Animal Paradigms to Assess Cognition with Translation to Humans
Abstract
Cognition is a complex brain function that represents processes such as learning and memory, attention, working memory, and executive functions amongst others. Impairments in cognition are prevalent in many neuropsychiatric and neurological disorders with few viable treatment options. The development of new therapies is challenging, and poor efficacy in clinical development continues to be one of the most consistent reasons compounds fail to advance, suggesting that traditional animal models are not predictive of human conditions and behavior. An effort to improve the construct validity of neuropsychological testing across species with the intent of facilitating therapeutic development has been strengthening over recent years. With an emphasis on understanding the underlying biology, optimizing the use of appropriate systems (e.g., transgenic animals) to model targeted disease states, and incorporating non-rodent species (e.g., non-human primates) that may enable a closer comparison to humans, an improvement in the translatability of the results will be possible. This chapter focuses on some promising translational cognitive paradigms for use in rodents, non-human primates, and humans.
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Using appropriate cognitive paradigms in rodents is effective for exploring pharmacological action, underlying mechanisms, and anticipating side effects.
“In preclinical study, using appropriate cognitive paradigms in rodents are effective for pharmacological action and the underlying mechanisms exploration, as well as side effects anticipation (23).”
Cites
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · see citing works
Abnormal neural oscillations and synchrony in schizophrenia
Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120 · see citing works
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · see citing works
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466 · see citing works
Localization of a human system for sustained attention by positron emission tomography
Pardo, J. V., Fox, P. T., & Raichle, M. E. (1991) · Nature · doi:10.1038/349061a0 · Cited by 1,284 · see citing works
Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755 · see citing works
The Neuroscience of Mammalian Associative Learning
Fanselow, M. S., & Poulos, A. M. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070213 · Cited by 683 · see citing works
Prefrontal mechanisms in extinction of conditioned fear
Quirk, G. J., Garcia, R., & González-Lima, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.010 · Cited by 682 · see citing works
Wang, M., Ramos, B. P., Paspalas, C. D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Brennan, A., Dudley, A., Nou, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.015 · Cited by 672 · see citing works
Fear extinction in rats: Implications for human brain imaging and anxiety disorders
Milad, M. R., Rauch, S. L., Pitman, R. K., & Quirk, G. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.008 · Cited by 597 · see citing works
Coull, J. T., Frith, C. D., Frackowiak, R. S. J., & Grasby, P. M. (1996) · Neuropsychologia · doi:10.1016/0028-3932(96)00029-2 · Cited by 566 · see citing works
Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538 · see citing works
Frontal lesions and sustained attention
Wilkins, A. J., Shallice, T., & McCarthy, R. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90024-8 · Cited by 450 · see citing works
Swainson, R., Hodges, J. R., Galton, C. J., Semple, J., Michael, A., Dunn, B. D., Iddon, J. L., Robbins, T. W., & Sahakian, B. J. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051269 · Cited by 375 · see citing works
Is Pharma Running Out of Brainy Ideas?
Miller, G. (2010) · Science · doi:10.1126/science.329.5991.502 · Cited by 284 · see citing works
Riby, D. M., & Hancock, P. J. B. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0641-z · Cited by 259 · see citing works
Gamo, N. J., Wang, M., & Arnsten, A. F. T. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.015 · Cited by 232 · see citing works
Sahakian, B. J., Owen, A. M., Morant, N. J., Eagger, S. A., Boddington, S., Crayton, L., Crockford, H. A., Crooks, M., Hill, K., & Levy, R. (1993) · Psychopharmacology · doi:10.1007/bf02244644 · Cited by 226 · see citing works
McGaughy, J., & Sarter, M. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1519 · Cited by 147 · see citing works
Vicarious reinforcement in rhesus macaques (Macaca Mulatta)
Chang, S. W. C., Winecoff, A. A., & Platt, M. L. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00027 · Cited by 124 · see citing works
Effects of guanfacine on three forms of distraction in the aging macaque
O'Neill, J., Fitten, L. J., Siembieda, D. W., Ortiz, F., & Halgren, E. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00681-0 · Cited by 32 · see citing works
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Jian-min, C., Zhi-yuan, W., Shi-xuan, W., Rui, S., Ning, W., & Jin, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.885574 · Cited by 7 · see citing works
“In preclinical study, using appropriate cognitive paradigms in rodents are effective for pharmacological action and the underlying mechanisms exploration, as well as side effects anticipation (23).”
Background
- Authors
- Wallace, T. L., Ballard, T. M., & Glavis-Bloom, C.
- Affiliations
- SRI International (US)
- F. Hoffmann-La Roche AG (CH)
- Corresponding author
- Wallace, Tanya L.
- Venue
- Handbook of Experimental Pharmacology
- Publisher
- Springer International Publishing
- Published
- 2015
- Volume
- 228
- Pages
- 27-57
- ISSN
- 0171-2004 (ISSN-L)
- 1865-0325
- OpenAlex
- W213386604
- Cited by
- 26
- References
- 21
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4
- FWCI
- 17.66
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Handbook of experimental pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- cognitive paradigm, animal models of cognition, translational research, construct validity, neuropsychological assessment, transgenic animals, non-human primates, rodents, cognitive impairment, neuropsychiatric disorders, neurological disorders
- MeSH terms
- Animals, Attention, Behavior, Animal, Mental Disorders, Brain, Cognition, Cognition Disorders, Disease Models, Animal, Electrocardiography, Eye Movements, Humans, Magnetic Resonance Imaging, Memory, Neuropsychological Tests, Predictive Value of Tests, Cognitive Behavioral Therapy, Nootropic Agents, Executive Function, Translational Research, Biomedical
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