Soluble adhesion molecules and angiotensin-converting enzyme in dementia
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We aimed to determine plasma and cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and platelet endothelial cell adhesion molecule-1 (sPECAM-1) as surrogate markers for endothelial cell activation in clinically diagnosed patients with Alzheimer's disease (AD, n=260), dementia with Lewy bodies (DLB, n=39) and non-demented controls (n=34). Plasma sICAM-1 and sPECAM-1 were higher and CSF sVCAM-1 were lower in AD and DLB patients than in controls (p<0.001). DLB patients had higher CSF sICAM-1, but lower CSF sVCAM-1 (p<0.001). No difference in ACE levels was found between the dementia groups and controls. In controls and AD patients CSF sICAM and sVCAM-1 strongly correlated with each other and with blood barrier permeability whereas in DLB group these correlations were weaker. The observed patterns in adhesion molecules may reflect distinctions in the pathophysiological basis of their generation in dementia patients.
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Earlier investigations that have measured CSF and blood levels of ICAM-1, VCAM-1, and IL-15 in AD have produced conflicting results.
“Earlier investigations that have measured CSF and blood levels of ICAM-1, VCAM-1, and IL-15 in AD have produced conflicting results.38–42”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [40]
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- Authors
- Nielsen, H. M., Londos, E., Minthon, L., & Janciauskiene, S. M.
- Affiliations
- Lund University (SE)
- Corresponding author
- Janciauskiene, Sabina M.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 26
- Issue
- 1
- Pages
- 27-35
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2007769449
- Cited by
- 80
- References
- 96
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lithuanian University of Health Sciences (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Vetenskapsrådet
- Jiangsu National Synergistic Innovation Center for Advanced Materials
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, dementia with Lewy bodies, soluble adhesion molecules, angiotensin-converting enzyme, sICAM-1, sVCAM-1, cerebrospinal fluid biomarkers, plasma biomarkers, endothelial activation, blood-brain barrier permeability, dementia pathophysiology
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alleles, Alzheimer Disease, Blood Pressure, Blood-Brain Barrier, Cognition, Dementia, Female, Humans, Peptidyl-Dipeptidase A, Male, Middle Aged, Permeability, Psychiatric Status Rating Scales, Intercellular Adhesion Molecule-1, Neural Cell Adhesion Molecules, Vascular Cell Adhesion Molecule-1, Platelet Endothelial Cell Adhesion Molecule-1, Lewy Body Disease, Apolipoprotein E4
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