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Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

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DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

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Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

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Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

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Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

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Induction of calcium-dependent nitric oxide synthases by sex hormones.

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Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

Lowenstein, C. J., Alley, E. W., Raval, P., Snowman, A. M., Snyder, S. H., Russell, S. W., & Murphy, W. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9730 · Cited by 1,064

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

Lamas, S., Marsden, P. A., Li, G. K., Tempst, P., & Michel, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6348 · Cited by 982

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 980

Nitric oxide in skeletal muscle

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Robbins, R. C., McManus, R. P., Mitchell, R. S., Latter, D. R., Moon, M. R., Olinger, G. N., & Miller, D. C. (1993) · PubMed · Cited by 892

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

Marsden, P. A., Heng, H. H., Scherer, S. W., Stewart, R. J., Hall, A. V., Shi, X. M., Tsui, L. C., & Schappert, K. T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85359-0 · Cited by 871

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

Lyons, C. R., Orloff, G. J., & Cunningham, J. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42704-4 · Cited by 864

Nitric oxide synthase: Aspects concerning structure and catalysis

Marletta, M. A. (1994) · Cell · doi:10.1016/0092-8674(94)90268-2 · Cited by 854

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

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Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

Geller, D. A., Lowenstein, C. J., Shapiro, R. A., Nussler, A. K., Di Silvio, M., Wang, S. C., Nakayama, D. K., Simmons, R. L., Snyder, S. H., & Billiar, T. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3491 · Cited by 821

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

Scheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.943 · Cited by 819

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

Kobzik, L., Bredt, D. S., Lowenstein, C. J., Drazen, J., Gaston, B., Sugarbaker, D., & Stamler, J. S. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/9.4.371 · Cited by 810

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life

Yoshizumi, M., Perrella, M. A., Burnett, J. C., & Lee, M. E. (1993) · Circulation Research · doi:10.1161/01.res.73.1.205 · Cited by 771

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

TRUSS, M., & BEATO, M. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-4-459 · Cited by 741

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S. P., Uematsu, M., Nerem, R. M., Alexander, R. W., & Murphy, T. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116092 · Cited by 735

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

Geller, D. A., Nussler, A. K., Di Silvio, M., Lowenstein, C. J., Shapiro, R. A., Wang, S. C., Simmons, R. L., & Billiar, T. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.522 · Cited by 665

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

Vodovotz, Y., Bogdan, C., Paik, J., Xie, Q. W., & Nathan, C. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.2.605 · Cited by 655

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

Dinerman, J. L., Dawson, T. M., Schell, M. J., Snowman, A., & Snyder, S. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4214 · Cited by 649

Calmodulin is a subunit of nitric oxide synthase from macrophages.

Cho, H. J., Xie, Q. W., Calaycay, J., Mumford, R. A., Swiderek, K. M., Lee, T. D., & Nathan, C. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.2.599 · Cited by 634

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

Schmidt, H. H., Gagne, G. D., Nakane, M., Pollock, J. S., Miller, M. F., & Murad, F. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.10.1382087 · Cited by 610

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

Lowenstein, C. J., Glatt, C. S., Bredt, D. S., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6711 · Cited by 604

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

Janssens, S. P., Shimouchi, A., Quertermous, T., Bloch, D. B., & Bloch, K. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42066-2 · Cited by 592

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

Förstermann, U., Pollock, J. S., Schmidt, H. H., Heller, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1788 · Cited by 592

Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells.

Asano, K., Chee, C. B., Gaston, B., Lilly, C. M., Gerard, C., Drazen, J. M., & Stamler, J. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10089 · Cited by 587

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

Nakane, M., Schmidt, H. H. H. W., Pollock, J. S., Förstermann, U., & Murad, F. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81210-q · Cited by 546

Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women.

