Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology

Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium

McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop

McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

Montine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,992 · see citing works

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933 · see citing works

Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115 · see citing works

Prion-like spreading of pathological α-synuclein in brain

Masuda-Suzukake, M., Nonaka, T., Hosokawa, M., Oikawa, T., Arai, T., Akiyama, H., Mann, D. M. A., & Hasegawa, M. (2013) · Brain · doi:10.1093/brain/awt037 · Cited by 867 · see citing works

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Imamura, K., Hishikawa, N., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0766-2 · Cited by 791 · see citing works

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

the Arizona Parkinson’s Disease Consortium, Beach, T. G., Adler, C. H., Lue, L., Sue, L. I., Bachalakuri, J., Henry-Watson, J., Sasse, J., Boyer, S., Shirohi, S., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0538-8 · Cited by 698 · see citing works

Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses

Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works

Synuclein activates microglia in a model of Parkinson's disease

Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474 · cited 3× · see citing works

<scp>A</scp>rizona <scp>S</scp>tudy of <scp>A</scp>ging and <scp>N</scp>eurodegenerative <scp>D</scp>isorders and <scp>B</scp>rain and <scp>B</scp>ody <scp>D</scp>onation <scp>P</scp>rogram

Beach, T. G., Adler, C. H., Sue, L. I., Serrano, G., Shill, H. A., Walker, D. G., Lue, L., Roher, A. E., Dugger, B. N., Maarouf, C., et al. (2015) · Neuropathology · doi:10.1111/neup.12189 · Cited by 460 · see citing works

Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration

Gao, H., Kotzbauer, P. T., Uryu, K., Leight, S., Trojanowski, J. Q., & Lee, V. M. ‐. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0143-07.2008 · Cited by 435 · see citing works

Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition

Croisier, E., Moran, L. B., Dexter, D. T., Pearce, R. K., & Graeber, M. B. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-14 · Cited by 414 · see citing works

Inflammatory Process in Parkinsons Disease: Role for Cytokines

Nagatsu, T., & Sawada, M. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381620 · Cited by 412 · see citing works

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S. W., Horrocks, M. H., Banushi, B., Little, D., Devine, M. J., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6343 · Cited by 360 · see citing works

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

Gao, H.-M., Zhang, F., Zhou, H., Kam, W., Wilson, B., & Hong, J.-S. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003013 · Cited by 355 · cited 3× · see citing works

Inflammatory biomarkers in coronary artery disease

Zakynthinos, E. G., & Pappa, N. (2009) · Journal of Cardiology · doi:10.1016/j.jjcc.2008.12.007 · Cited by 355 · see citing works

Role of cytokines in inflammatory process in Parkinson’s disease

Sawada, M., Imamura, K., & Nagatsu, T. (2006) · Parkinson’s Disease and Related Disorders · doi:10.1007/978-3-211-45295-0_57 · Cited by 331 · see citing works

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.013 · Cited by 327 · see citing works

The influence of microglia on the pathogenesis of Parkinson's disease

Long-Smith, C. M., Sullivan, A. M., & Nolan, Y. M. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.08.001 · Cited by 296 · see citing works

Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

Qin, H., Buckley, J. A., Li, X., Liu, Y., Fox, T. H., Meares, G. P., Yu, H., Yan, Z., Harms, A. S., Li, Y., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4658-15.2016 · Cited by 275 · see citing works

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

Walker, D. G., Dalsing-Hernandez, J. E., Campbell, N. A., & Lue, L. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.09.003 · Cited by 268 · see citing works

α-Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

Lee, E.-J., Woo, M.-S., Moon, P., Baek, M., Choi, I.-Y., Kim, W.-K., Junn, E., & Kim, H.-S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903480 · Cited by 267 · see citing works

The Sun Health Research Institute Brain Donation Program: Description and Eexperience, 1987–2007

Beach, T., Sue, L., Walker, D., Roher, A., Lue, L., Vedders, L. J., Connor, D., Sabbagh, M., & Rogers, J. (2007) · Cell and Tissue Banking · doi:10.1007/s10561-008-9067-2 · Cited by 265 · see citing works

Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys

Judith Miklossy, A., Doudet, D., Schwab, C., Yu, S. Y., McGeer, E. G., & McGeer, P. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.034 · Cited by 255 · see citing works

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

Osterberg, V. R., Spinelli, K. J., Weston, L. J., Luk, K. C., Woltjer, R. L., & Unni, V. K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.060 · Cited by 240 · see citing works

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

Klegeris, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.013 · Cited by 227 · see citing works

α-Synuclein Alters Toll-Like Receptor Expression

Béraud, D., Twomey, M. A., Bloom, B., Mittereder, A., Ton, V., Neitzke, K., Chasovskikh, S., Mhyre, T. R., & Maguire‐Zeiss, K. A. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00080 · Cited by 199 · see citing works

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

Alvarez‐Erviti, L., Couch, Y., Richardson, J. C., Cooper, J. A. D., & Wood, M. J. A. (2011) · Neuroscience Research · doi:10.1016/j.neures.2010.12.020 · Cited by 193 · see citing works

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions

Koning, N., Swaab, D. F., Hoek, R. M., & Huitinga, I. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181964113 · Cited by 188 · see citing works

Gene expression changes by amyloid β peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes

Walker, D. G., Link, J., Lue, L., Dalsing-Hernandez, J. E., & Boyes, B. E. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0705377 · Cited by 180 · see citing works

Concomitant pathologies among a spectrum of parkinsonian disorders

Dugger, B. N., Adler, C. H., Shill, H. A., Caviness, J. N., Jacobson, S. A., Driver‐Dunckley, E. D., & Beach, T. G. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.02.012 · Cited by 160 · see citing works

CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

Zhang, S., Wang, X.-J., Tian, L.-P., Pan, J., Lu, G.-Q., Zhang, Y.-J., Ding, J.-Q., & Chen, S.-D. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-154 · Cited by 154 · see citing works

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

Walker, D. G., Lue, L., Adler, C. H., Shill, H. A., Caviness, J. N., Sabbagh, M. N., Akiyama, H., Serrano, G. E., Sue, L. I., & Beach, T. G. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.11.020 · Cited by 150 · see citing works

Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells

Mihrshahi, R., Barclay, A. N., & Brown, M. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901531 · Cited by 146 · see citing works

Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker

Sacino, A. N., Brooks, M., McKinney, A. B., Thomas, M. A., Shaw, G., Golde, T. E., & Giasson, B. I. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2102-14.2014 · Cited by 141 · see citing works

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L. (1993) · Acta Neuropathologica · doi:10.1007/bf00334673 · Cited by 137 · see citing works

Misfolded α-synuclein and toll-like receptors: therapeutic targets for Parkinson's disease

Béraud, D., & Maguire‐Zeiss, K. A. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70008-6 · Cited by 135 · see citing works

The Neuromelanin of Human Substantia Nigra: Physiological and Pathogenic Aspects

Zucca, F. A., Giaveri, G., Gallorini, M., Albertini, A., Toscani, M., Pezzoli, G., Lucius, R., Wilms, H., Sulzer, D. L., Ito, S., et al. (2004) · Pigment Cell Research · doi:10.1111/j.1600-0749.2004.00201.x · Cited by 134 · see citing works

Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains

Imamura, K., Hishikawa, N., Ono, K., Suzuki, H., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0919-y · Cited by 131 · see citing works

Activated microglia in dementia with Lewy bodies

Mackenzie, I. R. (2000) · Neurology · doi:10.1212/wnl.55.1.132 · Cited by 126 · see citing works

Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease

Frohman, E. M., Frohman, T. C., Gupta, S., de Fougerolles, A., & van den Noort, S. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90202-i · Cited by 120 · see citing works

Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK

Wang, X.-J., Zhang, S., Yan, Z.-Q., Zhao, Y.-X., Zhou, H.-Y., Wang, Y., Lu, G.-Q., & Zhang, J.-D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.032 · Cited by 108 · see citing works

CNS inflammation and neuronal degeneration is aggravated by impaired CD200–CD200R-mediated macrophage silencing

Meuth, S. G., Simon, O. J., Grimm, A. M., Melzer, N., Herrmann, A. M., Spitzer, P., Landgraf, P., & Wiendl, H. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.11.013 · Cited by 107 · see citing works

Does Oxidative Stress Participate in Nerve Cell Death in Parkinson’s Disease?

