Cited by 20Microbial Metabolic Engineering and BioproductionAlgal biology and biofuel productionMetalloenzymes and iron-sulfur proteins

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Rewiring of Cyanobacterial Metabolism for Hydrogen Production: Synthetic Biology Approaches and Challenges

Krishnan, Anagha, Qian, Xiao, Ananyev, Gennady, Lun, Desmond S., Dismukes, G. Charles·2018·Advances in Experimental Medicine and Biology

DOI 10.1007/978-981-13-0854-3_8

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Abstract

With the demand for renewable energy growing, hydrogen (H 2 ) is becoming an attractive energy carrier. Developing H 2 production technologies with near-net zero carbon emissions is a major challenge for the "H 2 economy." Certain cyanobacteria inherently possess enzymes, nitrogenases, and bidirectional hydrogenases that are capable of H 2 evolution using sunlight, making them ideal cell factories for photocatalytic conversion of water to H 2 . With the advances in synthetic biology, cyanobacteria are currently being developed as a "plug and play" chassis to produce H 2 . This chapter describes the metabolic pathways involved and the theoretical limits to cyanobacterial H 2 production and summarizes the metabolic engineering technologies pursued.

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Authors: Krishnan, A., Qian, X., Ananyev, G., Lun, D. S., & Dismukes, G. C.
Affiliations: University of Alberta (CA)
Rutgers, The State University of New Jersey (US)
Corresponding author: Dismukes, G. Charles
ORCID: Krishnan, Anagha
Lun, Desmond S.
Dismukes, G. Charles
Venue: Advances in Experimental Medicine and Biology
Publisher: Springer Singapore
Published: 2018
Volume: 1080
Pages: 171-213
ISSN: 0065-2598 (ISSN-L)
2214-8019
DOI: 10.1007/978-981-13-0854-3_8
OpenAlex: W2886991948
Cited by: 20
References: 231
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2
FWCI: 3.37
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
Keywords: cyanobacteria, hydrogen production, metabolic engineering, synthetic biology, nitrogenase, bidirectional hydrogenase, photocatalytic water splitting, chassis organisms
MeSH terms: Cyanobacteria, Hydrogen, Synthetic Biology, Metabolic Engineering

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Rewiring of Cyanobacterial Metabolism for Hydrogen Production: Synthetic Biology Approaches and Challenges

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