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Cited by 322

The DOI matches its Crossref record; 231 of the 231 references it cites were found in a registry or an index.

The Genomic Action Potential

Clayton, David F·2000·Neurobiology of Learning and Memory
DOI 10.1006/nlme.2000.3967
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Abstract

Neurons compute in part by integrating, on a time scale of milliseconds, many synaptic inputs and generating a digital output-the "action potential" of classic electrophysiology. Recent discoveries indicate that neurons also perform a second, much slower, integration operating on a time scale of minutes or even hours. The output of this slower integration involves a pulse of gene expression which may be likened to the electrophysiological action potential. Its function, however, is not directed toward immediate transmission of a synaptic signal but rather toward the experience-dependent modification of the underlying synaptic circuitry. Commonly termed the "immediate early gene" (IEG) response, this phenomenon is often assumed to be a necessary component of a linear, deterministic cascade of memory consolidation. Critical review of the large literature describing the phenomenon, however, leads to an alternative model of IEG function in the brain. In this alternative, IEG activation is not directed at the consolidation of memories of a specific inducing event; instead, it sets the overall gain or efficiency of memory formation and directs it to circuits engaged by behaviorally significant contexts. The net result is a sharpening of the selectivity of memory formation, a recruitment of temporally correlated associations, and an ultimate enhancement of long-term memory retrieval.

Overview

Integrity signals

Registry

Crossref · 10.1006/nlme.2000.3967

Cites

231 of 231 references verified0 citation errors · 0 not checkable

Statistics

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Verification

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Citations

Cites

Cited by

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Metadata

Authors
Clayton, D. F.
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2000-11
Volume
74
Issue
3
Pages
185-216
ISSN
1074-7427
DOI
10.1006/nlme.2000.3967
Cited by
322
References
231
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.