Hirsch, É. C., & Hirsch, É. C. (2008) · European Neurology · doi:10.1159/000118538 · Cited by 106 · see citing works

Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.

(1994) · PubMed Central · Cited by 105 · see citing works

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide

Lyons, A., McQuillan, K., Deighan, B. F., O’Reilly, J.-A., Downer, E. J., Murphy, A. C., Watson, M., Piazza, A., O’Connell, F., Griffin, R., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.060 · Cited by 98 · see citing works

Common Inflammatory Mechanisms in Lewy Body Disease and Alzheimer Disease

Mrak, R. E., & Griffin, W. S. T. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31812503e1 · Cited by 86 · see citing works

Activation and Control of CNS Innate Immune Responses in Health and Diseases: A Balancing Act Finely Tuned by Neuroimmune Regulators (NIReg)

Hoarau, J., Trotot, P. K., Jaffar‐Bandjee, M., Das, T., Thon-hon, G. V., Kumar, S., Neal, J. W., & Gasque, P. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794488601 · Cited by 82 · see citing works

Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging

Maarouf, C. L., Daugs, I. D., Kokjohn, T. A., Walker, D. G., Hunter, J. M., Kruchowsky, J., Woltjer, R. L., Kaye, J. A., Castaño, E. M., Sabbagh, M. N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027291 · Cited by 80 · see citing works

Clinicopathological Outcomes of Prospectively Followed Normal Elderly Brain Bank Volunteers

Dugger, B. N., Hentz, J. G., Adler, C. H., Sabbagh, M. N., Shill, H. A., Jacobson, S. A., Caviness, J. N., Belden, C. M., Driver‐Dunckley, E. D., Davis, K. J., et al. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000046 · Cited by 80 · see citing works

Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease

Eikelenboom, P., Zhan, S., Kamphorst, W., van der Valk, P., & Rozemüller, A. J. M. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00190565 · Cited by 78 · see citing works

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease

Varnum, M. M., Kiyota, T., Dixie, K. L. I., Ikezu, S., & Ikezu, T. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.027 · Cited by 75 · see citing works

Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies

Togo, T., Iseki, E., Marui, W., Akiyama, H., Uéda, K., & Kosaka, K. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00498-6 · Cited by 67 · see citing works

Cortical Inflammation in Alzheimer Disease but Not Dementia With Lewy Bodies

Shepherd, C. E., Thiel, E., McCann, H., Harding, A. J., & Halliday, G. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.817 · Cited by 67 · see citing works

Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies

Lue, L., Walker, D. G., Adler, C., Shill, H. A., Tran, H., Akiyama, H., Sue, L., Caviness, J., Sabbagh, M. N., & Beach, T. G. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00585.x · Cited by 65 · see citing works

Microglia in Alzheimer Brain: A Neuropathological Perspective

Mrak, R. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/165021 · Cited by 58 · see citing works

Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using α-synuclein-immunohistochemistry

Iseki, E., Marui, W., Akiyama, H., Uéda, K., & Kosaka, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01090-9 · Cited by 55 · see citing works

Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies

Katsuse, O., Iseki, E., & Kosaka, K. (2003) · Neuropathology · doi:10.1046/j.1440-1789.2003.00483.x · Cited by 54 · see citing works

Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability

Kaufmann, T. J., Harrison, P. M., Richardson, M. J. E., Pinheiro, T. J. T., & Wall, M. J. (2016) · The Journal of Physiology · doi:10.1113/jp271968 · Cited by 53 · see citing works

Identification of the amino acid sequence motif of α-synuclein responsible for macrophage activation

Lee, S.-B., Park, S. M., Ahn, K. J., Chung, K. C., Paik, S. R., & Kim, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.002 · Cited by 52 · see citing works

Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia

Lyons, A., Downer, E. J., Costello, D. A., Murphy, N., & Lynch, M. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-107 · Cited by 50 · see citing works

Activated microglial cells and complement factors are unrelated to cortical Lewy bodies

Rozemuller, A. J. M., Eikelenboom, P., Theeuwes, J. W., Jansen Steur, E. N. H., & de Vos, R. A. I. (2000) · Acta Neuropathologica · doi:10.1007/s004010000225 · Cited by 50 · see citing works

Lack of Alpha-Synuclein Modulates Microglial Phenotype In Vitro

Austin, S. A., Rojanathammanee, L., Golovko, M. Y., Murphy, E. J., & Combs, C. K. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0439-9 · Cited by 49 · see citing works

Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α -Synucleinopathies

Sekiyama, K., Sugama, S., Fujita, M., Sekigawa, A., Takamatsu, Y., Waragai, M., Takenouchi, T., & Hashimoto, M. (2012) · Parkinson s Disease · doi:10.1155/2012/271732 · Cited by 48 · see citing works

Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases

Walker, D. G., Lue, L., Serrano, G. E., Adler, C. H., Caviness, J. N., Sue, L. I., & Beach, T. G. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00507 · Cited by 44 · see citing works

Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease

Luo, X., Zhang, J.-J., Zhang, C., Liu, R., Zheng, L., Wang, X., Chen, S., & Ding, J. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0094-6 · Cited by 42 · see citing works

Presence of Striatal Amyloid Plaques in Parkinson's Disease Dementia Predicts Concomitant Alzheimer's Disease: Usefulness for Amyloid Imaging

Dugger, B. N., Serrano, G. E., Sue, L. I., Walker, D. G., Adler, C. H., Shill, H. A., Sabbagh, M. N., Caviness, J. N., Hidalgo, J., Saxon‐LaBelle, M., et al. (2012) · Journal of Parkinson s Disease · doi:10.3233/jpd-2012-11073 · Cited by 41 · see citing works

Interleukin-1 exerts distinct actions on different cell types of the brain in vitro

Quan, N., An, ., & Chen, Q. (2011) · Journal of Inflammation Research · doi:10.2147/jir.s15357 · Cited by 32 · see citing works

Temporal Pattern of ICAM-I Mediated Regulatory T Cell Recruitment to Sites of Inflammation in Adoptive Transfer Model of Multiple Sclerosis

Doerck, S., Göbel, K., Weise, G., Schneider‐Hohendorf, T., Reinhardt, M., Hauff, P., Schwab, N., Linker, R. A., Mäurer, M., Meuth, S. G., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015478 · Cited by 27 · see citing works

Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer’s Disease

Maarouf, C. L., Kokjohn, T. A., Walker, D. G., Whiteside, C. M., Kalback, W. M., Whetzel, A. M., Sue, L. I., Serrano, G. E., Jacobson, S. A., Sabbagh, M. N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105784 · Cited by 17 · see citing works

Blockade of ICAM-1: A novel way of vasculitis treatment

Xu, Y., & Li, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.111 · Cited by 15 · see citing works

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(2001) · PubMed · Cited by 12 · see citing works

Evaled Expression of ICAM-1 and Its Ligands in the Rat Spinal Cord Following Lipopolysaccharide Intraspinal Injection

Yang, J., Fei, M., Gu, Y., Sun, L., Ben, Z., Zhou, D., Chen, J., Wang, Y., Wang, P., Shen, A., et al. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8049-7 · Cited by 8 · see citing works

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

Janelidze, S., Mattsson, N., Stomrud, E., Lindberg, O., Palmqvist, S., Zetterberg, H., Blennow, K., & Hansson, O. (2018) · Neurology · doi:10.1212/wnl.0000000000006082 · Cited by 359 · see citing works

Immune system responses in Parkinson's disease: Early and dynamic

Tansey, M. G., & Romero‐Ramos, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14290 · Cited by 183 · see citing works

The Role of Intercellular Adhesion Molecule-1 in the Pathogenesis of Psychiatric Disorders

Müller, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01251 · Cited by 169 · see citing works

Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease

Das, R., & Chinnathambi, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03132-2 · Cited by 147 · see citing works

Neutralization of IL‐17 rescues amyloid‐β‐induced neuroinflammation and memory impairment

Cristiano, C., Volpicelli, F., Lippiello, P., Buono, B., Raucci, F., Piccolo, M., Iqbal, A. J., Irace, C., Miniaci, M. C., Perrone‐Capano, C., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14586 · Cited by 140 · see citing works

Beneficial Effects of Spirulina Consumption on Brain Health

Trotta, T., Porro, C., Cianciulli, A., & Panaro, M. A. (2022) · Nutrients · doi:10.3390/nu14030676 · Cited by 98 · see citing works

Stress and aging act through common mechanisms to elicit neuroinflammatory priming

Fonken, L. K., Frank, M. G., Gaudet, A. D., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.012 · Cited by 94 · see citing works

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

Yang, G., Xu, X., Gao, W., Wang, X., Zhao, Y., & Xu, Y. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1700692 · Cited by 85 · see citing works

The Potential Role of Dysfunctions in Neuron-Microglia Communication in the Pathogenesis of Brain Disorders

Chamera, K., Trojan, E., Szuster-Głuszczak, M., & Basta‐Kaim, A. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191113101629 · Cited by 80 · see citing works

Parallels between retinal and brain pathology and response to immunotherapy in old, late‐stage Alzheimer's disease mouse models

Doustar, J., Rentsendorj, A., Torbati, T., Regis, G. C., Fuchs, D.-T. S., Sheyn, J., Mirzaei, N., Graham, S. L., Shah, P. K., Mastali, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13246 · Cited by 47 · see citing works

Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies

van Wetering, J., Geut, H., Bol, J. G. J. M., Galis, Y., Timmermans, E., Twisk, J. W. R., Hepp, D. H., Morella, M. L., Pihlstrøm, L., Lemstra, A. W., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01786-z · Cited by 36 · see citing works

Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer’s disease

Piniella‐Matamoros, B., Marín‐Prida, J., & Pentón‐Rol, G. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00161-7 · Cited by 34 · see citing works

The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host’s Defense Strategy against Neuroinflammation

Bedoui, Y., Neal, J. W., & Gasque, P. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9793-6 · Cited by 27 · see citing works

Alzheimer’s Disease Research Using Human Microglia

Lue, L., Beach, T. G., & Walker, D. G. (2019) · Cells · doi:10.3390/cells8080838 · Cited by 26 · see citing works

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease

Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13181554 · Cited by 24 · see citing works

Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review

Loveland, P. M., Yu, J. J., Churilov, L. P., Yassi, N., & Watson, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512116 · Cited by 21 · see citing works

α‐synuclein abnormalities trigger focal tau pathology, spreading to various brain areas in Parkinson disease

Hadi, F., Akrami, H., Totonchi, M., Barzegar, A., Nabavi, S. M., & Shahpasand, K. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15257 · Cited by 20 · see citing works

Altered expression of the immunoregulatory ligand-receptor pair CD200-CD200R1 in the brain of Parkinson’s disease patients

Rabaneda‐Lombarte, N., Vidal-Taboada, J. M., Valente, T., Ezquerra, M., Fernández‐Santiago, R., Martı́, M. J., Compta, Y., Saura, J., & Solà, C. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00290-2 · Cited by 17 · see citing works

CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes

Chiarini, A., Armato, U., Hu, P., & Prà, I. D. (2020) · Cells · doi:10.3390/cells9061386 · Cited by 15 · see citing works

Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer

Saviano, A., Casillo, G. M., Raucci, F., Pernice, A., Santarcangelo, C., Piccolo, M., Ferraro, M. G., Ciccone, M., Sgherbini, A., Pedretti, N., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111579 · Cited by 15 · see citing works

Ageing-related changes in the regulation of microglia and their interaction with neurons

Rommy von Bernhardi, M., & Eugenín, J. L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110241 · Cited by 10 · see citing works

Changes in inflammatory factors and prognosis of patients complicated with non-alcoholic fatty liver disease undergoing coronary artery bypass grafting

