The influence of vitamin C on systemic markers of endothelial and inflammatory cell activation in smokers and non-smokers
Abstract
Objective and design To determine the influence of vitamin C supplementation (500 mg, bd, 14 days) on the circulating concentrations of soluble ICAM-1 (a marker of endothelial activation), neopterin (a marker of monocyte activation), and neutrophil elastase (a marker of neutrophil activation) in smokers and non-smokers in a randomised, double-blind, placebo-controlled trial in a hospital setting.Subjects Twenty smokers (serum cotinine > or = 20 ng ml(-1)) and 20 age- and gender-matched non-smokers (serum cotinine < or = 13.7 ng ml(-1)).Results At baseline, there was a significant elevation in the concentration of sICAM-1 in smokers (median 247, IQR 199 to 357 ng ml(-1)) compared to non-smokers (median 207, IQR 189 to 227 ng ml(-1); p = 0.014). Vitamin C supplementation did not influence the circulating concentrations of ICAM-1 or neopterin, or leukocyte elastase activity, in smokers, non-smokers, or in the total population.Conclusions Markers of monocyte and neutrophil activation were not influenced by smoking status in this study population. However, sICAM-1 concentrations were significantly elevated in tobacco smokers, reflecting tobacco-induced vascular activation that is unaffected by Vitamin C supplementation.
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Higher iron intake, especially haem iron, and higher iron status are associated with increased risk of type 2 diabetes, atherosclerosis and coronary heart disease, although the literature is not fully consistent.
“There is some epidemiological evidence that higher Fe intake, particularly that of haem Fe, and higher Fe status are associated with increased risk of type 2 diabetes, atherosclerosis and CHD (702 -714) , although not all of the literature is consistent.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [708]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
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- Authors
- Scott, D. A., Poston, R. N., Wilson, R. F., Coward, P. Y., & Palmer, R. M.
- Affiliations
- University of Louisville (US)
- King's College London (GB)
- Corresponding author
- Scott, D. A.
- Venue
- Inflammation Research
- Published
- 2005-03
- Volume
- 54
- Issue
- 3
- Pages
- 138-144
- ISSN
- 1023-3830 (ISSN-L)
- 1420-908X
- OpenAlex
- W2053240306
- Cited by
- 22
- References
- 63
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 2 · 2012: 2
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Inflammation Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- vitamin C supplementation, smoking, endothelial activation, soluble ICAM-1, neopterin, neutrophil elastase, monocyte activation, neutrophil activation, inflammatory markers, cotinine
- MeSH terms
- Adult, Antioxidants, Ascorbic Acid, Cotinine, Endothelium, Female, Humans, Inflammation, Lung, Male, Middle Aged, Placebos, Smoking, Time Factors, Biomarkers, Intercellular Adhesion Molecule-1, Leukocyte Elastase, Neopterin
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