Gilligan, D. M., Quyyumi, A. A., & Cannon, R. O. (1994) · Circulation · doi:10.1161/01.cir.89.6.2545 · Cited by 544

Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase

Liao, J. K., Shin, W. S., Lee, W. Y., & Clark, S. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.319 · Cited by 541

Macrophage deactivating factor and transforming growth factors- beta 1 - beta 2 and - beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

Ding, A., Nathan, C. F., Graycar, J., Derynck, R., Stuehr, D. J., & Srimal, S. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.3.940 · Cited by 500

Molecular cloning and characterization of human endothelial nitric oxide synthase

Marsden, P. A., Schappert, K. T., Chen, H. S., Flowers, M., Sundell, C. L., Wilcox, J. N., Lamas, S., & Michel, T. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80697-f · Cited by 489

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

Akerblom, I. E., Slater, E. P., Beato, M., Baxter, J. D., & Mellon, P. L. (1988) · Science · doi:10.1126/science.2838908 · Cited by 481

Role of interferon regulatory factor 1 in induction of nitric oxide synthase.

Martin, E., Nathan, C., & Xie, Q. W. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.3.977 · Cited by 477

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

Willott, E., Balda, M. S., Fanning, A. S., Jameson, B., Van Itallie, C., & Anderson, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7834 · Cited by 468

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

Sessa, W. C., Harrison, J. K., Barber, C. M., Zeng, D., Durieux, M. E., D'Angelo, D. D., Lynch, K. R., & Peach, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49528-8 · Cited by 467

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

Hevel, J. M., White, K. A., & Marletta, M. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54421-5 · Cited by 455

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

Di Rosa, M., Radomski, M., Carnuccio, R., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91583-e · Cited by 453

Purification of a Ca2+/calmodulin‐dependent nitric oxide synthase from porcine cerebellum: Cofactor‐role of tetrahydrobiopterin

Mayer, B., John, M., & Böhme, E. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80848-d · Cited by 449

Nuclear Receptor/AP-1 Interaction*

PFAHL, M. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-5-651 · Cited by 446

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

Chartrain, N. A., Geller, D. A., Koty, P. P., Sitrin, N. F., Nussler, A. K., Hoffman, E. P., Billiar, T. R., Hutchinson, N. I., & Mudgett, J. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37441-0 · Cited by 394

Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.

Weiss, G., Goossen, B., Doppler, W., Fuchs, D., Pantopoulos, K., Werner‐Felmayer, G., Wachter, H., & Hentze, M. W. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06039.x · Cited by 389

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

Cunha, F. Q., Mohcada, S., & Liew, F. Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91852-h · Cited by 383

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

Schmidt, H. H., Pollock, J. S., Nakane, M., Gorsky, L. D., Förstermann, U., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.365 · Cited by 381

Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms

McQuillan, L. P., Leung, G. K., Marsden, P. A., Kostyk, S. K., & Kourembanas, S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.5.h1921 · Cited by 375

Expression of Inducible Nitric Oxide in Human Lung Epithelial Cells

Robbins, R. A., Barnes, P. J., Springall, D. R., Warren, J. B., Kwon, O. J., Buttery, L. D. K., Wilson, A. J., Geller, D. A., & Polak, J. M. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2169 · Cited by 341

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.

Michel, T., Li, G. K., & Busconi, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6252 · Cited by 323

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

Nunokawa, Y., Ishida, N., & Tanaka, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1188 · Cited by 317

Structural organization of the human neuronal nitric oxide synthase gene (NOS1)

Hall, A. V., Antoniou, H., Wang, Y., Cheung, A. H., Arbus, A. M., Olson, S. L., Lu, W. C., Kau, C. L., & Marsden, P. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30099-5 · Cited by 297

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

Charles, I. G., Palmer, R. M., Hickery, M. S., Bayliss, M. T., Chubb, A. P., Hall, V. S., Moss, D. W., & Moncada, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11419 · Cited by 291

Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells

Peunova, N., & Enikolopov, G. (1993) · Nature · doi:10.1038/364450a0 · Cited by 286

Nitric Oxide Destroys Zinc-Sulfur Clusters Inducing Zinc Release from Metallothionein and Inhibition of the Zinc Finger-Type Yeast Transcription Activator LAC9

Kroncke, K. D., Fehsel, K., Schmidt, T., Zenke, F. T., Dasting, I., Wesener, J. R., Bettermann, H., Breunig, K. D., & Kolbbachofen, V. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1564 · Cited by 278

Endogenous and Exogenous Nitric Oxide Inhibits Norepinephrine Release From Rat Heart Sympathetic Nerves

Schwarz, P., Diem, R., Dun, N. J., & Förstermann, U. (1995) · Circulation Research · doi:10.1161/01.res.77.4.841 · Cited by 275

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

Nakane, M., Mitchell, J., Förstermann, U., & Murad, F. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81351-8 · Cited by 274

Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed.