Wang, L., Li, Y., & Gong, X. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5476 · Cited by 10 · see citing works

CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease

Comella-Bolla, A., Valente, T., Miguez, A., Brito, V., Ginés, S., Solà, C., Straccia, M., & Canals, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224901 · Cited by 10 · see citing works

A network pharmacological approach to investigate the pharmacological effects of CZ2HF decoction on Alzheimer's disease

Wei, Y., Gao, J., Xu, F., Shi, J., Yu, C., & Gong, Q. (2021) · Ibrain · doi:10.1002/j.2769-2795.2021.tb00080.x · Cited by 7 · see citing works

CD157 and CD200 at the crossroads of endothelial remodeling and immune regulation

Katoh, M., & Katoh, M. (2019) · Stem Cell Investigation · doi:10.21037/sci.2019.04.01 · Cited by 7 · see citing works

High CD200 Expression on T CD4+ and T CD8+ Lymphocytes as a Non-Invasive Marker of Idiopathic Pulmonary Hypertension–Preliminary Study

Tomaszewski, M., Grywalska, E., Topyła, W., Błaszczak, P., Kurzyna, M., Roliński, J., & Kopeć, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10050950 · Cited by 6 · see citing works

Co-signaling Molecules in Neurological Diseases

Kivisäkk, P., & Khoury, S. J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9717-3_9 · Cited by 4 · see citing works

Bioactive Compounds of the Genus Spirulina Can Prevent the Progression of Neurological Diseases

Elkader, H. A. E. A., Essawy, A. E., & Al‐Shami, A. S. (2024) · Neurochemical Journal · doi:10.1134/s1819712424010057 · Cited by 4 · see citing works

Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride

Zakaria, D., Yamashita, T., & Kosugi, Y. (2025) · Neurotoxicity Research · doi:10.1007/s12640-025-00737-3 · Cited by 3 · see citing works

Linking CD200 in brains and dementia

Walker, D. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00023-2

Role of Inflammation in Lewy Body Dementia

Surendranathan, A., & O'Brien, J. T. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108539623.011

Exploratory Blood Biomarker Patterns in a Mixed Dementia CohortPreprint

Gezegen, H., Alaylıoğlu, M., Şahin, E., Swann, O., Veleva, E., Güven, G., Yaman, Ü., Salih, D. A. M., Bılgıç, B., Hanağası, H. A., et al. (2024) · medRxiv · doi:10.1101/2024.11.07.24316927

Additional file 1 of Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies

van Wetering, J., Geut, H., Bol, J. G. J. M., Galis, Y., Timmermans, E., Twisk, J. W. R., Hepp, D. H., Morella, M. L., Pihlstrøm, L., Lemstra, A. W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26716930

[O2–15–04]: INFLAMMATION IN DEMENTIA WITH LEWY BODIES

Amin, J., Williams, T., Teeling, J. L., Dorey, R. B., Williams, D. M., Tommasino, E., Holmes, C., & Boche, D. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.07.232 · Cited by 1 · see citing works

Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer’s disease but not Lewy body dementias

Chai, Y. L., Lee, J. H., Chong, J. R., Ballard, C. G., Francis, P. T., Kennedy, B. K., Arumugam, T. V., Chen, C., Aarsland, D., & Lai, M. K. P. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02789-8 · Cited by 23 · see citing works

Cortical Inflammation in Alzheimer Disease but Not Dementia With Lewy Bodies

Shepherd, C. E., Thiel, E., McCann, H., Harding, A. J., & Halliday, G. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.817 · Cited by 67 · see citing works

Interleukin-1 mediates Alzheimer and Lewy body pathologies

Griffin, W. S. T., Liu, L., Li, Y., Mrak, R. E., & Barger, S. W. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-5 · Cited by 262 · see citing works

Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias

King, E., O'Brien, J., Donaghy, P. C., Morris, C. M., Barnett, N., Olsen, K., Martin-Ruiz, C. M., Taylor, J., & Thomas, A. J. (2018) · Newcastle University ePrints (Newcastle Univesity) · doi:10.25405/ncl.34351557