Cited by 80Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Soluble adhesion molecules and angiotensin-converting enzyme in dementia

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Abstract

We aimed to determine plasma and cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and platelet endothelial cell adhesion molecule-1 (sPECAM-1) as surrogate markers for endothelial cell activation in clinically diagnosed patients with Alzheimer's disease (AD, n=260), dementia with Lewy bodies (DLB, n=39) and non-demented controls (n=34). Plasma sICAM-1 and sPECAM-1 were higher and CSF sVCAM-1 were lower in AD and DLB patients than in controls (p<0.001). DLB patients had higher CSF sICAM-1, but lower CSF sVCAM-1 (p<0.001). No difference in ACE levels was found between the dementia groups and controls. In controls and AD patients CSF sICAM and sVCAM-1 strongly correlated with each other and with blood barrier permeability whereas in DLB group these correlations were weaker. The observed patterns in adhesion molecules may reflect distinctions in the pathophysiological basis of their generation in dementia patients.

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Crossref · 10.1016/j.nbd.2006.11.011

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Authors
Nielsen, H. M., Londos, E., Minthon, L., & Janciauskiene, S. M.
Affiliations
Lund University (SE)
Corresponding author
Janciauskiene, Sabina M.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2007-04
Volume
26
Issue
1
Pages
27-35
ISSN
0969-9961 (ISSN-L)
OpenAlex
W2007769449
Cited by
80
References
96
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 5
FWCI
3.42
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Lithuanian University of Health Sciences (submittedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • Vetenskapsrådet
  • Jiangsu National Synergistic Innovation Center for Advanced Materials
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, dementia with Lewy bodies, soluble adhesion molecules, angiotensin-converting enzyme, sICAM-1, sVCAM-1, cerebrospinal fluid biomarkers, plasma biomarkers, endothelial activation, blood-brain barrier permeability, dementia pathophysiology
MeSH terms
Aged, Aged, 80 and over, Aging, Alleles, Alzheimer Disease, Blood Pressure, Blood-Brain Barrier, Cognition, Dementia, Female, Humans, Peptidyl-Dipeptidase A, Male, Middle Aged, Permeability, Psychiatric Status Rating Scales, Intercellular Adhesion Molecule-1, Neural Cell Adhesion Molecules, Vascular Cell Adhesion Molecule-1, Platelet Endothelial Cell Adhesion Molecule-1, Lewy Body Disease, Apolipoprotein E4

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