Amphetamine-type reinforcement by dopaminergic agonists in the rat
Abstract
Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil. The dopaminergic agonists appear to suppress amphetamine intake in the same way as do 'free' amphetamine injections, by extending drug satiation in a given interresponse period. Clonidine, an alpha noradrenergic agonist, did not have similar effects. Apomorphine and piribedil did not increase 14C-amphetamine levels in rat brains, nor did they retard disappearance of 14C-amphetamine; thus their amphetamine-like effects are not due to alterations of amphetamine metabolism. Rats responding for amphetamine continued to respond for apomorphine or peribedil when the latter drugs were substituted for the former. Rats experienced in amphetamine self-administration readily initiated and maintained responding for apomorphine and piribedil. The dopaminergic blocker (+)-butaclamol disrupted responding for apomorphine and piribedil, although it produced no marked increase in responding for the dopaminergic agonists, as it does for amphetamine. These data add to the evidence that actions in the dopaminergic synapse account for amphetamine's reinforcing properties.
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Direct DA receptor agonists can mimic the effects of substances of abuse and are self-administered both systemically and locally into the NAc in rats and monkeys.
“Direct DA receptor agonists can mimic the effects of substances of abuse, and these agonists are self-administered both systemically and locally into the NAc in rats and monkeys [131-133].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [133]
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- Authors
- Yokel, R. A., & Wise, R. A.
- Affiliations
- Concordia University (CA)
- Venue
- Psychopharmacology
- Published
- 1978
- Volume
- 58
- Issue
- 3
- Pages
- 289-296
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2018079054
- Cited by
- 181
- References
- 35
- Citations by year
- 2026: 2 · 2024: 1 · 2021: 1 · 2020: 6 · 2019: 2 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amphetamine, self-administration, dopamine agonists, apomorphine, piribedil, clonidine, butaclamol, dopamine, reinforcement, drug substitution, amphetamine metabolism, dopaminergic synapse
- MeSH terms
- Amphetamine, Animals, Butaclamol, Clonidine, Dextroamphetamine, Dopamine, Male, Piribedil, Reinforcement, Psychology, Self Administration, Time Factors, Rats
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