Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease

Frohman, Elliot M.; Frohman, Teresa C.; Gupta, Sudhir; de Fougerolles, Antonin; van den Noort, Stanley

doi:10.1016/0022-510x(91)90202-i

Cited by 121Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease

Frohman, Elliot M., Frohman, Teresa C., Gupta, Sudhir, de Fougerolles, Antonin, van den Noort, Stanley·1991·Journal of the Neurological Sciences

DOI 10.1016/0022-510x(91)90202-i

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Abstract

In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-1), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.

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ICAM-1 is highly expressed in endothelial cells of AD patients.
“However, the intercellular adhesion molecule-1 (ICAM-1) was shown to be highly expressed in endothelial cells of AD patients.486”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [486]
ICAM-1, a biomarker of endothelial dysfunction, is increased in Alzheimer's disease, and endothelial cells, astrocytes and microglia show enhanced levels of ICAM-1 in pathological states.
“Experimental evidence confirmed that biomarkers of endothelial dysfunction, such as intercellular adhesion molecule 1 (ICAM-1), are increased in AD; endothelial cells, astrocytes and microglia show enhanced levels of ICAM-1 in pathological states”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [146]
ICAM-1 plays a role in neuritic plaques on neurite growth and neurodegeneration.
“and this plays a role in neuritic plaques on neurite growth and neurodegeneration [145,146,147].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [146]

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Authors: Frohman, E. M., Frohman, T. C., Gupta, S., de Fougerolles, A., & van den Noort, S.
Affiliations: University of California, Irvine (US)
Corresponding author: Frohman, Elliot M.
ORCID: Frohman, Elliot M.
Gupta, Sudhir
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 1991-11
Volume: 106
Issue: 1
Pages: 105-111
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/0022-510x(91)90202-i
OpenAlex: W1968283018
Cited by: 120
References: 18
Citations by year: 2025: 2 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 3
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 00538)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: ICAM-1, Alzheimer's disease, ICAM-2, LFA-1, HLA-DR, neuritic plaques, cerebrovascular endothelium, microglial cells, leukocytes, antigen presentation, glial cells, neurodegeneration, neurite outgrowth
MeSH terms: Alzheimer Disease, Cerebral Arteries, Endothelium, Vascular, HLA-DR Antigens, Humans, Macrophages, Nerve Tissue Proteins, Neuroglia, Biomarkers, Antigens, CD, Cell Adhesion Molecules, Lymphocyte Function-Associated Antigen-1, Intercellular Adhesion Molecule-1

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Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease

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