Lamontagne, D., Pohl, U., & Busse, R. (1992) · Circulation Research · doi:10.1161/01.res.70.1.123 · Cited by 253

Up-regulation of nitric oxide synthase (NOS) gene expression together with NOS activity in the rat hypothalamo-hypophysial system after chronic salt loading: evidence of a neuromodulatory role of nitric oxide in arginine vasopressin and oxytocin secretion

Kadowaki, K. (1994) · Endocrinology · doi:10.1210/en.134.3.1011 · Cited by 252

Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages.

Schmidt, H. H., Warner, T. D., Nakane, M., Förstermann, U., & Murad, F. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08977-1 · Cited by 249

Pyrrolidine Dithiocarbamate Inhibits Induction of Nitric Oxide Synthase Activity in Rat Alveolar Macrophages

Sherman, M. P., Aeberhard, E. E., Wong, V. Z., Griscavage, J. M., & Ignarro, L. J. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1359 · Cited by 249

Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages

Bogdan, C., Vodovotz, Y., Paik, J., Xie, Q.-W., & Nathan, C. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.2.227 · Cited by 231

Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase Gene

Nadaud, S., Bonnardeaux, A., Lathrop, M., & Soubrier, F. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1146 · Cited by 226

Functional Analysis of the Human Endothelial Nitric Oxide Synthase Promoter

Zhang, R., Min, W., & Sessa, W. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.15320 · Cited by 225

Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide.

Griscavage, J. M., Rogers, N. E., Sherman, M. P., & Ignarro, L. J. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.11.6329 · Cited by 223

Agonist-modulated Palmitoylation of Endothelial Nitric Oxide Synthase

Robinson, L. J., Busconi, L., & Michel, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.995 · Cited by 220

Nitric oxide synthase: MRNA expression of different isoforms in human monocytes/macrophages

Reiling, N., Ulmer, A. J., Duchrow, M., Ernst, M., Flad, H., & Hauschildt, S. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240836 · Cited by 213

Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after local cerebral ischemia in rat

Gang Zhang, Z., Chopp, M., Gautman, S., Zaloga, C., Lan Zhang, R., Schmidt, H. H. H. W., Pollack, J. S., & Förstermann, U. (1994) · Brain Research · doi:10.1016/0006-8993(94)91574-1 · Cited by 198

Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line

Sherman, P. A., Laubach, V. E., Reep, B. R., & Wood, E. R. (1993) · Biochemistry · doi:10.1021/bi00094a017 · Cited by 198

Immunohistochemical localization of nitric oxide synthase in the human placenta

Myatt, L., Brockman, D. E., Eis, A. L. W., & Pollock, J. S. (1993) · Placenta · doi:10.1016/s0143-4004(05)80202-4 · Cited by 197

Nitric oxide synthase immunoreactivity in rat spinal cord

Dun, N. J., Dun, S. L., Forstermann, U., & Tseng, L. F. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90599-3 · Cited by 190

Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide

Fehsel, K., Jalowy, A., Qi, S., Burkart, V., Hartmann, B., & Kolb, H. (1993) · Diabetes · doi:10.2337/diab.42.3.496 · Cited by 188

Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines.

Koide, M., Kawahara, Y., Nakayama, I., Tsuda, T., & Yokoyama, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74557-8 · Cited by 185

HORMONE RESPONSE DOMAINS IN GENE TRANSCRIPTION

Lucas, P. C., & Granner, D. K. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005411 · Cited by 185

Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury

Wu, W., Liuzzi, F. J., Schinco, F. P., Depto, A. S., Li, Y., Mong, J. A., Dawson, T. M., & Snyder, S. H. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90394-8 · Cited by 184

Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies

Pollock, J. S., Nakane, M., Buttery, L. D., Martinez, A., Springall, D., Polak, J. M., Forstermann, U., & Murad, F. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.5.c1379 · Cited by 183

Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth

Arnal, J. F., Yamin, J., Dockery, S., & Harrison, D. G. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.5.c1381 · Cited by 183

Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.

