaling, Receptors, Calcium-Sensing, Rats, Neurocalcin, Plaque, Amyloid, Calbindins, S100 Calcium Binding Protein G, Calbindin 1
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