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Cited by 152Pancreatic function and diabetesIon channel regulation and functionIon Transport and Channel Regulation

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Electrophysiology of Islet Cells

Drews, Gisela, Krippeit-Drews, Peter, Düfer, Martina·2010·Advances in Experimental Medicine and Biology
DOI 10.1007/978-90-481-3271-3_7
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Abstract

Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical activity. Changes of the membrane potential (V(m)) are regulated by metabolism-dependent alterations in ion channel activity. This coupling is best explored in beta-cells. The effect of glucose is directly linked to mitochondrial metabolism as the ATP/ADP ratio determines the open probability of ATP-sensitive K(+) channels (K(ATP) channels). Nucleotide sensitivity and concentration in the direct vicinity of the channels are controlled by several factors including phospholipids, fatty acids, and kinases, e.g., creatine and adenylate kinase. Closure of K(ATP) channels leads to depolarization of beta-cells via a yet unknown depolarizing current. Ca(2+) influx during action potentials (APs) results in an increase of the cytosolic Ca(2+) concentration ([Ca(2+)](c)) that triggers exocytosis. APs are elicited by the opening of voltage-dependent Na(+) and/or Ca(2+) channels and repolarized by voltage- and/or Ca(2+)-dependent K(+) channels. At a constant stimulatory glucose concentration APs are clustered in bursts that are interrupted by hyperpolarized interburst phases. Bursting electrical activity induces parallel fluctuations in [Ca(2+)](c) and insulin secretion. Bursts are terminated by I(Kslow) consisting of currents through Ca(2+)-dependent K(+) channels and K(ATP) channels. This review focuses on structure, characteristics, physiological function, and regulation of ion channels in beta-cells. Info…

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Metadata

Authors
Drews, G., Krippeit-Drews, P., & Düfer, M.
Affiliations
University of Tübingen (DE)
Corresponding author
Drews, Gisela
ORCID
Venue
Advances in Experimental Medicine and Biology
Publisher
Springer Netherlands
Published
2010
Volume
654
Pages
115-163
ISSN
0065-2598 (ISSN-L)
DOI
10.1007/978-90-481-3271-3_7
OpenAlex
W1886288445
Cited by
152
References
0
Citations by year
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FWCI
135.74
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
pancreatic beta cells, stimulus-secretion coupling, ATP-sensitive potassium channels, beta-cell electrical activity, glucose-stimulated insulin secretion, L-type calcium channels, oxidative stress, alpha cells, delta cells, ion channels, membrane potential, exocytosis, voltage-gated sodium channels
MeSH terms
Adenosine Triphosphate, Animals, Calcium, Cell Membrane, Electrophysiology, Glucose, Humans, Ion Channels, Islets of Langerhans, Membrane Potentials, Oscillometry, Potassium Channels, Mice, Knockout, Oxidative Stress, Mice

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