Zhang, Z. G., Chopp, M., Zaloga, C., Pollock, J. S., & Förstermann, U. (1993) · Stroke · doi:10.1161/01.str.24.12.2016 · Cited by 178

Triggering of human monocyte activation through CD69, a member of the natural killer cell gene complex family of signal transducing receptors.

De Maria, R., Cifone, M. G., Trotta, R., Rippo, M. R., Festuccia, C., Santoni, A., & Testi, R. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.5.1999 · Cited by 176

Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy

Herdegen, T., Brecht, S., Mayer, B., Leah, J., Kummer, W., Bravo, R., & Zimmermann, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04130.1993 · Cited by 171

In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1, and glycophorin C.

Marfatia, S. M., Lue, R. A., Branton, D., & Chishti, A. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37012-6 · Cited by 166

Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.

Perrella, M. A., Yoshizumi, M., Fen, Z., Tsai, J. C., Hsieh, C. M., Kourembanas, S., & Lee, M. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36665-6 · Cited by 165

Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation after acute estrogen withdrawal.

Collins, P., Shay, J., Jiang, C., & Moss, J. (1994) · Circulation · doi:10.1161/01.cir.90.4.1964 · Cited by 165

Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.

Sessa, W. C., Barber, C. M., & Lynch, K. R. (1993) · Circulation Research · doi:10.1161/01.res.72.4.921 · Cited by 165

Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells.

Kunz, D., Mühl, H., Walker, G., & Pfeilschifter, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5387 · Cited by 164

Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-gamma and bacterial lipopolysaccharide. Transcriptional and post-transcriptional regulation.

Weisz, A., Oguchi, S., Cicatiello, L., & Esumi, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37197-1 · Cited by 163

Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages.

Dong, Z., Qi, X., Xie, K., & Fidler, I. J. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.5.2717 · Cited by 161

Cloning and structural characterization of the human endothelial nitric‐oxide‐synthase gene

Miyahara, K., Kawamoto, T., Sase, K., Yui, Y., Toda, K., Li‐Xia, Y. A. N. G., Hattori, R., Aoyama, T., Yamamoto, Y., Doi, Y., et al. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19045.x · Cited by 154

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats

Kleemann, R., Rothe, H., Kolb-Bachofen, V., Xie, Q. W., Nathan, C., Martin, S., & Kolb, H. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80954-s · Cited by 152

Low Concentration of Oxidized Low-Density Lipoprotein and Lysophosphatidylcholine Upregulate Constitutive Nitric Oxide Synthase mRNA Expression in Bovine Aortic Endothelial Cells

Hirata, K., Miki, N., Kuroda, Y., Sakoda, T., Kawashima, S., & Yokoyama, M. (1995) · Circulation Research · doi:10.1161/01.res.76.6.958 · Cited by 151

Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation.

Goureau, O., Lepoivre, M., Becquet, F., & Courtois, Y. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4276 · Cited by 148

Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity

DINERMAN, J. L., Steiner, J. P., Dawson, T. M., Dawson, V. L., & Snyder, S. H. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90023-x · Cited by 132

Nitric oxide: A signal for ADP-ribosylation of proteins

Brüne, B., Dimmeler, S., Vedia, L. M. Y., & Lapetina, E. G. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00775-6 · Cited by 131

Isolation and Chromosomal Localization of the Human Endothelial Nitric Oxide Synthase (NOS3) Gene

Robinson, L. J., Weremowicz, S., Morton, C. C., & Michel, T. M. (1994) · Genomics · doi:10.1006/geno.1994.1068 · Cited by 130

Norepinephrine Suppresses Inducible Nitric Oxide Synthase Activity in Rat Astroglial Cultures

Feinstein, D. L., Galea, E., & Reis, D. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13425.x · Cited by 129

Diethyldithiocarbamate inhibits induction of macrophage NO synthase

Mülsch, A., Schray-Utz, B., Mordvintcev, P. I., Hauschildt, S., & Busse, R. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80111-7 · Cited by 129

Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.

