Reactive oxygen species and mitochondrial diseases

Hydroperoxide metabolism in mammalian organs.

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Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy

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Mitochondrial Complex I Deficiency in Parkinson's Disease

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Oxidative damage and mitochondrial decay in aging.

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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

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Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

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Abnormalities of the electron transport chain in idiopathic parkinson's disease

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Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

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Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia

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Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

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Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

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Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction

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Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication

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Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

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Nitric oxide and mitochondrial respiration

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The Fenton reagents

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Mitochondrial disease in mouse results in increased oxidative stress

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Peroxynitrite‐mediated oxidative protein modifications

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Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

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Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

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Production of Nitric Oxide by Mitochondria

Giulivi, C., Poderoso, J. J., & Boveris, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11038 · Cited by 575

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

Brown, G. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00763-y · Cited by 540

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531

Do Mitochondria Produce Oxygen Radicals in vivo?

NOHL, H., & HEGNER, D. (1978) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1978.tb12051.x · Cited by 523

Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

Bolaños, J. P., Heales, S. J. R., Land, J. M., & Clark, J. B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64051965.x · Cited by 492

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

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A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

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The effect of hyperoxia on superoxide production by lung submitochondrial particles

Turrens, J. F., Freeman, B. A., Levitt, J. G., & Crapo, J. D. (1982) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(82)90518-5 · Cited by 448

Exercise Intolerance Due to Mutations in the Cytochrome b Gene of Mitochondrial DNA

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Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

Tu, P. H., Raju, P., Robinson, K. A., Gurney, M. E., Trojanowski, J. Q., & Lee, V. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3155 · Cited by 415

Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

Pitkanen, S., & Robinson, B. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118798 · Cited by 388

Titrating the Effects of Mitochondrial Complex I Impairment in the Cell Physiology

Barrientos, A., & Moraes, C. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16188 · Cited by 383

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

WANAGAT, J., CAO, Z., PATHARE, P., & AIKEN, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0320com · Cited by 378

The Molecular and Genetic Basis of Neurological Disease

TROJANOWSKI, J. Q. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199309000-00013 · Cited by 341

Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

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Mitochondrial Nitric-oxide Synthase Stimulation Causes Cytochrome c Release from Isolated Mitochondria

Ghafourifar, P., Schenk, U., Klein, S. D., & Richter, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31185 · Cited by 328

Purification and Characterization of a Nitric-oxide Synthase from Rat Liver Mitochondria

Tatoyan, A., & Giulivi, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11044 · Cited by 327

Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease

Brookes, P. S., Salinas, E. P., Darley-Usmar, K., Eiserich, J. P., Freeman, B. A., Darley-Usmar, V. M., & Anderson, P. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001077200 · Cited by 321

Mitochondrial involvement in Parkinson’s disease, Huntington’s disease, hereditary spastic paraplegia and Friedreich’s ataxia

Schapira, A. H. V. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00164-9 · Cited by 310

Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.

Murphy, M. E., & Sies, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10860 · Cited by 303

The role of glutathione in the transport and catabolism of nitric oxide

Hogg, N., Singh, R. J., & Kalyanaraman, B. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00086-5 · Cited by 274

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

Wang, Y., Michikawa, Y., Mallidis, C., Bai, Y., Woodhouse, L., Yarasheski, K. E., Miller, C. A., Askanas, V., Engel, W. K., Bhasin, S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061013598 · Cited by 271

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

Cassarino, D. S., Fall, C. P., Swerdlow, R. H., Smith, T. S., Halvorsen, E. M., Miller, S. W., Parks, J. P., Parker, W. D., & Bennett, J. P. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(97)00070-7 · Cited by 265

Age‐Dependent Impairment of Mitochondrial Function in Primate Brain

Bowling, A. C., Mutisya, E. M., Walker, L. C., Price, D. L., Cork, L. C., & Beal, M. H. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13430.x · Cited by 264

Tyrosine Modifications and Inactivation of Active Site Manganese Superoxide Dismutase Mutant (Y34F) by Peroxynitrite

MacMillan-Crow, L. A., & Thompson, J. A. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1202 · Cited by 229

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson’s disease

Merad-Boudia, M., Nicole, A., Santiard-Baron, D., Saillé, C., & Ceballos-Picot, I. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00647-3 · Cited by 226

Human complex I deficiency: Clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect

Robinson, B. H. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00033-4 · Cited by 223

Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain

Mecocci, P., Beal, M. F., Cecchetti, R., Polidori, M. C., Cherubini, A., Chionne, F., Avellini, L., Romano, G., & Senin, U. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815160 · Cited by 215

Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism

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Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids

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Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex

Polidori, M. C., Mecocci, P., Browne, S. E., Senin, U., & Beal, M. F. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00578-9 · Cited by 211

Mitochondrial dysfunction in neurodegenerative disorders

Schapira, A. H. V. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00115-7 · Cited by 209

Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite

SHARPE, M. A., & COOPER, C. E. (1998) · Biochemical Journal · doi:10.1042/bj3320009 · Cited by 203

Neuroprotective Properties of Nitric Oxide

CHIUEH, C. C. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08007.x · Cited by 199

Human Xenomitochondrial Cybrids

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The Regulation of Mitochondrial Oxygen Uptake by Redox Reactions Involving Nitric Oxide and Ubiquinol

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The Molecular and Genetic Basis of Neurological Disease.

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Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system.

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A Familial Amyotrophic Lateral Sclerosis-associated A4V Cu,Zn-Superoxide Dismutase Mutant Has a Lower K for Hydrogen Peroxide

Yim, H., Kang, J., Chock, P. B., Stadtman, E. R., & Yim, M. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8861 · Cited by 149

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

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Occurrence of a Particular Base Substitution (3243 A to G) in Mitochondrial DNA of Tissues of Ageing Humans

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Astrocyte‐Derived Nitric Oxide Causes Both Reversible and Irreversible Damage to the Neuronal Mitochondrial Respiratory Chain

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Mitochondrial toxins in models of neurodegenerative diseases. I: in vivo brain hydroxyl radical production during sytemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions

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Peroxynitrite and Brain Mitochondria: Evidence for Increased Proton Leak

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An out-of-frame cytochromeb gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production

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Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

Packer, M. A., Porteous, C. M., & Murphy, M. P. (1996) · IUBMB Life · doi:10.1080/15216549600201103 · Cited by 118

Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice

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Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischaemic pathologies

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Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency.

Luo, X., Pitkänen, S., Kassovska‐Bratinova, S., Robinson, B. H., & Lehotay, D. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119481 · Cited by 96

Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome

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Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischaemic pathologies

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Chapter 19 Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture

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Mitochondrial Dysfunction in Neurodegenerative Diseases

Schapira, A. H. V. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9855-x · Cited by 85

Peroxynitrite formed by mitochondrial NO synthase promotes mitochondrial Ca2+ release

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Advanced Telomere Shortening in Respiratory Chain Disorders

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Lacticacidemia

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Accumulation of Deletions and Point Mutations in Mitochondrial Genome in Degenerative Diseases

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Overproduction of Cu/Zn-Superoxide Dismutase or Bcl-2 Prevents the Brain Mitochondrial Respiratory Dysfunction Induced by Glutathione Depletion

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Molecular genetics and pathogenesis of Friedreich ataxia

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Defective intramitochondrial NADH oxidation in skin fibroblasts from an infant with fatal neonatal lacticacidemia.

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In vivo hydroxyl radical generation in the striatum following systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

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Large-scale mitochondrial DNA deletions in skeletal muscle of patients with end-stage renal disease

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Synergistic Depletion of Astrocytic Glutathione by Glucose Deprivation and Peroxynitrite: Correlation with Mitochondrial Dysfunction and Subsequent Cell Death

Ju, C., Yoon, K., Oh, Y., Kim, H., Shin, C.-Y., Ryu, J. R., Ko, K. H., & Kim, W. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741989.x · Cited by 50

Mitochondrial DNA damage and altered membrane potential ([Delta ][Psi ]) in pancreatic acinar cells induced by reactive oxygen species

Ehlers, R. A., Hernandez, A., Bloemendal, L. S., Ethridge, R. T., Farrow, B. J., & Evers, B. M. (1999) · Surgery · doi:10.1067/msy.1999.98725 · Cited by 44

Dysfunctional mitochondrial respiration in the wobbler mouse brain

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Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle

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Apolipoprotein E Level in Cerebrospinal Fluid Increases With Aging

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Diagnosis of mitochondrial energy metabolism defects in tissue culture. Induction of MnSOD and bcl‐2 in mitochondria from patients with complex I (NADH‐CoQ reductase) deficiency

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INCREASED OXIDATIVE DAMAGE IN LYMPHOCYTES OF ALZHEIMER'S DISEASE PATIENTS

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Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights substrates of disability

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Increased activity of surviving locus ceruleus neurons in Alzheimer's disease

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Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism

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The Role of Oxidative Stress in Parkinson's Disease

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Toxicity of nanomaterials

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Determination of Antioxidants by DPPH Radical Scavenging Activity and Quantitative Phytochemical Analysis of Ficus religiosa

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ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

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