Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice
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Other mouse strains are also used sometimes in the cuprizone model.
“However, other strains are also used sometimes [7–10].”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [7]
Astrocyte reactivity is associated with increased activity of oxidative enzymes, which may contribute to ROS mediated toxicity.
“Astrocyte reactivity is associated with increased activity of oxidative enzymes (glutamate dehydrogenase, lactate dehydrogenase, NAD(P)H dehydrogenase, NADH dehydrogenase) [42, 178, 179] which may contribute to ROS mediated toxicity.”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [179]
After 5-6 weeks of cuprizone exposure, there is complete demyelination of distinct subregions (acute demyelination), paralleled by extensive microglial and astrocytic proliferation and damage to axons.
“After 5–6 weeks of cuprizone exposure, there is complete demyelination of distinct subregions (called acute demyelination), paralleled by extensive microglial and astrocytic proliferation and damage to axons [22,23,24,25].”
From How to Use the Cuprizone Model to Study De- and Remyelination (2024) · cites this paper as [24]
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Self-citation
- Authors
- Blakemore, W. F.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Blakemore, W. F.
- Venue
- Journal of Neurocytology
- Published
- 1972-12
- Volume
- 1
- Issue
- 4
- Pages
- 413-426
- ISSN
- 0300-4864 (ISSN-L)
- 1573-7381
- OpenAlex
- W1980249948
- Cited by
- 217
- References
- 31
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 17 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 6
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurocytology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- cuprizone, oligodendrocyte degeneration, status spongiosus, remyelination, demyelination, astrocyte activation, microglia, mice
- MeSH terms
- Animals, Cuprizone, Male, Mice, Inbred Strains, Myelin Sheath, Nerve Degeneration, Oligodendroglia, Prion Diseases, Mice
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