GZhang, Z., MChopp, CZaloga, et al. (1993) · Stroke · Cited by 128

In Murine 3T3 Fibroblasts, Different Second Messenger Pathways Resulting in the Induction of NO Synthase II (iNOS) Converge in the Activation of Transcription Factor NF-κB

Kleinert, H., Euchenhofer, C., Ihrig‐Biedert, I., & Förstermann, U. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6039 · Cited by 125

Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells.

Kanno, K., Hirata, Y., Tasuku, I. M. A. I., & Marumo, F. (1993) · Hypertension · doi:10.1161/01.hyp.22.1.34 · Cited by 123

Organization of the bovine gene encoding the endothelial nitric oxide synthase

Venema, R. C., Nishida, K., Alexander, R. W., Harrison, D. G., & Murphy, T. J. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90195-3 · Cited by 121

Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus.

Yallampalli, C., Byam-Smith, M., Nelson, S. O., et al. (1994) · Endocrinology · doi:10.1210/endo.134.4.8137765 · Cited by 121

gp120 HIV envelope glycoprotein increases the production of nitric oxide in human monocyte-derived macrophages

Pietraforte, D., Tritarelli, E., Testa, U., & Minetti, M. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.2.175 · Cited by 120

Regulation of Inducible Nitric Oxide Synthase mRNA Levels by LPS, INF-γ, TGF-β, and IL-10 in Murine Macrophage Cell Lines and Rat Peritoneal Macrophages

Chesrown, S. E., Monnier, J. M., Visner, G. A., & Nick, H. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1424 · Cited by 115

Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages

Hortelano, S., Genaro, A. M., & Boscá, L. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80078-9 · Cited by 112

Hepatocytes and Macrophages Express an Identical Cytokine-Inducible Nitric Oxide Synthase Gene

Wood, E., Berger, H., Sherman, P. A., & Lapetina, E. G. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1283 · Cited by 111

Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.

Förstermann, U., Gorsky, L. D., Pollock, J. S., Ishii, K., Schmidt, H. H. H. W., Heller, M., & Murad, F. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09447-7 · Cited by 111

Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart

Hassall, C. J. S., Saffrey, M. J., Belai, A., Hoyle, C. H. V., Moules, E. W., Moss, J., Schmidt, H. H. H. W., Murad, F., Förstermann, U., & Burnstock, G. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90234-x · Cited by 109

Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells

Tracey, W. R., Pollock, J. S., Murad, F., Nakane, M., & Förstermann, U. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.1.c22 · Cited by 107

Primary cultures of rat islet capillary endothelial cells. Constitutive and cytokine-inducible macrophagelike nitric oxide synthases are expressed and activities regulated by glucose concentration.

Suschek, C. V., Fehsel, K., Kröncke, K. D., Sommer, A., & Kolb‐Bachofen, V. (1994) · PubMed · Cited by 98

The induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGFAB and PDGFBB in vascular smooth muscle cells

Schini‐Kerth, V. B., Durante, W., Elizondo, E., Scott‐Burden, T., Junquero, D. C., Schafer, A. I., & Vanhoutte, P. M. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90434-6 · Cited by 97

Nitric Oxide Limits Transcriptional Induction of Nitric Oxide Synthase in CNS Glial Cells

Park, S. K., Lin, H. L., & Murphy, S. P. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1766 · Cited by 95

Expression of nitric oxide synthase immunoreactivity by interstitial cells of the canine proximal colon

Xue, C., Pollock, J. S., Schmidt, H. H. H. W., Ward, S. M., & Sanders, K. M. (1994) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)90015-9 · Cited by 93

Immunochemical detection of inducible NO synthase in human lung

Tracey, W. R., Xue, C., Klinghofer, V., Barlow, J., Pollock, J. S., Förstermann, U., & Johns, R. A. (1994) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1994.266.6.l722 · Cited by 91

Endothelial nitric oxide synthase is myristylated

Pollock, J. S., Klinghofer, V., Förstermann, U., & Murad, F. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80816-y · Cited by 90

Colocalization of nitric oxide synthase and somatostatin immunoreactivity in rat dentate hilar neurons.

