Cited by 181Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Amphetamine-type reinforcement by dopaminergic agonists in the rat

Yokel, Robert A., Wise, Roy A.·1978·Psychopharmacology

Abstract

Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil. The dopaminergic agonists appear to suppress amphetamine intake in the same way as do 'free' amphetamine injections, by extending drug satiation in a given interresponse period. Clonidine, an alpha noradrenergic agonist, did not have similar effects. Apomorphine and piribedil did not increase 14C-amphetamine levels in rat brains, nor did they retard disappearance of 14C-amphetamine; thus their amphetamine-like effects are not due to alterations of amphetamine metabolism. Rats responding for amphetamine continued to respond for apomorphine or peribedil when the latter drugs were substituted for the former. Rats experienced in amphetamine self-administration readily initiated and maintained responding for apomorphine and piribedil. The dopaminergic blocker (+)-butaclamol disrupted responding for apomorphine and piribedil, although it produced no marked increase in responding for the dopaminergic agonists, as it does for amphetamine. These data add to the evidence that actions in the dopaminergic synapse account for amphetamine's reinforcing properties.

Integrity signals

Registry

Crossref · 10.1007/bf00427393

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yokel, R. A., & Wise, R. A.
Affiliations
Concordia University (CA)
Venue
Psychopharmacology
Published
1978
Volume
58
Issue
3
Pages
289-296
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2018079054
Cited by
181
References
35
Citations by year
2026: 2 · 2024: 1 · 2021: 1 · 2020: 6 · 2019: 2 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 2
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
amphetamine, self-administration, dopamine agonists, apomorphine, piribedil, clonidine, butaclamol, dopamine, reinforcement, drug substitution, amphetamine metabolism, dopaminergic synapse
MeSH terms
Amphetamine, Animals, Butaclamol, Clonidine, Dextroamphetamine, Dopamine, Male, Piribedil, Reinforcement, Psychology, Self Administration, Time Factors, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review