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Cited by 128Stress Responses and CortisolSex and Gender in HealthcareChild and Adolescent Psychosocial and Emotional Development

Seeing the unexpected: How sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders

Klein, Laura Cousino, Corwin, Elizabeth J.·2002·Current Psychiatry Reports
DOI 10.1007/s11920-002-0072-z
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Abstract

In this report, the authors propose that underlying sex differences in the biobehavioral response to stress may contribute to the variance in prevalence of some psychiatric disorders based on sex. The authors begin with a discussion of stress physiology and review a new theory on sex differences in stress responses (ie, the "tend-and-befriend" response), which may provide a recent framework for considering sex differences in the manifestation of some psychiatric illnesses. The authors then move to a discussion of major depression and attention deficit hyperactivity disorder as examples of how sex differences in stress responses may influence the behavioral symptoms of psychiatric disorders that are more often diagnosed in one sex compared with another. The authors conclude with a brief discussion of the implications of this new perspective on treatment approaches and encourage further inquiry into the importance of sex-based differences in the behavioral manifestation of some psychiatric illnesses.

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  • Disorders that first manifest in childhood are usually more prevalent in boys, and this is true for autism spectrum disorders (ASD).

    “Another general distinction with respect to prevalence, is that disorders that first manifest in childhood are usually more prevalent in boys. This is true for autism spectrum disorders (ASD) (10, 11).”

    From Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness (2022) · cites this paper as [10]

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Authors
Klein, L. C., & Corwin, E. J.
Affiliations
Pennsylvania State University (US)
ORCID
Venue
Current Psychiatry Reports
Publisher
Springer Science and Business Media LLC
Published
2002-11
Volume
4
Issue
6
Pages
441-448
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
DOI
10.1007/s11920-002-0072-z
OpenAlex
W2094159484
Cited by
128
References
86
Citations by year
2026: 2 · 2024: 13 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 11 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 12 · 2012: 3
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Psychiatry Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
sex differences, stress response, stress physiology, major depressive disorder, attention deficit hyperactivity disorder, sex differences in prevalence
MeSH terms
Adrenocorticotropic Hormone, Aggression, Attention Deficit Disorder with Hyperactivity, Autonomic Nervous System, Mental Disorders, Major Depressive Disorder, Depressive Disorder, Major, Estrogens, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Life Change Events, Male, Oxytocin, Pituitary-Adrenal System, Sex Factors, Sleep Wake Disorders, Cytokines, Substance-Related Disorders

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