Dun, N. J., Dun, S. L., Wong, R. K. S., & Förstermann, U. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2955 · Cited by 88

Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression

Maier, R., Bilbe, G., Rediske, J. J., & Lotz, M. (1994) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(94)90171-6 · Cited by 85

Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription.

Xie, J., Roddy, P., Rife, T. K., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.1242 · Cited by 81

Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.

Szabó, C., Mitchell, J. A., Gross, S. S., Thiemermann, C., & Vane, J. R. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38153-x · Cited by 80

Purification of Insoluble Nitric Oxide Synthase from Rat Cerebellum1

Hiki, K., Hattori, R., Kawai, C., et al. (1992) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123795 · Cited by 73

Characterization and localization of nitric oxide synthase in non‐adrenergic non‐cholinergic nerves from bovine retractor penis muscles

Sheng, H., Schmidt, H. H. H. W., Nakane, M., Mitchell, J. A., Pollock, J. S., Föstermann, U., & Murad, F. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14411.x · Cited by 73

Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-ß

Förstermann, U., Schmidt, H. H. H. W., Kohlhaas, K. L., & Murad, F. (1992) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(92)90096-e · Cited by 72

Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils

McCall, T., Palmer, R. M. J., & Moncada, S. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90800-z · Cited by 66

Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2→24.31 by fluorescent in situ hybridization

Xu, W., Gorman, P. A., Sheer, D., Bates, G. P., Kishimoto, J., Liu, L., & Emson, P. C. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133562 · Cited by 62

Characterisation of functional inhibition of the glucocorticoid receptor by Fos/Jun.

Touray, M., Ryan, F., Jaggi, R. B., & Martin, F. (1991) · PubMed · Cited by 59

Mapping of the Genes Encoding Human Inducible and Endothelial Nitric Oxide Synthase (NOS2 and NOS3) to the Pericentric Region of Chromosome 17 and to Chromosome 7, Respectively

Xu, W., Charles, I. G., Moncada, S., et al. (1994) · Genomics · doi:10.1006/geno.1994.1286 · Cited by 58

Dexamethasone differentially affects interleukin 1β- and cyclic AMP-induced nitric oxide synthase mRNA expression in renal mesangial cells

Kunz, D., Walker, G., & Pfeilschifter, J. M. (1994) · Biochemical Journal · doi:10.1042/bj3040337 · Cited by 57

Inhibition of Gene Expression by Steroid Hormone Receptors Via a Negative Glucocorticoid Response Element: Evidence for the Involvement of DNA-Binding and Agonistic Effects of the Antiglucocorticoid/Antiprogestin RU486

Cairns, C. A., Cairns, W. J., & Okret, S. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.695 · Cited by 55

“Macrophage” nitric oxide synthase is a glucocorticoid‐inhibitable primary response gene in 3T3 cells

Gilbert, R. S., & Herschman, H. R. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041570117 · Cited by 51

Dissociation between Interleukin-1β-Induced Expression of mRNA for Superoxide-Dismutase and Nitric Oxide Synthase in Insulin-Producing Cells

Bigdeli, N., Niemann, A., Sandler, S., & Eizirik, D. L. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2361 · Cited by 17

Nitric oxide as modulator of neuronal function

Prast, H., & Philippu, A. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00044-7 · Cited by 937

Biosynthesis and action of nitric oxide in mammalian cells

Mayer, B., & Hemmens, B. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01147-x · Cited by 600

β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism

Akama, K. T., & Van Eldik, L. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7918 · Cited by 287

Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease

Bivalacqua, T. J., Usta, M. F., Champion, H. C., Kadowitz, P. J., & Hellstrom, W. J. G. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02743.x · Cited by 268

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

Ambs, S., Hussain, S. P., & Harris, C. C. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.6.9194524 · Cited by 233